Controversies in timing of dialysis initiation and the role of race and demographics.

Abstract:

:Dialysis remains the predominant form of renal replacement therapy in the United States, but the optimal timing for the initiation of dialysis remains poorly defined. Not only clinical factors such as signs/symptoms of uremia, co-existing cardiovascular disease, and presence of diabetes but also key demographic characteristics including age, gender, race/ethnicity, and socioeconomics have all been considered as potential modifying factors in the decision for the timing of dialysis initiation. The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of chronic kidney disease (CKD) suggests that dialysis be initiated when signs/symptoms attributable to kidney failure such as serositis, acid-base or electrolyte abnormalities, pruritus, poorly controlled volume status or blood pressure, deteriorating nutritional status despite dietary intervention, or cognitive impairment are visible or noted. These signs/symptoms typically occur when the glomerular filtration rate (GFR) is in the range of 5-10 ml/minute/1.73 m(2) , although they may occur at higher levels of GFR. We review recent data on the timing of dialysis initiation, their implications for managing patients with late-stage CKD, and the important role of considering key demographics in making patient-centered decisions for the timing of dialysis initiation.

journal_name

Semin Dial

journal_title

Seminars in dialysis

authors

Streja E,Nicholas SB,Norris KC

doi

10.1111/sdi.12130

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

658-66

issue

6

eissn

0894-0959

issn

1525-139X

journal_volume

26

pub_type

杂志文章,评审
  • We Do Too Many Parathyroidectomies for Calciphylaxis.

    abstract::Calciphylaxis, a disorder of dermal arteriolar calcification with a distinct predilection for patients with advanced kidney disease, remains an enigmatic condition that challenges clinicians. Observations regarding positive associations between levels of circulating parathyroid hormone (PTH) and the risk of calciphyla...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12502

    authors: Nigwekar SU,Sprague SM

    更新日期:2016-07-01 00:00:00

  • Improving hemodialysis patient outcomes: a step-by-step approach.

    abstract::Hemodialysis patient outcomes are often suboptimal, with one-sixth of patients receiving an inadequate dialysis dose, one-fourth using catheters for vascular access, and more than one-half being malnourished. This review describes a four-step approach for improving dialysis patient outcomes. First, select an outcome t...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2002.00013.x

    authors: Sehgal AR

    更新日期:2002-01-01 00:00:00

  • Sympathetic nervous system function and dysfunction in chronic hemodialysis patients.

    abstract::Adequate sympathetic nervous system activation is essential for the compensatory mechanisms of blood pressure maintenance during the hemodialysis (HD) procedure. Chronic sympathetic nervous system overactivity, however, may lead to the development of hypertension and cardiovascular disease in HD patients. The present ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12093

    authors: Rubinger D,Backenroth R,Sapoznikov D

    更新日期:2013-05-01 00:00:00

  • Dietary phosphorus restriction in advanced chronic kidney disease: merits, challenges, and emerging strategies.

    abstract::Hyperphosphatemia is an independent risk factor for mortality in patients on maintenance dialysis. Since phosphorus clearance by standard three times-weekly dialysis is insufficient to balance ongoing dietary phosphorus intake, strategies to prevent absorption of dietary phosphorus are essential for attenuating increa...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2010.00750.x

    authors: Gutiérrez OM,Wolf M

    更新日期:2010-07-01 00:00:00

  • Sources of Mortality on Dialysis with an Emphasis on Microemboli.

    abstract::Patients on chronic hemodialysis have a shortened survival compared to the general population. There are multiple sources of morbidity and mortality unique to the dialysis population that account for this. Reasons include the effects of blood membrane interactions, intradialytic hypotension, myocardial stunning, exces...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12527

    authors: Stegmayr BG

    更新日期:2016-11-01 00:00:00

  • Evidence-based review of therapeutic plasma exchange in neurological disorders.

    abstract::Several neurologic disorders have been treated with therapeutic plasma exchange (TPE). Case reports, case series, and clinical trials have published results regarding the outcomes in such patients. The data gathered have been used to formulate evidence-based guidelines, which can be used to guide therapy in patients w...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2011.01023.x

    authors: Chhibber V,Weinstein R

    更新日期:2012-03-01 00:00:00

  • Comparison of peritoneal dialysis catheter insertion techniques by nephrologists: Surgical vs blind methods.

    abstract:BACKGROUND:The aim of the present study was to perform a comparative analysis of peritoneal dialysis catheter (PDC) insertion between blind and surgical methods by nephrologists. PATIENTS AND METHODS:The present study enrolled 249 peritoneal dialysis patients who received first-time PDC insertion. All PDC insertions w...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12904

    authors: Kang SH,Park JW,Cho KH,Do JY

    更新日期:2020-07-23 00:00:00

  • Ethical conflicts for physicians treating ESRD patients.

    abstract::Managing an end-stage renal disease (ESRD) patient is complex and presents many ethical challenges for the physician. Ownership of dialysis facilities has shifted over the past decade from largely nonprofit organizations to large companies whose shareholders are primarily interested in the profitability of their inves...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139x.2004.17102.x

    authors: Bennett WM

    更新日期:2004-01-01 00:00:00

  • Assessment of nutritional status in maintenance hemodialysis patients: A multicenter cross-sectional study in Iran.

    abstract:INTRODUCTION:Protein-energy wasting (PEW) is common in hemodialysis patients and is linked with a high rate of morbidity and mortality. Regarding importance of nutrition in these patients, a recent study was administered to evaluate the nutritional status of hemodialysis patients. MATERIALS:In this cross-sectional stu...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12917

    authors: Akhlaghi Z,Sharifipour F,Nematy M,Safarian M,Malekahmadi M,Barkhidarian B,Norouzy A

    更新日期:2020-10-14 00:00:00

  • Peritoneal dialysis in acute kidney injury: lessons learned and applied.

    abstract::Peritoneal dialysis (PD) is a simple, safe, gentle, and efficient renal replacement therapy (RRT) method. It is able to correct acute kidney injury (AKI)-induced metabolic, electrolytic, and acid-base disorders and volume overload both in and out the intensive care unit setting. Some PD modalities, such as high-volume...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2011.00868.x

    authors: Burdmann EA,Chakravarthi R

    更新日期:2011-03-01 00:00:00

  • Sonography of Arteriovenous Fistulas and Grafts.

    abstract::Arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) are the vascular accesses of choice for long-term hemodialysis. Strategies to establish and maintain functioning AVFs and AVGs are essential. In addition to clinical evaluation, ultrasound plays a critical role in the evaluation and maintenance of AVFs and ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12599

    authors: Pietryga JA,Little MD,Robbin ML

    更新日期:2017-07-01 00:00:00

  • We Use Heparin as the Anticoagulant for CRRT.

    abstract::Continuous Renal Replacement Therapy (CRRT) usually requires anticoagulation to prevent clotting of the extracorporeal circuit. Interruptions due to filter clotting significantly reduce total therapy time and CRRT efficacy. Although heparin has traditionally been the most common anticoagulant used for CRRT, increasing...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12503

    authors: Karakala N,Tolwani A

    更新日期:2016-07-01 00:00:00

  • APD in the developing world: is there a future?

    abstract::Automated peritoneal dialysis (APD) has experienced significant growth in highly developed nations in the last few years, while in developing countries with important social, educational, and financial constraints this treatment modality is, at best, trying to emerge. APD offers advantages that make it popular. Some o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1046/j.1525-139x.2002.00096.x

    authors: Correa-Rotter R

    更新日期:2002-11-01 00:00:00

  • Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity.

    abstract::Computed tomographic (CT) peritoneography has been widely used as reference standard to evaluate continuous ambulatory peritoneal dialysis-related complications. However, given the varying CT peritoneography approaches used across different institutions, there is no standard value for non-ionic iodinated contrast medi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12867

    authors: Bai J,Dong J,Shu J,Xu Y,Ding W,Chen J

    更新日期:2020-03-01 00:00:00

  • Treatment of nephrogenic systemic fibrosis: limited options but hope for the future.

    abstract::Nephrogenic systemic fibrosis has now been linked to gadolinium-based contrast exposure in those with compromised kidney function. When present, symptoms can be quite devastating for the patient including severe pain and immobility. Unfortunately there is a lack of a universally effective therapy at this time and the ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2007.00407.x

    authors: Linfert DR,Schell JO,Fine DM

    更新日期:2008-03-01 00:00:00

  • Impact of drugs on intradialytic hypotension: Antihypertensives and vasoconstrictors.

    abstract::Intradialytic hypotension (IDH) is a common complication of hemodialysis and is associated with numerous adverse outcomes including cardiovascular events, inadequate dialysis, loss of vascular access, and death. It is estimated that approximately 20%-30% of all dialysis sessions are affected by IDH. In seeking ways to...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12633

    authors: Chang TI

    更新日期:2017-11-01 00:00:00

  • Bullous skin lesions in a patient undergoing chronic hemodialysis.

    abstract::Porphyria cutanea tarda (PCT) is a vesiculobullous skin disorder characterized by a defect in heme biosynthesis. Reduced activity of the hepatic enzyme uroporphyrinogen decarboxylase (URO-D) results in accumulation of photosensitive porphyrins; this ultimately leads to the skin fragility and blistering that is charact...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/j.1525-139X.2009.00672.x

    authors: Ryali ME,Whittier WL

    更新日期:2010-01-01 00:00:00

  • The economic burden of geriatric ESRD.

    abstract::The elderly represent the fastest growing segment of incident patients entering end-stage renal disease (ESRD). Increasingly, social scientists and caregivers are faced with changing models of care, which will challenge traditional patterns of patient acceptance into costly medical therapies. This paper analyzes the o...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12015

    authors: Parker TF 3rd

    更新日期:2012-11-01 00:00:00

  • How do calcimimetics fit into the management of parathyroid hormone, calcium, and phosphate disturbances in dialysis patients?

    abstract::As suggested by its American brand name (Sensipar), the calcimimetic cinacalcet sensitizes the parathyroid cells to the extracellular calcium signal, suppressing parathyroid hormone (PTH) release and synthesis and preventing parathyroid cell proliferation. This primary PTH suppression decreases the release of calcium ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2005.18318.x

    authors: Shahapuni I,Mansour J,Harbouche L,Maouad B,Benyahia M,Rahmouni K,Oprisiu R,Bonne JF,Monge M,El Esper N,Presne C,Moriniere P,Choukroun G,Fournier A

    更新日期:2005-05-01 00:00:00

  • How I do it: endovascular treatment of arteriovenous graft pseudoaneurysms-watch out for the mouth.

    abstract::We present a case of arteriovenous graft pseudoaneurysms treated endovascularly with stent grafts and make suggestions regarding the technique of evaluating the pseudoaneurysms and choosing the proper location to deploy the stent grafts to maximize the outcomes and minimize the length of the graft covered by the stent...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12142

    authors: Florescu MC,Fillaus JA,Plumb TJ

    更新日期:2014-03-01 00:00:00

  • Management of hyperkalemia in dialysis patients.

    abstract::Hyperkalemia is common in patients with end-stage renal disease, and may result in serious electrocardiographic abnormalities. Dialysis is the definitive treatment of hyperkalemia in these patients. Intravenous calcium is used to stabilize the myocardium. Intravenous insulin and nebulized albuterol lower serum potassi...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/j.1525-139X.2007.00312.x

    authors: Putcha N,Allon M

    更新日期:2007-09-01 00:00:00

  • Endotoxemia in end-stage kidney disease.

    abstract::Chronic unexplained inflammation remains a prevalent and clinically significant problem for patients with end-stage kidney disease (ESKD), especially in the dialysis population. The causes of persistent inflammation are likely to be multifactorial, but the underlying mechanisms remain to be elucidated. Endotoxins are ...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1111/sdi.12280

    authors: Wong J,Vilar E,Farrington K

    更新日期:2015-01-01 00:00:00

  • The effect of chronic renal failure on hepatic drug metabolism and drug disposition.

    abstract::There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2003.03011.x

    authors: Dreisbach AW,Lertora JJ

    更新日期:2003-01-01 00:00:00

  • Inadequate treatment of congestive heart failure in dialysis patients.

    abstract::Congestive heart failure (CHF) is highly prevalent in patients on renal replacement therapy and is a leading cause of death in such patients. Several studies suggest that therapeutic agents for the treatment of CHF, particularly angiotensin converting enzyme inhibitors and beta-blockers, are underused in end-stage ren...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2007.00313.x

    authors: Bouchard J,Madore F

    更新日期:2007-09-01 00:00:00

  • Dialysate leaks in peritoneal dialysis.

    abstract::Dialysate leakage represents a major noninfectious complication of peritoneal dialysis (PD). An exit-site leak refers to the appearance of any moisture around the PD catheter identified as dialysate; however, the spectrum of dialysate leaks also includes any dialysate loss from the peritoneal cavity other than via the...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-139x.2001.00014.x

    authors: Leblanc M,Ouimet D,Pichette V

    更新日期:2001-01-01 00:00:00

  • When should iron supplementation in dialysis patients be avoided, minimized or withdrawn?

    abstract::Parenteral iron is used to restore the body's iron pool before and during erythropoiesis-stimulating agent (ESA) therapy; together these agents form the backbone of anemia management in end-stage renal disease (ESRD) patients undergoing hemodialysis. ESRD patients receiving chronic intravenous iron products, which exc...

    journal_title:Seminars in dialysis

    pub_type: 社论,评审

    doi:10.1111/sdi.12732

    authors: Rostoker G

    更新日期:2019-01-01 00:00:00

  • Dialysis access failure: an indication for immediate kidney transplantation.

    abstract::In the United States, presently there are more than 50,000 patients with end-stage renal disease (ESRD) awaiting a cadaveric kidney and each year less than a quarter receive kidney transplantation. Although the real incidence in unknown, a significant number of these patients die due to lack of dialysis access. While ...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1046/j.1525-139x.2002.00001.x

    authors: Laskow DA,Ahsan N

    更新日期:2002-01-01 00:00:00

  • an Obituary for GFR as the main marker for kidney function?

    abstract::This publication comments on the recently published findings of a study by Eloot et al. (cJASN, 6: 1266-1273, 2011) that evaluated the correlation between several formulae for calculating estimated GFR (eGFR) and different low molecular weight uremic toxins; eGFRs were based on serum creatinine (SCrea), cystatin C (Cy...

    journal_title:Seminars in dialysis

    pub_type: 社论

    doi:10.1111/j.1525-139X.2011.01003.x

    authors: Vanholder R,Eloot S,Schepers E,Neirynck N,Glorieux G,Massy Z

    更新日期:2012-01-01 00:00:00

  • Intensive hemodialysis in the (nursing) home: the bright side of geriatric ESRD care?

    abstract::Elderly ESRD patients often lose functionality when they start dialysis, which may be due to a variety of clinical problems. We recently postulated that intensive (longer and/or more frequent) hemodialysis (HD) may be the ideal strategy to try to prevent these ESRD- and dialysis-related complications, including dialys...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章

    doi:10.1111/sdi.12011

    authors: Cornelis T,Kotanko P,Goffin E,van der Sande FM,Kooman JP,Chan CT

    更新日期:2012-11-01 00:00:00

  • Stenosis surveillance of hemodialysis grafts by duplex ultrasound reduces hospitalizations and cost of care.

    abstract::Most recent randomized controlled trials (RCTs) have found that hemodialysis graft surveillance combined with preemptive correction of stenosis does not prolong graft survival. Nevertheless, such programs may be justified if they reduce other adverse outcomes or decrease the cost of care. This study tested this hypoth...

    journal_title:Seminars in dialysis

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1525-139X.2005.00102.x

    authors: Dossabhoy NR,Ram SJ,Nassar R,Work J,Eason JM,Paulson WD

    更新日期:2005-11-01 00:00:00