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Inhibitory effect of ionized free intracellular calcium enhanced by ruthenium red and m-chloro-carbonylcyanide phenyl hydrazon on the evoked release of acetylcholine.

Abstract：

:In order to understand the relationship between the free ionized calcium concentration in the axon terminals and the transmitter release we have investigated the effect of ruthenium red (RuR) and m-chloro-carbonylcyanide phenyl hydrazon (CCCP), mitochondrial uncoupler agents on the liberation of acetylcholine from myenteric plexus of guinea-pig ileum. Both compounds are able to enhance intracellular free Ca2+. In the presence of RuR and CCCP the spontaneous release of radioactivity from isolated myenteric-plexus preparation, previously loaded with (methyl-3H)-choline chloride was significantly enhanced while that evoked by electrical stimulation was decreased. Atropine did not affect the electrically evoked release in the presence of CCCP, indicating that in the effect of CCCP the presynaptic muscarinic receptors mediated negative feedback modulation does not play any role. Our findings are consistent with the hypothesis that the enhanced level of intracellular free Ca2+ enhances the spontaneous while depresses the electrically evoked release of transmitter.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Bernath S,Vizi ES

doi

10.1016/0006-2952(87)90020-7

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

3683-7

issue

21

eissn

0006-2952

issn

1873-2968

pii

0006-2952(87)90020-7

journal_volume

36

pub_type

杂志文章

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