Immunophenotypic analysis of lymphocytes and myeloma cells in patients with multiple myeloma.

abstract：:Granulocytic sarcoma of the small intestine preceding or as the presenting feature of acute myelogenous leukemia with chromosome 16 abnormalities has been observed in at least 4 patients. We report the case of a patient initially diagnosed with eosinophilic gastroenteritis, responding to corticosteroid treatment for 2...

journal_title：Acta haematologica

authors： Julia A,Nomdedeu JF

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To investigate a family with factor VII (FVII) deficiency from Argentina. PATIENTS AND METHODS:The proposita is a 14-year-old girl who presented with a mild to moderate bleeding tendency. Menorrhagia is controlled with periodical administration of small doses of recombinant FVII concentrate. The mother of th...

journal_title：Acta haematologica

authors： Girolami A,Paoletti M,Ferrari S,Garcia D

更新日期：2021-01-01 00:00:00

abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a rare lymphoproliferative disorder characterized by diffuse lymphadenopathy, fever, hepatosplenomegaly, hemolytic anemia, and polyclonal hypergammaglobulinemia. Morphologically, the involved lymph nodes demonstrate complete effacement of the normal arch...

journal_title：Acta haematologica

authors： Sallah S,Gagnon GA

更新日期：1998-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a B cell malignancy characterized by accumulation of plasma cells (PCs) in the bone marrow. Traditional methods for the detection of minimal residual disease (MRD) measure the presence of monoclonal immunoglobulin protein secreted by the malignant PCs. However, changes in the level of MRD in M...

journal_title：Acta haematologica

authors： Rasmussen T,Knudsen LM,Huynh TK,Johnsen HE

更新日期：2004-01-01 00:00:00

abstract：:We have used the gel retardation assay to investigate the binding of nuclear proteins to the duplicated CACCC boxes in the beta-globin gene promoter region. The effect of beta-thalassemia mutations affecting both of these consensus sequences (the -88 C-->T and -101 C-->T mutations) were studied by using appropriate mu...

journal_title：Acta haematologica

authors： Baysal E,Ribeiro ML,Huisman TH

更新日期：1994-01-01 00:00:00

abstract：:The objective of this study was to assess the pharmacokinetics of rhG-CSF after a single intraperitoneal injection 2 h post-TBI in B6D2F1 lethally irradiated mice and to analyze the effect of rhG-CSF on the endogenous response of interleukin-3 (IL-3), interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating ...

journal_title：Acta haematologica

authors： Kádár E,Sureda A,Mangues MA,Inglés-Esteve J,Valls A,García J

更新日期：1997-01-01 00:00:00

abstract：:We investigated double (specific and nonspecific) esterase (DE) staining in marrow cells of 237 patients with the myelodysplastic syndromes (MDS). Additional abnormalities of neutrophilic granules were examined cytochemically and immunocytochemically for myeloperoxidase activity and antigen elastase, lactoferrin and C...

journal_title：Acta haematologica

authors： Elghetany MT,Peterson B,MacCallum J,Nelson DA,Varney JF,Sullivan AK,Silverman LR,Schiffer CA,Davey FR,Bloomfield CD

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) down-regulation by preferentially expressed antigen of melanoma (PRAME) is a general phenomenon in different types of solid tumours, but research on the correlation between PRAME and TRAIL gene expression in leukaemia patients is rare. METHO...

journal_title：Acta haematologica

authors： Zhang W,Chi K,Zhang Y,Ma B,Shi J,Chen Y,Lei P,Li Y,Sun K

更新日期：2013-01-01 00:00:00

abstract：:Fourteen patients with hematologic neoplasia (11 acute myeloid leukemias, 2 non-Hodgkin's lymphomas and 1 blast crisis of chronic myeloid leukemia) who underwent high-dose cytosine arabinoside (HIDARAC) therapy with or without sequential asparaginase (ASNase) were investigated in order to evaluate liver toxicity and a...

journal_title：Acta haematologica

authors： Marra R,Pagano L,De Stefano V,Leone G,Bizzi B

更新日期：1986-01-01 00:00:00

abstract：:Drug-induced immune hemolytic anemia is a rare but underdiagnosed and potentially fatal condition. We report a case of severe hemolytic anemia induced by cefoxitin in a 45-year-old woman admitted with menometrorrhagia. Hemoglobin levels reached a nadir of 4.7 g/dl approximately 72 h after cefoxitin initiation, and hem...

journal_title：Acta haematologica

authors： Leaf DE,Langer NB,Markowski M,Garratty G,Diuguid DL

更新日期：2010-01-01 00:00:00

abstract：:To assess the effect of prophylactic treatment with antithymocyte globulin (ATG) on graft-versus-host disease (GvHD) in myeloablative transplant patients, we performed a meta-analysis of randomized and cohort studies. Medline, Embase, the Cochrane Controlled Trial Register and the Science Citation Index were searched ...

journal_title：Acta haematologica

authors： Sheng Z,Ma H,Pang W,Niu S,Xu J

更新日期：2013-01-01 00:00:00

abstract：:Low-risk patients with myelodysplastic syndromes (MDS) are inclined to long-term accumulation of iron in the organs due mostly to red blood cell transfusion and ineffective erythropoiesis. The effect of free toxic iron species in the liver and heart sites is well known, but recent knowledge assumes that oxidant-mediat...

journal_title：Acta haematologica

authors： Pilo F,Caocci G,Mele G,La Nasa G

更新日期：2020-10-02 00:00:00

abstract：:RAS mutations are found in about 25% of acute myeloid leukemia (AML) cases. The importance of these changes is unknown. If RAS mutations confer growth advantage to leukemia subclones in which they emerge, substantially more nonconservative than conservative mutations should be found. The incidence of conservative muta...

journal_title：Acta haematologica

authors： Aurer I,Labar B,Nemet D,Ajduković R,Bogdanić V,Gale RP

更新日期：1994-01-01 00:00:00

abstract：:A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormaliti...

journal_title：Acta haematologica

authors： Vellenga E,Mulder NH

更新日期：1980-01-01 00:00:00

abstract：:A patient developed a drug rash and neutropenia while receiving tobramycin, ticarcillin and flucloxacillin intravenously for osteomyelitis. Incorporation of these antibiotics into in vitro cultures of bone marrow granulocyte macrophage precursors (CFU-C) showed no inhibition of the patient's marrow or normal marrow by...

journal_title：Acta haematologica

authors： Irvine AE,Morris TC,Kelly GJ,McCracken N

更新日期：1983-01-01 00:00:00

abstract：:350 patients with idiopathic thrombocytopenic purpura (ITP) aged 2/12-15 years (mean 6.3 +/- 2.7) were followed up during the period January 1st, 1975 to March 31, 1992. They constituted 40% of cases with hemorrhagic diathesis attending the Hematology/Oncology Clinic, Children's Hospital, Ain Shams University (relativ...

journal_title：Acta haematologica

authors： Khalifa AS,Tolba KA,el-Alfy MS,Gadallah M,Ibrahim FH

更新日期：1993-01-01 00:00:00

abstract：:Pyruvate kinase (PK) from four patients with moderate to severe congenital non-spherocytic haemolytic anaemia was characterized by methods recommended by the ICSH. The possibility that two of the patients are true homozygotes cannot be ruled out, while the other two apparently represent double heterozygotes. All but o...

journal_title：Acta haematologica

authors： Tegos C,Anagnostoulis G

更新日期：1994-01-01 00:00:00

abstract：:Many bovine leukemic lymphocytes produce virus particles when kept in survival cultures in Eagle's Minimum Essential Medium supplemented with 20 percent of inactivated fetal calf serum. Virus particles equilibrate at a density of 1.16 g/ml in sucrose gradients and at a density of 1.12 g/ml in metrizamide gradients. Si...

journal_title：Acta haematologica

authors： Kettmann R,Mammerickx M,Dekegel D,Ghysdael J,Portetelle D,Burny A

更新日期：1975-01-01 00:00:00

abstract：:Downregulation of apoptosis has been proposed as a mechanism of clonal expansion in low-grade B cell neoplasms. We have previously described an unusual case of CD5+ B cell lymphoma characterized by cycles of leukemic phase alternating with spontaneous remission. In the present study, we examined the involvement of apo...

journal_title：Acta haematologica

authors： Aizman I,Many A,Peller S,Ramot B,Kaufmann Y

更新日期：2000-01-01 00:00:00

abstract：:The frequency of chronic lymphocytic leukemia (CLL) varies a great deal from one population to another. We have undertaken to compare the aspects of CLL in Maghreb and Europe through two series of comparable importance, studied during the same period and under similar conditions in Algiers and Amiens. This comparison ...

journal_title：Acta haematologica

authors： Bellabes S,Hamman P,Desablens B,Colonna P,Messerschmitt J

更新日期：1983-01-01 00:00:00

abstract：:Although multiple myeloma (MM) remains an incurable disease, its treatment has improved over the past decade. This improvement has been at least in part due to the introduction of novel antimyeloma agents with new mechanisms of action, including those that target both myeloma cells and the tumor microenvironment, with...

journal_title：Acta haematologica

authors： Cibeira MT,Mercadal S,Arenillas L,Muntañola A,Salamero O,Bladé J

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to study the effect of vitamin E treatment in oxidative stress of red and white cells of beta-thalassaemia intermedia patients. METHODS:Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15-74), were recruited for oral daily admi...

journal_title：Acta haematologica

authors： Pfeifer WP,Degasperi GR,Almeida MT,Vercesi AE,Costa FF,Saad ST

更新日期：2008-01-01 00:00:00

abstract：:Primary lymphoma of the female genital tract is very rare. We report the case of a 36-year-old woman who was referred to our hospital because of an indeterminate Pap smear test. The colposcopy showed a thickening of the posterior vaginal wall and various irregular ulcerated nodular lesions. Histological examination, i...

journal_title：Acta haematologica

authors： Guastafierro S,Tedeschi A,Criscuolo C,Celentano M,Cobellis L,Rossiello R,Falcone U

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The relation with SNF5 mutation and chromosome 22 abnormalities is not clear in hematological neoplasms. METHODS:To elucidate the relevance of the SNF5 gene on 22q11.2, karyotypes were reviewed in 283 hematological neoplasms. Loss of heterozygosity (LOH) on 22q was analyzed in 21 plasma cell myelomas withou...

journal_title：Acta haematologica

authors： Mori N,Inoue K,Okada M,Motoji T

更新日期：2011-01-01 00:00:00

abstract：:Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support hematopoietic differentiation of allogeneic cord blood cells in ...

journal_title：Acta haematologica

authors： Thalmeier K,Meissner P,Moosmann S,Sagebiel S,Wiest I,Huss R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIMS:The study was undertaken to understand the characteristic of plasma cell leukemia (PCL) in China. METHODS:We reviewed and compared medical data of 22 primary PCL, 9 secondary PCL and 461 multiple myeloma (MM) diagnosed at our institute from January 2000 to January 2008. RESULTS:The median onset ages o...

journal_title：Acta haematologica

authors： Peijing Q,Yan X,Yafei W,Dehui Z,Zengjun L,Junyuan Q,Yaozhong Z,Lugui Q

更新日期：2009-01-01 00:00:00

abstract：:We have retrospectively analyzed a series of 19 patients with hepatitis C virus (HCV) infection and chronic thrombocytopenia not attributable to hypersplenism or to other causes. Antiplatelet antibodies were present in 81% of cases. Response to prednisone was observed in 6 of 7 patients and 1 of 3 patients responded t...

journal_title：Acta haematologica

authors： Hernández F,Blanquer A,Linares M,López A,Tarín F,Cerveró A

更新日期：1998-01-01 00:00:00

abstract：:Immunologic abnormalities have been described in patients with Hodgkin lymphoma, including autoimmune hemolytic anemia and immune thrombocytopenic purpura. The concurrent diagnoses of Hodgkin lymphoma and acquired aplastic anemia, however, is extremely rare. We report a 56-year-old Japanese female patient with severe ...

journal_title：Acta haematologica

authors： Saitoh T,Matsushima T,Yamane A,Sakuraya M,Irisawa H,Yokohama A,Handa H,Tsukamoto N,Karasawa M,Nojima Y,Murakami H

更新日期：2007-01-01 00:00:00

abstract：:A study of E-rosette ultrathin sections has been undertaken in an attempt to analyze changes induced during the T-lymphocyte-sheep red blood cell interaction on the rosetted lymphocyte surface architecture. The formation of nonimmune rosettes implies different types of attachment between lymphocytes and sheep red bloo...

journal_title：Acta haematologica

authors： Renau-Piqueras J,Cervera J

更新日期：1979-01-01 00:00:00

abstract：:Three consecutive patients considered to have end-stage acquired aplastic anaemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 x 10(8) nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC-positive family donors. All patients showed autologous marrow reco...

journal_title：Acta haematologica

authors： Jeannet M,Speck B,Rubinstein A,Pelet B,Wyss M,Kummer H

更新日期：1976-01-01 00:00:00