Abstract：
:Fetal proislets (islet precursors) were transplanted to isogeneic diabetic CBA/H mice for analysis of their development and function post-transplant. Immunohistochemically, proislets contained scattered populations of insulin-, glucagon- and somatostatin-producing cells; following isotransplantation proislets developed into mature islet tissue with normal endocrine cell composition. Proislet isografts also developed normal endocrine function after transplantation to diabetic mice. Isografts of eight and four donor-equivalents of proislets reversed streptozotocin-induced diabetes by 30 +/- 7 and 74 +/- 26 days, respectively. Following stimulation with intragastric glucose (50 mg) mice carrying established isografts of four donor-equivalents of proislets exhibited normal blood glucose responses; those grafted with eight donor-equivalents of proislets showed decreased blood glucose levels. The beta cell mass of proislets continued to grow and differentiate post-transplant; established proislet grafts contained greater than 100-fold the total insulin content of the corresponding number of fetal pancreases from which the proislets were derived. The mean insulin content of eight and four donor-equivalent proislet grafts was 231% and 156%, respectively, that of the mean content of adult mouse pancreas. The data show that glucose homeostasis can be restored in diabetic mice following isotransplantation of fetal proislets and that the quantity of tissue transplanted is a critical parameter in achieving optimal control.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Simeonovic CJ,Mackie DJ,Wilson JDdoi
10.1016/0168-8227(90)90127-fsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
275-81issue
3eissn
0168-8227issn
1872-8227pii
0168-8227(90)90127-Fjournal_volume
8pub_type
杂志文章abstract：AIMS:To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). METHODS:The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2D...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2008.08.012
更新日期：2008-11-01 00:00:00
abstract：:Social determinants of health (SDH) impact clinical outcomes and are often poorly described in research trials. Using a validated tool, SDH dimensions were compared between adolescents enrolled and not enrolled into a large diabetes study. We observed that our study cohort reflected a SDH profile mirroring the eligibl...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.01.031
更新日期：2016-03-01 00:00:00
abstract：:Diabetes mellitus is associated with increased frequency, severity and more rapid progression of cardiovascular diseases. Metabolic perturbations from hyperglycemia result in disturbed endothelium-dependent relaxation, activation of coagulation pathways, depressed fibrinolysis, and other abnormalities in vascular home...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(99)00036-4
更新日期：1999-09-01 00:00:00
abstract：AIMS:Myopia may have protective effects against diabetic retinopathy (DR). However, the data from epidemiologic studies are inconsistent. We aimed to examine the association between myopia and DR by conducting a meta-analysis. METHODS:We identified studies by searching the PubMed and EMBASE databases. Study-specific o...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.diabres.2015.10.020
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n=379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examinat...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2004.11.004
更新日期：2005-07-01 00:00:00
abstract：:Potassium (K) channels regulate cellular excitability. Their opening hyperpolarises the membrane potential and induces quiescence whereas their closure produces depolarisation and excitation. One K-channel superfamily includes the delayed rectifier (KV), the A-type (KA) and the large conductance, Ca-sensitive (BKCa) c...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/0168-8227(95)01080-w
更新日期：1995-08-01 00:00:00
abstract：AIMS:To evaluate whether progressively higher fasting plasma glucose (FPG) is associated to thickening of the interventricular septum (IVS) among non-diabetic subjects with obesity. METHODOLOGY:We studied 227 consecutive non diabetic patients (155 women and 72 men, age range 18-72 years) with overweight or obesity (BM...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108436
更新日期：2020-11-01 00:00:00
abstract：AIMS:To explore associations between multimorbidity condition counts (total; concordant (diabetes-related); discordant (unrelated to diabetes)) and glycaemia (HbA1c; glycaemic variability (GV); time in range (TIR)) using data from a randomised controlled trial examining effectiveness of continuous glucose monitoring (C...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108451
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:The literature on health aspects of Ramadan fasting is widely spread in many journals making it not readily available to those interested in the subject. MATERIALS AND METHODS:A narrative, non-systematic review of the international literature from two major online databases (viz. Scopus, PubMed) in one ye...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2020.108593
更新日期：2020-12-11 00:00:00
abstract：:The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any di...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2005.07.008
更新日期：2006-03-01 00:00:00
abstract：:Administration of insulin with premeal boluses of short-acting insulin using a new injection device (Novopen) was compared with a conventional three times daily injection regimen regarding aspects of quality of life and metabolic control in insulin-dependent diabetes mellitus (IDDM). Eighteen C-peptide-negative patien...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(89)90055-7
更新日期：1989-01-03 00:00:00
abstract：AIMS:Body-weight fluctuation is associated with an increased risk of all-cause mortality. Yet no studies investigate its association with risk of diabetes in adults aged ≥ 60 years. This study aimed to address this issue. METHODS:A total of 1,565 participants free of diabetes at baseline in the CHARLS were followed fo...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108419
更新日期：2020-11-01 00:00:00
abstract：:The results of various studies suggest that hypertriglyceridaemia is associated with an increased risk of coronary artery disease. It is unclear, however, which particular triglyceride (TG)-rich lipoproteins contribute to the risk. Different types of TG-rich lipoprotein differ in function, composition, size and densit...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/s0168-8227(98)00040-0
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To explore the apoptotic role of amylin on human mesangial cell (MC). MATERIALS AND METHODS:Primarily cultured human MCs were applied and treated with fresh amylin preparation. Human MCs were identified by the morphology and immunofluorescence staining. The apoptotic cells were determined by ultrastructure c...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.02.018
更新日期：2007-10-01 00:00:00
abstract：AIMS:The aim of this study was to investigate the effect of yoga intervention on the biochemical, oxidative stress markers and inflammatory markers and sleep quality among subjects with type 2 diabetes. METHODS:Subjects with type 2 diabetes attending a tertiary care centre for diabetes during Feb 2017 to Oct 2019 in C...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108644
更新日期：2020-12-25 00:00:00
abstract：BACKGROUND:While CKD is a common finding in patients with type 2 diabetes, the clinical response to its identification is often problematic. This study aims to determine the frequency of albuminuria in patients with type 2 diabetes in the primary care setting and examine the factors which influence its management. MET...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2007.10.024
更新日期：2008-04-01 00:00:00
abstract：:To investigate the cumulative incidence and mortality of COVID-19 and the prevalence of comorbidities such as diabetes, obesity and hypertension in regions with different altitude levels ranging from sea level to high altitude. METHODOLOGY: Analytical study in which we correlated secondary data obtained from reports o...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2020.108463
更新日期：2020-11-01 00:00:00
abstract：:There is a paucity of data regarding outcomes of Type 2 diabetes mellitus. A cohort of 447 Type 2 diabetic subjects (208 male, 239 female; age range 30-82 years, median 62 years; and of predominantly European origin) was characterised in a clinic survey in 1989. Individual status (dead or alive) at 1 June 1995 was asc...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(98)00048-5
更新日期：1998-06-01 00:00:00
abstract：UNLABELLED:The endothelium plays an integral role in the regulation of vascular tone, platelet activity, leukocyte adhesion, and thrombosis and is intimately involved in the development of atherosclerosis. Endothelial dysfunction has been observed in patients with established coronary artery disease or coronary risk fa...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2008.12.013
更新日期：2009-04-01 00:00:00
abstract：:To critically evaluate the relative importance of coagulation abnormalities over other clinical variables for micro- and macrovascular diabetic complications, prothrombin fragment (F1+2), thrombin-antithrombin III complex (TAT), fibrin degradation product d-dimer, and alpha2 plasmin inhibitor complex were determined i...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/s0168-8227(00)00134-0
更新日期：2000-07-01 00:00:00
abstract：AIMS:The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece. METHODS:In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed criticall...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2020.108331
更新日期：2020-08-01 00:00:00
abstract：:Abnormalities of pulmonary function tests have been described in type 1 (insulin-dependent) diabetes mellitus (IDDM). To better characterise such abnormalities and to verify whether these latter are associated with the presence of diabetic microvascular disease we compared 23 non-smoking patients who had IDDM with 24 ...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章
doi：10.1016/0168-8227(94)90004-3
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:The impact of cardiovascular complications on health-related quality-of-life (HRQoL) in type 2 diabetes mellitus has not been clearly established. Using EQ5D utility data from SAVOR-TIMI 53, a large phase IV trial of saxagliptin versus placebo, we quantified the impact of cardiovascular and other major event...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2016.12.019
更新日期：2017-08-01 00:00:00
abstract：AIMS:Dipeptidyl peptidase-4 inhibitor (DPP-4i) is commonly used worldwide for the treatment of type 2 diabetes mellitus. In addition to its hypoglycemic activity, DPP-4i might have anti-inflammatory effects. In this study we examined the effects of DPP-4i on the serum levels of soluble CD163 (sCD163), a marker for acti...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.diabres.2017.02.010
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To examine the association between screen time and the metabolic syndrome (MetS) in a nationally representative sample of children and adolescents. METHODS:A cross-sectional survey was conducted in 845 children and adolescents (10-18 years of age) from the 2005 Korean National Health and Nutrition Examinatio...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2010.02.016
更新日期：2010-07-01 00:00:00
abstract：:Strategies for management of pre-diabetes within the community setting are needed. An adaptation of the successful Diabetes Prevention Program lifestyle intervention delivered by trained diabetes educators was evaluated. Results indicate that trained diabetes educators offer an important community resource for health ...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,多中心研究
doi：10.1016/j.diabres.2014.10.012
更新日期：2014-12-01 00:00:00
abstract：:The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum sample...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/j.diabres.2009.09.027
更新日期：2010-01-01 00:00:00
abstract：:Lucigenin-enhanced chemiluminescence was examined as an index of neutrophil superoxide production in four groups of 20 subjects: controls with/without infection and type 1 diabetics with/without infection. At 5 mM glucose there was no significant difference in chemiluminescence output between neutrophils from the four...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章
doi：10.1016/0168-8227(92)90015-j
更新日期：1992-02-01 00:00:00
abstract：AIM:To perform a network meta-analysis between long-acting insulin analogues (glargine and detemir) and Neutral Protamine Hagedorn (NPH) insulin on adults with type 1 diabetes. METHODS:A systematic review of the literature was conducted according to the Cochrane Collaboration guidelines. The search for randomized cont...
journal_title：Diabetes research and clinical practice
pub_type： 杂志文章,评审
doi：10.1016/j.diabres.2011.09.001
更新日期：2011-12-01 00:00:00
abstract：:We evaluated the effect of a diet rich in natural (NF) or extractive fibres (guar gum) on 12 male IDD (insulin-dependent diabetes) out-patients. The treatment lasted for 2 months. During the first month the patients were on an isocaloric diet containing 30 g of fibres and then they were randomly subdivided into two gr...
journal_title：Diabetes research and clinical practice
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0168-8227(89)90120-4
更新日期：1989-02-15 00:00:00
