Abstract:
:Widespread use of thrombolytic agents in a variety of settings has highlighted the need for measures of safety and efficacy. Previously used laboratory parameters, such as decreasing levels of fibrinogen and increasing levels of fibrin(ogen) degradation products (FDPs), have failed to correlate consistently with hemorrhagic events and have not yet been useful in predicting patients at risk for bleeding. Although the bleeding time (BT) has been considered primarily to reflect platelet function, it also reflects the interaction of platelets with vessel wall and coagulation pathways. Recently, the BT has been considered as a potential predictor of clinical bleeding during thrombolysis. The BT, as a measure of in vivo hemostatic competence, may be particularly well-suited for this application. Serial BTs during thrombolytic therapy may provide valuable information regarding safety and efficacy, but further studies are needed to confirm preliminary findings.
journal_name
Chestjournal_title
Chestauthors
Hirsch DR,Goldhaber SZdoi
10.1378/chest.97.4_supplement.124ssubject
Has Abstractpub_date
1990-04-01 00:00:00pages
124S-131Sissue
4 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(15)41150-Xjournal_volume
97pub_type
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