HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4.

abstract：:The effects of temperature in the fever range (37-42 degrees) on the membrane potentials of normal and simian virus 40-transformed hamster lymphocytes were analyzed. The transmembrane distributions of radiolabeled triphenylmethylphosphonium and thiocyanate were measured, and they provide upper and lower limits for the...

journal_title：Cancer research

authors： Mikkelsen RB,Koch B

更新日期：1981-01-01 00:00:00

abstract：:Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA), PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting angiogenesis and tumor cell survival. In this review, we summarize preclinical evidence in support of the protumorigenic function of PAI-1 that...

journal_title：Cancer research

authors： Placencio VR,DeClerck YA

更新日期：2015-08-01 00:00:00

abstract：:Despite the fact that osteosarcoma is one of the most common primary bone malignancies with poor prognosis, the mechanism behind the pathogenesis of osteosarcoma is only partially known. Here we characterized differentially expressed genes by extensive analysis of several publicly available gene expression profile dat...

journal_title：Cancer research

authors： Chen Y,Wang T,Huang M,Liu Q,Hu C,Wang B,Han D,Chen C,Zhang J,Li Z,Liu C,Lei W,Chang Y,Wu M,Xiang D,Chen Y,Wang R,Huang W,Lei Z,Chu X

更新日期：2020-06-15 00:00:00

abstract：:Breast cancer is a heterogeneous disease with distinct molecular subtypes characterized by differential response to targeted and chemotherapeutic agents. Enhanced understanding of the genetic alterations characteristic of different subtypes is needed to pave the way for more personalized administration of therapeutic ...

journal_title：Cancer research

authors： O'Brien C,Cavet G,Pandita A,Hu X,Haydu L,Mohan S,Toy K,Rivers CS,Modrusan Z,Amler LC,Lackner MR

更新日期：2008-07-01 00:00:00

abstract：:The relative abundance of primary transcript and mature mRNA of the c-myc, calcyclin, S14 ribosomal protein, and rRNA genes was determined densitometrically after reverse transcriptase-polymerase chain reaction and Northern blotting analysis in resting and mitogen-stimulated lymphocytes, proliferating and terminally d...

journal_title：Cancer research

authors： Ferrari S,Tagliafico E,Manfredini R,Grande A,Rossi E,Zucchini P,Torelli G,Torelli U

更新日期：1992-01-01 00:00:00

abstract：:Hollow organs lined by columnar epithelial cells normally secrete mucins and their proteolytic fragments vectorially into the lumen. These heterogeneously O-glycosylated molecules are known to aberrantly enter the bloodstream in the setting of epithelial carcinomas and possibly during injury or inflammation. We have r...

journal_title：Cancer research

authors： Wahrenbrock MG,Varki A

更新日期：2006-02-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple GBM cell subpopulations could be purified from the specimens o...

journal_title：Cancer research

authors： Mazzoleni S,Politi LS,Pala M,Cominelli M,Franzin A,Sergi Sergi L,Falini A,De Palma M,Bulfone A,Poliani PL,Galli R

更新日期：2010-10-01 00:00:00

abstract：:Metabolite profiling using (1)H nuclear magnetic resonance (NMR) spectroscopy was used to investigate the metabolic changes associated with deletion of the gene for the transcriptional coactivator p300 in the human colon carcinoma cell line HCT116. Multivariate statistical methods were used to distinguish between meta...

journal_title：Cancer research

authors： Bundy JG,Iyer NG,Gentile MS,Hu DE,Kettunen M,Maia AT,Thorne NP,Brenton JD,Caldas C,Brindle KM

更新日期：2006-08-01 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:During a 2-yr study of carcinogenesis by CdCl2 in male Wistar [Crl:(WI)BR] rats, weekly clinical observations during the last 6 mo of the study revealed many cases of persistent tumor-like masses at the site of the metal identification tags in the ears of the animals. A total of 14 tumors (mostly compound osteosarcoma...

journal_title：Cancer research

authors： Waalkes MP,Rehm S,Kasprzak KS,Issaq HJ

更新日期：1987-05-01 00:00:00

abstract：:Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum in...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1982-04-01 00:00:00

abstract：:Multimodal therapy is generally more effective than single-agent treatment for cancer. rRp450 is an engineered herpes simplex viral mutant that replicates in and kills tumor cells in a relatively selective fashion. It also expresses, in infected cells, the cyclophosphamide (CPA)-sensitive rat cytochrome P450 2B1 (CYP2...

journal_title：Cancer research

authors： Aghi M,Chou TC,Suling K,Breakefield XO,Chiocca EA

更新日期：1999-08-15 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:Erythrocytes containing micronuclei serve as an indicator of genotoxic exposure in splenectomized individuals. Micronucleated erythrocytes, derived from cytogenetically damaged RBC precursors, are not selectively removed from peripheral blood in individuals who lack splenic function. The relationship between micronucl...

journal_title：Cancer research

authors： Smith DF,MacGregor JT,Hiatt RA,Hooper NK,Wehr CM,Peters B,Goldman LR,Yuan LA,Smith PA,Becker CE

更新日期：1990-08-15 00:00:00

abstract：:Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors ...

journal_title：Cancer research

authors： Yamashina T,Baghdadi M,Yoneda A,Kinoshita I,Suzu S,Dosaka-Akita H,Jinushi M

更新日期：2014-05-15 00:00:00

abstract：:Heterozygous mutations in the BRCA1 gene predispose women to breast and ovarian cancer, while biallelic BRCA1 mutations are a cause of Fanconi anemia (FA), a rare genetic disorder characterized by developmental abnormalities, early-onset bone marrow failure, increased risk of cancers, and hypersensitivity to DNA-cross...

journal_title：Cancer research

authors： Park D,Bergin SM,Jones D,Ru P,Koivisto CS,Jeon YJ,Sizemore GM,Kladney RD,Hadjis A,Shakya R,Ludwig T

更新日期：2020-10-01 00:00:00

abstract：:We evaluated the usefulness of L-dopa decarboxylase (DDC) as a tumor marker of neuroendocrine (NE) cell differentiation by measuring its expression in 432 human tumors of diverse types and origins. A subset of these tumors and cell lines derived from them also were studied for expression of two other general NE cell m...

journal_title：Cancer research

authors： Gazdar AF,Helman LJ,Israel MA,Russell EK,Linnoila RI,Mulshine JL,Schuller HM,Park JG

更新日期：1988-07-15 00:00:00

abstract：:We investigated the potential role of mitochondrial manganese superoxide dismutase (Mn-SOD) in protective activity against irradiation by analyzing cell viability by a colony formation assay and by detecting apoptosis in stably human Mn-SOD gene-transfected HLE, a hepatocellular carcinoma cell line. We found that over...

journal_title：Cancer research

authors： Motoori S,Majima HJ,Ebara M,Kato H,Hirai F,Kakinuma S,Yamaguchi C,Ozawa T,Nagano T,Tsujii H,Saisho H

更新日期：2001-07-15 00:00:00

abstract：:We postulated that increased expression of the cell cycle regulators cyclin D1 and cyclin-dependent kinase (Cdk) 4 may be involved in the development of intestinal adenomas associated with familial adenomatous polyposis (FAP). In the present study of multiple intestinal neoplasia (Min) mice and human FAP patients, the...

journal_title：Cancer research

authors： Zhang T,Nanney LB,Luongo C,Lamps L,Heppner KJ,DuBois RN,Beauchamp RD

更新日期：1997-01-01 00:00:00

abstract：:Recent preclinical studies have shown that frequent administration in vivo of low doses of chemotherapeutic drugs ("metronomic" dosing) can affect tumor endothelium and inhibit tumor angiogenesis, reducing significant side effects (e.g., myelosuppression) involving other tissues, even after chronic treatment. This sug...

journal_title：Cancer research

authors： Bocci G,Nicolaou KC,Kerbel RS

更新日期：2002-12-01 00:00:00

abstract：:The clinically relevant polyamine analogue N(1),N(11)-diethylnorspermine (DENSPM) inhibits cell growth by down-regulating polyamine biosynthesis, up-regulating polyamine catabolism at the level of spermidine/spermine N(1)-acetyltransferase (SSAT), and depleting intracellular polyamine pools. Among human melanoma cell ...

journal_title：Cancer research

authors： Chen Y,Alm K,Vujcic S,Kramer DL,Kee K,Diegelman P,Porter CW

更新日期：2003-07-01 00:00:00

abstract：:Increased sialylation and branching of asparagine-linked oligosaccharides have recently been associated with both neoplastic transformation and the metastatic phenotype. Swainsonine, an inhibitor of Golgi alpha-mannosidase II blocks the synthesis of sialylated tri- and tetraantennary asparagine-linked oligosaccharides...

journal_title：Cancer research

authors： Dennis JW

更新日期：1986-10-01 00:00:00

abstract：:Malignant neuroblastomas contain stem-like cells. These tumors also overexpress the Forkhead box transcription factor FoxM1. In this study, we investigated the roles of FoxM1 in the tumorigenicity of neuroblastoma. We showed that depletion of FoxM1 inhibits anchorage-independent growth and tumorigenicity in mouse xeno...

journal_title：Cancer research

authors： Wang Z,Park HJ,Carr JR,Chen YJ,Zheng Y,Li J,Tyner AL,Costa RH,Bagchi S,Raychaudhuri P

更新日期：2011-06-15 00:00:00

abstract：:We developed a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DNA methylation patterns in clinical samples. A massively parallel sequencing-by-synthesis method (454 sequencing) was used to directly sequence >100 bisulfite PCR products in a single sequencing run without...

journal_title：Cancer research

authors： Taylor KH,Kramer RS,Davis JW,Guo J,Duff DJ,Xu D,Caldwell CW,Shi H

更新日期：2007-09-15 00:00:00

abstract：:The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes the chemotaxis, survival, and tumorigenesis of highly malignant human glioblastoma cells. Because glioblastoma cells may also express other receptors for growt...

journal_title：Cancer research

authors： Huang J,Hu J,Bian X,Chen K,Gong W,Dunlop NM,Howard OM,Wang JM

更新日期：2007-06-15 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:Correlation was greater than 90% between feline leukemia virus (FeLV), group-specific antigen (GSA) in leukocytes, and viral infectivity (VI) in serum or plasma from 132 cats infected with either the Rickard strain of FeLV, the Snyder-Theilen strain of feline sarcoma virus, or field strains of FeLV. Detection of GSA i...

journal_title：Cancer research

authors： Hoover EA,Olsen RG,Mathes LE,Schaller JP

更新日期：1977-10-01 00:00:00

abstract：:The mechanisms by which cells accurately distinguish between DNA double-strand break (DSB) ends and telomeric DNA ends remain poorly defined. Recent investigations have revealed intriguing interactions between DNA repair and telomeres. We were the first to report a requirement for the nonhomologous end-joining (NHEJ) ...

journal_title：Cancer research

authors： Williams ES,Klingler R,Ponnaiya B,Hardt T,Schrock E,Lees-Miller SP,Meek K,Ullrich RL,Bailey SM

更新日期：2009-03-01 00:00:00