Immunological experimental arthritis in pigs. I. Propagation dynamics of the attenuated strain of Aujeszky's disease virus in the pig organism and the humoral immunity formation.

Abstract:

:Studies on the propagation dynamics of Aujeszky's disease virus and the formation of general and local joint immunity were to provide information explaining the mechanism of experimental rheumatoid arthritis in animals. It was shown that: Aujeszky's disease virus administered intramuscularly caused viremy on 3-4th day after its application and disappeared from the blood circulation on 5-6th day, introduced into the pig ankle joint, the virus was eliminated from the articular fluid two hours after injection, but it appeared again 3-7 days later probably due to the propagation in the cells of the synovial membrane, and that first parenteral administration of the virus induced the formation of neutralizing antibodies in low titer (5-10 units); application of the virus for the second time brought about a considerable increase of antibodies titer within 40-80 units.

authors

Wawrzkiewicz J,Majer-Dziedzic B,Lipińska M,Silmanowicz P

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

807-12

issue

1-6

eissn

0004-069X

issn

1661-4917

journal_volume

26

pub_type

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