Membrane disrupting lytic peptides for cancer treatments.

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：:From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics face a considerably higher risk of developing cardiovascular and cerebrovascular diseases. Both large and small blood vessels are susceptible to alterations from diabetes. Endothelial cell dysfunction associated with small ve...

journal_title：Current pharmaceutical design

authors： Huber JD

更新日期：2008-01-01 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of morbidity and mortality among postmenopausal women in western societies. There are still no specific and highly efficient methods of preservation of women's vascular health in modern preventive medicine. For many years physicians have assumed that hormone replacement...

journal_title：Current pharmaceutical design

authors： Sobenin IA,Myasoedova VA,Orekhov AN

更新日期：2016-01-01 00:00:00

abstract：:Risk reduction and the attainment of good outcomes in contemporary cataract surgery depend in part on patient compliance with a postoperative regimen of topical eye drops. Topical drops are expensive and challenging to instill properly for patients. The consequences of noncompliance or poor compliance can be significa...

journal_title：Current pharmaceutical design

authors： Lindstrom RL,Galloway MS,Grzybowski A,Liegner JT

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of ...

journal_title：Current pharmaceutical design

authors： Cenko E,Bugiardini R

更新日期：2016-01-01 00:00:00

abstract：:The so-called demographic transition has changed the age structure of the population worldwide, with profound effects on societal organization. The growing number and percentage of old and very old people has compelled the scientific community to focus on age related diseases and peculiar consequences of aging itself ...

journal_title：Current pharmaceutical design

authors： Paganelli R,Di Iorio A,Cherubini A,Lauretani F,Mussi C,Volpato S,Abate M,Abate G,Ferrucci L

更新日期：2006-01-01 00:00:00

abstract：:Various growth factors such as the platelet derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) transduce their mitogenic signals through the activation of tyrosine kinase receptors (RTKs). Since en...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Sachinidis A

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To summarize the main findings from research on food uses of Pine Bark Phenolic Extracts (PBPE), their origin, methods of extraction, composition, health effects, and incorporation into food products. METHODS:A narrative review of all the relevant papers known to the authors was conducted. RESULTS:PBPE are ma...

journal_title：Current pharmaceutical design

authors： Dridi W,Bordenave N

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research focused on identifying compounds that restore cognition and memory in AD patients is a very active investigational pursuit, but unfortunately, it has been only successful in terms of developing symptomatic treatments. Aβ deposition a...

journal_title：Current pharmaceutical design

authors： Solas M,Puerta E,Ramirez MJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Coronavirus Disease-2019 belongs to the family of viruses which cause a serious pneumonia along with fever, breathing issues and infection of lungs for the first time in China and later spread worldwide. OBJECTIVE:Several studies and clinical trials have been conducted to identify potential drugs and vaccin...

journal_title：Current pharmaceutical design

authors： Bibi S,Sarfraz A,Mustafa G,Ahmed Z,Zeb MA,Wang YB,Khan T,Khan MS,Kamal MA,Yu H

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:The failing heart is characterized by a depleted metabolic energy reserve and the upregulation of several molecular mechanisms leading to cardiac hypertrophy, inflammation, fibrosis, angiogenesis, and apoptosis. Dietary or non-dietary supplementation of vitamins could potentially benefit energy balance. OBJ...

journal_title：Current pharmaceutical design

authors： Georgiopoulos G,Chrysohoou C,Vogiatzi G,Magkas N,Bournelis I,Bampali S,Gruson D,Tousoulis D

更新日期：2017-01-01 00:00:00

abstract：:The treatment of skin wounds represents an important research area due to the important physiological and aesthetic role of this tissue. During the last years, nanoparticles have emerged as important platforms to treat skin wounds. Silver, gold, and copper nanoparticles, as well as titanium and zinc oxide nanoparticle...

journal_title：Current pharmaceutical design

authors： Oyarzun-Ampuero F,Vidal A,Concha M,Morales J,Orellana S,Moreno-Villoslada I

更新日期：2015-01-01 00:00:00

abstract：:Sarcopenia is defined as the loss of muscle mass associated with a loss of muscle function, e.g., walking speed. A number of consensus definitions exist for sarcopenia with cut-off points being ethnically specific. A rapid screen test (SARC-F) is available and does not require different ethnic cut-off points. Sarcopen...

journal_title：Current pharmaceutical design

authors： Morley JE

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Cancer is the world's second-largest cause of death, with an estimated 9.6 million fatalities in 2018. Malignant tumour (cancer) is caused by a mixture of genetic modifications due to the environmental variables that tend to activate or inactivate different genes, ultimately resulting in neoplastic transform...

journal_title：Current pharmaceutical design

authors： Jindal M,Nagpal M,Singh M,Aggarwal G,Dhingra GA

更新日期：2020-01-01 00:00:00

abstract：:Bisphosphonates are widely use for pathologies such as osteoporosis, Paget's disease or bone metastasis. However, their potent antiresorptive properties open new therapeutic opportunities for other conditions associated with an increased focal or systemic bone remodelling. Moreover, apart from their antiresorptive act...

journal_title：Current pharmaceutical design

authors： Le Goff B,Berthelot JM,Maugars Y,Romas E

更新日期：2010-01-01 00:00:00

abstract：:Mast cells are important in the development of allergic and anaphylactic reactions, but also in acquired and innate immunity. There is also increasing evidence that mast cells participate in inflammatory diseases, where they can be activated by non-allergic triggers, such as neuropeptides and cytokines, often having s...

journal_title：Current pharmaceutical design

authors： Sismanopoulos N,Delivanis DA,Alysandratos KD,Angelidou A,Therianou A,Kalogeromitros D,Theoharides TC

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Multi-drug resistant infections are a growing worldwide health concern. There is an urgent need to produce alternative antimicrobial agents. OBJECTIVE:The study aimed to design a new hybrid antimicrobial peptide, and to evaluate its antimicrobial activity alone and in combination with traditional antibiotic...

journal_title：Current pharmaceutical design

authors： Tall YA,Al-Rawashdeh B,Abualhaijaa A,Almaaytah A,Masadeh M,Alzoubi KH

更新日期：2020-01-01 00:00:00

abstract：:Cell Penetrating Peptides (CPPs) equipped with a high penetrating ability are used as a promising tool to gain access to the cell interior, cross the cell membrane and deliver bioactive small or macromolecular cargos into the cytoplasm or nucleus. The superiority of wide range of applications, high transport efficienc...

journal_title：Current pharmaceutical design

authors： Zhang F,Yang D,Jiang S,Wu L,Qin L,He H,Zhang P

更新日期：2018-01-01 00:00:00

abstract：:The discovery of the delicate role of endogenous nitric oxide in the homeostasis of various cellular functions and the dynamic behaviour of the airways, has led to a new, rapidly progressing area of physiological science, that has direct bearing for our understanding of multiple airway diseases. The potentially protec...

journal_title：Current pharmaceutical design

authors： Folkerts G,Nijkamp FP

更新日期：2006-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) are well recognized for playing a dual role as both deleterious and beneficial species. ROS are products of normal cellular metabolism and under physiological conditions, participate in maintenance of cellular 'redox homeostasis. Overproduction of ROS, results in oxidative stress. Oxidati...

journal_title：Current pharmaceutical design

authors： Rosanna DP,Salvatore C

更新日期：2012-01-01 00:00:00

abstract：:Mass spectrometry information has long offered the potential of discovering biomarkers that would enable clinicians to diagnose disease, and treat it with targeted therapies. PeptideAtlas currently provides access to large-scale spectra data and identification information. This data, and the generation of targeted pep...

journal_title：Current pharmaceutical design

authors： Killcoyne S,Deutsch EW,Boyle J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI). METHODS:A c...

journal_title：Current pharmaceutical design

authors： Li F,Li H,Xiao Z,Lu R,Zhang Z,Zhu H,Ren L

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Arterial hypertension (AH) and peripheral arterial disease (PAD) frequently coincide. While significant attention is paid to AH, PAD is often underestimated. It is known that both AH and PAD present high cardiovascular risks for ischemic events. To date, the use of the most common anti-hypertensive drugs in ...

journal_title：Current pharmaceutical design

authors： Signorelli SS

更新日期：2017-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the main endogenous pro-angiogenic cytokines. Inhibition of the VEGF signaling pathways is an effective treatment for cancer patients. In addition, local anti- VEGF therapy was developed and established to treat proliferative diabetic retinopathy, age-related macular...

journal_title：Current pharmaceutical design

authors： van der Giet M,Henkel C,Schuchardt M,Tolle M

更新日期：2015-01-01 00:00:00

abstract：:The apoptosis inducing factor (AIF) was first discovered as a caspase-independent apoptosis effector that promoted cell death upon release from the mitochondria (triggered by pro-apoptotic stimuli) and relocalization into the nucleus, where it promotes chromatin condensation and DNA fragmentation. AIF is a mammalian m...

journal_title：Current pharmaceutical design

authors： Ferreira P,Villanueva R,Cabon L,Susín SA,Medina M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19) by the World Health Organization, is a newly emerging zoonotic agent that emerged in China in December 2019. No specific treatment for COVID-19 is currently available. Usual palliative treatment includes ...

journal_title：Current pharmaceutical design

authors： Lovato ECW,Barboza LN,Wietzikoski S,de Souza ANV,Auth PA,Junior AG,Dos Reis Lívero FA

更新日期：2020-07-07 00:00:00

abstract：:High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. This proteolytic event results in a nonapeptide, bradykinin (BK), and a kinin-free derivative of HK, namel...

journal_title：Current pharmaceutical design

authors： Colman RW

更新日期：2006-01-01 00:00:00

abstract：:The introduction of highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus (HIV) infection has significantly improved the life expectancy of HIV positive patients. Hepatitis C virus (HCV) co-infection is common in HIV infected patients and is now a significant cause of morbidity and mortality. ...

journal_title：Current pharmaceutical design

authors： Fabris P,Barnes E,Tositti G,Giordani MT,Grasso A,De Lalla F

更新日期：2004-01-01 00:00:00

abstract：:Tumor metastasis is an important prognostic factor regarding long-term survival rate of cancer patients. At present, no imaging modality or technique is ideal for diagnosis of metastases. Molecular imaging has provided a fantastic tool for tumor metastases imaging. Based on the current medical imaging tools such as ma...

journal_title：Current pharmaceutical design

authors： Qiao R,Zhu R,Gao M

更新日期：2015-01-01 00:00:00

abstract：:The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within the first weeks or months of life is inevitable. Some diseases ca...

journal_title：Current pharmaceutical design

authors： McKay TR,Rahim AA,Buckley SM,Ward NJ,Chan JK,Howe SJ,Waddington SN

更新日期：2011-01-01 00:00:00