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abstract：BACKGROUND AND OBJECTIVES:Patients treated with regional anesthesia often require concomitant medication for comfort and sedation. Propofol is widely used for this purpose. Remifentanil, a new ultra-short-acting opioid, exhibits at low doses distinct sedative properties that may be useful for supplementation of regiona...

journal_title：Regional anesthesia and pain medicine

authors： Lauwers MH,Vanlersberghe C,Camu F

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Anesthesia and analgesia with paravertebral block are reportedly variable. Existence of an endothoracic fascia has been proposed as one of the possible mechanisms leading to variability. We undertook an electron-microscopy imaging study to investigate the endothoracic fascia in the thoracic pa...

journal_title：Regional anesthesia and pain medicine

authors： Stopar Pintaric T,Veranic P,Hadzic A,Karmakar M,Cvetko E

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Cervical erector spinae plane (ESP) block has been described to anesthetize the brachial plexus (BP), however, the mechanism of its clinical effect remains unknown. As the prevertebral fascia encloses the phrenic nerves, BP and erector spinae muscles to form a prevertebral compartment, a local anesthetic inj...

journal_title：Regional anesthesia and pain medicine

authors： Elsharkawy H,Ince I,Hamadnalla H,Drake RL,Tsui BCH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Many patients experience moderate to severe postoperative pain. Nitrous oxide (N₂O) exerts analgesia by inhibition of N-methyl-D-aspartate receptors. Ketamine, another N-methyl-D-aspartate receptor antagonist, reduces postoperative opioid consumption and pain. A similar effect of N₂O is plausi...

journal_title：Regional anesthesia and pain medicine

authors： Duma A,Helsten D,Brown F,Bottros MM,Nagele P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We have investigated how the vascular components of the spine determine the resistance and capacitance of the spinal epidural space and determined the magnitude of the longitudinal pressure gradient in the space during fluid infusion. METHODS:Pigs were studied during isoflurane anesthesia. Tu...

journal_title：Regional anesthesia and pain medicine

authors： Blix EU,Buffington CW

更新日期：2009-03-01 00:00:00

abstract：:Contemporary nonmalignant pain treatment algorithms commence with conservative non-invasive strategies, later progressing from minimally invasive interventions to invasive techniques or implantable devices. The most commonly used implantable devices are spinal cord stimulation (SCS) systems or targeted drug delivery (...

journal_title：Regional anesthesia and pain medicine

authors： Mekhail N,Mehanny DS,Armanyous S,Costandi S,Saweris Y,Azer G,Bolash R

更新日期：2020-01-12 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The typical blind insertion of a catheter into the epidural space risks catheter misplacement into the intrathecal space. The epidural stimulation test is designed to confirm the correct epidural location of a catheter but may also detect unintended intrathecal catheter placement by evaluating...

journal_title：Regional anesthesia and pain medicine

authors： Sutherland MA,Viscomi CM,Dominick TS,Anderson EL

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study is to examine the effects of head-up tilt (70 degrees ) 30 minutes after right or left stellate ganglion block (SGB) on RR interval, QT interval, the rate-corrected QT (QTc) interval, QT dispersion (QTD), and the rate-corrected QT dispersion (QTcD) using computerized meas...

journal_title：Regional anesthesia and pain medicine

authors： Fujii K,Yamaguchi S,Egawa H,Hamaguchi S,Kitajima T,Minami J

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The transversus abdominis plane (TAP) block can be used as part of a multimodal analgesia protocol after abdominal surgery. This study investigated whether a pneumoperitoneum during abdominal surgery influences the spread of local anesthetics. METHODS:Nine fresh frozen cadavers were used for ...

journal_title：Regional anesthesia and pain medicine

authors： Desmet M,Helsloot D,Vereecke E,Missant C,van de Velde M

更新日期：2015-07-01 00:00:00

abstract：:Perioperative outcomes research has gained widespread interest and is viewed as increasingly important among different specialties, including anesthesiology. Outcomes research studies serve to help in the adjustment of risk, allocation of resources, and formulation of hypotheses to guide future research. Pursuing high...

journal_title：Regional anesthesia and pain medicine

authors： Memtsoudis SG,Mazumdar M,Stundner O,Hargett MJ

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pregabalin is often used as a perioperative analgesic adjunct; some studies show benefit, but others do not. Adverse effects, such as confusion and sedation, have been attributed to perioperative use of pregabalin. We tested the hypothesis that pregabalin, when used as part of a multimodal ana...

journal_title：Regional anesthesia and pain medicine

authors： Yadeau JT,Paroli L,Kahn RL,Jules-Elysee KM,Lasala VR,Liu SS,Lin E,Powell K,Buschiazzo VL,Wukovits B,Roberts MM,Levine DS

更新日期：2012-05-01 00:00:00

abstract：:This study aimed to describe the anatomical distribution of dye injected in the erector spinae plane (ESP) in a porcine living model, which could aid to reveal factors potentially relevant to the unexplained clinical effects of the ESP block. Six pigs received 0.6 mL/kg of 0.25% new methylene blue at the level of the ...

journal_title：Regional anesthesia and pain medicine

authors： Otero PE,Fuensalida SE,Russo PC,Verdier N,Blanco C,Portela DA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The acetylcholinesterase inhibitor neostigmine has shown peripherally mediated analgesic action in recent preclinical and clinical studies. The present study investigates the effectiveness of adding neostigmine to a local anesthetic, mepivacaine, in patients receiving axillary brachial plexus ...

journal_title：Regional anesthesia and pain medicine

authors： Bone HG,Van Aken H,Booke M,Bürkle H

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After peripheral inflammatory stimuli, spinal cord cyclooyxgenase-2 (COX-2) mRNA and protein levels increase, whereas COX-1 is unchanged. In animal models of inflammatory pain, intrathecal COX-2 selective inhibitors suppress hyperalgesia. However, the role of spinal COX-2 inhibition in postope...

journal_title：Regional anesthesia and pain medicine

authors： Kroin JS,Buvanendran A,McCarthy RJ,Hemmati H,Tuman KJ

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Lipid infusion reverses systemic local anesthetic toxicity. The acceptable upper limit for lipid administration is unknown and has direct bearing on clinical management. We hypothesize that high volumes of lipid could have undesirable effects and sought to identify the dose required to kill 50% of the animal...

journal_title：Regional anesthesia and pain medicine

authors： Hiller DB,Di Gregorio G,Kelly K,Ripper R,Edelman L,Boumendjel R,Drasner K,Weinberg GL

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of the study was to examine the analgesic effects of the anticonvulsant, gabapentin, in a validated model of acute inflammatory pain. METHODS:Twenty-two volunteers were investigated in a double-blind, randomized, placebo-controlled cross-over study. Gabapentin 1,200 mg or placebo was ...

journal_title：Regional anesthesia and pain medicine

authors： Werner MU,Perkins FM,Holte K,Pedersen JL,Kehlet H

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We present 2 case reports that illustrate that chronic intrathecal (IT) baclofen administration may be efficacious in treating patients with long-standing complex regional pain syndrome, type I (CRPS I) who have failed treatment with multiple drugs and procedures. CASE REPORTS:Both cases pres...

journal_title：Regional anesthesia and pain medicine

authors： Zuniga RE,Perera S,Abram SE

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Prior to this investigation, there was no approach to compare both the potency of local anesthetics and their time course of action in a reproducible nociceptive system in humans. We tested whether the vascularly isolated vein segment is appropriate for such an approach. METHODS:In six health...

journal_title：Regional anesthesia and pain medicine

authors： Holthusen H,Lipfert P,Klement W

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:We report a case of perioperative management of a single-ventricle patient with Fontan-associated liver disease undergoing hepatectomy. CASE REPORT:A 12-year-old boy with Fontan circulation was scheduled for partial hepatectomy to remove a liver mass in segment 6. He received stent implantation to relieve co...

journal_title：Regional anesthesia and pain medicine

authors： Maeda A,Shibata SC,Okitsu K,Imada T,Takahashi A,Uchiyama A,Kamibayashi T,Fujino Y

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chronic pain is both prevalent and costly. Despite advances in understanding the anatomy, physiology, and biochemistry of nociception and development of potent analgesic agents and advanced technology, a significant number of people continue to experience pain and related disability. The perce...

journal_title：Regional anesthesia and pain medicine

authors： Turk DC

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Epidural anesthesia (EA) is known to reduce postoperative thromboembolic complications, but mechanisms are incompletely understood. In this study, we tested the hypothesis that local anesthetics (LA) prevent postoperative hypercoagulability without affecting physiologic aggregation and coagula...

journal_title：Regional anesthesia and pain medicine

authors： Hollmann MW,Wieczorek KS,Smart M,Durieux ME

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Major ankle surgery causes intense postoperative pain, and whereas the importance of a sciatic nerve block is well established, the clinical significance of a supplemental saphenous nerve block has never been determined in a prospective, randomized, double-blind, placebo-controlled trial. We h...

journal_title：Regional anesthesia and pain medicine

authors： Bjørn S,Wong WY,Baas J,Nielsen KK,Børglum J,Hauritz RW,Bendtsen TF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hematoma is typically cited as one mechanism of nerve injury following axillary block. However, documented cases of this are lacking. METHODS:A healthy 38-year-old man was scheduled for surgical removal of a tumor of the hand. A transarterial axillary block was performed with a 22-gauge short...

journal_title：Regional anesthesia and pain medicine

authors： Ben-David B,Stahl S

更新日期：1999-05-01 00:00:00

abstract：:The past century has seen immense progress in the advancement of methodology to evaluate efficacy of treatment interventions for acute and chronic pain. Continuing challenges revolve around how to best select and measure primary efficacy outcomes for a given analgesic trial. Recognizing the complex, multidimensional, ...

journal_title：Regional anesthesia and pain medicine

authors： Gilron I,Jensen MP

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The underlying mechanisms of neuropathic pain remain unclear. This work aimed to investigate the role of Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+-dependent histone deacetylase, in the development of neuropathic pain induced by type 2 diabetes mellitus (T2DM) and to explore the associated mec...

journal_title：Regional anesthesia and pain medicine

authors： Zhou C,Zhang Y,Jiao X,Wang G,Wang R,Wu Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We wished to determine which long-acting local anesthetic would produce the least pain on injection for treatment of myofascial pain disorders. We compared the pain on intramuscular injection of bupivacaine, ropivacaine, bupivacaine with dexamethasone, ropivacaine with dexamethasone, and needl...

journal_title：Regional anesthesia and pain medicine

authors： Krishnan SK,Benzon HT,Siddiqui T,Canlas B

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Histologic evidence of the comparative neurotoxicity of lidocaine, mepivacaine, and prilocaine is incomplete. We compared the intrathecal neurotoxicity in rats among these 3 drugs based on morphologic and neurofunctional findings. METHODS:Rats (n=169) randomly received 0.12 microL/g of 0%, 2%...

journal_title：Regional anesthesia and pain medicine

authors： Takenami T,Yagishita S,Nara Y,Hoka S

更新日期：2004-09-01 00:00:00

abstract：:This article qualitatively assesses and summarizes randomized, controlled studies regarding benefits of ultrasound (US) for brachial plexus block and also examines those studies that have compared different brachial plexus block techniques using US.Studies were identified by a search of PUBMED and EMBASE databases usi...

journal_title：Regional anesthesia and pain medicine

authors： McCartney CJ,Lin L,Shastri U

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Several studies have evaluated the impact of preoperative depression on outcomes following total joint arthroplasty (TJA), however few have studied new-onset depression or anxiety after TJA. We aimed to identify the incidence of and risk factors for new-onset depression/anxiety after TJA, specifically focusi...

journal_title：Regional anesthesia and pain medicine

authors： Wilson L,Bekeris J,Fiasconaro M,Liu J,Poeran J,Kim DH,Gonzalez Della Valle A,Memtsoudis SG

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Gabapentin is an anticonvulsant that has been shown to be effective in the treatment of neuropathic and inflammatory pain in animal and human studies. The analgesic effect of its perioperative use has not been fully elucidated. METHODS:This systematic review (meta-analysis) included 12 random...

journal_title：Regional anesthesia and pain medicine

authors： Hurley RW,Cohen SP,Williams KA,Rowlingson AJ,Wu CL

更新日期：2006-05-01 00:00:00