Abstract:
:This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs) by means of inhalation in people living in the vicinity of the largest chemical production site in the Mediterranean area. Eighty-six VOCs were initially selected for this study based on their adverse environmental and health effects. The monitoring campaign was conducted for 276 days in three different locations around the chemical site. The analytical method used for the characterisation was based on European standard method EN-14662-2, which consists of the active sampling of air for 24h in charcoal tubes, followed by extraction with carbon disulphide and GC-MS analysis. Forty-four VOCs with toxicological data available concerning their carcinogenic and non-carcinogenic health effects were quantified during the monitoring campaign. None of the quantified VOCs showed average concentrations exceeding their chronic reference concentrations and, therefore, no non-carcinogenic health effects are expected as a result of this exposure. However, the global average cancer risk due to VOC exposure in the area (3.3×10(-4)) was found to be above the values recommended by the WHO and USEPA. The influence of the analytical method was also evaluated by comparing cancer risk estimates using a thermal desorption (TD) method based on method EN-14662-1. The results of the 24-h samples for the solvent extraction method were compared with the average of 12 daily samples of 2-h for the TD method for 24 sampling days. Although the global estimated lifetime cancer risk was statistically comparable for both methods, some differences were found in individual VOC risks. To our knowledge, this is the first study that estimates the carcinogenic and non-carcinogenic risks posed by the inhalation of VOCs in people living near a chemical site of this size, and compares the estimated cancer risk obtained using two different standard analytical methods.
journal_name
Environ Intjournal_title
Environment internationalauthors
Ramírez N,Cuadras A,Rovira E,Borrull F,Marcé RMdoi
10.1016/j.envint.2011.11.002subject
Has Abstractpub_date
2012-02-01 00:00:00pages
200-9issue
1eissn
0160-4120issn
1873-6750pii
S0160-4120(11)00259-5journal_volume
39pub_type
杂志文章abstract::The mechanisms involved in thyroid homeostasis are complex, and perfluoroalkyl substances (PFASs) have been indicated to interfere at several levels in this endocrine system. Disruption of the maternal thyroid homeostasis during early pregnancy is of particular concern, where subclinical changes in maternal thyroid ho...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.01.007
更新日期:2015-04-01 00:00:00
abstract::The presence anti-infectives in environmental waters is of interest because of their potential role in the dissemination of anti-infective resistance in bacteria and other harmful effects on non-target species such as algae and shellfish. Since no information on global trends regarding the contamination caused by thes...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.04.001
更新日期:2015-07-01 00:00:00
abstract::It was recently hypothesized that pets may serve as sentinels to explore human exposure to organohalogenated chemicals (OHCs) via indoor environments and adverse health effects. The current study investigates OHCs contamination in domestic cats suffering from diabetes mellitus (DM), particularly DM induced by acromega...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.04.004
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications for pregnancy outcomes. OBJECTIVE:We aimed to investigate main effe...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.01.042
更新日期:2019-04-01 00:00:00
abstract::In Nantes, low-cost sensors were installed in the city center and deployed on driving school cars, ambulances and service vehicles to measure PM10 concentrations. This work aims to use the large amount of observations provided by the sensors for air quality mapping at the urban scale in order to show the potential add...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105965
更新日期:2020-10-01 00:00:00
abstract::This study provides information on the current status of contamination by organochlorines (DDTs, PCBs, PCDDs and PCDFs) in the declining red kite (Milvus milvus L.) population breeding in the Doñana National Park (DNP), south-western Spain. Analyses were performed in addled eggs collected between 1999 and 2001. DDE co...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2007.07.002
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Animal experiments indicate that prenatal exposure to mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) can induce fetal neural tube defects (NTDs). The objectives of this study were to determine the levels of maternal exposure to Hg, Pb, Cd and As during early pregnancy in rural areas of Shanxi Provinc...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.01.016
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Telomere length (TL) is considered as a surrogate of biological aging and has been related to aging-related diseases. The initial setting of newborn TL has important implications for telomere dynamics in adulthood, and is affected by the intrauterine environment. However, the effects of prenatal air pollutio...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.04.064
更新日期:2019-07-01 00:00:00
abstract::Japanese encephalitis (JE) is the most common cause of viral encephalitis and an important public health concern in the Asia-Pacific region, particularly in China where 50% of global cases are notified. To explore the association between environmental factors and human JE cases and identify the high risk areas for JE ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.004
更新日期:2014-12-01 00:00:00
abstract::There is an increased awareness that medicinal products for human use may cause negative effects in the environment. In Sweden a voluntary environmental classification system for drugs has been established in collaboration between producers, authorities and the public health care, and used for five years. The idea is ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2008.12.008
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Higher blood lead levels (BLLs) have been linked to neurologic deficits and impaired growth, but few studies have evaluated their association with timing of sexual maturity or pubertal progression in boys. METHODS:In a longitudinal cohort of Russian boys enrolled at age 8-9 and followed to adulthood, BLLs w...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.01.070
更新日期:2019-04-01 00:00:00
abstract::Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/DFs) have been unintentionally produced and emitted from the lifecycle of products containing brominated flame retardants, such as polybrominated diphenyl ether, which is suspected to cause developmental neurotoxicity (DNT). Although it is plausible that PBDD/DF...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105833
更新日期:2020-09-01 00:00:00
abstract::Although various pesticides were used globally, the pesticides profiles in human blood serum remain largely unknown. We determined pesticide exposure profiles using solid-phase extraction and gas chromatography tandem with triple quadrupole mass spectrometry in 200 human blood serum samples from the adult population i...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.03.004
更新日期:2017-05-01 00:00:00
abstract::Perfluorinated compounds (PFCs) form a diverse group of chemicals with surface-active properties manufactured for over 50 years. In recent years, a number of studies have reported the ubiquitous distribution of PFCs in human tissues and wildlife. Although the relative importance of the routes of human exposure to thes...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2011.08.001
更新日期:2012-04-01 00:00:00
abstract::Ambient ultrafine particle number concentrations (PNC) have inhomogeneous spatio-temporal distributions and depend on a number of different urban factors, including background conditions and distant sources. This paper quantitatively compares exposure to ambient ultrafine particles at urban schools in two cities in de...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.12.029
更新日期:2016-03-01 00:00:00
abstract::Cumulative environmental impacts driven by anthropogenic stressors lead to disproportionate effects on indigenous communities that are reliant on land and water resources. Understanding and counteracting these effects requires knowledge from multiple sources. Yet the combined use of Traditional Knowledge (TK) and Scie...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.02.008
更新日期:2017-05-01 00:00:00
abstract::A risk assessment strategy considering the impact of chemicals on the whole ecosystem has been developed in order to create a sound and useful method for quantifying and comparing the global risk posed by the main different hazardous chemicals found in the environment. This index, called Environmental Risk Index for C...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2010.04.019
更新日期:2010-10-01 00:00:00
abstract::China has experienced a dramatic change in atmospheric reactive nitrogen (Nr) emissions over the past four decades. However, it remains unclear how nitrogen (N) deposition has responded to increases and/or decreases in Nr emissions. This study quantitatively assesses temporal and spatial variations in measurements of ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106022
更新日期:2020-11-01 00:00:00
abstract::Occupational medical surveillance is highly desirable in manufacturing facilities where exposure to chemicals is significant. The insecticide fipronil is generally considered safe for humans but with increasing use, exposure to fipronil is of concern. Identification of urinary metabolites of fipronil may allow develop...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.03.012
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Phenol exposure during pregnancy has been associated with preterm birth, but the potential effect of preconception exposure in either parent is unknown. There is a growing body of evidence to suggest that the preconception period is a critical window of vulnerability for adverse pregnancy outcomes. OBJECTIV...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105523
更新日期:2020-04-01 00:00:00
abstract::Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, availabl...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106293
更新日期:2021-01-01 00:00:00
abstract::The occurrence of nineteen mixed halogenated (bromo-chloro) dibenzo-p-dioxins, dibenzofurans (PXDD/Fs) and biphenyls (PXBs) in a range of foods (n>100) was investigated. The analytical methodology used dual activated carbon column fractionation with high resolution mass spectrometric measurement (13,500-15,000 res). O...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.007
更新日期:2014-12-01 00:00:00
abstract::Oil spills are serious environmental issues that potentially can cause adverse effects on marine ecosystems. In some marine areas, like the Baltic Sea, there is a large number of wrecks from the first half of the 20th century, and recent monitoring and field work have revealed release of oil from some of these wrecks....
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.02.037
更新日期:2019-05-01 00:00:00
abstract::The biochemical response of wild sticklebacks collected in Autumn 2005 at seven stations in the North of France was studied using a set of complementary biomarkers. Here, data on biotransformation of xenobiotics, oxidative stress exposure and damages, neurotoxicity and endocrine disruption are provided. All the sites ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2007.11.003
更新日期:2008-05-01 00:00:00
abstract::Global profiling of xenobiotics in human matrices in an untargeted mode is gaining attention for studying the environmental chemical space of the human exposome. Defined as the study of a comprehensive inclusion of environmental influences and associated biological responses, human exposome science is currently evolvi...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2016.11.026
更新日期:2017-03-01 00:00:00
abstract::Reduction of preterm births (<37 completed weeks of gestation) would substantially reduce neonatal and infant mortality, and deleterious health effects in survivors. Maternal fine particulate matter (PM2.5) exposure has been identified as a possible risk factor contributing to preterm birth. The aim of this study was ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.01.023
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Unstable weather, such as intra- and inter-day temperature variability, can impair the health and shorten the survival time of population around the world. Climate change will cause Earth's surface temperature rise, but has unclear effects on temperature variability, making it urgent to understand the charac...
journal_title:Environment international
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1016/j.envint.2017.09.012
更新日期:2017-12-01 00:00:00
abstract::In recent years, fuzzy-logic-based methods have demonstrated to be appropriated to address uncertainty and subjectivity in environmental problems. In the present study, a methodology based on fuzzy inference systems (FIS) to assess water quality is proposed. A water quality index calculated with fuzzy reasoning has be...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2006.03.009
更新日期:2006-08-01 00:00:00
abstract::Understanding cities comprehensively as systems is a costly challenge and is typically not feasible for policy makers. Nevertheless, focusing on some key systemic characteristics of cities can give useful insights for policy to advance health and well-being outcomes. Moreover, if we take a coevolutionary systems view ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.04.014
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to pr...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.11.007
更新日期:2017-01-01 00:00:00