New thoughts on the initiation of mucositis.

Abstract:

:It has been slightly more than a decade since the classic mechanistic paradigm that defined the pathogenesis of mucositis was revised. A five-stage sequence of linked biological events forms the basis for our current understanding of how regimen-related mucosal injury occurs. The first stage is the initiation phase, although the gateway to toxicity has been the least studied. This essay proposes new thoughts on the phase's components, how they might interact, and how they present new opportunities for treatment interventions and mucositis risk prediction.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Sonis ST

doi

10.1111/j.1601-0825.2010.01681.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

597-600

issue

7

eissn

1354-523X

issn

1601-0825

journal_volume

16

pub_type

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