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Subtle perturbations of genital microflora alter mucosal immunity among low-risk pregnant women.

Abstract：

OBJECTIVE:Alteration in the vaginal flora has been associated with adverse pregnancy outcomes. The objective of this study was to examine the impact of changes in individual microflora on genital immunity among low-risk pregnant women in early pregnancy. DESIGN:Cross-sectional study. SETTING:Large, tertiary care, academic hospital clinic. POPULATION:Low-risk women were enrolled prior to 14 weeks' gestation. METHODS:Women were included if they had no medical or previous obstetrical complications, were non-smokers, had no sexually transmitted infections and no intercourse in the last 48 hours. Consenting women underwent speculum examination for collection of vaginal culture and Dacron swabs for cytokine analysis. Semi-quantitative vaginal cultures were performed in a reference laboratory. MAIN OUTCOME MEASURES:Concentrations of immune mediators were compared in the presence of various organisms. Concentrations were converted to multiples of the median to standardize the values of each mediator. Regression analyses were performed to control for race. RESULTS:We enrolled 47 women. The frequencies of genital microorganisms were: H(2)O(2) -producing lactobacilli (70%), Ureaplasma urealyticum (66%), Gardnerella vaginalis (45%), anaerobic non-pigmented Gram-negative rods (ANPGNR, 40%), anaerobic pigmented Gram-negative rods (APGNR, 17%). After adjusting for race and body mass index, interleukin-1β, interferon-γ, tumor necrosis factor-α and granulocyte macrophage-colony stimulating factor were increased in the presence of G. vaginalis, ANPGNR, and APGNR. There was no consistent impact on the other markers of immune activation. CONCLUSION:The presence of individual species impacts genital immunity among low-risk pregnant women. Perturbations in genital immunity could partially explain heterogeneity in adverse pregnancy outcomes.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Anderson BL,Cu-Uvin S,Raker CA,Fitzsimmons C,Hillier SL

doi

10.1111/j.1600-0412.2011.01082.x

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

510-5

issue

eissn

0001-6349

issn

1600-0412

journal_volume

pub_type

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Subtle perturbations of genital microflora alter mucosal immunity among low-risk pregnant women.