当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis.

Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis.

Abstract：

OBJECTIVES:The aim of this study was to measure soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid of knee osteoarthritis (OA) patients and to determine the correlation between sRAGE levels and disease severity. DESIGN AND METHODS:Thirty-six OA patients and 15 healthy controls were enrolled in this study. OA grading was performed using the Kellgren-Lawrence classification. sRAGE levels in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay. RESULTS:Plasma sRAGE levels were significantly lower in OA patients than in healthy controls (P=0.01). sRAGE levels in plasma were remarkably higher with regard to paired synovial fluid (P=0.001). Additionally, sRAGE concentrations in plasma and synovial fluid showed significant inverse correlation with disease severity (r=-0.65, P<0.001 and r=-0.55, P=0.001, respectively). Further analysis showed that there was a strong positive correlation between plasma and synovial sRAGE concentration (r=0.81, P<0.001). CONCLUSIONS:sRAGE levels were significantly lower in OA patients compared with controls, and sRAGE levels in plasma and synovial fluid also decreased significantly as the disease severity increased. Accordingly, sRAGE levels could be used as a biochemical marker for assessing the severity and progression of knee OA.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Chayanupatkul M,Honsawek S

doi

10.1016/j.clinbiochem.2010.07.007

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

1133-7

issue

13-14

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(10)00322-X

journal_volume

43

pub_type

杂志文章

相关文献

CLINICAL BIOCHEMISTRY文献大全
  • Alterations of serum enzymes during therapy directed at human malignant sarcomas: a radiological follow-up study of tumor transformation.

    abstract：:1. When a malignant growth is developing in a patient, one often observes in the serum an increased activity of serum enzymes due to necrosis and increased membrane permeability caused by the altered metabolism of malignant cells. Conversely, I considered it interesting to check the enzymes of the malate-aspartate sh...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(77)92378-5

    authors： Nyandieka HS

    更新日期：1977-08-01 00:00:00

  • Effect of ischemic preconditioning on reactive oxygen species-mediated ischemia--reperfusion injury in the isolated perfused rat lung.

    abstract：OBJECTIVE:To investigate the protective effect of ischemic preconditioning (IP) in the early phase of reperfusion injury. DESIGN AND METHODS:Control rat lungs were subjected to 3 h of perfusion, whereas the lungs of the ischemia-then-reperfusion (I/R) group were subjected to 2 h of cold ischemia following 30 min of pe...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.04.002

    authors： Ucar G,Topaloglu E,Kandilci HB,Gümüsel B

    更新日期：2005-07-01 00:00:00

  • Influences of sleep and the circadian rhythm on iron-status indices.

    abstract：OBJECTIVES:The aim was to study the influence of sampling time, food intake and sleep on tests used to screen for and monitor conditions of iron deficiency and overload. DESIGN AND METHODS:The 24 h variations of iron, transferrin, transferrin saturation (TS) and ferritin were studied in seven healthy individuals durin...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.clinbiochem.2010.08.023

    authors： Ridefelt P,Larsson A,Rehman JU,Axelsson J

    更新日期：2010-11-01 00:00:00

  • Performance characteristics of beta-2-microglobulin measurements on a Beckman Immage analyzer with the DakoCytomation reagent kit.

    abstract：OBJECTIVE:Evaluation of serum beta-2-microglobulin (beta2M) in an automated analyzer. DESIGN AND METHODS:The DakoCytomation beta2M kit is an antibody based reagent intended for quantitative determination of beta2M in serum and plasma by rate nephelometry. RESULTS:The limit of blank is 0.16 mg/L. The method is linear ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.06.030

    authors： De BK,Jimenez E,De S

    更新日期：2009-10-01 00:00:00

  • Plasma vaspin concentrations are decreased in acute coronary syndrome, but unchanged in patients without coronary lesions.

    abstract：OBJECTIVE:Previous studies suggested that decreased serum vaspin levels were associated with coronary artery disease (CAD). The present study aimed to investigate the association between plasma vaspin levels and different states of CAD. DESIGN AND METHODS:A total of 162 patients with coronary angiography (CAG) proved ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.06.028

    authors： Zhang B,Peng W,Li H,Lu Y,Zhuang J,Wang K,Su Y,Xu Y

    更新日期：2013-10-01 00:00:00

  • Correlation of endothelin 1 plasma levels with plasma antioxidant capacity in elderly patients treated for hypertension.

    abstract：UNLABELLED:Experimental studies confirmed that reactive oxygen species increase endothelin-1 (ET-1) synthesis, and modulate ET-1 signaling pathway resulting in vasoconstriction and vascular remodeling. The aim of this study was to evaluate the relationship between plasma ET-1 concentration and antioxidant status in pat...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.11.002

    authors： Skalska AB,Pietrzycka A,Stepniewski M

    更新日期：2009-03-01 00:00:00

  • Influence of reduction in the elution times on HPLC glycohaemoglobin results.

    abstract：OBJECTIVES:To compare HPLC methods with short and long elution times for HbA1c measurement in blood. METHODS:Comparison between G7-Tosoh (1.2 min); Bio-Rad-Variant-II-Turbo (1.3 min) and Arkray-HA-8160 (2.9 min). RESULTS:Passing-Bablok regression equations were: Y=0.17+0.96X; Y=-0.39+1.01X; Y=-0.40+1.0X and the means...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.07.003

    authors： Leon-Justel A,Santotoribio JD,Dominguez-Pascual I,Delgado AL,Macias C,Herrera MT,Leal A,Mangas MA,Acosta D,Guerrero JM

    更新日期：2009-10-01 00:00:00

  • Evaluation of BD Vacutainer® Barricor™ blood collection tubes for routine chemistry testing on a Roche Cobas® 8000 Platform.

    abstract：INTRODUCTION:Barricor™ Vacutainers® are a novel non-gel separator blood collection tube. These tubes enable faster pre-analytical processing which could reduce turnaround time and be beneficial in an acute care setting. We sought to evaluate the bias, stability, and integrity of plasma generated from these tubes compar...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2018.06.002

    authors： Fournier JE,Northrup V,Clark C,Fraser J,Howlett M,Atkinson P,Shea JL

    更新日期：2018-08-01 00:00:00

  • Stratus CS cardiac troponin I method: performance characteristics including imprecision at low concentrations.

    abstract：OBJECTIVES:Define performance characteristics of the Stratus CS cardiac troponin I (cTnI) assay in routine practice. METHODS:Imprecision at low cTnI values was assessed according to NCCLS EP5-A. Linearity was assessed by regression analysis; the reference interval was determined in 345 healthy individuals. Minimum det...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2004.03.009

    authors： Christenson RH,Cervelli DR,Bauer RS,Gordon M

    更新日期：2004-08-01 00:00:00

  • Cox proportional hazard model analysis of survival in end-stage renal disease patients with small-sized high-density lipoprotein particles.

    abstract：OBJECTIVE:Dyslipidemia is commonly seen in patients with end-stage renal disease (ESRD). This prospective study investigates whether small-sized high-density lipoprotein (HDL) particles alone or in combination with high sensitivity C-reactive protein (hsCRP) are independent determinants of ESRD mortality. DESIGN AND M...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2011.02.002

    authors： Vekic J,Zeljkovic A,Bogavac-Stanojevic N,Jelic-Ivanovic Z,Spasojevic-Kalimanovska V,Simic-Ogrizovic S,Dopsaj V,Spasic S

    更新日期：2011-06-01 00:00:00

  • Diagnostic concordance between NT-proBNP and BNP for suspected heart failure.

    abstract：OBJECTIVES:BNP and NT-proBNP are viewed as comparable in their ability to diagnose and monitor HF in clinical guidelines. However, no recent large-scale study has directly established diagnostic concordance between BNP and NT-proBNP. This study sought to assess diagnostic concordance of BNP and NT-proBNP for ruling in ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2018.07.002

    authors： Farnsworth CW,Bailey AL,Jaffe AS,Scott MG

    更新日期：2018-09-01 00:00:00

  • Utility of CA 15-3 and CEA in monitoring breast cancer patients with bone metastases: special emphasis on "spiking" phenomena.

    abstract：OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MAT...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(96)00133-6

    authors： Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

    更新日期：1997-02-01 00:00:00

  • Association between FSH, E1, and E2 levels in urine and serum in premenopausal and postmenopausal women.

    abstract：OBJECTIVE:We aimed to establish correlations for the levels of follicle-stimulating hormone (FSH), estrone (E1) and estradiol (E2) between urine and serum in premenopausal and postmenopausal women using immunoassays. METHODS:In this study of 92 women (61 postmenopausal, 31 premenopausal), both urine and blood specimen...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.clinbiochem.2019.08.009

    authors： Onizuka Y,Nagai K,Ideno Y,Kitahara Y,Iwase A,Yasui T,Nakajima-Shimada J,Hayashi K

    更新日期：2019-11-01 00:00:00

  • Determinants of drug disposition in man.

    abstract：:This article reviews some of the important determinants of variation in drug disposition such as age, gender, body weight, diet, environmental influences, drug - protein interactions, compliance, drug - drug interactions, endogenous substances, disease states, circadian variation and genetics. ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-9120(86)80050-9

    authors： MacLeod SM,Soldin SJ

    更新日期：1986-04-01 00:00:00

  • The value of biliary amylase and Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in diagnosing biliary malignancies.

    abstract：BACKGROUND/OBJECTIVES:Elevated concentrations of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in pancreatic juice have been reported in patients with pancreatic adenocarcinoma and have been considered as a promising tumor marker. This study was conducted to investigate whether biliar...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.01.012

    authors： Chen CY,Lin XZ,Wu HC,Shiesh SC

    更新日期：2005-06-01 00:00:00

  • Superiority of high sensitivity cardiac troponin T vs. I for long-term prognostic value in patients with chest pain; data from the Akershus cardiac Examination (ACE) 3 study.

    abstract：BACKGROUND:Cardiac troponins (cTn) are essential in the diagnostic assessment of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). Elevated concentrations of cTnT and cTnI predict cardiovascular events in non-acute settings, but the individual troponin isotype association with long-term mortality in patients...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2019.12.016

    authors： Tveit SH,Myhre PL,Hoff NJS,Le TM,Seljeflot I,Røysland R,Høiseth AD,Røsjø H,Omland T

    更新日期：2020-04-01 00:00:00

  • Plasma TNF-R1 and insulin concentrations in relation to leptin levels among normal and overweight children.

    abstract：OBJECTIVES:Leptin is a multifunctional polypeptide produced primarily by adipocytes and associated with the occurrence of obesity and insulin resistance. Tumor necrosis factor-alpha (TNF-alpha), a polypeptide cytokine produced primarily by mononuclear phagocytes, plays a key role in the initiation of the inflammatory r...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(02)00314-4

    authors： Chu NF,Shen MH,Wu DM,Shieh SM

    更新日期：2002-06-01 00:00:00

  • Human bone cells contain a fluoride sensitive acid phosphatase: evidence that this enzyme functions at neutral pH as a phosphotyrosyl protein phosphatase.

    abstract：:Fluoride is a potent therapeutic agent that increases spinal bone density in osteoporotic subjects. Based on work with animal cells previously, we proposed fluoride acts by inhibiting phosphotyrosyl protein phosphatase (EC 3.1.3.48) activity in bone cells. The presence of fluoride sensitive acid phosphatase (EC 3.1.3....

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/0009-9120(92)80045-i

    authors： Wergedal JE,Lau KH

    更新日期：1992-02-01 00:00:00

  • IDH1 and IDH2 mutations in patients with acute myeloid leukemia: Suitable targets for minimal residual disease monitoring?

    abstract：OBJECTIVES:Molecular screening plays a major role in prognostic categorization and subsequent definition of treatment strategies for acute myeloid leukemia. The possibility of using IDH1/2 mutations as a marker for the monitoring of minimal residual disease (MRD) is still under investigation and remains unclear. METHO...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2018.08.012

    authors： Petrova L,Vrbacky F,Lanska M,Zavrelova A,Zak P,Hrochova K

    更新日期：2018-11-01 00:00:00

  • Heparin affects matrix metalloproteinases and tissue inhibitors of metalloproteinases circulating in peripheral blood.

    abstract：OBJECTIVES:Blood sampling/handling alters matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression. The aim of this study is to evaluate the effects of high molecular weight heparin on MMP and TIMP expression in blood. DESIGN AND METHODS:We analyzed by gelatin zymography and ELISA ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.09.104

    authors： Mannello F,Jung K,Tonti GA,Canestrari F

    更新日期：2008-12-01 00:00:00

  • Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia?

    abstract：OBJECTIVES:The circulating lipoproteins may cause some abnormalities in platelet composition and function in hypercholesterolemia. The aim of this study was to investigate whether platelet apoptosis, platelet activation, platelet aggregation, platelet-leukocyte aggregate (PLA) formation and lipid peroxidation occur sim...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.09.005

    authors： Sener A,Ozsavci D,Oba R,Demirel GY,Uras F,Yardimci KT

    更新日期：2005-12-01 00:00:00

  • Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood.

    abstract：OBJECTIVES:Regulatory T cells (Tregs) which may indicate operational tolerance provide a promising biomarker for individualization of immunosuppression. Naturally thymus-derived Tregs (nTregs) represent the major suppressive phenotype and can be identified by their demethylation status in the Tregs Specific Demethylate...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2016.05.019

    authors： Metzker M,Shipkova M,von Ahsen N,Andag R,Abe M,Canzler O,Klett C,Leicht S,Olbricht C,Wieland E

    更新日期：2016-10-01 00:00:00

  • The differential diagnostic model for serous peptidomics in HBV carriers established by MALDI-TOF-MS analysis.

    abstract：OBJECTIVES:Hepatitis B virus (HBV) can result in asymptomatic carrier (AsC) state or chronic inflammation of liver, which depends on the host immunity. We therefore investigated the peptidomic profiling in the process of HBV infection. DESIGN AND METHODS:In this study, serum from 116 HBV infected (AsC and chronic hepa...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.10.016

    authors： Tian L,Wang Y,Xu D,Gao Y,Wen X,Tian Y

    更新日期：2014-01-01 00:00:00

  • Haplotypes in the UGT1A1 gene and their role as genetic determinants of bilirubin concentration in healthy German volunteers.

    abstract：BACKGROUND:Genetic variations of UDP-glucuronyltransferase 1A1 (UGT1A1) influence the concentration of serum bilirubin. We investigated the association of four common polymorphisms including UGT1A1-53(TA)(n), and common haplotypes of the UGT1A1 gene with bilirubin levels in 218 Caucasian volunteers. METHODS:Total bili...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2009.08.011

    authors： Borucki K,Weikert C,Fisher E,Jakubiczka S,Luley C,Westphal S,Dierkes J

    更新日期：2009-11-01 00:00:00

  • Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease.

    abstract：OBJECTIVES:To investigate the polymorphism distribution of Val-9Ala and Ile+58Thr of the Mn-superoxide dismutase (Mn-SOD) gene among subjects with Parkinson's disease (PD) by analyses of genders and clinical severity. DESIGN AND METHODS:We examined the DNA genotypes of Val-9Ala and Ile+58Thr from 295 PD subjects and 1...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2010.05.009

    authors： Wang V,Chen SY,Chuang TC,Shan DE,Soong BW,Kao MC

    更新日期：2010-08-01 00:00:00

  • Cathepsin D levels are reduced in patients with preeclampsia in Korean population.

    abstract：OBJECTIVES:To compare the circulating levels of cathepsin D in preeclamptic and normotensive pregnancies. DESIGN AND METHODS:Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study. Of the 50 pregnant patients, 15 were preeclamptic and 35 patients were normotensive. Serum levels of soluble cath...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.07.022

    authors： Kim HY,Lee M,Kang HW,Moon C

    更新日期：2013-12-01 00:00:00

  • Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer.

    abstract：BACKGROUND:L-Dopa decarboxylase (DDC) is a pyridoxal 5'-phosphate-dependent enzyme that was found to be involved in many malignancies. The aim of this study was to investigate the mRNA expression levels of DDC in prostate tissues and to evaluate its clinical utility in prostate cancer (CaP). METHODS:Total RNA was isol...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.04.026

    authors： Avgeris M,Koutalellis G,Fragoulis EG,Scorilas A

    更新日期：2008-10-01 00:00:00

  • Procalcitonin for the diagnosis of early-onset neonatal sepsis: a multilevel probabilistic approach.

    abstract：OBJECTIVES:To compare the accuracy of procalcitonin (PCT) in early-onset neonatal sepsis (EOS) using standard cut-off values and a multilevel probabilistic approach. DESIGN AND METHODS:A retrospective study of PCT was performed in 149 newborns at risk of EOS, including preterm or prolonged rupture of membranes, chorio...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.05.015

    authors： Santuz P,Soffiati M,Dorizzi RM,Benedetti M,Zaglia F,Biban P

    更新日期：2008-10-01 00:00:00

  • The importance of circulating levels of salusin-α, salusin-β, and heregulin-β1 in atherosclerotic coronary arterial disease.

    abstract：OBJECTIVE:The relationship between the severity of atherosclerotic coronary artery disease (CAD) and circulating levels of salusin-α, salusin-β and heregulin-β1 has been investigated. In addition, the relationship with these peptides and high sensitive C-reactive protein (hsCRP) has been investigated. METHODS:The stud...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2020.10.003

    authors： Arkan A,Atukeren P,Ikitimur B,Simsek G,Koksal S,Gelisgen R,Ongen Z,Uzun H

    更新日期：2021-01-01 00:00:00

  • External validation of heart-type fatty acid binding protein, high-sensitivity cardiac troponin, and electrocardiography as rule-out for acute myocardial infarction.

    abstract：OBJECTIVE:To externally validate a clinical decision rule incorporating heart fatty acid binding protein (h-FABP), high-sensitivity troponin (hs-cTn) and electrocardiogram (ECG) for the detection of acute myocardial infarction (AMI) on presentation to the Emergency Department. We also investigated whether this clinical...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2017.10.001

    authors： Van Hise CB,Greenslade JH,Parsonage W,Than M,Young J,Cullen L

    更新日期：2018-02-01 00:00:00