Bleeding time and other laboratory tests to monitor the safety and efficacy of thrombolytic therapy.

Abstract:

:Widespread use of thrombolytic agents in a variety of settings has highlighted the need for measures of safety and efficacy. Previously used laboratory parameters, such as decreasing levels of fibrinogen and increasing levels of fibrin(ogen) degradation products (FDPs), have failed to correlate consistently with hemorrhagic events and have not yet been useful in predicting patients at risk for bleeding. Although the bleeding time (BT) has been considered primarily to reflect platelet function, it also reflects the interaction of platelets with vessel wall and coagulation pathways. Recently, the BT has been considered as a potential predictor of clinical bleeding during thrombolysis. The BT, as a measure of in vivo hemostatic competence, may be particularly well-suited for this application. Serial BTs during thrombolytic therapy may provide valuable information regarding safety and efficacy, but further studies are needed to confirm preliminary findings.

journal_name

Chest

journal_title

Chest

authors

Hirsch DR,Goldhaber SZ

doi

10.1378/chest.97.4_supplement.124s

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

124S-131S

issue

4 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)41150-X

journal_volume

97

pub_type

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