Evidence-based review of therapeutic plasma exchange in neurological disorders.


:Several neurologic disorders have been treated with therapeutic plasma exchange (TPE). Case reports, case series, and clinical trials have published results regarding the outcomes in such patients. The data gathered have been used to formulate evidence-based guidelines, which can be used to guide therapy in patients with these neurological disorders. Adequately designed and powered randomized controlled trials have proven the efficacy of TPE in some disease entities, while other diseases are lacking such data. In the latter, decisions for the use of TPE must be made using the limited published data available. In this review, we discuss the published evidence regarding the use of TPE in neurological disorders, focusing on the most recent guidelines published by the American Society of Apheresis in 2010 and the American Academy of Neurology in 2011.


Semin Dial


Seminars in dialysis


Chhibber V,Weinstein R




Has Abstract


2012-03-01 00:00:00












  • Extracorporeal treatment for tricyclic antidepressant poisoning: recommendations from the EXTRIP Workgroup.

    abstract::The Extracorporeal Treatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatments (ECTR) in poisoning. Here, the workgroup presents its results for tricyclic antidepressants (TCAs). After an extensive literature search, using a predefined methodology, the subgr...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Yates C,Galvao T,Sowinski KM,Mardini K,Botnaru T,Gosselin S,Hoffman RS,Nolin TD,Lavergne V,Ghannoum M,EXTRIP workgroup.

    更新日期:2014-07-01 00:00:00

  • Obesity as a barrier to kidney transplantation: Time to eliminate the body weight bias?

    abstract::There is clear evidence that survival rates following transplantation far exceed those for remaining on dialysis, regardless of body size measured by body mass index (BMI). Studies over the past 15 years also suggest little to no difference in long-term outcomes, including graft survival and mortality, irrespective of...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: MacLaughlin HL,Campbell KL

    更新日期:2019-05-01 00:00:00

  • Should the target hemoglobin for patients with chronic kidney disease treated with erythropoietic replacement therapy be changed?

    abstract::Recombinant human erythropoietin (rHuEPO, epoetin) revolutionized the treatment of anemia in patients with chronic kidney disease (CKD) when it was approved for use in the United States in 1989. Among dialysis patients, the mean hemoglobin (Hb) in patients undergoing dialysis rose from 7-8 g/dl prior to 1989 to 11-12 ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Berns JS

    更新日期:2005-01-01 00:00:00

  • Hyperkalemia in hemodialysis patients.

    abstract::Hyperkalemia contributes significantly to high mortality among ESRD patients. Excess intake and inadequate removal are the most common etiologies in HD patients. Although dialysis is the definitive treatment, classical medical therapy must be employed as a temporizing measure to acutely lower serum potassium. Reducing...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pani A,Floris M,Rosner MH,Ronco C

    更新日期:2014-11-01 00:00:00

  • Vancomycin use in patients requiring hemodialysis: a literature review.

    abstract::Vancomycin, a glycopeptide antibiotic, has remained a popular antimicrobial agent throughout the past five decades, and is often included in empiric antibiotic regimens. With gram-positive coverage, it has found a niche in the treatment of methicillin-resistant Staphylococcus aureus. Although vancomycin has been in ex...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Pallotta KE,Manley HJ

    更新日期:2008-01-01 00:00:00

  • Cerebral ischemia during hemodialysis-finding the signal in the noise.

    abstract::Hemodialysis patients have multiple risk factors for small vessel cerebrovascular disease and cognitive dysfunction. Hemodialysis itself may cause clinically significant neurological injury through repetitive cerebral ischemia. However, supporting evidence to date consists of epidemiological associations, expert opini...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: MacEwen C,Watkinson P,Tarassenko L,Pugh C

    更新日期:2018-05-01 00:00:00

  • Blood pressure control in conventional hemodialysis.

    abstract::Hypertension among patients on hemodialysis is common, difficult to diagnose and often inadequately controlled. Although specific blood pressure (BP) targets in this particular population are not yet established, meta-analyses of randomized trials showed that deliberate BP-lowering with antihypertensive drugs improves...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Georgianos PI,Agarwal R

    更新日期:2018-11-01 00:00:00

  • The economic burden of geriatric ESRD.

    abstract::The elderly represent the fastest growing segment of incident patients entering end-stage renal disease (ESRD). Increasingly, social scientists and caregivers are faced with changing models of care, which will challenge traditional patterns of patient acceptance into costly medical therapies. This paper analyzes the o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Parker TF 3rd

    更新日期:2012-11-01 00:00:00

  • What the non-nephrologist needs to know about dialysis.

    abstract::The End-Stage Renal Disease (ESRD) program now serves approximately 675,000 individuals in the United States at a cost of $26.1 billion to the Medicare system. Given the size of this population, healthcare providers from all disciplines will deliver care to patients on dialysis. Mortality remains high among patients o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Foy M,Sperati CJ

    更新日期:2018-03-01 00:00:00

  • Adequacy and complication rates with 14- vs. 16-gauge automated needles in percutaneous renal biopsy of native kidneys.

    abstract::In performing percutaneous renal biopsy (PRB) of native kidneys, an increasing use of 16-gauge automated biopsy needles has been observed. We compare the adequacy and safety of PRBs in adults performed with a 14-gauge (n = 82) vs. 16-gauge (n = 55) automated needle using real-time ultrasound (US) from 1/2010 to 12/201...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Chunduri S,Whittier WL,Korbet SM

    更新日期:2015-03-01 00:00:00

  • Central vein hardware: cannot live with it, cannot live without it.

    abstract::Central vein catheters for dialysis have become an integral and unavoidable access modality for providing hemodialysis therapy despite all their major drawbacks. We report a clinical decision dilemma that every nephrologist will encounter while considering an ideal dialysis access for the steadily aging dialysis popul...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Vachharajani TJ,Moossavi S,Kaufman T,Rocco M

    更新日期:2009-09-01 00:00:00

  • Perioperative management of the hemodialysis patient.

    abstract::Dialysis-dependent chronic kidney disease (CKD) is an expanding problem for healthcare systems worldwide. The prevalence of end-stage renal disease (ESRD) has increased by 20% since 2000 and stands at 1699 per million people in the USA. ESRD is associated with an increased risk of cardiovascular comorbidity, increased...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Trainor D,Borthwick E,Ferguson A

    更新日期:2011-05-01 00:00:00

  • an Obituary for GFR as the main marker for kidney function?

    abstract::This publication comments on the recently published findings of a study by Eloot et al. (cJASN, 6: 1266-1273, 2011) that evaluated the correlation between several formulae for calculating estimated GFR (eGFR) and different low molecular weight uremic toxins; eGFRs were based on serum creatinine (SCrea), cystatin C (Cy...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Vanholder R,Eloot S,Schepers E,Neirynck N,Glorieux G,Massy Z

    更新日期:2012-01-01 00:00:00

  • Is there an established hemoglobin target range for patients undergoing chronic dialysis?

    abstract::Anemia is a common complication of advanced chronic kidney disease (CKD). Treatment with erythropoiesis-stimulating agents (ESAs) remains a common approach in managing anemia of CKD. The 2012 Kidney Disease Improving Global Outcomes Clinical Practice Guideline for Anemia in CKD suggests avoiding ESA therapy use to mai...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Shah HH,Fishbane S

    更新日期:2018-07-01 00:00:00

  • The medical-legal responsibilities of a dialysis unit medical director.

    abstract::The specialty of Nephrology, by virtue of its relationship with the dialysis procedure, is highly vulnerable to litigation. As is the case with all nephrologists, a dialysis unit medical director is not immune to medical malpractice suits, and can be held liable for any act of perceived or potential harm to any dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Vaqar S,Murray B,Panesar M

    更新日期:2014-09-01 00:00:00

  • Oral iron for patients receiving dialysis: what is the evidence?

    abstract::This review aims to summarize the available evidence of the effectiveness of oral iron in patients receiving dialysis. Four small randomized controlled trials (105 evaluated patients) compared oral iron supplements with placebo or no treatment; hemoglobin and ferritin levels did not differ significantly between groups...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审


    authors: Hodson EM,Craig JC

    更新日期:2014-01-01 00:00:00

  • Percutaneous and surgical insertion of peritoneal catheter in patients starting in chronic dialysis therapy: a comparative study.

    abstract::Percutaneous peritoneal catheter insertion can be performed by trained nephrologists. The objective of this study was to compare the outcome of peritoneal dialysis (PD) catheters percutaneous inserted with the traditional surgical technique. One hundred twenty-one PD catheters were placed in 121 stage-5 Chronic kidney...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Chula DC,Campos RP,de Alcântara MT,Riella MC,do Nascimento MM

    更新日期:2014-05-01 00:00:00

  • Transplantation in diabetic kidney failure patients: modalities, outcomes, and clinical management.

    abstract::Diabetes mellitus (DM) is a common and devastating disease, affecting up to 19.3 million Americans. It is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in the United States. Diabetic patients with ESRD have a high incidence of cardiovascular disease and death. For those kidney tr...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Luan FL,Samaniego M

    更新日期:2010-03-01 00:00:00

  • Is surgical salvage of arteriovenous grafts feasible after unsuccessful percutaneous mechanical thrombectomy?

    abstract::Treatment of thrombosed dialysis ateriovenous (AV) grafts in the radiology interventional suite requires percutaneous mechanical thrombectomy, along with angioplasty of the underlying stenotic lesion. We analyzed the anatomic reasons for unsuccessful percutaneous thrombectomy of AV grafts, and assessed the feasibility...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Maya ID,Smith T,Young CJ,Allon M

    更新日期:2008-03-01 00:00:00

  • Clinical features of patients undergoing hemodialysis with COVID-19.

    abstract::Hemodialysis patients are susceptible to coronavirus disease 2019 (COVID-19). The aim of this study was to describe the epidemiological, clinical characteristics, and mortality-related risk factors for those who undergoing hemodialysis with COVID-19. We conducted a retrospective study. A total of 49 hemodialysis patie...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Tian M,Li H,Yan T,Dai Y,Dong L,Wei H,Song X,Dong J,Cheng F,Li W

    更新日期:2020-10-29 00:00:00

  • Drug therapy for hypertension in hemodialysis patients.

    abstract::The majority of end-stage renal disease (ESRD) patients are hypertensive. Drug therapy for hypertension in hemodialysis (HD) patients includes all classes of antihypertensive drugs, with the sole exception of diuretics. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers may decrease mo...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Hörl MP,Hörl WH

    更新日期:2004-07-01 00:00:00

  • Highlights and hotspots of protein glycation in end-stage renal disease.

    abstract::Analysis of tissues, plasma, urine, other body fluids, and dialysate for glycation adducts has revealed the presence of two major forms: glycation adduct residues of proteins and related glycated amino acids--called glycation free adducts. The major effect on protein glycation in uremia is loss of clearance of glycati...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Thornalley PJ,Rabbani N

    更新日期:2009-07-01 00:00:00

  • A case of uremia-associated pleural effusion in a peritoneal dialysis patient.

    abstract::The development of pleural effusions in ESRD patients is a relatively common occurrence. Uremia, currently a rare cause of effusion, can lead to the development of hemorrhagic pleural fluid collections in patients who are underdialyzed. Uremic pleural effusions should be considered when common etiologies of effusions ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Krishnan M,Choi M

    更新日期:2001-05-01 00:00:00

  • Past, present, and future of quantified peritoneal dialysis.

    abstract::The role of peritoneal dialysis (PD) as a modality in renal replacement therapy has been well established. In this article we review various aspects in the evolution of PD, with special emphasis on adequacy. Until the late 1950s PD was still considered as a last resort in the treatment of terminal uremia. The introduc...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Haq NU,Nolph KD

    更新日期:2001-07-01 00:00:00

  • Intensive hemodialysis in the (nursing) home: the bright side of geriatric ESRD care?

    abstract::Elderly ESRD patients often lose functionality when they start dialysis, which may be due to a variety of clinical problems. We recently postulated that intensive (longer and/or more frequent) hemodialysis (HD) may be the ideal strategy to try to prevent these ESRD- and dialysis-related complications, including dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Cornelis T,Kotanko P,Goffin E,van der Sande FM,Kooman JP,Chan CT

    更新日期:2012-11-01 00:00:00

  • Conventional dialysis in the elderly: How lenient should our guidelines be?

    abstract::There has been a dramatic, worldwide expansion in life expectancy across the last century. This has resulted in a progressively more elderly and comorbid population. It is increasingly recognized that healthcare in this group needs to move to the concept of "adding life to years". Recognition and assessment of frailty...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Corbett RW,Brown EA

    更新日期:2018-11-01 00:00:00

  • APD in the elderly.

    abstract::Few elderly patients with end-stage renal disease (ESRD) are treated with peritoneal dialysis (PD). Among dialysis patients >or=65 years of age reported by the U.S. Renal Data System (USRDS), the percentage treated with chronic peritoneal dialysis (CPD) is lower than in any other age group. To evaluate the effectivene...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章


    authors: Kadambi P,Troidle L,Gorban-Brennan N,Kliger AS,Finkelstein FO

    更新日期:2002-11-01 00:00:00

  • Changing dialysate composition to optimize acid-base therapy.

    abstract::In response to rapid alkali delivery during hemodialysis, hydrogen ions (H+ ) are mobilized from body buffers and from stimulation of organic acid production in amounts sufficient to convert most of the delivered bicarbonate to CO2 and water. Release of H+ from nonbicarbonate buffers serves to back-titrate them to a m...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Sargent JA,Marano M,Marano S,Gennari FJ

    更新日期:2019-05-01 00:00:00

  • Dialysis cannot be dosed.

    abstract::Adequate dialysis is difficult to define because we have not identified the toxic solutes that contribute most to uremic illness. Dialysis prescriptions therefore cannot be adjusted to control the levels of these solutes. The current solution to this problem is to define an adequate dose of dialysis on the basis of fr...

    journal_title:Seminars in dialysis

    pub_type: 社论


    authors: Meyer TW,Sirich TL,Hostetter TH

    更新日期:2011-09-01 00:00:00

  • The impact of dialysis modality and membrane characteristics on intradialytic hypotension.

    abstract::The risk of intradialytic hypotension (IDH) is determined by various factors, among them dialysis modality and dialyzer membrane. We conducted a literature search in PubMed on November 1, 2016 and selected relevant randomized controlled and cross-over trials, and prospective and retrospective cohort studies published ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审


    authors: Patel S,Raimann JG,Kotanko P

    更新日期:2017-11-01 00:00:00