The peripheral analgesic effect of meperidine in reducing propofol injection pain is not naloxone-reversible.

Abstract:

BACKGROUND AND OBJECTIVES:Meperidine is frequently used in general anesthesia and perioperative analgesia. In addition to its opioid action, meperidine possesses some local anesthetic properties. A preliminary study using the tourniquet venous retention technique found meperidine to be more effective in reducing propofol injection pain than fentanyl or morphine, both of which were slightly better than placebo. This study was undertaken to evaluate whether this peripheral analgesic effect of meperidine is affected by naloxone. METHODS:In a randomized, double-blind manner, after venous occlusion with a tourniquet, meperidine 40 mg was given intravenously to patients in group A (n = 31), meperidine 40 mg followed by naloxone 0.04 mg to group B (n = 32), meperidine 40 mg followed by naloxone 0.2 mg to group C (n = 30), and normal saline placebo to group D (n = 30). The venous retention of drug(s) was maintained for 1 minute, followed by tourniquet release and intravenous administration of propofol 100 mg. Pain assessment was made immediately after the propofol injection. RESULTS:All three groups given meperidine had significantly less propofol injection pain (P < .01 ) than the group given saline placebo, and there was no difference among groups A, B, and C. CONCLUSION:The peripheral analgesic effect of meperidine in reducing propofol injection pain is not mediated by its opioid activity.

journal_name

Reg Anesth Pain Med

authors

Pang WW,Mok MS,Huang S,Chung YT,Hwang MH

doi

10.1097/00115550-199823020-00014

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

197-200

issue

2

eissn

1098-7339

issn

1532-8651

pii

S1098733998000285

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验
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