Endocan--a novel inflammatory indicator in newly diagnosed patients with hypertension: a pilot study.

Abstract:

:Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell-specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we assessed serum levels of endocan in newly diagnosed patients with untreated essential hypertension (HT). A total of 18 patients with HT and 23 normotensive control participants were included in the study. Serum endocan levels, carotid intima-media thickness (cIMT), and high-sensitivity C-reactive protein (hsCRP) were measured. Serum endocan levels were significantly higher in the HT group (P < .001). In patients with HT, serum endocan levels correlated positively with cIMT and hsCRP (r = .551, P < .001 and r = .644, P < .001, respectively). Our findings suggest that circulating endocan levels represent a new marker in patients with essential HT. Endocan may be a surrogate endothelial dysfunction marker and may have a functional role in endothelium-dependent pathological disorders.

journal_name

Angiology

journal_title

Angiology

authors

Balta S,Mikhailidis DP,Demirkol S,Ozturk C,Kurtoglu E,Demir M,Celik T,Turker T,Iyisoy A

doi

10.1177/0003319713513492

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

773-7

issue

9

eissn

0003-3197

issn

1940-1574

pii

0003319713513492

journal_volume

65

pub_type

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