当前位置： SCI文献检索 > CLINICAL HEMORHEOLOGY AND MICROCIRCULATION期刊下所有文献 > Association between hemorheological alterations and metabolic syndrome.

Association between hemorheological alterations and metabolic syndrome.

Abstract：

:The contribution of hemorheological alterations in the prothrombotic condition in patients with metabolic syndrome (MS) remains a question of debate. We aimed to determine the association between MS and hemorheological parameters by means of a case-control study in 61 MS patients and 89 controls without MS. We determined blood viscosity at 230 s(-1) (Brookfield DVIII viscosimeter); plasma viscosity (Fresenius capillary plasma viscosimeter); erythrocyte aggregation at stasis and 3 s(-1) (MA-1 erythrocyte aggregometer); erythrocyte deformability (Rheodyn SSD at shear stresses of 12, 30 and 60 Pascals) and fibrinogen, along with anthropometric, lipidic and inflammatory parameters. MS patients showed increased blood viscosity (p = 0.018), plasma viscosity (p < 0.001), fibrinogen (p < 0.001), erythrocyte aggregation (p < 0.001), and decreased erythrocyte deformability (p = 0.033). In the multivariate regression analysis, fibrinogen and triglycerides predicted plasma viscosity and erythrocyte aggregability, whereas erythrocyte deformability was associated with alterations in the hydrocarbonate metabolism. Blood viscosity related to abdominal obesity. The logistic regression analysis revealed that of all the MS components, only hypertriglyceridemia independently predicts plasma hyperviscosity (OR 3.75 CI 1.44-9.77 p = 0.007) and erythrocyte hyperaggregability (OR 2.41 CI 1.00-5.80 p = 0.050). Erythrocyte hyperaggregability (EA > 8.23) and hyperfibrinogenemia (fibrinogen > 358 mg/dL) were independent predictors of MS: OR 3.34, 95% CI 1.40-7.93, p = 0.006 and OR 2.42 95% CI 1.04-5.66, p = 0.041, respectively. We conclude that MS is associated with an altered hemorheological profile related to inflammatory, lipidic and glucose intolerance parameters which could favor the development of thrombo-embolic and athero-thrombotic events in MS patients.

journal_name

Clin Hemorheol Microcirc

journal_title

Clinical hemorheology and microcirculation

authors

Vayá A,Hernández-Mijares A,Bonet E,Sendra R,Solá E,Pérez R,Corella D,Laiz B

doi

10.3233/CH-2011-1499

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

493-503

issue

1-4

eissn

1386-0291

issn

1875-8622

pii

H17428G7234N401M

journal_volume

pub_type

杂志文章

在线工具

Association between hemorheological alterations and metabolic syndrome.