Cholestasis as a side effect of bupivacaine?

abstract：BACKGROUND AND OBJECTIVE:Long-acting nociceptive-selective regional anesthesia has remained an elusive clinical goal. We aspired to identify a novel compound that would produce nociceptive-selective regional anesthesia through the transient receptor potential vanilloid 1 (TRPV1) channels. METHODS:We designed and synth...

journal_title：Regional anesthesia and pain medicine

authors： Zhou C,Tang L,Yin Q,Yang L,Gong D,Kang Y,Cao H,Fan J,Zhang Y,Qian D,Zhang Q,Ke B,Liu J,Zhang W,Yang J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Use of nonsteroidal anti-inflammatory drug (NSAIDs) analgesics is controversial because of cardiovascular risk, but perioperative use may be advantageous for total joint replacement. Thus, we performed this single-center observational cohort study to determine any association between NSAID use...

journal_title：Regional anesthesia and pain medicine

authors： Liu SS,Bae JJ,Bieltz M,Ma Y,Memtsoudis S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stellate ganglion block (SGB) is one treatment option for human trigeminal nerve injury. The aim of this study was to evaluate the effectiveness of cervical sympathetic ganglia blocks (SB) by comparing the recovery of severed nerves in 2 rat models, treated or not treated by SB. METHODS:The i...

journal_title：Regional anesthesia and pain medicine

authors： Hanamatsu N,Yamashiro M,Sumitomo M,Furuya H

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Gabapentin is an anticonvulsant that has been shown to be effective in the treatment of neuropathic and inflammatory pain in animal and human studies. The analgesic effect of its perioperative use has not been fully elucidated. METHODS:This systematic review (meta-analysis) included 12 random...

journal_title：Regional anesthesia and pain medicine

authors： Hurley RW,Cohen SP,Williams KA,Rowlingson AJ,Wu CL

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Although complications of the epidural technique are known to affect the fetus adversely, there are no data indicating that regional analgesia directly causes harmful effects to the fetus. Our purpose was to determine the effect of epidural labor analgesia on the Doppler velocimetric indices of the uterine an...

journal_title：Regional anesthesia and pain medicine

authors： Chen LK,Yang YM,Yang YH,Lee CN,Chen SS,Sun WZ

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stimulation of the radial nerve at the axilla may cause either a proximal movement (forearm extension) or distal movements (supination, wrist or finger extension). In the most recent studies on axillary block, only a distal twitch was accepted as valid. However, this approach was based only on...

journal_title：Regional anesthesia and pain medicine

authors： Sia S,Lepri A,Magherini M,Doni L,Di Marco P,Gritti G

更新日期：2005-09-01 00:00:00

abstract：:The surgeon August Gustav Bier significantly influenced surgery, general medicine, and especially anesthesia. He was the father of spinal anesthesia (1898) and intravenous regional anesthesia (1908). Both anesthetic techniques are still valuable and widely applied in everyday anesthesia practices throughout the world,...

journal_title：Regional anesthesia and pain medicine

authors： van Zundert A,Helmstädter A,Goerig M,Mortier E

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Continuous brachial plexus blocks at the interscalene level are associated with known diaphragm dysfunction from phrenic nerve paresis. More distal blocks along the brachial plexus may provide postsurgical analgesia while potentially having less effect on diaphragm function. Continuous intersc...

journal_title：Regional anesthesia and pain medicine

authors： Auyong DB,Yuan SC,Choi DS,Pahang JA,Slee AE,Hanson NA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients treated with regional anesthesia often require concomitant medication for comfort and sedation. Propofol is widely used for this purpose. Remifentanil, a new ultra-short-acting opioid, exhibits at low doses distinct sedative properties that may be useful for supplementation of regiona...

journal_title：Regional anesthesia and pain medicine

authors： Lauwers MH,Vanlersberghe C,Camu F

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chronic pain is both prevalent and costly. Despite advances in understanding the anatomy, physiology, and biochemistry of nociception and development of potent analgesic agents and advanced technology, a significant number of people continue to experience pain and related disability. The perce...

journal_title：Regional anesthesia and pain medicine

authors： Turk DC

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:We present a case of reappearance of spinal anesthesia despite the use of plain (isobaric) lidocaine and without an associated cough or Valsalva maneuver. CASE REPORT:A 66-year-old man had spinal anesthesia for knee arthroscopy. Two hours after the induction of spinal anesthesia and after the patient's motor...

journal_title：Regional anesthesia and pain medicine

authors： Deleon AM,Benzon HT,Eisenman TS,Doty RA Jr,Newell B,McLaughlin K

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mexiletine is an oral sodium channel antagonist that has been reported to be effective in a variety of neuropathic pain syndromes. However, recent reports question the efficacy of oral mexiletine in neuropathic pain. The objectives of this study were to examine the effect of oral mexiletine on...

journal_title：Regional anesthesia and pain medicine

authors： Wallace MS,Magnuson S,Ridgeway B

更新日期：2000-09-01 00:00:00

abstract：:The development of chronic pain is a complex mechanism that is still not fully understood. Multiple somatic and visceral afferent pain signals, when experienced over time, cause a strengthening of certain neural circuitry through peripheral and central sensitization, resulting in the physical and emotional perceptual ...

journal_title：Regional anesthesia and pain medicine

authors： Castellanos JP,Woolley C,Bruno KA,Zeidan F,Halberstadt A,Furnish T

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:No studies have examined the long-term benefits of regional anesthesia (RA) for pain management after combat-related injury. The objective of this prospective cohort study was to examine the relationship between RA administration and patient-reported pain-related outcomes among Operation Enduring Freedom (OE...

journal_title：Regional anesthesia and pain medicine

authors： Gallagher RM,Polomano RC,Giordano NA,Farrar JT,Guo W,Taylor L,Oslin D,Goff BJ,Buckenmaier CC

更新日期：2019-09-27 00:00:00

abstract：BACKGROUND:The ideal spread of local anesthetic for effective, rapid, and safe sciatic nerve block is debated. We hypothesized that subparaneural ultrasound-guided injection results in faster onset and has a better success rate than extraneural circumferential spread. METHODS:Patients undergoing elective tibial, foot,...

journal_title：Regional anesthesia and pain medicine

authors： Choquet O,Noble GB,Abbal B,Morau D,Bringuier S,Capdevila X

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Neosaxitoxin (NeoSTX) is a potent site-1 sodium-channel blocker being developed as a local anesthetic. Doses of 100 μg have been used by local infiltration in anesthetized adult humans without adverse effect. We hypothesized that similar doses could cause significant respiratory, neuromuscular, and cardiovas...

journal_title：Regional anesthesia and pain medicine

authors： Wylie MC,Johnson VM,Carpino E,Mullen K,Hauser K,Nedder A,Kheir JN,Rodriguez-Navarro AJ,Zurakowski D,Berde CB

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The transversus abdominis plane (TAP) block can be used as part of a multimodal analgesia protocol after abdominal surgery. This study investigated whether a pneumoperitoneum during abdominal surgery influences the spread of local anesthetics. METHODS:Nine fresh frozen cadavers were used for ...

journal_title：Regional anesthesia and pain medicine

authors： Desmet M,Helsloot D,Vereecke E,Missant C,van de Velde M

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:This report describes the effects of ganglionic local opioid application (GLOA) in patients with chronic headache and persistent idiopathic facial pain. CASE REPORT:We present 2 patients with chronic headaches and 1 patient with persistent idiopathic facial pain who were refractory to medical treatment. Thes...

journal_title：Regional anesthesia and pain medicine

authors： Harris CL,Hamid B,Rosenquist RW,Schultz-Stubner SH

更新日期：2006-09-01 00:00:00

abstract：:The COVID-19 outbreak is on the world. While many countries have imposed general lockdown, emergency services are continuing. Healthcare professionals have been infected with the virulent severe acute respiratory syndrome coronavirus-2 (SARS), which spreads by close contact and aerosols. The anesthesiologist is partic...

journal_title：Regional anesthesia and pain medicine

authors： Ashokka B,Chakraborty A,Subramanian BJ,Karmakar MK,Chan V

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dorsal root ganglion stimulation is an emerging therapy in the treatment of chronic pain. Compared with traditional spinal cord stimulation, it allows a discretely targeted stimulation profile and may act via differing mechanisms of action. Despite these advantages, little is known about the c...

journal_title：Regional anesthesia and pain medicine

authors： Sivanesan E,Bicket MC,Cohen SP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transversus abdominis plane (TAP) blocks have been shown to reduce postoperative pain after various abdominal surgical procedures in several studies. The motor nerves of the abdominal wall are located in the same plane as the sensory nerves affected by the TAP block. The aim of this study was ...

journal_title：Regional anesthesia and pain medicine

authors： Petersen M,Elers J,Børglum J,Belhage B,Mortensen J,Maschmann C

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:0.1% bupivacaine for obstetric epidural analgesia is given by infusion, using a loading dose of a higher concentration alone or in combination with opioid analgesics. A single dose of 0.1% without any additive for relief of first-stage labor pain has not yet been documented. METHODS:Fifty-eig...

journal_title：Regional anesthesia and pain medicine

authors： Christiaens F,Verborgh C,Dierick A,Camu F

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release, dual-acting local anesthetic, in reducing both postoperative pain ...

journal_title：Regional anesthesia and pain medicine

authors： Viscusi E,Gimbel JS,Pollack RA,Hu J,Lee GC

更新日期：2019-05-21 00:00:00

abstract：:The Accreditation Council for Graduate Medical Education has shifted to competency-based medical education. This educational framework requires the description of educational outcomes based on the knowledge, skills and behaviors expected of competent trainees. It also requires an assessment program to provide formativ...

journal_title：Regional anesthesia and pain medicine

authors： Woodworth G,Maniker RB,Spofford CM,Ivie R,Lunden NI,Machi AT,Elkassabany NM,Gritsenko K,Kukreja P,Vlassakov K,Tedore T,Schroeder K,Missair A,Herrick M,Shepler J,Wilson EH,Horn JL,Barrington M

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ultrasound-guided infiltration of the interspace between the popliteal artery and capsule of the knee (iPACK) block, a new regional analgesic technique, is believed to relieve posterior knee pain, after total knee arthroplasty, by targeting the articular branches innervating posterior aspect o...

journal_title：Regional anesthesia and pain medicine

authors： Tran J,Giron Arango L,Peng P,Sinha SK,Agur A,Chan V

更新日期：2019-05-06 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Epinephrine, 25 microg and 200 microg, has been found to prolong the duration of intrathecal labor analgesia when added to an opioid. In our hospital we use the standard epidural mixture, prepared by the pharmacist, containing epinephrine 1:800,000; i.e., 1.25 microg/mL for both spinal and epi...

journal_title：Regional anesthesia and pain medicine

authors： Vercauteren MP,Jacobs S,Jacquemyn Y,Adriaensen HA

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ropivacaine is a potent local anesthetic that, experimentally at low concentrations, produces an effective block of pain conducting nerve fibers. Therefore, it was hypothesized that 0.1% and 0.2% ropivacaine would provide clinically adequate postoperative analgesia in continuous axillary plexu...

journal_title：Regional anesthesia and pain medicine

authors： Salonen MH,Haasio J,Bachmann M,Xu M,Rosenberg PH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:A difficult neuraxial block (DNB) may be associated with complications. The aims of this study were to estimate the prevalence of DNB, assess patient-related and organizational factors associated with DNB, and evaluate the diagnostic accuracy of an accumulated risk score for predicting DNB. METHODS:A consec...

journal_title：Regional anesthesia and pain medicine

authors： Stendell L,Lundstrøm LH,Wetterslev J,Itenov TS,Rosenstock CV

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:In ambulatory lower limb surgery, spinal anesthesia with rapid onset and a short duration of block is preferable. We hypothesized that the use of 2-chloroprocaine would be associated with a faster motor block recovery compared with prilocaine in knee arthroscopy. A difference of 15 min was considered clinica...

journal_title：Regional anesthesia and pain medicine

authors： Wesselink E,Hurk GJD,Vegt RV,Slagt C,Aa JV,Franssen E,Ven PV,Swart N,Boer C,Leeuw M

更新日期：2019-08-21 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Quadratus lumborum (QL) block is a new regional analgesic technique for upper and lower abdominal surgeries as part of a multimodal analgesic regime. It has also been reported to relieve pain after total hip arthroplasty (THA). In this prospective, randomized, double-blind study, we compared Q...

journal_title：Regional anesthesia and pain medicine

authors： Kukreja P,MacBeth L,Sturdivant A,Morgan CJ,Ghanem E,Kalagara H,Chan VWS

更新日期：2019-10-25 00:00:00