Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus.

abstract：OBJECTIVE:To compare the effects of the angiotensin II receptor antagonist candesartan with the angiotensin-converting enzyme inhibitor enalapril on myocardial fibrosis evaluated by echoreflectivity analysis. METHODS:Hypertensive patients (n = 196) with echocardigraphically documented left ventricular hypertrophy were...

journal_title：Journal of hypertension

authors： Ciulla MM,Paliotti R,Esposito A,Cuspidi C,Muiesan ML,Rosei EA,Magrini F,Zanchetti A

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:Current evidence demonstrates that both genetic and environmental factors influence blood pressure. The sympathetic nervous system is a key player in blood pressure control and functional genetic variants of the beta-2 adrenergic receptor (B2AR) have been identified and implicated in the pathogenesis of hype...

journal_title：Journal of hypertension

authors： Binder A,Garcia E,Wallace C,Gbenga K,Ben-Shlomo Y,Yarnell J,Brown P,Caulfield M,Skrabal F,Kotanko P,Munroe P

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:The L/N-type calcium channel blocker (CCB) cilnidipine suppresses sympathetic nerve activity and has a superior renoprotective effect compared with L-type CCBs such as amlodipine. The cardioprotective action of cilnidipine has remained largely uncharacterized, however. We have now investigated the effects of ...

journal_title：Journal of hypertension

authors： Takatsu M,Hattori T,Murase T,Ohtake M,Kato M,Nashima K,Nakashima C,Takahashi K,Ito H,Niinuma K,Aritomi S,Murohara T,Nagata K

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...

journal_title：Journal of hypertension

authors： Tanaka K,Honda M,Kuramochi T,Hashimoto M,Masumura S,Mansoor AM,Ishikawa S,Morioka S

更新日期：1994-10-01 00:00:00

abstract：AIM:Studies addressing the association between a reduced drop of heart rate (HR) at night with subclinical organ damage and cardiovascular events in the general population are scanty. We evaluated this issue in individuals enrolled in the Pressioni Monitorate E Loro Associazioni study. METHODS:At entry, 2021 individua...

journal_title：Journal of hypertension

authors： Cuspidi C,Facchetti R,Bombelli M,Sala C,Tadic M,Grassi G,Mancia G

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:The physiopathological mechanisms implicated in hypertensive heart disease are multi-factorial, including myocyte hypertrophy, apoptosis and myocardial remodelling. In this process, some hormonal and local growth factors have a regulatory influence. The aim of this study was to evaluate the potential role of ...

journal_title：Journal of hypertension

authors： Fernández-Solà J,Borrisser-Pairó F,Antúnez E,Tobías E

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS:Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimate...

journal_title：Journal of hypertension

authors： Viazzi F,Ceriello A,Fioretto P,Giorda C,Guida P,Russo G,Greco E,De Cosmo S,Pontremoli R,AMD-Annals Study Group.

更新日期：2018-08-01 00:00:00

abstract：:Ca2+ pump kinetics were investigated in erythrocytes from 22 essential hypertensive patients and 20 normotensive controls (under initial-rate and steady-state conditions, using Sr2+ as a Ca2+ analogue). The mean value of the apparent dissociation constant for total internal Ca2+ (KCa) was slightly but significantly in...

journal_title：Journal of hypertension

authors： de la Sierra A,Hannaert P,Ollivier JP,Senn N,Garay R

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:To investigate the role of an activated endothelin system in the renal dysfunction observed in chronic heart failure after myocardial infarction. METHODS:In rats with heart failure after myocardial infarction and in sham-operated animals (Sham), we investigated the effect on renal function of long-term oral ...

journal_title：Journal of hypertension

authors： Bauersachs J,Braun C,Fraccarollo D,Widder J,Ertl G,Schilling L,Kirchengast M,Rohmeiss P

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Work stress contributes to risk of coronary heart disease and hypertension. This study tested the influence of job control on ambulatory blood pressure, and ratings of perceived stress and happiness in men and women systematically sampled by socio-economic status from the Whitehall II epidemiological cohort. ...

journal_title：Journal of hypertension

authors： Steptoe A,Willemsen G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The screening for primary aldosteronism is based on the aldosterone-renin ratio calculated with the plasma renin activity (PRA) value as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains unclear. METHOD:We, therefore compar...

journal_title：Journal of hypertension

authors： Rossi GP,Barisa M,Belfiore A,Desideri G,Ferri C,Letizia C,Maccario M,Morganti A,Palumbo G,Patalano A,Roman E,Seccia TM,Pessina AC,Mantero F,PAPY study Investigators.

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:Current clinical guidelines of primary aldosteronism recommend adrenalectomy (AdX) for unilateral primary aldosteronism based on the studies showing the potential superiority of AdX over the medical treatment. However, since most medically treated cases consisted of bilateral primary aldosteronism and all su...

journal_title：Journal of hypertension

authors： Katabami T,Fukuda H,Tsukiyama H,Tanaka Y,Takeda Y,Kurihara I,Ito H,Tsuiki M,Ichijo T,Wada N,Shibayama Y,Yoshimoto T,Ogawa Y,Kawashima J,Sone M,Inagaki N,Takahashi K,Fujita M,Watanabe M,Matsuda Y,Kobayashi H,Shib

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Microalbuminuria (MA) is a marker of adverse outcome in hypertension. The aim of this study was to investigate the association of MA with cardiovascular risk factors and glomerular hyperfiltration in the early stage of hypertension and to assess its predictive value for the development of sustained hypertensi...

journal_title：Journal of hypertension

authors： Palatini P,Mormino P,Mos L,Mazzer A,Dorigatti F,Zanata G,Longo D,Garbelotto R,De Toni R,Graniero G,Pessina AC,HARVEST Study Group.

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Blood pressure (BP) measurement in atrial fibrillation (AF) patients is problematic and automated monitors are regarded as inaccurate. The optimal procedure for validating BP monitors in AF is questionable. This study evaluated the accuracy of a novel professional oscillometric upper-arm cuff device (Microli...

journal_title：Journal of hypertension

authors： Stergiou GS,Kyriakoulis KG,Bountzona I,Menti A,Destounis A,Kalogeropoulos P,Kollias A

更新日期：2020-10-16 00:00:00

abstract：OBJECTIVE:The existence and localization of renin in situ was examined in human arteries under non-pathological conditions. DESIGN:Biochemical and immunohistochemical procedures were adopted to examine the existence of renin in human gastroepiploic arteries using an antibody raised against human recombinant renin or a...

journal_title：Journal of hypertension

authors： Okamura T,Aimi Y,Kimura H,Murakami K,Toda N

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:We demonstrated in a previous cross-sectional study that arterial compliance is elevated in postmenopausal women taking estrogen-containing hormonal therapy, which may partially account for the reduction in cardiovascular risk observed. OBJECTIVE:To investigate the effects of withdrawal and recommencement o...

journal_title：Journal of hypertension

authors： Waddell TK,Rajkumar C,Cameron JD,Jennings GL,Dart AM,Kingwell BA

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVES:To assess the expression of early cardiac genes, implicated in the hypertrophic growth response of the adult heart, in peripheral blood mononuclear cells in patients with essential hypertension and its relationship to ambulatory blood pressure monitoring (ABPM) parameters and to echocardiographic left ventri...

journal_title：Journal of hypertension

authors： Kontaraki JE,Marketou ME,Zacharis EA,Parthenakis FI,Vardas PE

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:This study aimed to explore the predictive role of CHA2DS2-VASc score between venous thromboembolism (VTE) and ischemic stroke. METHODS:The current study was analyzed from the in-patient claims data of the Taiwan National Health Insurance Research Database. We identified the patients diagnosed with VTE (for St...

journal_title：Journal of hypertension

authors： Hu WS,Lin CL

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The objective of the present studies is to investigate if the enhanced expression of Gs alpha protein and their mRNA observed in various models of hypertensive rats is due to the expressed hypertrophy or hypertension. METHODS:Hypertension, in Sprague-Dawley rats was induced by the oral administration of the ...

journal_title：Journal of hypertension

authors： Di Fusco F,Anand-Srivastava MB

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that apelin protects against angiotensin II (Ang II)-induced cardiovascular fibrosis and vascular remodeling. METHODS AND RESULTS:Wild-type mice administered apelin or apelin along with Ang II exhibited less cardiovascular fibrosis and decreased plasminogen activator inhibitor type-1 (...

journal_title：Journal of hypertension

authors： Siddiquee K,Hampton J,Khan S,Zadory D,Gleaves L,Vaughan DE,Smith LH

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:We studied the vasoconstrictor effects of the thromboxane A2 (TxA2) analogue U46619 in the perfused hind limb of rats under constant flow before and after intravenous injection of irbesartan, an angiotensin II AT1 receptor antagonist, to test whether irbesartan interacts in vivo with the thromboxane A2/prosta...

journal_title：Journal of hypertension

authors： Fukuhara M,Neves LA,Li P,Diz DI,Ferrario CM,Brosnihan KB

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To ascertain the relationships between the kinetic properties of erythrocyte Na+-H+ exchange [maximum kinetic energy (Vmax), Michaelis constant (Km) for internal H+ and Hill's coefficient], Na+-Li+ (Vmax and Km for external Na+), and metabolic parameters in normotensive controls and hypertensive subjects. MA...

journal_title：Journal of hypertension

authors： Semplicini A,Ceolotto G,Felice M,Reato S,Valle R,Gebbin A,Fontebasso A,Serena L,Pessina AC

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:We examined the relationship between brachial-ankle pulse wave velocity and the development of cardiovascular disease in a general Japanese population. METHODS:A total of 2916 community-dwelling Japanese individuals without history of cardiovascular disease aged at least 40 years were followed up for an aver...

journal_title：Journal of hypertension

authors： Ninomiya T,Kojima I,Doi Y,Fukuhara M,Hirakawa Y,Hata J,Kitazono T,Kiyohara Y

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence and risk markers of arterial hypertension in the context of a rapidly growing urbanization in Africa. DESIGN:A cross-sectional study was performed on a representative sample of inhabitants of Pikine, an urban suburb of Dakar, Senegal. METHODS:Blood pressure was measured by properly ...

journal_title：Journal of hypertension

authors： Astagneau P,Lang T,Delarocque E,Jeannee E,Salem G

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To determine the effects of angiotensin II (AII) (1-8) on cytosolic free calcium concentrations in the absence and in the presence of the selective angiotensin subtype 1 (AT1) receptor antagonist losartan and of the selective angiotensin subtype 2-receptor antagonist P-186 in human peripheral blood mononuclea...

journal_title：Journal of hypertension

authors： Lijnen P,Fagard R,Petrov V

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the clinic and ambulatory blood pressure (BP)-lowering efficacy and safety of an aliskiren/amlodipine/hydrochlorothiazide (HCT) triple combination compared with the component dual combinations, in patients with moderate-to-severe hypertension. METHODS:This 8-week, double-blind, randomized, activ...

journal_title：Journal of hypertension

authors： Lacourcière Y,Taddei S,Konis G,Fang H,Severin T,Zhang J

更新日期：2012-10-01 00:00:00

abstract：:The benefit of blood pressure-lowering therapy in individuals with normal blood pressure who are at high cardiovascular risk creates a challenge in how best to advocate such therapy. Arguments based on a putative causal role for blood pressure and the need to reduce blood pressure may be less likely to succeed than ar...

journal_title：Journal of hypertension

authors： Campbell DJ

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:In essential hypertensive patients, blunted renal plasma flow responsiveness to angiotensin II suggests a pathologic increase in angiotensin II in the kidneys. This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determ...

journal_title：Journal of hypertension

authors： Patel TV,Williams GH,Fisher ND

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Enhanced oxidative stress has been observed in hypertension, but the underlying mechanism has not been fully clarified. OBJECTIVE:To study the relationship between oxygen free radicals and hypertension, using platelets as a tool to measure the cellular production of superoxide anion (O2). DESIGN:Forty pati...

journal_title：Journal of hypertension

authors： Germanò G,Sanguigni V,Pignatelli P,Caccese D,Lenti L,Ragazzo M,Lauro R,Violi F

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:A causal relationship has been established between hyperglycemia and cardiovascular diseases, but no threshold has been retained to determine a 'glycemia-associated' cardiovascular risk. Carotid intima-media thickness (CIMT) is an independent predictor for cardiovascular events. High blood pressure is a majo...

journal_title：Journal of hypertension

authors： Tropeano AI,Boutouyrie P,Katsahian S,Laloux B,Laurent S

更新日期：2004-11-01 00:00:00