Platelet dysfunction and end-stage renal disease.

abstract：:There is abundant evidence that chronic renal failure (CRF) and end-stage renal disease (ESRD) alter drug disposition by affecting protein and tissue binding and reducing systemic clearance of renally cleared drugs. What is not fully appreciated is that CRF can significantly reduce nonrenal clearance and alter the bio...

journal_title：Seminars in dialysis

authors： Dreisbach AW,Lertora JJ

更新日期：2003-01-01 00:00:00

abstract：:Determining dry weight and assessing extracellular fluid volume in hemodialysis (HD) patients is one of the greatest challenges to practicing nephrologists. The clinical examination has limited accuracy, so different strategies have been investigated to aid in this evaluation. Biochemical markers of volume overload (A...

journal_title：Seminars in dialysis

authors： Ishibe S,Peixoto AJ

更新日期：2004-01-01 00:00:00

abstract：:Bacteremia is a common infectious complication in hemodialysis patients. Metastatic sites of infection including infective endocarditis, vertebral osteomyelitis, spinal epidural abscess, and septic arthritis occur relatively frequently. These complications are associated with increased morbidity and mortality in hemod...

journal_title：Seminars in dialysis

authors： Lewis SS,Sexton DJ

更新日期：2013-01-01 00:00:00

abstract：:In patients receiving hemodialysis, the provision of safe and effective vascular access using an arteriovenous fistula or graft is regarded as a critical priority by patients and health professionals. Vascular access failure is associated with morbidity and mortality, such that strategies to prevent these outcomes are...

journal_title：Seminars in dialysis

authors： Viecelli AK,Mori TA,Roy-Chaudhury P,Polkinghorne KR,Hawley CM,Johnson DW,Pascoe EM,Irish AB

更新日期：2018-05-01 00:00:00

abstract：:We describe the use of directional atherectomy (DA) to restore patency of a thrombosed polytetrafluoroethylene arteriovenous graft with an in-stent restenosis at the venous anastomosis. Technically, the procedure described is not an atherectomy per se, but rather the removal of fibrosis and intimal hyperplasia with sh...

journal_title：Seminars in dialysis

authors： Yevzlin AS,Guttormsen B,Chan MR,Gimelli G

更新日期：2008-05-01 00:00:00

abstract：:Over 60% of patients initiating chronic hemodialysis in the United States have a chronic central venous catheter (CVC) as their first blood access device. Although it would be better if these patients started dialysis with fistulas, the CVC is used because it is a reliable and relatively safe method for obtaining bloo...

journal_title：Seminars in dialysis

authors： Ash SR

更新日期：2007-05-01 00:00:00

abstract：:Almost 30% of prevalent hemodialysis patients use catheters for vascular access although outcomes are superior with the use of either an arteriovenous fistula or a synthetic graft. Catheter complications are a major cause of morbidity and mortality for hemodialysis patients and increase the burden on the health care s...

journal_title：Seminars in dialysis

authors： Dwyer A

更新日期：2008-11-01 00:00:00

abstract：:In healthy individuals, vitamin D produced in the skin or derived from nutritional sources is converted to 25-hydroxyvitamin D (25[OH]D) in the liver, and then 1,25-dihydroxyvitamin D (1,25[OH](2)D) by 1 alpha-hydroxylase in the kidney. Chronic kidney disease (CKD) is accompanied by a progressive decline in the abilit...

journal_title：Seminars in dialysis

authors： Bhan I,Hewison M,Thadhani R

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Protein-energy wasting (PEW) is common in hemodialysis patients and is linked with a high rate of morbidity and mortality. Regarding importance of nutrition in these patients, a recent study was administered to evaluate the nutritional status of hemodialysis patients. MATERIALS:In this cross-sectional stu...

journal_title：Seminars in dialysis

authors： Akhlaghi Z,Sharifipour F,Nematy M,Safarian M,Malekahmadi M,Barkhidarian B,Norouzy A

更新日期：2020-10-14 00:00:00

abstract：:Until the discovery of calcimimetics, the management of secondary hyperparathyroidism (SHPT) relied exclusively on treatment with phosphate binders, vitamin D derivatives or surgical parathyroidectomy with limited success. The therapeutic use of calcimimetic agents, together with a better understanding of the pivotal ...

journal_title：Seminars in dialysis

authors： Rodríguez M,Goodman WG,Liakopoulos V,Messa P,Wiecek A,Cunningham J

更新日期：2015-09-01 00:00:00

abstract：:Adequate sympathetic nervous system activation is essential for the compensatory mechanisms of blood pressure maintenance during the hemodialysis (HD) procedure. Chronic sympathetic nervous system overactivity, however, may lead to the development of hypertension and cardiovascular disease in HD patients. The present ...

journal_title：Seminars in dialysis

authors： Rubinger D,Backenroth R,Sapoznikov D

更新日期：2013-05-01 00:00:00

abstract：:Catheter malfunction due to poor flow is a common problem. When it occurs early, the cause is generally technical. Late occurrences are most often related to thrombus formation. Several types of thrombus may be seen, differing by location and supposed mechanism of formation. The most common offender, however, is the f...

journal_title：Seminars in dialysis

authors： Beathard GA

更新日期：2001-11-01 00:00:00

abstract：:Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been establi...

journal_title：Seminars in dialysis

authors： Hoye NA,Wilson LC,Jardine DL,Walker RJ

更新日期：2019-05-01 00:00:00

abstract：:Hypermagnesemia is an uncommon electrolyte abnormality, due to the fact that magnesium toxicity is only seen in the setting of a massive exposure to exogenous magnesium, often in the setting of renal insufficiency. Here, we report a case of severe hypermagnesemia that resulted in complete paralysis that was secondary ...

journal_title：Seminars in dialysis

authors： Bansal AD,Negoianu D,Warburton KM

更新日期：2016-05-01 00:00:00

abstract：:This publication comments on the recently published findings of a study by Eloot et al. (cJASN, 6: 1266-1273, 2011) that evaluated the correlation between several formulae for calculating estimated GFR (eGFR) and different low molecular weight uremic toxins; eGFRs were based on serum creatinine (SCrea), cystatin C (Cy...

journal_title：Seminars in dialysis

authors： Vanholder R,Eloot S,Schepers E,Neirynck N,Glorieux G,Massy Z

更新日期：2012-01-01 00:00:00

abstract：:Depression has been documented as the most frequently encountered psychological problem in end-stage renal disease (ESRD) patients and has been correlated with both mortality and morbidity in these patients. Previous work by our group has shown that clinical depression is treatable with psychotropic medications in the...

journal_title：Seminars in dialysis

authors： Wuerth D,Finkelstein SH,Kliger AS,Finkelstein FO

更新日期：2003-11-01 00:00:00

abstract：:This report reviews the most common surgical interventions and complications of chronic peritoneal dialysis (PD) patients. Based on the current knowledge as well as our experience we detail the role of these surgical procedures. We supplement the reported knowledge in the field with our own experience in this area. Th...

journal_title：Seminars in dialysis

authors： Ratajczak A,Lange-Ratajczak M,Bobkiewicz A,Studniarek A

更新日期：2017-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular ...

journal_title：Seminars in dialysis

authors： Henson JB,Sise ME

更新日期：2019-03-01 00:00:00

abstract：:Measurements of the concentration of parathyroid hormone (PTH) in serum or plasma are used widely for the initial diagnostic assessment of patients with renal bone disease, to monitor disease progression, and to gauge responses to treatment. Several analytical methods are used to measure plasma PTH levels, and a varie...

journal_title：Seminars in dialysis

authors： Goodman WG

更新日期：2007-01-01 00:00:00

abstract：:Hyperphosphatemia is an independent risk factor for mortality in patients on maintenance dialysis. Since phosphorus clearance by standard three times-weekly dialysis is insufficient to balance ongoing dietary phosphorus intake, strategies to prevent absorption of dietary phosphorus are essential for attenuating increa...

journal_title：Seminars in dialysis

authors： Gutiérrez OM,Wolf M

更新日期：2010-07-01 00:00:00

abstract：:Hyperkalemia is common in patients with end-stage renal disease, and may result in serious electrocardiographic abnormalities. Dialysis is the definitive treatment of hyperkalemia in these patients. Intravenous calcium is used to stabilize the myocardium. Intravenous insulin and nebulized albuterol lower serum potassi...

journal_title：Seminars in dialysis

authors： Putcha N,Allon M

更新日期：2007-09-01 00:00:00

abstract：:The role of peritoneal dialysis (PD) as a modality in renal replacement therapy has been well established. In this article we review various aspects in the evolution of PD, with special emphasis on adequacy. Until the late 1950s PD was still considered as a last resort in the treatment of terminal uremia. The introduc...

journal_title：Seminars in dialysis

authors： Haq NU,Nolph KD

更新日期：2001-07-01 00:00:00

abstract：:Elderly ESRD patients often lose functionality when they start dialysis, which may be due to a variety of clinical problems. We recently postulated that intensive (longer and/or more frequent) hemodialysis (HD) may be the ideal strategy to try to prevent these ESRD- and dialysis-related complications, including dialys...

journal_title：Seminars in dialysis

authors： Cornelis T,Kotanko P,Goffin E,van der Sande FM,Kooman JP,Chan CT

更新日期：2012-11-01 00:00:00

abstract：:Caring for patients with end-stage kidney disease (ESKD) in the United States is challenging, due in part to the complex epidemiology of the disease's progression as well as the ways in which care is delivered. As CKD progresses toward ESKD, the number of comorbidities increases and care involves multiple healthcare p...

journal_title：Seminars in dialysis

authors： Sloan CE,Zhong J,Mohottige D,Hall R,Diamantidis CJ,Boulware LE,Wang V

更新日期：2020-11-01 00:00:00

abstract：:The majority of end-stage renal disease (ESRD) patients are hypertensive. Drug therapy for hypertension in hemodialysis (HD) patients includes all classes of antihypertensive drugs, with the sole exception of diuretics. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers may decrease mo...

journal_title：Seminars in dialysis

authors： Hörl MP,Hörl WH

更新日期：2004-07-01 00:00:00

abstract：:The term "reverse epidemiology" is used to indicate that such surrogates of cardiovascular risk and metabolic syndrome as obesity, hypercholesterolemia and hypertension are paradoxically associated with greater survival in individuals with chronic disease states and wasting, including dialysis patients, in whom the sh...

journal_title：Seminars in dialysis

authors： Kalantar-Zadeh K

更新日期：2007-11-01 00:00:00

abstract：:Home hemodialysis is not a new therapy; rather it is a therapy in which interest has been rekindled due to both the continually growing end-stage renal disease population and concern about poor outcomes in patients on conventional thrice-weekly in-center dialysis. The practical issues to be considered when starting a ...

journal_title：Seminars in dialysis

authors： Moran J,Kraus M

更新日期：2007-01-01 00:00:00

abstract：:The increased frequency of cardiovascular disease observed in hemodialysis patients is secondary to the combination of many traditional (age, male sex, hypertension, smoking, diabetes mellitus, and dyslipidemia) and novel and uremia-related (inflammation, uremic toxins, adipokine imbalance, coagulation disorders, prot...

journal_title：Seminars in dialysis

authors： Bossola M,Tazza L

更新日期：2015-05-01 00:00:00

abstract：:Cardiovascular complications are the leading cause of mortality in patients with end-stage renal disease (ESRD). The excess cardiovascular risk and mortality is already demonstrable in early renal disease and in patients with chronic renal failure (CRF), with the highest relative risk of mortality in the youngest pati...

journal_title：Seminars in dialysis

authors： London GM

更新日期：2003-03-01 00:00:00

abstract：:Iodinated contrast agents are well tolerated in ESRD patients. Certain types of ICM, i.e., LOCM and the nonionic agents are associated with better safety profiles. Current available evidence, although not optimal, does not support the need for additional hemodialysis for ICM removal to preserve residual renal function...

journal_title：Seminars in dialysis

authors： Khan SF,Kalantari K

更新日期：2014-11-01 00:00:00