Abstract：
:Detecting differences in the effect of two antihypertensive agents is bedevilled by the inherent variability of blood pressure itself. Using an ambulatory blood pressure monitoring technique, we compared, in a cross-over design study, the effects of four weeks' treatment with enalapril, 10 mg once daily, to lisinopril, 10 mg once daily, on the blood pressure of 19 patients with mild to moderate hypertension. A significant reduction in blood pressure was shown by both drugs. However, lisinopril produced a greater fall in mean 24 hour systolic pressure than did enalapril (difference; 5.94 (C.I. -0.77 to -11.1) mmHg, P = 0.027). The difference of 3.3 mmHg (C.I. +0.54 to -7.10) in diastolic pressure between the two agents, though in the same direction, was not significant. Plasma renin activity did not predict the responses to either agent. Studying the prevailing information for these two drugs one might expect there to be little difference between them when administered once daily in terms of antihypertensive effect. The explanation for the superiority of lisinopril may lie in the slightly longer pharmacokinetic half-life and possibly in differences in tissue distribution or persistence. The side effects of both drugs were mild and of similar frequency to those recorded during placebo treatment, illustrating the generally well tolerated nature of this class of antihypertensive therapy. The use of ambulatory blood pressure monitoring provides a method that can detect small, but possibly important differences between drugs. In the clinical setting it allows a more thorough assessment of a particular patient's response to therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Conway J,Coats AJ,Bird Rsubject
Has Abstractpub_date
1990-06-01 00:00:00pages
235-9issue
3eissn
0950-9240issn
1476-5527journal_volume
4pub_type
临床试验,杂志文章,随机对照试验abstract：:The effect of sulindac on ACE inhibitor-induced cough was studied in eight hypertensive subjects in a randomised placebo-controlled double blind cross-over trial. There was no significant improvement in cough or sense of well-being. Blood pressure, renal function, plasma renin and ACE activity were unchanged. Sulindac...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-12-01 00:00:00
abstract：:Both trandolapril and verapamil are effective and widely used antihypertensive agents. The aim of this study was to estimate the efficacy and tolerability of trandolapril/verapamil (Tr/Ve) combination for blood pressure control and renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant studies....
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/jhh.2010.60
更新日期：2011-03-01 00:00:00
abstract：:Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), have well-recognized effects on the cardiovascular system. However, the evidence is lacking regarding the relationship between repeated FT3, FT4, and thyroid-stimulating hormone (TSH) measurements and incident hypertension. The aim of this ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-00474-4
更新日期：2021-01-18 00:00:00
abstract：:Hypertension is the number one risk factor for cardiovascular diseases worldwide and yet its diagnosis among adolescents, based on blood pressure percentiles which are age, height, and sex-specific, is complex. Our study intended to determine the suitability of blood pressure height index in defining adolescent hypert...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0292-x
更新日期：2020-01-01 00:00:00
abstract：:Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, ev...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0337-1
更新日期：2020-04-29 00:00:00
abstract：:The current study comprehensively examined the association between common variants in the Na(+)-coupled bicarbonate transporter (NCBT) genes and blood pressure (BP) responses to dietary sodium intervention. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1906 Han participant...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/jhh.2015.113
更新日期：2016-09-01 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) levels and ACE gene polymorphisms have been related with hypertension but with contradictory results between populations. We have investigated the association among the allelic distribution of the insertion-deletion (I/D) polymorphism of the ACE gene, identified by polymerase chain ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000958
更新日期：2000-02-01 00:00:00
abstract：:Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2011.88
更新日期：2012-12-01 00:00:00
abstract：:Aortic dissection is a disease of immediate consequence,as mortality of a proximal dissection is in excess of 50% when left untreated. Early recognition of the dissection event can lead to faster definitive correction with surgical and/or novel percutaneous approaches. Widely varying signs and symptoms can, however, m...
journal_title：Journal of human hypertension
pub_type： 信件
doi：10.1038/sj.jhh.1002208
更新日期：2007-10-01 00:00:00
abstract：:When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Early life prevention of obesity and associated metabolic disease is necessary to address the current obesity epidemic. Latino children have a higher risk of obesity, and associated comorbidities such as hypertension than Caucasian children. This study focuses on perinatal childhood and maternal risk factors associate...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0306-8
更新日期：2020-11-01 00:00:00
abstract：:The divergence in cardiovascular disease risk among Asian countries may be related to differences in economics, lifestyles, and cultural backgrounds. We examined the differential association of overweight and hypertension between the high- and middle-income Asian countries, namely Japan and Thailand and extended to co...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0118-2
更新日期：2019-02-01 00:00:00
abstract：:The aim of this study was to evaluate the prevalence of renal artery stenosis in patients with clinical signs of peripheral vascular disease and hypertension. One hundred patients, mean age 69 years (range 45-88) with symptoms and clinical signs of severe peripheral ischemia, underwent aortography to determine the deg...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Ambulatory blood pressure variability (ABPV) is a predictor of cardiovascular risk in hypertensives. Factors that contribute to ABPV are not well described. This pilot study aimed to investigate the relationship between ABPV and urine catecholamine metabolites in order to rationalise further therapeutic intervention i...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.23
更新日期：2015-01-01 00:00:00
abstract：:While the arterial tree is exposed to increased pressure flow, paradoxically the complications of hypertension are mainly thrombotic rather than haemorrhage. Improved techniques have allowed the identification of haemorrheological indices, coagulation factors and markers of arteriolar endothelial and platelet dysfunct...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1994-09-01 00:00:00
abstract：:In our study we investigated 36 patients with renal disease, 22 of whom were hypertensive. In all proteinuria was present (4.30 +/- 5.05 g protein/day) and renal lesions were proved by renal biopsy. Blood cadmium in non-smokers was significantly (P less than 0.05) lower than in smokers. We found a positive correlation...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.10
更新日期：2014-11-01 00:00:00
abstract：:Patients with hypertension, particularly those with diabetes mellitus, are at heightened risk for cardiovascular and renal disease. Accumulated evidence indicates that the majority of hypertensive patients at high risk will require more than one antihypertensive agent to reach their blood pressure (BP) target. A reaso...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1002254
更新日期：2007-10-01 00:00:00
abstract：:The commonly used methods of estimating the 24-h urinary sodium (UNa) and urinary potassium (UK) from spot urine (SU) are the Kawasaki method (K-method), INTERSALT method (I-method), and Tanaka method (T-method), but the method that is suitable for use in the general Chinese population is still uncertain. We aimed to ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0274-z
更新日期：2020-02-01 00:00:00
abstract：:The purpose of this study is to review the role of dopamine in hypertension and associated conditions. The analysis of literature indicates that present knowledge is mostly based on poor markers and indirect evidence of dopaminergic activity and only few molecular biological data. Alternative markers such as plasma do...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000870
更新日期：1999-09-01 00:00:00
abstract：:The aim of the present study was to evaluate effects of long-term treatment with rilmenidine compared with atenolol on lipid and glucose metabolism and cardiovascular remodelling in hypertension. In total, 37 patients with hypertension were randomised to rilmenidine 1-2 mg/day or atenolol 50-100 mg/day for 26 weeks. S...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.jhh.1002004
更新日期：2006-06-01 00:00:00
abstract：:The clinical correlates and risk profile of prediabetes (fasting plasma glucose (FPG) values in the upper normal limits but below the diabetic threshold) in hypertension, an insulin-resistant, prodiabetogenic condition, are scarcely known. For this reason, we evaluated 982 non-diabetic (FPG,<126 mg 100 ml(-1) and no a...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.142
更新日期：2009-05-01 00:00:00
abstract：:Exercise has been proved to promote the number and activity of circulating endothelial progenitor cells (EPCs) in humans, which contributes to improvement in endothelial function and maintenance of cardiovascular homoeostasis. However, the mechanism underlying the effect of exercise on circulating EPCs in healthy subj...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002171
更新日期：2007-06-01 00:00:00
abstract：:Several studies have proposed a relationship between blood pressure and inflammation. Interleukin-6 (IL-6) is a multifunctional cytokine involved in inflammation and tissue injury and potentially influencing blood pressure. Recently, a common polymorphism of the IL-6 gene, associated with differences in the transcript...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001462
更新日期：2002-09-01 00:00:00
abstract：:To assess vascular compliance in patients with antiphospholipid syndrome (APS), or antiphospholipid antibodies (aPLs) positivity in comparison to healthy people and diabetes mellitus patients. Twenty-five patients with APS or aPLs, 33 healthy people (HP), 28 patients with diabetes mellitus (DM) underwent pulse wave an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002020
更新日期：2006-07-01 00:00:00
abstract：:Diabetic patients with hypertension are at particularly high risk of vascular damage and consequently cardiovascular and renal disease. Fibulin-1, an extracellular matrix glycoprotein, is increased in arterial tissue and plasma from individuals with type 2 diabetes. This study aimed to evaluate whether antihypertensiv...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2014.27
更新日期：2015-01-01 00:00:00
abstract：:Footshocks increases mean arterial pressure and heart rate. Systemic or intracerebroventricular (IVT) administration of losartan, a specific angiotensin AT1 receptor antagonist, not only inhibited the pressor response to footshocks but resulted in vasodepression. Peripheral or IVT administration of PD 123319, a specif...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000986
更新日期：2000-04-01 00:00:00
abstract：:There is growing evidence that hypertension, one of the major modifiable risk factors for cardiovascular disease (CVD), is established early in life. Given this, it is important to discover when hypertension first becomes apparent. Further, it is of particular importance to examine the ethnic differences in blood pres...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001674
更新日期：2004-04-01 00:00:00
abstract：:The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:A total of 930 patients have been evaluated for safety in a programme of clinical trials for lisinopril-hydrochlorothiazide combination treatment. Combination therapy with these two agents is generally well tolerated. In clinical trials, adverse experiences in patients treated with a lisinopril-hydrochlorothiazide com...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
