Abstract：
OBJECTIVES:Silymarin is a plant extract with strong antioxidant properties in addition to anti-inflammatory and anticarcinogenic actions. The aim of this study was to investigate the potential preventive effect of silymarin on cisplatin ototoxicity in an auditory cell line, HEI-OC1 cells. METHODS:Cultured HEI-OC1 cells were exposed to cisplatin (30 μM) with or without pre-treatment with silymarin (50 μM). Cell viability was evaluated using MTT assay. Hoechst 33258 staining was used to identify cells undergoing apoptosis. Western blot analysis was done to evaluate whether silymarin inhibits cisplatin-induced caspase and PARP activation. Cell-cycle analysis was done by flow cytometry to investigate whether silymarin is capable of protecting cisplatin-induced cell cycle arrest. RESULTS:Cell viability significantly increased in cells pretreated with silymarin compared with cells exposed to cisplatin alone. Pre-treatment of silymarin appeared to protect against cisplatin-induced apoptotic features on Hoechst 33258 staining. Cisplatin increased cleaved caspase-3 and PARP on Western blot analysis. However, pre-treatment with silymarin inhibited the expression of cleaved caspase-3 and PARP. Silymarin did attenuate cell cycle arrest and apoptosis in HEI-OC1 cells. CONCLUSIONS:Our results demonstrate that silymarin treatment inhibited cisplatin-induced cytotoxicity in the auditory cell line, HEI-OC1. Silymarin may be a potential candidate drug to eliminate cisplatin induced ototoxicity.
journal_name
Int J Pediatr Otorhinolaryngoljournal_title
International journal of pediatric otorhinolaryngologyauthors
Cho SI,Lee JE,Do NYdoi
10.1016/j.ijporl.2013.12.024subject
Has Abstractpub_date
2014-03-01 00:00:00pages
474-8issue
3eissn
0165-5876issn
1872-8464pii
S0165-5876(13)00670-8journal_volume
78pub_type
杂志文章abstract：:An analysis of the results of 100 temporalis fascia underlay myringoplasties in children between the ages of 2-17 years is presented. The follow-up period in this retrospective review was from 6 to 24 months. There was no statistically significant correlation between the age of patient, a history of previous ear surge...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(94)01067-8
更新日期：1995-01-01 00:00:00
abstract：:The objective of the current study was to investigate possible differences in word count use per day (number of adult words) by caregivers of different gender, in a sample of Norwegian children (N = 17) with hearing impairment (HI) (n = 8) and normal hearing (NH) (n = 9), aged 18-56 months. The current study had a cro...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2019.109809
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:To measure maternal breast feeding benefit after infant frenotomy. To investigate if timing of neonatal/infant frenotomy affects outcome. STUDY DESIGN:Cohort survey and retrospective review. METHODS:Medical records of neonates and infants suspected to have ankyloglossia between April 2006 and February 2011...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2012.05.009
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:To evaluate vestibular and long-term audiometric findings in patients with Pendred syndrome. STUDY DESIGN:Retrospective analysis of long-term clinical data. SETTING:University hospital department. PATIENTS:Three patients with Pendred syndrome caused by a mutation in the SLC26A4 gene. METHODS:Perchlorate d...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(01)00573-0
更新日期：2001-12-01 00:00:00
abstract：:Adenoid cystic carcinoma of the external auditory canal is very rare in a child, and has not previously been reported in an individual younger than 18 years. We report an 8-year-old girl with adenoid cystic carcinoma of the external auditory canal associated with cholesteatoma. At the time of diagnosis, the tumor had ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2012.09.034
更新日期：2013-01-01 00:00:00
abstract：:One hundred seventy children and 103 adults from a rural Nigerian village were examined for the presence of middle and external ear pathology. Ear, nose and throat examination included: (1) pneumatic otoscopic exam, (2) tympanometry and (3) contralateral acoustic reflex. A diagnostic algorithm was applied to these 3 f...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s0165-5876(83)80004-4
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Comprehensive quantitative evaluation of the intercarotid artery distance (ICD) in the pediatric population has not been sufficiently explored. This study aims to measure the minimal ICDs at multiple levels of the skull base to assess changes in the ICD during development. METHODS:Measurement of the ICDs bet...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2020.110520
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:Several test batteries have been suggested for auditory processing disorder (APD) diagnosis. One of the important tests is dichotic listening tests. Significant ear asymmetry (usually right ear advantage) can be indicative of (APD). Two main trainings have been suggested for dichotic listening disorders: Dif...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2018.05.014
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:Parameters to distinguish normal from deviant voices in early childhood have not been established. The current study sought to auditorily and acoustically characterize voices of children, and to study the relationship between vocal behavior reported by teachers and the presence of vocal aberrations. METHODS:...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2012.02.067
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To describe differential features of giant cervical dermoid cysts and other cystic lesions of the head and neck. METHODS:Case report including magnetic resonance imaging, surgical excision, pathologic examination and correlation. RESULTS:We report the case of a 15-year-old boy who presented for evaluation o...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2006.11.020
更新日期：2007-04-01 00:00:00
abstract：:Two cases of neurogenic tumours of parapharyngeal space in children of 7 years old are presented. Difficulties during the diagnosis, investigations and management are discussed along with a review of the available literature. CAT scan with sialography, carotid angiography during surgery, angle mandibulectomy and liber...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(91)90039-e
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:The objective of the present study was to investigate the longitudinal performance on open-set word perception in Mandarin children with cochlear implants (CIs). METHODS:Prospective cohort study. One hundred and five prelingually deaf children implanted with CIs participated in the study. The Standard-Chines...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.07.023
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:To assess prevalence and risk factors of tinnitus reported by 7- and 12-year-old children from primary schools in Warsaw. A secondary objective was to test the relationship between hearing loss and tinnitus prevalence. METHODS:Observational cross-sectional study of 15,199 students aged 7 and 12 years (66.9%...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.06.008
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Velopharyngeal insufficiency (VPI) occurs when the velopharyngeal sphincter (VPS) is unable to completely seal anatomical closure between the nasal and oral cavities during speech. Palatal repair can restore VPS function but the prevalence of VPI after repair has been reported ranging from 20% to 40%. The co...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2019.02.022
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:The aim of our study is to evaluate, in accordance with EUROCLEFT guidelines, the aesthetics of nasolabial area in a sample of complete unilateral cleft of lip and palate patients (UCLP), after surgical correction with Delaire' technique. METHODS:Twenty-two UCLP patients (16 males and 6 females, 9 right and ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2005.07.017
更新日期：2006-03-01 00:00:00
abstract：:Thirty-eight hydrocephalic children (mean age 11.5 years; range 5.1-17.9) were examined on average 7.9 years after initial shunting. The etiology of the hydrocephalus was divided into 5 groups: perinatal intraventricular hemorrhage 14, congenital obstructive hydrocephalus 14, central nervous system infections 4, intra...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(92)90077-3
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the long term results of treatment and rehabilitation of childhood dysphonia. METHODS:This study included a group of adolescents (n=29) aged from 15 to 20 who were treated due to pediatric hyperfunctional dysphonia and soft vocal fold nodules during their pre-mutational pe...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2014.02.002
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To date, the impact of conductive hearing loss on the auditory pathway at brainstem level has only been investigated in animal studies, which showed a species-specific delay of maturation. In this study, the functional maturation of auditory brainstem response (ABR) parameters in humans with unilateral atresi...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2017.01.029
更新日期：2017-04-01 00:00:00
abstract：:Physical illness in children is affected by a variety of factors unique to pediatrics. They include a child's developmental level, family environment and the presence of premorbid behavior patterns. Therefore, pediatric care requires special considerations pertaining to the patient-physician relationship and the poten...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(94)01113-c
更新日期：1995-05-01 00:00:00
abstract：:Hyper Immunoglobulin E Syndrome, or Job's Syndrome, is a rare multisystem disorder that classically presents in early childhood with a triad of clinical manifestations that include severe eczematous dermatitis, recurrent infections (skin and lung), and elevated serum immunoglobulin E. Hyper Immunoglobulin E Syndrome i...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2011.03.005
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:To provide age-equivalent norms for a 500Hz logon evoked ABR obtained in a group of children ranging 40 weeks-4 years old and compare these 500Hz tonal norms to age-equivalent norms for click-evoked ABR. METHODS:Seventy-seven infants and children ranging from conceptional age of 40 weeks (term babies) to 4 ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2007.01.016
更新日期：2007-05-01 00:00:00
abstract：:Congenital rests of gastric epithelium have been reported in a variety of head and neck locations. Presenting symptoms of these lesions range from an asymptomatic cyst to one which is compromising the airway. The true diagnosis is rarely suspected prior to excision. A case of a gastric choristoma of the tongue is pres...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(92)90070-6
更新日期：1992-07-01 00:00:00
abstract：OBJECTIVE:The aim of the present study is to discuss the basics of atopy in children in relationship to the principal ENT allergic disorders such as allergic rhinitis, rhinosinusitis and their impact on lower airways, allergic otitis media, and oral cavity focusing on their natural history. METHODS:An updated and exha...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/S0165-5876(09)70005-9
更新日期：2009-12-01 00:00:00
abstract：:A random sample of 2512 children were monitored to an average age of two years to determine the occurrence of acute otitis media (AOM). A life-table methodology was employed in the analysis. The cumulative incidence of the first episode of AOM up to 12 months of age was 42.4% (95% confidence interval 40.4-44.4) and th...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(91)90054-f
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVES:To evaluate outcome of surgical excision of sialoblastoma in the parotid gland in newborn. PATIENTS AND METHODS:This was a retrospective review of 3 pediatric patients with sialoblastoma in the parotid gland that underwent surgical resections. All patients are newborn boys. The lesions ranged from 5 cm × 5 ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2013.05.006
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Drooling of saliva is a common problem in children with cerebral palsy. In addition to causing impairment in articulation, drooling also affects socialization, interpersonal relationships and integration into society for these children. There are various methods to assess drooling which measure directly the ...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2018.06.029
更新日期：2018-09-01 00:00:00
abstract：:This study analyzed the occurrence of negative middle ear pressure in various groups of children by comparing them with control groups. A screening procedure recording middle ear pressure and screening audiogram was performed several times throughout the year in an unselected group of 352 seven-year-old children. From...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(79)90015-6
更新日期：1979-12-01 00:00:00
abstract：OBJECTIVE:This paper reports the performance of a newly implemented hospital-based universal newborn hearing screening programme and the challenges to the effective implementation. METHODS:Data of 4437 babies screened from April 2003 to February 2004 at Hospital Universiti Kebangsaan Malaysia was analyzed to measure t...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2005.09.018
更新日期：2006-05-01 00:00:00
abstract：:Acquired tracheoesophageal fistulas (TEF) are rare but dangerous complications of disc-battery ingestion. Management approaches include endoscopic or open surgical repair. Unfortunately, these procedures can be complicated by high rates of recurrent laryngeal nerve injury, tracheal stenosis, recurrent fistula and sign...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2008.01.015
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:The term "fibro-osseous lesion" is a generic description for a group of lesions involving the paranasal sinuses and anterior skull base. We aim to improve understanding of the clinical and pathological presentation of fibro-osseous lesions in children. METHODS AND RESULTS:We report two cases of aggressive "f...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.ijporl.2005.09.031
更新日期：2006-02-01 00:00:00
