Abstract:
:"Molecular recognition" is one of the most important molecular processes for living systems in order to maintain their life, since most of the biological functions are initiated with the process. Understanding of the process is also important for designing a new drug. Firstly, it is important to find a target of a drug, which is in many cases a function of protein or DNA to be inhibited. Secondly, binding a drug molecule to the active site of a biomolecule itself is a "molecular recognition process". In the present article, we review our recent studies on the molecular recognition process, carried out by means of the 3D-RISM theory, a statistical mechanics theory of liquids. Studies on the conduction mechanisms in two types of molecular channels, aquaporin and the M2 channels, are reviewed.
journal_name
Curr Pharm Desjournal_title
Current pharmaceutical designauthors
Phongphanphanee S,Yoshida N,Hirata Fdoi
10.2174/138161211796355100subject
Has Abstractpub_date
2011-01-01 00:00:00pages
1740-57issue
17eissn
1381-6128issn
1873-4286pii
BSP/CPD/E-Pub/000475journal_volume
17pub_type
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journal_title:Current pharmaceutical design
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abstract::Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system. The brain modulates the immune system by the endocrine and autonomic nervous system. Vice versa, the immune system modulates brain activity including sleep and body temperature. Based...
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abstract::The aging phenomenon is intrinsically responsible for diseases and lifestyle-associated conditions afflicting the aging male. In particular, male infertility seems to result from deleterious lifestyle choices. However, the aging effect at the individual gene/protein level is poorly discussed and valuable information i...
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