Modulating pain in the periphery: gene-based therapies to enhance peripheral opioid analgesia: Bonica lecture, ASRA 2010.

abstract：BACKGROUND AND OBJECTIVES:The typical blind insertion of a catheter into the epidural space risks catheter misplacement into the intrathecal space. The epidural stimulation test is designed to confirm the correct epidural location of a catheter but may also detect unintended intrathecal catheter placement by evaluating...

journal_title：Regional anesthesia and pain medicine

authors： Sutherland MA,Viscomi CM,Dominick TS,Anderson EL

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mexiletine is an oral sodium channel antagonist that has been reported to be effective in a variety of neuropathic pain syndromes. However, recent reports question the efficacy of oral mexiletine in neuropathic pain. The objectives of this study were to examine the effect of oral mexiletine on...

journal_title：Regional anesthesia and pain medicine

authors： Wallace MS,Magnuson S,Ridgeway B

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This study aimed to describe and assess the accuracy and feasibility of a novel technique for ultrasound-guided maxillary nerve block using the lateral pterygoid plate (LPP) approach via the pterygopalatine fossa (PPF) in a soft cadaveric model. METHODS:Ten soft cadavers were studied. The cur...

journal_title：Regional anesthesia and pain medicine

authors： Kampitak W,Tansatit T,Shibata Y

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The underlying mechanisms of neuropathic pain remain unclear. This work aimed to investigate the role of Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+-dependent histone deacetylase, in the development of neuropathic pain induced by type 2 diabetes mellitus (T2DM) and to explore the associated mec...

journal_title：Regional anesthesia and pain medicine

authors： Zhou C,Zhang Y,Jiao X,Wang G,Wang R,Wu Y

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Sacroiliac joint injections are frequently performed procedures in the management of acute and chronic low-back pain, including patients with various immunocompromised states. Infectious complications following these procedures along with other spinal injections are rarely reported, but the true incidence is ...

journal_title：Regional anesthesia and pain medicine

authors： Nagpal G,Flaherty JP,Benzon HT

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The acetylcholinesterase inhibitor neostigmine has shown peripherally mediated analgesic action in recent preclinical and clinical studies. The present study investigates the effectiveness of adding neostigmine to a local anesthetic, mepivacaine, in patients receiving axillary brachial plexus ...

journal_title：Regional anesthesia and pain medicine

authors： Bone HG,Van Aken H,Booke M,Bürkle H

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:0.1% bupivacaine for obstetric epidural analgesia is given by infusion, using a loading dose of a higher concentration alone or in combination with opioid analgesics. A single dose of 0.1% without any additive for relief of first-stage labor pain has not yet been documented. METHODS:Fifty-eig...

journal_title：Regional anesthesia and pain medicine

authors： Christiaens F,Verborgh C,Dierick A,Camu F

更新日期：1998-03-01 00:00:00

abstract：:Directors for Regional Anesthesiology and Acute Pain Medicine fellowships develop and maintain guidelines for fellowship training in the subspecialty. The first edition of the guidelines was published in 2005 with a revision published in 2010. This set of guidelines updates the 2010 revision. The guidelines address 3 ...

journal_title：Regional anesthesia and pain medicine

authors： Regional Anesthesiology and Acute Pain Medicine Fellowship Directors Group.

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the possible local neurotoxicity of a number of lipid-depot formulations of local anesthetics in relation to their duration of action in sciatic-nerve block. METHODS:Formulations that contain 2%, 4%, 8%, 16%, 32%, or 64% of a mixture of bupivacaine and...

journal_title：Regional anesthesia and pain medicine

authors： Dyhre H,Söderberg L,Björkman S,Carlsson C

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This prospective randomized trial compared ultrasound-guided single-injection (SI) and triple-injection (TI) subparaneural popliteal sciatic nerve block. We hypothesized that multiple injections are not required when local anesthetic (LA) is deposited under the paraneurium because the latter e...

journal_title：Regional anesthesia and pain medicine

authors： Tiyaprasertkul W,Bernucci F,González AP,Leurcharusmee P,Yazer MS,Techasuk W,Arnuntasupakul V,de la Garza DC,Finlayson RJ,Tran DQ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recent clinical trials suggest that subfascial (sometimes termed subepineural) injections result in faster block onset and success compared with conventional techniques. This prospective, randomized, observer-blinded study measured and compared the 3-dimensional spread pattern and volume of pe...

journal_title：Regional anesthesia and pain medicine

authors： Missair A,Weisman RS,Suarez MR,Yang R,Gebhard RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cholestasis has been proposed as a side effect of interpleural bupivacaine. Therefore, the effects of various application techniques on liver enzymes were studied following ethics committee approval and informed patient consent. METHODS:Patients following scheduled thoracotomy and laparoscopi...

journal_title：Regional anesthesia and pain medicine

authors： Wulf H,Leger R,Raetzell M,Olmer A,Scheiderer U

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The benefit of adding sciatic nerve block (SNB) to femoral nerve block to improve analgesia after total knee arthroplasty (TKA) is uncertain. We hypothesized that the effective duration of single-injection SNB is too short to improve postoperative analgesia and that this contributes to conflic...

journal_title：Regional anesthesia and pain medicine

authors： Sato K,Adachi T,Shirai N,Naoi N

更新日期：2014-05-01 00:00:00

abstract：:β-Adrenergic blockade is an important mechanism for reducing morbidity and mortality in patients with hypertension and heart failure. Esmolol has been used widely for its chronotropic and antihypertensive effects. However, there has been recent inquiry regarding perioperative esmolol use and nociceptive modulation. Co...

journal_title：Regional anesthesia and pain medicine

authors： Bahr MP,Williams BA

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/IMPORTANCE:Ultrasound (US)-guided cervical selective nerve root injections (CSNRI) have been proposed as an alternative to fluoroscopic (FL) -guided injections. When choosing US guidance, the proceduralist should be aware of potential issues confirming vertebral level, be clear regarding terminology, and up ...

journal_title：Regional anesthesia and pain medicine

authors： Ehsanian R,Schneider BJ,Kennedy DJ,Koshkin E

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The current intensity at which a motor response is elicited with an intraneural needle placement has been inadequately studied. We hypothesized that electrical current delivered through an intraneurally placed needle does not always result in an evoked motor response. Our secondary objective w...

journal_title：Regional anesthesia and pain medicine

authors： Tsai TP,Vuckovic I,Dilberovic F,Obhodzas M,Kapur E,Divanovic KA,Hadzic A

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Perineural dexamethasone or dexmedetomidine prolongs the duration of single-injection peripheral nerve block when added to the local anesthetic solution. In a randomized, controlled, double-blinded study in patients undergoing thoracoscopic pneumonectomy, we tested the hypothesis that combined...

journal_title：Regional anesthesia and pain medicine

authors： Zhang P,Liu S,Zhu J,Rao Z,Liu C

更新日期：2019-08-08 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Peripheral nerve blocks reduce postoperative pain and enhance recovery after total knee arthroplasty (TKA). This study aims to assess the benefits of addition of intravenous dexmedetomidine (DexM) to intravenous dexamethasone on the analgesic duration of quadruple nerve blocks. METHODS:This d...

journal_title：Regional anesthesia and pain medicine

authors： Chassery C,Marty P,Rontes O,Chaubard M,Vuillaume C,Basset B,Merouani M,Marquis C,De Lussy A,Delbos MC,Casalprim J,Bataille B,Naudin C,Ferre F,Delbos A

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Central sensitization is often seen in chronic pain. A relevant and potent mechanism of central sensitization is the central integration of nociceptive impulses. Temporal summation in humans and the wind-up process in animals share common features of central integration. This preclinical and c...

journal_title：Regional anesthesia and pain medicine

authors： Arendt-Nielsen L,Mansikka H,Staahl C,Rees H,Tan K,Smart TS,Monhemius R,Suzuki R,Drewes AM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The purpose of this randomized, double-blind study was to evaluate if use of an asymmetric spinal block affects the incidence of hypotension during spinal anesthesia. METHODS:With Ethical Committee approval and patient consent, 120 patients undergoing lower limb surgery were placed in the lat...

journal_title：Regional anesthesia and pain medicine

authors： Casati A,Fanelli G,Aldegheri G,Colnaghi E,Casaletti E,Cedrati V,Torri G

更新日期：1999-05-01 00:00:00

abstract：UNLABELLED:Neurologic injury after regional anesthesia or pain medicine procedures is rare. Postprocedural neurologic deficits may create high levels of anxiety for the patient and practitioner, although most deficits are limited in severity and can be expected to fully resolve with time. Postoperative anesthesia-relat...

journal_title：Regional anesthesia and pain medicine

authors： Watson JC,Huntoon MA

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Multimodal analgesia protocols have shortened hospitalizations after total joint arthroplasty. It is unclear whether individual components of these protocols are associated with respiratory depression during phase I postanesthesia recovery. OBJECTIVES:To test the hypothesis that sedating analgesics used in ...

journal_title：Regional anesthesia and pain medicine

authors： Weingarten TN,Jacob AK,Njathi CW,Wilson GA,Sprung J

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The ideal spread of local anesthetic for effective, rapid, and safe sciatic nerve block is debated. We hypothesized that subparaneural ultrasound-guided injection results in faster onset and has a better success rate than extraneural circumferential spread. METHODS:Patients undergoing elective tibial, foot,...

journal_title：Regional anesthesia and pain medicine

authors： Choquet O,Noble GB,Abbal B,Morau D,Bringuier S,Capdevila X

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Epidural anesthesia is a technically challenging regional anesthetic technique that can be difficult to teach to novices. Epidural simulators are now available to allow realistic training within a safe and controlled environment before attempting the procedure on patients. Potentially, this ma...

journal_title：Regional anesthesia and pain medicine

authors： Friedman Z,Siddiqui N,Katznelson R,Devito I,Bould MD,Naik V

更新日期：2009-05-01 00:00:00

abstract：:The American Society of Regional Anesthesia and Pain Medicine (ASRA) periodically updates its practice advisories and associated cognitive aids. The 2020 version of the ASRA Local Anesthetic Systemic Toxicity checklist was created in response to user feedback, simulation studies and advances in medical knowledge. This...

journal_title：Regional anesthesia and pain medicine

authors： Neal JM,Neal EJ,Weinberg GL

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stellate ganglion block (SGB) is one treatment option for human trigeminal nerve injury. The aim of this study was to evaluate the effectiveness of cervical sympathetic ganglia blocks (SB) by comparing the recovery of severed nerves in 2 rat models, treated or not treated by SB. METHODS:The i...

journal_title：Regional anesthesia and pain medicine

authors： Hanamatsu N,Yamashiro M,Sumitomo M,Furuya H

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Continuous brachial plexus blocks at the interscalene level are associated with known diaphragm dysfunction from phrenic nerve paresis. More distal blocks along the brachial plexus may provide postsurgical analgesia while potentially having less effect on diaphragm function. Continuous intersc...

journal_title：Regional anesthesia and pain medicine

authors： Auyong DB,Yuan SC,Choi DS,Pahang JA,Slee AE,Hanson NA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study is to clarify the influence of acute cigarette smoking on vasodilation induced by sympathetic block. METHODS:We measured mean arterial pressure, heart rate, left brachial artery blood flow (BABF), right femoral artery blood flow (FABF), and plasma catecholamines in dogs ...

journal_title：Regional anesthesia and pain medicine

authors： Kitajima T,Okuda Y,Mishio M,Hamaguchi S,Yamaguchi S,Kimura Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Anesthesiologists are increasingly utilizing the Internet for personal and professional purposes. Without guidance, the task of searching the Internet for information may be time-consuming and frustrating. This article includes a basic introduction to the Internet with suggestions and guidelin...

journal_title：Regional anesthesia and pain medicine

authors： Smith MP,Tetzlaff JE,Sheplock GJ

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Femoral nerve block (FNB) is increasingly used as an analgesic modality in patients with femoral fracture both in the emergency department and preoperatively. We describe an occurrence of unexpected dislocation of the fracture after FNB. CASE REPORT:An FNB was administered to treat pain in a 48-year-old pati...

journal_title：Regional anesthesia and pain medicine

authors： Marić S,Robinson A,Vandepitte C,Hadzic A

更新日期：2014-03-01 00:00:00