Abstract:
:Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
journal_name
Emerg Infect Disjournal_title
Emerging infectious diseasesauthors
Ladhani SN,Lucidarme J,Newbold LS,Gray SJ,Carr AD,Findlow J,Ramsay ME,Kaczmarski EB,Borrow Rdoi
10.3201/eid1801.110901subject
Has Abstractpub_date
2012-01-01 00:00:00pages
63-70issue
1eissn
1080-6040issn
1080-6059journal_volume
18pub_type
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