Abstract:
INTRODUCTION:visual inspection of the cervix with acetic acid is used to control the burden of cervical cancer in low and middle-income countries. This method has some limitations and HPV DNA testing may be an alternative, but it is expensive and requires a laboratory setup. A cheaper and faster HPV tests have been developed. This study describe the agreement between a fast HPV test (careHPV) and hybrid capture 2 (HC2) in detection of high-risk HPV among Tanzanian women. MATERIAL AND METHODS:study involving women attending routine cervical cancer screening at Ocean Road Cancer Institute and Kilimanjaro Christian Medical Centre in Tanzania. They were offered HIV testing. Two cervical samples were subsequently obtained, the 1st sample was processed at the clinics by using careHPV and the 2nd sample was transported to Denmark and Germany for cytology and hc2 analysis, respectively. Kappa statistic was calculated to assess the agreement between careHPV and HC2. The sensitivity, specificity and predictive values of careHPV was calculated using HC2 as reference. The analyses were done for the overall study population and stratified by testing site and HIV status. RESULTS:A total of 4080 women were enrolled with 437 being excluded due to invalid information, lack of careHPV or hc2 results. Overall agreement between the tests was substantial with a kappa value of 0.69 (95% CI: 0.66-0.72), sensitivity and specificity of careHPV was 90.7% (95%CI: 89.6 - 91.8) and 84.2% (95% CI: 81.2 - 86.8) respectively. the agreement was similar in the stratified analyses where the kappa values were 0.75 (95% CI:0.70-0.79) in women aged 25-34, 0.66 (95% CI:0.62-0.70) in women aged 35-60, 0.73 (95% CI: 0.70-0.77) at Ocean Road Cancer Institute, 0.64 (95% CI: 0.60-0.69) at Kilimanjaro Christian Medical Centre, 0.73 (95% CI: 0.68-0.79) in HIV positive and 0.66 (95% CI: 0.63-0.70) in HIV negative women. The kappa value of 0.64 (95% CI: 0.39 - 0.88) for cervical high-grade lesions indicates a substantial agreement between careHPV and HC2 in detecting HPV among women with cervical high-grade lesions. CONCLUSIONS:a substantial agreement was found between careHPV and HC2 in detecting HPV overall as well as detecting HPV among women with cervical high-grade lesions. However, given the limited resources available in low and middle-income countries, the HPV testing assay should be weighed against the cost effectiveness of the test.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Katanga J,Kjaer SK,Manongi R,Pembe AB,Iftner T,Waldstrom M,Mwaiselage J,Rasch Vdoi
10.1111/aogs.14101subject
Has Abstractpub_date
2021-01-26 00:00:00eissn
0001-6349issn
1600-0412pub_type
杂志文章abstract::The use of gonadotropin-releasing hormone (GnRH) agonists in a long protocol appears to enhance the probability of conception in the presence of endometriosis. In addition, there is evidence to suggest that the use of prolonged downregulation with GnRH agonists prior to ovarian stimulation for in vitro fertilization (...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.0001-6349.2004.00543.x
更新日期:2004-07-01 00:00:00
abstract::In 706 midtrimester amniocenteses, 180 (25.5%) samples yielded blood-stained amniotic fluid (macroscopically and microscopically), 152 (21.5%) contained maternal blood, 28 (3.9%) fetal blood and 8 samples contained both maternal and fetal blood. In the 180 cases of bloody midtrimester amniocentesis, the abortion rate ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348209156950
更新日期:1982-01-01 00:00:00
abstract::Puerperal inversion of the uterus is very rare but dramatic and life-threatening. Prompt treatment is necessary. A case is reported and the literature reviewed. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract:INTRODUCTION:Previous studies estimating the association of maternal country of birth and education with hypertensive disorders of pregnancy (HDP) have shown conflicting results. The aim of the study was to assess the prevalence of HDP and estimate the association of maternal country of birth and education level with p...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13393
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:To investigate the diagnostic efficacy of preoperative lymphoscintigraphy (LS), Ga-67 scintigraphy (GS) and computed tomography (CT) for detection of lymph node metastasis in patients with endometrial or ovarian carcinoma. METHODS:The results of preoperative LS, GS and CT used to detect lymph node metastasi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Long-term efficacy evaluations of a quadrivalent HPV type 6/11/16/18 vaccine are ongoing in the Nordic region. As there are limited epidemiological data on HPV infection in Norway, we determined prevalence and identified sociobehavioural correlates of HPV 6/11/16/18 infection in young Norwegian women. METHO...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016340701714703
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Fetal growth restriction (FGR) is associated with poor perinatal outcomes. Screening and prevention tools for FGR, such as uterine artery Doppler imaging and aspirin, underperform in high-risk groups, compared with general antenatal populations. There is a paucity of sensitive screening tests for the early...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12823
更新日期:2016-03-01 00:00:00
abstract::With advancing age, the postural balance function deteriorates as a consequence of decreased functional capacity. Deteriorating balance is a risk factor for bone fractures due to increased risks of falls. It has been suggested that the loss of estrogen, which occurs in relation to the menopause, may be associated with...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701207575
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Low-back pain (LBP) is a commonly observed symptom during pregnancy. Despite its high frequency the extent of the problem is less well documented and detailed studies concerning related risk factors are scarce. Furthermore, efforts to address the problem are hampered by the inability to predict accurately wh...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349409023441
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the impact of tension-free vaginal tape (TVT) procedure as anti-incontinence surgery on patients' urinary symptoms and quality of life. METHODS:Ninety-eight patients participated in the study. All patients were operated for urodynamic stress incontinence with the TVT proce...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600603759
更新日期:2006-01-01 00:00:00
abstract::The degree of hair growth of 64 hirsute women was clinically graded. The patients were divided into two groups with respect to the ratio between the serum luteinizing hormone (LH) and the follicle-stimulating hormone (FSH). The two groups did not differ in terms of the grade of hirsutism, serum testosterone (T), calcu...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348509158203
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The rate of cesarean section (CS) is increasing in Sweden as well as in most of the industrialized world. One of the most common indications for emergency CS is protracted labor. To what extent fetal pelvic disproportion is a cause of protracted labor is unclear. The value of pelvimetry has been questioned. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600593521
更新日期:2006-01-01 00:00:00
abstract::Information bias occurs when any information used in a study is either measured or recorded inaccurately. This paper describes some of the most common types of information bias, using examples from obstetrics and gynecology, and describes how information bias may affect results of observational studies. Non-differenti...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.13330
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the diagnostic value of transvaginal ultrasound measurement of endometrial thickness, cytology obtained by Gynoscann, and histology of the endometrium sampled by Uterine Explora Curette compared with histology of the uterine specimen as the gold standard. METHODS:Co...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349709024349
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:More than 30 000 legal abortions are performed every year in Sweden despite sexual education in schools, widespread youth-clinics and family planning services that are free of charge. The aim of this study was to investigate reasons for induced abortion, contraceptive habits and reasons for contraceptive fai...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.0001-6349.2001.00169.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To determine the performance of trained midwives in second trimester ultrasound screening for fetal structural abnormalities in a low-risk population. DESIGN:Retrospective study. SETTING:University Department of Obstetrics and Gynecology. POPULATION:About 13,882 women with singleton pregnancies. METHODS:T...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902934688
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:In a previous prospective randomised trial on pregnancies complicated by small-for-gestational-age fetuses fewer operative deliveries for fetal distress were found after antenatal surveillance with umbilical artery Doppler velocimetry (Doppler group) than after surveillance with cardiotocography (CTG group)....
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349509024383
更新日期:1995-08-01 00:00:00
abstract::The anatomy of the thrombus in acute deep vein thrombosis (DVT) in women using oral contraceptives was studied in 277 reports on DVT received by the Swedish Adverse Drug Reaction Advisory Committee (SADRAC). The study revealed a similarity between the anatomy of DVT in women on oral contraceptives and that of DVT in p...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348509155155
更新日期:1985-01-01 00:00:00
abstract::Invasive carcinoma of the uterine cervix is a common neoplasm even in countries with extensive screening programmes of several years. The incidence rate per 100,000 is still around 18 in Denmark. The reasons for these persistently high rates of incidence despite various prophylactic measures are many and have been tho...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The secretion patterns of human chorionic gonadotropin (HCG), human chorionic somatomammotropin (HCS), and human chorionic thyrotropin (HCT) were studied in 10 women with hydatidiform mole and 30 women in the early stage of normal pregnancy. Serum levels of the chorionic hormones were determined by radioimmunoassay w...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347409157754
更新日期:1974-01-01 00:00:00
abstract::We report a case of galactorrhea in a normoprolactinemic fertile woman (30 years old) wearing a copper intra-uterine device (Gravigard). The Gravigard was first inserted in July 1977. In February 1979 our patient noted spontaneous galactorrhea, mainly on the left, but it was also present on the right, after breast pre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409156269
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:This review presents an overview of descriptive knowledge on human embryonic cardiovascular physiology mostly based on noninvasive assessment by Doppler ultrasonography. Our objective was to identify and analyze published studies on embryonic cardiovascular function, and summarize available knowledge in th...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 评论,杂志文章,评审
doi:10.1111/aogs.12860
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To show that early discontinuation of oxytocin will not increase the mean duration of the active labor phase in a clinically significant way. DESIGN:Controlled non-inferiority study. SETTING:Department of Obstetrics and Gynecology, University of Caen, Clemenceau Hospital, France. POPULATION:A total of 138 ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802649816
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:This study aims to evaluate the feasibility and diagnostic validity of the sentinel lymph node technique in detecting inguinal lymph node metastases in patients with invasive squamous cancer of the vulva. DESIGN:Retrospective analysis of the in-house tumor registry. SETTING:Dr. Horst Schmidt Klinik, a terti...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016340903317982
更新日期:2009-01-01 00:00:00
abstract::The experience using pre-treatment with GnRH-agonists in an IVF-program are reported. 55 patients having a 'poor response', premature LH surge, or follicular luteinization in previous treatment cycles were treated for a total of 68 cycles. Therapy with GnRH agonists was initiated in the midluteal phase, and given by s...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007884
更新日期:1991-01-01 00:00:00
abstract::The urinary excretion of histamine and its metabolites methylhistamine (MeHi) and methylimidazoleacetic acid (MeImAA) was measured during the menstrual cycle in nine healthy women, one allergic woman and three non-pregnant women with anovulatory regular cycles. Simultaneous urinary analyses of luteinizing hormone (LH)...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347609158501
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe the quality of abortion services and women's experiences with the care they had received during their abortion. METHODS:A population-based postal survey of 3000 randomly selected 18-44-year old Finnish women in 1994. The response rate was 74% (n=2189). The following wer...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:Anal sphincter tears during vaginal delivery are a major cause of anal incontinence. We wanted to assess the incidence in a Norwegian county where primary repairs are performed in four hospitals using similar per- and postoperative protocol for the treatment of such injuries. METHODS:A postal questionnaire ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00647.x
更新日期:2004-10-01 00:00:00
abstract::This paper describes the collection and analysis of data by a group of international collaborators (International Collaborative Effort on Perinatal and Infant Mortality) interested in comparative studies on birthweight distributions and reproductive outcome. This is the first of a series of reports on the results of t...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348909087681
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:In women complaining of a wide vagina and decreased sexual satisfaction we performed colporrhaphy--including perineoplasty in most cases. METHODS:Between November 2003 and October 2004, a total of 53 patients were selected for operation at the Urogynecology and Vaginal Surgery Unit, Las Condes Clinic, Chile...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340600622544
更新日期:2006-01-01 00:00:00