Abstract：
OPINION STATEMENT:To date, there are no approved and established pharmacologic treatment options for tauopathies, a very heterogenous group of neuropsychiatric diseases often leading to dementia and clinically diagnosed as atypical Parkinson syndromes. Among these so-called Parkinson plus syndromes are progressive supranuclear palsy (PSP), also referred to as Steele-Richardson-Olszewski syndrome; frontotemporal dementia (FTD); and corticobasal degeneration (CBD). Available treatment strategies are based mainly on small clinical trials, miscellaneous case reports, or small case-controlled studies. The results of these studies and conclusions about the efficacy of the medication used are often contradictory. Approved therapeutic agents for Alzheimer´s dementia, such as acetylcholinesterase inhibitors and memantine, have been used off-label to treat cognitive and behavioral symptoms in tauopathies, but the outcome has not been consistent. Therapeutic agents for the symptomatic treatment of Parkinson's disease (levodopa or dopamine agonists) are used for motor symptoms in tauopathies. For behavioral or psychopathological symptoms, treatment with antidepressants-especially selective serotonin reuptake inhibitors-could be helpful. Antipsychotics are often not well tolerated because of their adverse effects, which are pronounced in tauopathies; these drugs should be given very carefully because of an increased risk of cerebrovascular events. In addition to pharmacologic options, physical, occupational, or speech therapy can be applied to improve functional abilities. Each pharmacologic or nonpharmacologic intervention should be fitted to the specific symptoms of the individual patient, and decisions about the type and duration of treatment should be based on its efficacy for the individual and the patient's tolerance. Currently, no effective treatment is available that targets the cause of these diseases. Current research focuses on targeting tau protein pathology, including pathologic aggregation or phosphorylation; these approaches seem to be very promising.
journal_name
Curr Treat Options Neuroljournal_title
Current treatment options in neurologyauthors
Karakaya T,Fußer F,Prvulovic D,Hampel Hdoi
10.1007/s11940-012-0168-7subject
Has Abstractpub_date
2012-04-01 00:00:00pages
126-36issue
2eissn
1092-8480issn
1534-3138journal_volume
14pub_type
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0586-x
更新日期：2019-09-27 00:00:00
abstract：OPINION STATEMENT:Infantile spasms (IS) represent a major therapeutic challenge, as cessation of spasms and normalization of the electroencephalogram (elimination of hypsarrhythmia) are mandatory to prevent cognitive deterioration in previously healthy infants, or to preserve neurocognitive function among those neurolo...
journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-996-0030-x
更新日期：2004-09-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-001-0006-9
更新日期：2001-05-01 00:00:00
abstract：OPINION STATEMENT:Melanoma-associated retinopathy is a rare paraneoplastic disorder that is challenging to diagnose and even more difficult to treat. Because of the rarity of the disease, therapy is based on analysis of case series and case reports. Based on evidence from these reports, first-line therapy is cytoreduct...
journal_title：Current treatment options in neurology
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-999-0027-3
更新日期：1999-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Sleep-related movement disorders (SRMD) include several different motor activities during sleep. Few of them are well known and well classified, whereas others are minor motor disorders of sleep which are neither thoroughly characterized and classified nor have been extensively investigated to clarify...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-019-0543-8
更新日期：2019-01-19 00:00:00
abstract：:Hemifacial spasm (HFS) is a peripheral movement disorder caused by direct or indirect compression or distortion of the root exit zone of the seventh cranial nerve, which is most commonly compressed by an arterial loop, but also may be compressed by a tumor, cyst, or aneurysm. All patients with HFS should undergo magne...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-004-0009-4
更新日期：2004-05-01 00:00:00
abstract：:Respiratory complications account for the majority of deaths occurring in patients suffering from amyotrophic lateral sclerosis (ALS). Patients normally succumb to their illness within an average of 3 to 5 years from the time of diagnosis from complications such as hypoventilation, hypoxemia, hypercarbia, aspiration, ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-001-0048-z
更新日期：2001-03-01 00:00:00
abstract：:Neuromyelitis optica (NMO, Devic's syndrome) is characterized by concurrence of optic neuritis and transverse myelitis, typically associated with a lesion in the spinal cord extending over three or more vertebral segments. It is an inflammatory, demyelinating central nervous system disorder, and although it is most co...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-008-0007-z
更新日期：2008-01-01 00:00:00
abstract：:Arteriovenous malformations (AVM) are a leading cause of intracerebral hemorrhage, especially among the young. Because they pose a lifelong risk of serious bleeding, definitive treatment to obliterate the AVM should be pursued in the majority of patients. Microsurgical resection of a small AVM located in the superfici...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-002-0011-7
更新日期：2002-11-01 00:00:00
abstract：OPINION STATEMENT:Narcolepsy is a severe, incurable, neurological disorder that is treated by pharmacological management of its symptoms. The main symptoms are excessive daytime sleepiness (EDS) and cataplexy, although addition symptoms that may require treatment include sleep paralysis, hypnagogic hallucinations, and ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-015-0347-4
更新日期：2015-05-01 00:00:00
abstract：OPINION STATEMENT:The purpose of this review is to provide an overview of visual snow (VS) and provide information regarding current treatment options for VS. Visual snow (VS) is a rare disorder manifesting with a persistent visual phenomenon of seeing numerous tiny snow-like dots throughout the visual field, and it ca...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
doi：10.1007/s11940-017-0448-3
更新日期：2017-03-01 00:00:00
abstract：:The challenge for the neurologist in the treatment of Lyme neuroborreliosis is not in the treatment per se, but in the diagnosis. Neurological manifestations of Lyme disease can present in many forms, and diagnostic techniques which detect the spirochete directly; the culture or polymerase chain reaction of the spiroc...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
abstract：:The mainstay of treatment of amyotrophic lateral sclerosis (ALS) is management of symptoms. Health care providers involved in the care of ALS patients should be armed with the most current knowledge about symptomatic management of these patients so that an aggressive approach to controlling symptoms can be undertaken ...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-008-0009-x
更新日期：2008-03-01 00:00:00
abstract：:The treatment of complex partial seizure (CPS) begins with accurate diagnosis. Episodes of staring and unresponsiveness due to nonepileptic causes must be ruled out. Absence seizures (typical and atypical petit mal) must be considered because the treatment strategy and prognosis for these seizures are very different f...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-999-0023-7
更新日期：1999-09-01 00:00:00
abstract：:Vision disturbances following traumatic brain injury (TBI) include anomalies of accommodation, version, vergence (nonstrabismic, as well as strabismic), photosensitivity, visual field integrity, and ocular health. Traumatic brain injury patients with complex diplopia patterns, noncomitant strabismic anomalies, and adv...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-002-0027-z
更新日期：2002-07-01 00:00:00
abstract：OPINION STATEMENT:Neurofibromatosis type 1 (NF1) is a genetic multisystemic disorder involving the skin, the central and peripheral nervous systems, bones, and the cardiovascular and endocrine systems. This condition is caused by inherited or de novo mutations of the NF1 gene at the 17q11.2 chromosomal region, a gene t...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-015-0355-4
更新日期：2015-06-01 00:00:00
abstract：:Dystonia is a neurologic disorder that can occur at any age and often results in significant disability. The therapeutic application of botulinum toxin has revolutionized the treatment of this disorder, particularly for the adult-onset focal forms such as cervical dystonia and blepharospasm. The two available commerci...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/BF02938412
更新日期：2007-05-01 00:00:00
abstract：OPINION STATEMENT:Therapeutic hypothermia has proven neuroprotective effects in global cerebral ischemia. Indications for hypothermia induction include cardiac arrest and neonatal asphyxia. The two general methods of induced hypothermia are either surface cooling or endovascular cooling. Hypothermia should be induced a...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-012-0201-x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE OF REVIEW:People with epilepsy have an increased risk of mortality when compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related death in children and adults. The purpose of this review is to discuss SUDEP, with an emphasis on SUDEP risk factor...
journal_title：Current treatment options in neurology
pub_type： 杂志文章,评审
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更新日期：2019-02-13 00:00:00
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journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-009-0001-0
更新日期：2009-01-01 00:00:00
abstract：:Herpes simplex virus (HSV) infections are ubiquitous. Children are infected with HSV resulting in totally asymptomatic acquisition to life-threatening disease. Therapy of HSV diseases of children can be considered according to severity and time of acquisition. Neonatal herpes simplex virus infections take one of three...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-002-0040-2
更新日期：2002-05-01 00:00:00
abstract：OPINION STATEMENT:The problem of short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) management remains unsolved. Despite a myriad of therapeutic trials, no convincingly e...
journal_title：Current treatment options in neurology
pub_type： 杂志文章
doi：10.1007/s11940-012-0211-8
更新日期：2013-02-01 00:00:00
