Clinical trial methodology of pain treatment studies: selection and measurement of self-report primary outcomes for efficacy.

abstract：BACKGROUND AND OBJECTIVES:No study has compared cervical interlaminar epidural steroid injection (CIESI) with epidural catheter advancement to the side and level of pathology versus standard C7-T1 CIESI. This study investigated whether cervical radicular pain is more effectively treated by CIESI with a targeted epidura...

journal_title：Regional anesthesia and pain medicine

authors： McCormick ZL,Nelson A,Bhave M,Zhukalin M,Kendall M,McCarthy RJ,Khan D,Nagpal G,Walega DR

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:It has recently been proposed that an infraclavicular brachial plexus block (BPB) at the costoclavicular (CC) space may overcome some of the limitations of the lateral sagittal (LS) approach. In this study, we hypothesized that the CC approach will produce faster onset of sensory blockade of t...

journal_title：Regional anesthesia and pain medicine

authors： Songthamwat B,Karmakar MK,Li JW,Samy W,Mok LYH

更新日期：2018-11-01 00:00:00

abstract：:β-Adrenergic blockade is an important mechanism for reducing morbidity and mortality in patients with hypertension and heart failure. Esmolol has been used widely for its chronotropic and antihypertensive effects. However, there has been recent inquiry regarding perioperative esmolol use and nociceptive modulation. Co...

journal_title：Regional anesthesia and pain medicine

authors： Bahr MP,Williams BA

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Epidural anesthesia is a technically challenging regional anesthetic technique that can be difficult to teach to novices. Epidural simulators are now available to allow realistic training within a safe and controlled environment before attempting the procedure on patients. Potentially, this ma...

journal_title：Regional anesthesia and pain medicine

authors： Friedman Z,Siddiqui N,Katznelson R,Devito I,Bould MD,Naik V

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We have investigated how the vascular components of the spine determine the resistance and capacitance of the spinal epidural space and determined the magnitude of the longitudinal pressure gradient in the space during fluid infusion. METHODS:Pigs were studied during isoflurane anesthesia. Tu...

journal_title：Regional anesthesia and pain medicine

authors： Blix EU,Buffington CW

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Long-acting nociceptive-selective regional anesthesia has remained an elusive clinical goal. We aspired to identify a novel compound that would produce nociceptive-selective regional anesthesia through the transient receptor potential vanilloid 1 (TRPV1) channels. METHODS:We designed and synth...

journal_title：Regional anesthesia and pain medicine

authors： Zhou C,Tang L,Yin Q,Yang L,Gong D,Kang Y,Cao H,Fan J,Zhang Y,Qian D,Zhang Q,Ke B,Liu J,Zhang W,Yang J

更新日期：2020-06-01 00:00:00

abstract：:Omission of a confidence interval (CI) associated with the risk of a serious complication can lead to inaccurate interpretation of risk data. The calculation of a CI for a risk or a single proportion typically uses the familiar Gaussian (normal) approximation. However, when the risk is small, "exact" methods or other ...

journal_title：Regional anesthesia and pain medicine

authors： Ho AM,Dion PW,Karmakar MK,Lee A

更新日期：2002-03-01 00:00:00

abstract：:Directors for Regional Anesthesiology and Acute Pain Medicine fellowships develop and maintain guidelines for fellowship training in the subspecialty. The first edition of the guidelines was published in 2005 with a revision published in 2010. This set of guidelines updates the 2010 revision. The guidelines address 3 ...

journal_title：Regional anesthesia and pain medicine

authors： Regional Anesthesiology and Acute Pain Medicine Fellowship Directors Group.

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stimulation of the radial nerve at the axilla may cause either a proximal movement (forearm extension) or distal movements (supination, wrist or finger extension). In the most recent studies on axillary block, only a distal twitch was accepted as valid. However, this approach was based only on...

journal_title：Regional anesthesia and pain medicine

authors： Sia S,Lepri A,Magherini M,Doni L,Di Marco P,Gritti G

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Perioperative systemic lidocaine provides postoperative analgesia, decreases opioid consumption, and facilitates rehabilitation in abdominal surgery. We hypothesized that systemic lidocaine has analgesic effects in women undergoing day-case laparoscopic sterilization. METHODS:Eighty women wer...

journal_title：Regional anesthesia and pain medicine

authors： Dewinter GB,Teunkens A,Vermeulen K,Al Tmimi L,Van de Velde M,Rex S

更新日期：2016-05-01 00:00:00

abstract：:This study aimed to describe the anatomical distribution of dye injected in the erector spinae plane (ESP) in a porcine living model, which could aid to reveal factors potentially relevant to the unexplained clinical effects of the ESP block. Six pigs received 0.6 mL/kg of 0.25% new methylene blue at the level of the ...

journal_title：Regional anesthesia and pain medicine

authors： Otero PE,Fuensalida SE,Russo PC,Verdier N,Blanco C,Portela DA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:After peripheral inflammatory stimuli, spinal cord cyclooyxgenase-2 (COX-2) mRNA and protein levels increase, whereas COX-1 is unchanged. In animal models of inflammatory pain, intrathecal COX-2 selective inhibitors suppress hyperalgesia. However, the role of spinal COX-2 inhibition in postope...

journal_title：Regional anesthesia and pain medicine

authors： Kroin JS,Buvanendran A,McCarthy RJ,Hemmati H,Tuman KJ

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Peripheral nerve and spinal cord stimulation techniques have been used for many years. However, electrical stimulation methods rarely have been used to confirm epidural catheter placement. This study examines the practicality of this technique to confirm epidural catheter placement in obstetri...

journal_title：Regional anesthesia and pain medicine

authors： Tsui BC,Gupta S,Finucane B

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the possible local neurotoxicity of a number of lipid-depot formulations of local anesthetics in relation to their duration of action in sciatic-nerve block. METHODS:Formulations that contain 2%, 4%, 8%, 16%, 32%, or 64% of a mixture of bupivacaine and...

journal_title：Regional anesthesia and pain medicine

authors： Dyhre H,Söderberg L,Björkman S,Carlsson C

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recent clinical trials suggest that subfascial (sometimes termed subepineural) injections result in faster block onset and success compared with conventional techniques. This prospective, randomized, observer-blinded study measured and compared the 3-dimensional spread pattern and volume of pe...

journal_title：Regional anesthesia and pain medicine

authors： Missair A,Weisman RS,Suarez MR,Yang R,Gebhard RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Multimodal analgesia protocols have shortened hospitalizations after total joint arthroplasty. It is unclear whether individual components of these protocols are associated with respiratory depression during phase I postanesthesia recovery. OBJECTIVES:To test the hypothesis that sedating analgesics used in ...

journal_title：Regional anesthesia and pain medicine

authors： Weingarten TN,Jacob AK,Njathi CW,Wilson GA,Sprung J

更新日期：2015-07-01 00:00:00

abstract：:This article qualitatively assesses and summarizes randomized, controlled studies regarding benefits of ultrasound (US) for brachial plexus block and also examines those studies that have compared different brachial plexus block techniques using US.Studies were identified by a search of PUBMED and EMBASE databases usi...

journal_title：Regional anesthesia and pain medicine

authors： McCartney CJ,Lin L,Shastri U

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND/IMPORTANCE:Ultrasound (US)-guided cervical selective nerve root injections (CSNRI) have been proposed as an alternative to fluoroscopic (FL) -guided injections. When choosing US guidance, the proceduralist should be aware of potential issues confirming vertebral level, be clear regarding terminology, and up ...

journal_title：Regional anesthesia and pain medicine

authors： Ehsanian R,Schneider BJ,Kennedy DJ,Koshkin E

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ultrasound-guided infiltration of the interspace between the popliteal artery and capsule of the knee (iPACK) block, a new regional analgesic technique, is believed to relieve posterior knee pain, after total knee arthroplasty, by targeting the articular branches innervating posterior aspect o...

journal_title：Regional anesthesia and pain medicine

authors： Tran J,Giron Arango L,Peng P,Sinha SK,Agur A,Chan V

更新日期：2019-05-06 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Anesthesiologists are increasingly utilizing the Internet for personal and professional purposes. Without guidance, the task of searching the Internet for information may be time-consuming and frustrating. This article includes a basic introduction to the Internet with suggestions and guidelin...

journal_title：Regional anesthesia and pain medicine

authors： Smith MP,Tetzlaff JE,Sheplock GJ

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Perineural dexamethasone or dexmedetomidine prolongs the duration of single-injection peripheral nerve block when added to the local anesthetic solution. In a randomized, controlled, double-blinded study in patients undergoing thoracoscopic pneumonectomy, we tested the hypothesis that combined...

journal_title：Regional anesthesia and pain medicine

authors： Zhang P,Liu S,Zhu J,Rao Z,Liu C

更新日期：2019-08-08 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Central sensitization is often seen in chronic pain. A relevant and potent mechanism of central sensitization is the central integration of nociceptive impulses. Temporal summation in humans and the wind-up process in animals share common features of central integration. This preclinical and c...

journal_title：Regional anesthesia and pain medicine

authors： Arendt-Nielsen L,Mansikka H,Staahl C,Rees H,Tan K,Smart TS,Monhemius R,Suzuki R,Drewes AM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We wished to determine which long-acting local anesthetic would produce the least pain on injection for treatment of myofascial pain disorders. We compared the pain on intramuscular injection of bupivacaine, ropivacaine, bupivacaine with dexamethasone, ropivacaine with dexamethasone, and needl...

journal_title：Regional anesthesia and pain medicine

authors： Krishnan SK,Benzon HT,Siddiqui T,Canlas B

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Sacroiliac joint injections are frequently performed procedures in the management of acute and chronic low-back pain, including patients with various immunocompromised states. Infectious complications following these procedures along with other spinal injections are rarely reported, but the true incidence is ...

journal_title：Regional anesthesia and pain medicine

authors： Nagpal G,Flaherty JP,Benzon HT

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Our objective was to describe the first reported use of an axillary brachial plexus block to treat the entrapment of a transradial artery catheter due to vasospasm. CASE REPORT:A 42-year-old man undergoing transradial arterial cardiac catheterization suffered arterial vasospasm causing the catheter to become...

journal_title：Regional anesthesia and pain medicine

authors： Fitzgerald BM,Babbel LA,Bacomo FK,Dhanjal ST

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There is increasing interest in local infiltration analgesia (LIA) to reduce postoperative pain with knee surgery. Despite widespread use of LIA, wide variations in drug combinations, infiltration techniques, and the concomitant use of systemic analgesics have made it difficult to determine th...

journal_title：Regional anesthesia and pain medicine

authors： Buvanendran A,Kroin JS,Della Valle CJ,Moric M,Tuman KJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The perception of high resistance during injection of a local anesthetic during regional anesthesia may indicate intraneural injection. Anesthetists' ability to detect high resistance by "syringe feel" has been questioned in the past. The aim of our study was to investigate the anesthetist's ability to detec...

journal_title：Regional anesthesia and pain medicine

authors： Theron PS,Mackay Z,Gonzalez JG,Donaldson N,Blanco R

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Major ankle surgery causes intense postoperative pain, and whereas the importance of a sciatic nerve block is well established, the clinical significance of a supplemental saphenous nerve block has never been determined in a prospective, randomized, double-blind, placebo-controlled trial. We h...

journal_title：Regional anesthesia and pain medicine

authors： Bjørn S,Wong WY,Baas J,Nielsen KK,Børglum J,Hauritz RW,Bendtsen TF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Meperidine is frequently used in general anesthesia and perioperative analgesia. In addition to its opioid action, meperidine possesses some local anesthetic properties. A preliminary study using the tourniquet venous retention technique found meperidine to be more effective in reducing propof...

journal_title：Regional anesthesia and pain medicine

authors： Pang WW,Mok MS,Huang S,Chung YT,Hwang MH

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surg...

journal_title：Regional anesthesia and pain medicine

authors： Ilfeld BM,Gabriel RA,Said ET,Monahan AM,Sztain JF,Abramson WB,Khatibi B,Finneran JJ 4th,Jaeger PT,Schwartz AK,Ahmed SS

更新日期：2018-08-01 00:00:00