Abstract：
:Recent studies indicate that ovarian cancer may be highly responsive to antivascular therapeutics. We have developed an antivascular tumor therapeutic using the F3 peptide to target cisplatin-loaded nanoparticles (F3-Cis-Np) to tumor vessels. We show that although F3-Cis-Np bind with high specificity to both human ovarian tumor cells and tumor endothelial cells in vitro, they only show cytotoxic activity against the tumor endothelial cells. In vivo these nanoparticles bind primarily to tumor endothelial cells. Therapeutic studies in both flank and orthotopic i.p. murine ovarian tumor models, as well as human tumor xenograft models, show rapid tumor regression with treatment. Treatment was associated with significant vascular necrosis consistent with an antivascular effect. Furthermore, treatment was active in both platinum-sensitive and platinum-resistant cell lines. Importantly, we show that F3-Cis-Np bind to human tumor endothelial cells in vitro and to human tumor vessels in vivo. Therapy targeting human vasculature in vivo with F3-Cis-Np led to near complete loss of all human tumor vessels in a murine model of human tumor vasculature. Our studies indicate that F3-targeted vascular therapeutics may be an effective treatment modality in human ovarian cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Winer I,Wang S,Lee YE,Fan W,Gong Y,Burgos-Ojeda D,Spahlinger G,Kopelman R,Buckanovich RJdoi
10.1158/0008-5472.CAN-10-1917subject
Has Abstractpub_date
2010-11-01 00:00:00pages
8674-83issue
21eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-10-1917journal_volume
70pub_type
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