Abstract:
OBJECTIVES:In this study we first aimed to assess the cochlear functions in children with Familial Mediterranean Fever. The second aim was to investigate the correlation between the hearing levels and some clinical features of Familial Mediterranean Fever including the duration of the disease, age at onset, genetic analysis and colchicine use. METHODS:Thirty-four children with Familial Mediterranean Fever and 27 age matched children were included in the study. Following otologic examination, all children underwent audiometric evaluation, including Pure Tone Average measurements and Distortion Product Otoaoustic Emission testing. Audiological results of the two groups were compared and correlation between the audiologic status and clinical parameters of the disease like the duration of disease, age at onset, mutations and colchicine treatment were studied. RESULTS:Pure tone audiometry hearing levels were within normal levels in both groups. Hearing thresholds of Familial Mediterranean Fever patients were found to be increased at frequencies 8000, 10,000, 12,500 and 16,000 (p<0.05). In otoacoustic emission evaluation, distortion products and signal-noise ratio of FMF children were lower in the tested frequencies, from 1400 Hz to 4000 Hz (p<0.05). Interaction of the disease duration and age of disease onset was found to predict hearing levels, distortion products and signal-noise ratios of children with Familial Mediterranean Fever (F value=2.034; p=0.033). CONCLUSIONS:To our knowledge this is the first study demonstrating cochlear involvement in children with Familial Mediterranean Fever which showed increased hearing thresholds at higher frequencies in audiometry together with decreased distortion products and signal-noise ratios demonstrated by distortion product otoacoustic emission testing. Similar studies must be carried out on adult patients to see if a clinical hearing impairment develops. The possible mechanisms that cause cochlear involvement and the effect of colchicine treatment on cochlear functions must be enlightened.
journal_name
Int J Pediatr Otorhinolaryngoljournal_title
International journal of pediatric otorhinolaryngologyauthors
Koybasi S,Atasoy Hİ,Bicer YO,Tug Edoi
10.1016/j.ijporl.2011.11.013subject
Has Abstractpub_date
2012-02-01 00:00:00pages
244-7issue
2eissn
0165-5876issn
1872-8464pii
S0165-5876(11)00576-3journal_volume
76pub_type
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journal_title:International journal of pediatric otorhinolaryngology
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 临床试验,杂志文章
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journal_title:International journal of pediatric otorhinolaryngology
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更新日期:2014-03-01 00:00:00
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更新日期:2020-08-01 00:00:00
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更新日期:1998-12-15 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
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更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
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更新日期:2015-08-01 00:00:00
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doi:10.1016/j.ijporl.2009.04.014
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-10-01 00:00:00
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更新日期:2005-12-01 00:00:00
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更新日期:2019-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-09-18 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 临床试验,杂志文章
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更新日期:2000-09-15 00:00:00
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更新日期:2013-04-01 00:00:00
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更新日期:2020-09-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 杂志文章
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更新日期:2002-05-15 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:International journal of pediatric otorhinolaryngology
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00