Abstract:
:Pressure from the vinyl chloride (VC) industry on researchers involved in industry-sponsored studies and on regulatory agencies has been documented since 1970s. This commentary describes the influence of a lawsuit pursued by workers of an Italian VC plant on the recent scientific debate on VC exposure and risk of hepatocellular carcinoma (HCC). Original studies carried out by consultants of the public prosecutors and by independent researchers supported the above association. VC-industry consultants published two reviews during the lawsuit, claiming that liver angiosarcoma was the only VC-related cancer. The judges concluded that the evidence of the association between HCC and VC was still not convincing. After the trial, the risk of HCC was confirmed by a re-assessment of VC carcinogenicity from the International Agency for Research on Cancer, but other subsequent industry-funded reviews criticized the new evidence. Industry-funded authors cited each other, and rarely disclosed conflicts of interest. Based on a network of collaborating researchers, industrial interests can shape the literature enhancing the background noise surrounding the scientific evidence.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Fedeli U,Mastroangelo Gdoi
10.1002/ajim.20941subject
Has Abstractpub_date
2011-06-01 00:00:00pages
470-3issue
6eissn
0271-3586issn
1097-0274journal_volume
54pub_type
杂志文章abstract:BACKGROUND:It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV(1) response following swine barn exposure. METHODS:Naïve males were test...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20339
更新日期:2006-09-01 00:00:00
abstract::Occupational health studies of agricultural workers have generally excluded migrant and seasonal farmworkers, and this population experiences a high degree of health risk from agricultural exposures. A survey of dermatologic disorders among migrant and seasonal farmworkers will be used to illustrate this point. Data f...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180317
更新日期:1990-01-01 00:00:00
abstract::Blood histamine levels were measured by the bioassay of histamine (on an isolated strip of guinea pig ileum) in workers exposed to cotton dust in a textile mill in Ahmedabad. Byssinotic subjects showed very high levels of blood histamine as compared to nonbyssinotic and control subjects. The blood histamine levels wer...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120409
更新日期:1987-01-01 00:00:00
abstract::Attitudes of occupational health care professionals toward smoking and their activity to address smoking issues were investigated by a questionnaire survey. Data were also collected on employees' exposure to environmental tobacco smoke and on smoking policies that existed in workplaces. Questionnaires were mailed to a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199807)34:1<73::aid-ajim10
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:In the city of Petrópolis, Brazil, artisans carve souvenirs from a variety of silica-containing minerals. The finding of pulmonary massive fibrosis in one of the workers motivated an investigation of the prevalence of silicosis in this group. METHODS:Between January 2000 and June 2002, a cross-sectional stu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10331
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:No previous studies investigated the interaction of effort-reward imbalance (ERI) and overcommitment on blood pressure. Our aim was to investigate associations of ERI and overcommitment (and their interaction) with blood pressure and hypertension within a Chinese population. METHODS:Seven hundred thirty-fou...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22254
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The aims of this study were to compare job demand-control (JDC) and effort-reward imbalance (ERI) models in examining the association of job stress with work-related musculoskeletal symptoms and to evaluate the utility of a combined model. METHODS:This study analyzed cross-sectional survey data obtained fro...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22274
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Engineering or administrative methods are often insufficient or impractical to control exposure to chemicals in anatomy laboratories. This study explored the feasibility of wearing one or a combination of respirators and goggles used as personal protective equipment (PPE) to control exposure in one such labo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10180
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:We evaluated particulate matter in combined induced sputum (IS) and oxidation in exhaled breath condensate (EBC) to test whether underlying inflammatory changes are present in asymptomatic welders. METHODS:Thirty welders from the Israel Defense Forces exposed to aluminum/iron (Group 1) or to cadmium/chromiu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20586
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Occupational bladder cancer mortality among minority racial/ethnic groups is not well described compared to occupational bladder cancer mortality among non-minority males in the United States. METHODS:Race/ethnicity- and sex-specific bladder cancer mortality (1985-1992) of workers employed in 21 states was ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/1097-0274(200007)38:1<90::aid-ajim10>3.0.c
更新日期:2000-07-01 00:00:00
abstract::Very sensitive and precise analytical methods for measuring total porphyrin excretion and the relative amounts of different porphyrins in urine are required in order to monitor the biological effects of porphyrinogenic substances in workers and the general population. Many analytical steps of a HPLC method for measuri...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700040409
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:First-line health care providers are the primary access point for workers' benefits. However, little is known about their impact on quality of care and return-to-work. Our objective was to critically compare literature on the practices of first-line providers for workers with musculoskeletal injuries in Onta...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.22972
更新日期:2019-07-01 00:00:00
abstract::To elucidate the effect of low level lead (Pb) exposure on somatic and autonomic peripheral nerve functions in ceramic painters, 58 males and 70 females, aged 29-75 years (mean 53.3 years), with lead concentrations in blood (Pb-B) ranging from 2.1 to 69.5 micrograms/dl (geometric mean 13.3 micrograms/dl), were examine...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199605)29:5<547::AID-AJIM1
更新日期:1996-05-01 00:00:00
abstract::A joint study on effects of formaldehyde exposure in industrial populations by the National Cancer Institute and the Formaldehyde Institute, Inc. (Blair et al. [1986]: J Natl Cancer Inst 76: 1071-1084; Blair and Stewart [1989]: J Occup Med 31: 881, Blair et al. [1990]: Am J Ind Med 17:683-700) reported no significant ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250413
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Work-related mortality is a relatively new concept which aims to widen occupational health and safety; to take into account not only recognized fatal occupational accidents and diseases but also other work-related deaths. Few countries in the world have a register for work-related diseases. METHODS:Estimate...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20411
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Construction industry workers are exposed to many hazards leading to fatal and nonfatal injuries. Information for nonfatal work-related injury surveillance may be vague and come from a variety of sources. METHODS:The Alaska Trauma Registry (ATR) is used as an injury surveillance tool to focus on hospitalize...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20158
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Asbestos fibers are known to accumulate in lung parenchyma and thoracic lymph nodes, but their presence and translocation into the extrapulmonary tissues need clarification. We assessed the presence of asbestos in the para-aortic (PA) and mesenteric (ME) lymph nodes. METHODS:PA and ME lymph nodes and lung t...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20694
更新日期:2009-06-01 00:00:00
abstract::An analysis of reported birth record variables by parental occupation suggests that certain birth outcomes may identify toxic or carcinogenic occupational exposures of the parents. Fathers coded to an asbestos and insulation worker rubric sired fewer plural births, and more stillbirths than expected. A number of other...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700160214
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:A 5-year longitudinal study examined nonmalignant respiratory effects of wood processing dust exposure. METHODS:Ten study plants, investigator selected from 447 candidate plants, included 1 sawmill-planing-plywood, 1 plywood, 1 milling, 3 cabinet and 4 furniture facilities. Personal dust samples (2363) were...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20594
更新日期:2008-08-01 00:00:00
abstract::Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were e...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700050403
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Organic solvents are widely used, but conflicting reports exist concerning paternal exposure and adverse pregnancy outcomes. We conducted a meta-analysis to assess the risks of spontaneous abortions (SAs) and major malformations (MMs) after paternal exposure to organic solvents. METHODS:Medline, Toxline, Re...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/ajim.20102
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Pre-placement testing was implemented during World War II. Its current use has been reshaped by economic factors, litigation, legislation, and advances in medicine. In response to a request from a local industry intent upon lowering their work-related injuries, a post-offer screening program was developed an...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20150
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Sensitivity to beryllium was investigated among workers at an aluminum smelter in Norway as a consequence of the findings in an occupational exposure survey. METHODS:Three hundred and sixty-two employees and 31 reference persons were tested for sensitization to beryllium with the beryllium lymphocyte prolif...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20816
更新日期:2010-07-01 00:00:00
abstract::The aim of the study was to evaluate the genotoxic risk to medical personnel concurrently exposed to ionizing radiation and antineoplastics, using changes in their lymphocyte cell genome as a bioindicator. The study comprised 12 female nurses employed in the nuclear medicine hospital department and an equal number of ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270610
更新日期:1995-06-01 00:00:00
abstract::A series of 206 necropsies in Western Australia (WA) have had routine counts made of asbestos bodies in samples of lung tissue using conventional light microscopy. Thirty-two cases had worked in the asbestos industry at Wittenoom, WA and (log) counts of asbestos bodies in their lung tissue correlated well with estimat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700280405
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Few epidemiologic studies have addressed the exposure-response relationships between work activities and symptomatic knee osteoarthritis (OA). This analysis used data from a national survey and ergonomists' ratings to address this issue. METHODS:Interview and knee X-ray data were obtained from the Third Nat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20512
更新日期:2008-01-01 00:00:00
abstract::Dermatological disorders in athletes may occur as a result of repeated mechanical trauma, physical and chemical agents, climatic conditions, infections, infestations, and exacerbations of pre-existing skin disorders. These include black heel, tennis toe and other causes of subungual hemorrhage, friction blisters, abra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700080422
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Previous studies of workers' compensation claims for low back pain (LBP) have revealed that the preponderance of disability is borne by a fraction of cases. However, less is known regarding the influence of occupational factors on these extreme conditions. METHODS:Workers' compensation claims (n=107,867) fo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(200005)37:5<558::aid-ajim1
更新日期:2000-05-01 00:00:00
abstract::A 30 year-old male polyurethane worker was exposed to an accidental spill of 4,4'-methylene-bis-2-chloroaniline (MBOCA) at a plant producing MBOCA-cured plastic products. Exposure to MBOCA is significant in that this compound is a known animal carcinogen and a suspected human carcinogen. The employee was sprayed over ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180508
更新日期:1990-01-01 00:00:00
abstract::In 1979, a pilot survey defined respiratory status and unmet health care needs of retired and former male asbestos workers in Hawaii. Of 1,401 identified subjects, 741 were contacted and 411 were interviewed. Forty-five subjects were between 39 and 54 years of age; 208, between 55 and 64; and 158, age 65 or more. They...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700060208
更新日期:1984-01-01 00:00:00