Association between serum gamma-glutamyltransferase activity and carotid intima-media thickness.

Abstract:

:Serum gamma-glutamyltransferase (GGT) activity is a marker of oxidative stress and activity is associated with cardiovascular disease. Carotid intima-media thickness (IMT) is a noninvasive predictor of atherosclerosis. We investigated the association between serum GGT activity and carotid IMT. Fifty-five persons who had normal liver function tests were consecutively enrolled. Carotid IMT was evaluated in the right and left common carotid arteries. The averaged values of carotid IMT and serum GGT activity were compared. Serum GGT activity correlated with carotid IMT (r = .396, P = .003). Serum GGT activities were increased in patients with carotid intimal hyperplasia compared with those without intimal hyperplasia (20.3 ± 11.2 vs 34.3 ± 16.1 U/L; P = .001). Serum GGT activity is associated with carotid IMT. This finding supports the concept that elevated serum GGT activity is a marker of atherosclerosis.

journal_name

Angiology

journal_title

Angiology

authors

Eroglu S,Sade LE,Polat E,Bozbas H,Ulus T,Muderrisoglu H

doi

10.1177/0003319710386471

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

107-10

issue

2

eissn

0003-3197

issn

1940-1574

pii

62/2/107

journal_volume

62

pub_type

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