Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4'-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage.

abstract：:MYC exerts both positive and negative functions in cancer cells, such that its procancerous effects are unmasked only after its anticancer effects are blocked. Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small...

journal_title：Cancer research

authors： Allen TD,Zhu CQ,Jones KD,Yanagawa N,Tsao MS,Bishop JM

更新日期：2011-03-15 00:00:00

abstract：:Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tum...

journal_title：Cancer research

authors： Lohr F,Lo DY,Zaharoff DA,Hu K,Zhang X,Li Y,Zhao Y,Dewhirst MW,Yuan F,Li CY

更新日期：2001-04-15 00:00:00

abstract：:We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LK...

journal_title：Cancer research

authors： Upadhyay S,Liu C,Chatterjee A,Hoque MO,Kim MS,Engles J,Westra W,Trink B,Ratovitski E,Sidransky D

更新日期：2006-08-15 00:00:00

abstract：:The human ether-a-go-go-related gene (herg) encodes a K+ current (IHERG) that plays a fundamental role in heart excitability by regulating the action potential repolarization (IKr); mutations of this gene are responsible for the chromosome 7-linked long QT syndrome (LQT2). In this report, we show that in a variety (n ...

journal_title：Cancer research

authors： Bianchi L,Wible B,Arcangeli A,Taglialatela M,Morra F,Castaldo P,Crociani O,Rosati B,Faravelli L,Olivotto M,Wanke E

更新日期：1998-02-15 00:00:00

abstract：:Cancer-secreted, extracellular vesicle (EV)-encapsulated miRNAs enable cancer cells to communicate with each other and with noncancerous cells in tumor pathogenesis and response to therapies. Here, we show that treatment with a sublethal dose of chemotherapeutic agents induces breast cancer cells to secrete EV with th...

journal_title：Cancer research

authors： Shen M,Dong C,Ruan X,Yan W,Cao M,Pizzo D,Wu X,Yang L,Liu L,Ren X,Wang SE

更新日期：2019-07-15 00:00:00

abstract：:Insulin-like growth factors (IGFs) have mitogenic and antiapoptotic properties and have been implicated in the development of lung cancer. The effects of IGFs are modulated by insulin-like growth factor binding proteins (IGFBPs). This study explored the effects of IGFBP-3 on non-small cell lung cancer (NSCLC) cells af...

journal_title：Cancer research

authors： Lee HY,Chun KH,Liu B,Wiehle SA,Cristiano RJ,Hong WK,Cohen P,Kurie JM

更新日期：2002-06-15 00:00:00

abstract：:Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 mM cis-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ul...

journal_title：Cancer research

authors： Abbas MK,Yoo TJ,Viles J

更新日期：1982-11-01 00:00:00

abstract：:The INK4a/ARF locus encodes two distinct tumor suppressors, p16INK4a and p14ARF. Although the contribution of p16INK4a to human tumorigenesis through point mutation, deletion, and hypermethylation has been widely documented, little is known about specific p14ARF lesions and their consequences. Recent data indicate tha...

journal_title：Cancer research

authors： Esteller M,Cordon-Cardo C,Corn PG,Meltzer SJ,Pohar KS,Watkins DN,Capella G,Peinado MA,Matias-Guiu X,Prat J,Baylin SB,Herman JG

更新日期：2001-04-01 00:00:00

abstract：:Suppression of synthesis of specific tropomyosin (TM) isoforms occurs commonly in human, murine, and avian fibroblasts transformed by retroviral oncogenes or other modalities. The resulting deficiency or altered distribution of TMs may predispose the cells to microfilament instability and contribute to expression of t...

journal_title：Cancer research

authors： Bhattacharya B,Prasad GL,Valverius EM,Salomon DS,Cooper HL

更新日期：1990-04-01 00:00:00

abstract：:Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not or...

journal_title：Cancer research

authors： Tse C,Shoemaker AR,Adickes J,Anderson MG,Chen J,Jin S,Johnson EF,Marsh KC,Mitten MJ,Nimmer P,Roberts L,Tahir SK,Xiao Y,Yang X,Zhang H,Fesik S,Rosenberg SH,Elmore SW

更新日期：2008-05-01 00:00:00

abstract：:H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2...

journal_title：Cancer research

authors： Stiff T,O'Driscoll M,Rief N,Iwabuchi K,Löbrich M,Jeggo PA

更新日期：2004-04-01 00:00:00

abstract：:Effect of pretransplantation hyperthermia of tumor bed on tumor growth was studied. Experimental tumors were isotransplants of a fibrosarcoma which arose spontaneously in C3Hf/Sed mice. The pretransplantation hyperthermia was given at 43.5 degrees fro 120 min by immersing the mouse foot into a constant temperature wat...

journal_title：Cancer research

authors： Urano M,Cunningham M

更新日期：1980-01-01 00:00:00

abstract：:c-abl, c-fos, c-Ha-ras, c-myc, and c-mos were expressed whereas c-sis, c-fms, c-rel, c-src, and c-myb expression was not detectable in C3H/10T1/2 Cl 8 (10T1/2) cells and in eight chemically and radiation-transformed 10T1/2 cell lines. The expression of c-abl, c-fos, c-Ha-ras, and c-myc was growth-related in nontransfo...

journal_title：Cancer research

authors： Shuin T,Billings PC,Lillehaug JR,Patierno SR,Roy-Burman P,Landolph JR

更新日期：1986-10-01 00:00:00

abstract：:Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a)...

journal_title：Cancer research

authors： Yasuda M,Takenoyama M,Obata Y,Sugaya M,So T,Hanagiri T,Sugio K,Yasumoto K

更新日期：2002-03-15 00:00:00

abstract：:Benz(a)anthracene (BA) and its five possible trans-dihydrodiols were evaluated for determination of their skin tumor-initiating activity and their mutagenic activity in Chinese hamster V79 cells. In addition, the skin tumor-initiating abilities of five diol-epoxides of BA were tested. Results showed (+/-)-trans-3,4-di...

journal_title：Cancer research

authors： Slaga TJ,Huberman E,Selkirk JK,Harvey RG,Bracken WM

更新日期：1978-06-01 00:00:00

abstract：:Metastatic cases of breast cancer pose the primary challenge in clinical management of this disease, demanding the identification of effective therapeutic strategies that remain wanting. In this study, we report that elevated levels of α-tubulin acetylation are a sufficient cause of metastatic potential in breast canc...

journal_title：Cancer research

authors： Boggs AE,Vitolo MI,Whipple RA,Charpentier MS,Goloubeva OG,Ioffe OB,Tuttle KC,Slovic J,Lu Y,Mills GB,Martin SS

更新日期：2015-01-01 00:00:00

abstract：:The cells of many solid tumors have been found to contain supernumerary centrosomes, a condition known as centrosome amplification. Centrosome amplification, accompanied by the overexpression of an associated kinase, Aurora A (AurA), has been implicated in mechanisms leading to mitotic spindle aberrations, aneuploidy,...

journal_title：Cancer research

authors： Goepfert TM,Adigun YE,Zhong L,Gay J,Medina D,Brinkley WR

更新日期：2002-07-15 00:00:00

abstract：:Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in s...

journal_title：Cancer research

authors： Walker EJ,Zhang C,Castelo-Branco P,Hawkins C,Wilson W,Zhukova N,Alon N,Novokmet A,Baskin B,Ray P,Knobbe C,Dirks P,Taylor MD,Croul S,Malkin D,Tabori U

更新日期：2012-02-01 00:00:00

abstract：:nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellu...

journal_title：Cancer research

authors： Iizuka N,Oka M,Noma T,Nakazawa A,Hirose K,Suzuki T

更新日期：1995-02-01 00:00:00

abstract：:To directly examine a multistage carcinogenesis model and the role of UV light in human tissues, we grafted human skin onto mice with severe combined immunodeficiency disease. We found that the maximum dose of UV radiation in the B range (UVB; 280-320 nm) tolerated by these grafts was 500 J/m2 three times weekly. One ...

journal_title：Cancer research

authors： Soballe PW,Montone KT,Satyamoorthy K,Nesbit M,Herlyn M

更新日期：1996-02-15 00:00:00

abstract：:A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. In lung SCC, one of the most frequently altered receptor tyrosine kinase families is the fibroblast...

journal_title：Cancer research

authors： Liao RG,Jung J,Tchaicha J,Wilkerson MD,Sivachenko A,Beauchamp EM,Liu Q,Pugh TJ,Pedamallu CS,Hayes DN,Gray NS,Getz G,Wong KK,Haddad RI,Meyerson M,Hammerman PS

更新日期：2013-08-15 00:00:00

abstract：:Small cell lung cancer (SCLC) produces several neuroendocrine peptides, including gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin. There is some evidence to support the suggestion that GRP is an autocrine regulator of SCLC growth. Therefore, we have tested the effect of bombesin and two antagonis...

journal_title：Cancer research

authors： Layton JE,Scanlon DB,Soveny C,Morstyn G

更新日期：1988-09-01 00:00:00

abstract：:The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negative...

journal_title：Cancer research

authors： Wang H,Liu K,Geng M,Gao P,Wu X,Hai Y,Li Y,Li Y,Luo L,Hayes JD,Wang XJ,Tang X

更新日期：2013-05-15 00:00:00

abstract：:Two molecular species of the pleotropic cytokine interleukin 1 (IL-1) are produced as products of two distinct genes transcribed by cells of the monocyte-macrophage lineage. We have shown previously that a significant proportion of human melanoma cell lines express IL-1 biological activity, but it has not been demonst...

journal_title：Cancer research

authors： Shabon U,Bennicelli JL,Guerry DP 4th,Koprowski H,Ricciardi RP

更新日期：1991-06-15 00:00:00

abstract：:A possible involvement of gender-dependent factors has been postulated in development of human non-small-cell lung cancers (NSCLC), but its details remain unclear. In this study, we examined biological significance of progesterone receptor in NSCLCs. Progesterone receptor immunoreactivity was detected in 106 of 228 NS...

journal_title：Cancer research

authors： Ishibashi H,Suzuki T,Suzuki S,Niikawa H,Lu L,Miki Y,Moriya T,Hayashi S,Handa M,Kondo T,Sasano H

更新日期：2005-07-15 00:00:00

abstract：:Drug sensitivity assays were performed using a variation of a colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)] assay on V79, CHO-AuxB1, CHRC5, NCI-H460, and NCI-H249 cell lines following optimization of experimental conditions for each cell line. Results from this assay were compared w...

journal_title：Cancer research

authors： Carmichael J,DeGraff WG,Gazdar AF,Minna JD,Mitchell JB

更新日期：1987-02-15 00:00:00

abstract：:The data of nine monolayer cultures, 48 multicellular spheroids, and 19 s.c. xenografts of LoVo cells were fitted, on an individual basis, by exponential and Gompertzian equations, respectively. The mean growth parameters alpha 0 (initial growth rate) and beta (retardation factor) of the three experimental systems pre...

journal_title：Cancer research

authors： Demicheli R,Foroni R,Ingrosso A,Pratesi G,Soranzo C,Tortoreto M

更新日期：1989-12-01 00:00:00

abstract：:Combining microtubule-targeting antimitotic drugs with targeted apoptosis potentiators is a promising new chemotherapeutic strategy to treat cancer. In this study, we investigate the cellular mechanism by which navitoclax (previously called ABT-263), a Bcl-2 family inhibitor, potentiates apoptosis triggered by paclita...

journal_title：Cancer research

authors： Shi J,Zhou Y,Huang HC,Mitchison TJ

更新日期：2011-07-01 00:00:00

abstract：:PTEN/MMAC1 is a major new tumor suppressor gene that encodes a dual-specificity phosphatase with sequence similarity to the cytoskeletal protein tensin. Recently, we reported that PTEN dephosphorylates focal adhesion kinase (FAK) and inhibits cell migration, spreading, and focal adhesion formation. Here, the effects o...

journal_title：Cancer research

authors： Tamura M,Gu J,Takino T,Yamada KM

更新日期：1999-01-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00