Abstract:
BACKGROUND:Apolipoprotein E is polymorphic in the human population. APOE4 has previously been reported to correlate with symptomatic oral and genital herpes disease. METHODS:APOE was genotyped in 182 subjects with herpes simplex virus (HSV) 2 and in 62 subjects with HSV-1, including 44 subjects with both viral types for a total of 200 adults. HSV shedding was measured by PCR from swab samples obtained daily from mucosa for at least 30 days. Participants also maintained a diary of oral or genital lesions. RESULTS:The APOE genotypes observed reflected the US white population and the Hardy-Weinberg equilibrium. Genital and oral HSV shedding was detected on 17.2% and 3.7% of overall days, respectively, whereas genital and oral lesion rates were 10.1% and 2.9%. Using Poisson regression and adjusting for known correlates of HSV shedding, a significant association was not observed between the APOE genotype and genital or oral HSV shedding, or genital HSV lesions. However, the presence of the APOE4 allele was associated with a higher rate of oral herpetic lesions, with a relative risk of 4.64 (95% CI 1.32 to 15.05, p=0.016). CONCLUSIONS:Variation at the APOE locus may be associated with clinical manifestations of HSV-1 infection, but does not appear to correlate with herpes simplex viral reactivation in humans.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Koelle DM,Magaret A,Warren T,Schellenberg GD,Wald Adoi
10.1136/sti.2009.039735subject
Has Abstractpub_date
2010-06-01 00:00:00pages
202-6issue
3eissn
1368-4973issn
1472-3263pii
sti.2009.039735journal_volume
86pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To analyse changes in testing for sexually transmissible infections (STI) among gay and bisexual men in Melbourne, Sydney and Queensland, Australia, particularly comprehensive STI testing (at least four tests from different anatomical sites in the previous year), and the characteristics of men who had such t...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2013-051294
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To inform control strategies undertaken as part of an outbreak of Shigella flexneri 3a among men who have sex with men (MSM). METHODS:All men aged ≥18 years diagnosed with S flexneri 3a between October 2012 and May 2013 were invited to participate. Semistructured in-depth quantitative interviews were conduc...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052014
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Sexually transmitted infections (STI) and bacterial vaginosis (BV) cause female genital tract inflammation. This inflammation, which is often present in the absence of symptoms, is associated with increased susceptibility to HIV infection. We aimed to evaluate genital cytokine profiles and the degree of infl...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2014-051601
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Drawing on policy theories, an assessment was made of the perceived political feasibility of scaling-up five evidence-based interventions to curb Pakistan's HIV epidemic: needle and syringe exchange programmes; targeted behaviour change communication; sexual health care for male and transgender sex workers; ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2008.034058
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To determine infection patterns of sexually transmitted infections that facilitate HIV transmission among HIV-discordant couples. METHODS:112 initial respondents were recruited in an impoverished neighbourhood of Brooklyn, New York. Their sexual (and injection) partners were recruited in up to four addition...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2007.026815
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate how an infection with Chlamydia trachomatis (CT) influenced patients' well-being and whether there were differences due to gender, age or relationship status, in an effort to strengthen preventive measures and provide better healthcare for patients with CT. METHODS:Patients diagnosed...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2017-053229
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To examine sources of repeat Chlamydia trachomatis infections using behavioural and molecular methods. METHODS:Women with C. trachomatis had baseline and 4-month follow-up visits consisting of behavioural surveys and genotyping of C. trachomatis. Frequencies and population-attributable risk percentages (PAR%...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.045484
更新日期:2011-04-01 00:00:00
abstract::Adamantiades-Behçet's disease was diagnosed in a 42 year old Turkish patient with recurrent oral aphthae, genital ulcerations, papules, and sterile pustules, histologically presenting as cutaneous vasculitis, and intermittent arthritis with joint effusion particularly of the knees. Six months after initial improvement...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.75.2.124
更新日期:1999-04-01 00:00:00
abstract::Despite having the highest prevalence of any sexually transmitted infection (STI) globally, there is a dearth of data describing Trichomonas vaginalis (TV) incidence and prevalence in the general population. The lack of basic epidemiological data is an obstacle to addressing the epidemic. Once considered a nuisance in...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2013-051075
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To describe patterns of HIV infection among stable sexual partnerships across sub-Saharan Africa (SSA). METHODS:The authors defined measures of HIV discordancy and conducted a comprehensive quantitative assessment of discordancy among stable partnerships in 20 countries in SSA through an analysis of the Demo...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2011-050114
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Australia has provided free quadrivalent human papillomavirus (HPV) vaccines to school girls since mid-2007 and a catch-up programme in the community to women aged up to 26 years in 2007-2009. We describe the temporal trend of genital warts in different populations in Melbourne. METHODS:We analysed the prop...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2014-051813
更新日期:2015-05-01 00:00:00
abstract::This review will delineate performance characteristics and limitations, as far as they are known, of the new glycoprotein G based, type specific HSV serologies. Several of these tests have been FDA approved in the United States for use in adults. With the departure of Gull/Meridian from the HSV serology market, it is ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.77.4.232
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:Data were collected from 270 detained male adolescents (aged 14-18 years) to determine the association between ever having been in a gang and a range of sexual behaviours such as sexual activity, male condom use, sex with multiple partners, and drug use during sex. METHODS:Participants answered survey questi...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2004.010926
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To develop and evaluate instructional and packaging materials for patient-delivered partner therapy (PDPT). METHODS:64 patients participated from an urban US sexually transmitted infection (STI) clinic. The research comprised three phases: individual interviews to elicit attitudes and beliefs regarding PDPT ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2008.033746
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To determine trends and correlates of chlamydia positivity among young heterosexuals attending Australian sexual health services and to compare these with population-based notification data. METHODS:Data from 18 sexual health services and the national notification scheme were analysed. A χ2 test assessed tr...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2011-050423
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:In 2006 a new variant of Chlamydia trachomatis (nvCT), with a deletion in the cryptic plasmid, was reported in Sweden. This deletion included the targets for the genetic diagnostic systems used in many clinical laboratories and resulted in thousands of false-negative results. The aim of this study was to cha...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.037572
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:Trichomoniasis (TV) is associated with an increased risk of acquisition of sexually transmitted diseases (STDs) and HIV. The purpose of this study is to evaluate factors associated with incidence TV among female STD clinic attendees in the USA. METHODS:Data were collected from women participating in a rando...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/sextrans-2015-052010
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVES:To compare normative beliefs about sexual health in young men and women from black Caribbean, black African, and white ethnic groups in order to better understand ethnic inequalities in sexual health. METHODS:Focus group discussions with young people living in an area with known high prevalence of gonorrhoe...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.005181
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess the prevalence of ciprofloxacin-resistant gonorrhoea in two South African cities and to investigate the association between the isolation of ciprofloxacin-resistant Neisseria gonorrhoeae and the HIV serostatus of patients. METHODS:Gonococci were cultured from endo...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2007.029611
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The use of mobile technologies to prevent STIs is recognised as a promising approach worldwide; however, evidence has been inconclusive, and the field has developed rapidly. With about 1 million new STIs a day globally, up-to-date evidence is urgently needed. OBJECTIVE:To assess the effectiveness of mobile ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2020-054853
更新日期:2021-01-15 00:00:00
abstract:OBJECTIVES:To determine the prevalence of HIV and associated risk factors among female sex workers (FSWs) in border provinces of Vietnam. METHODS:911 FSWs in five border provinces of Vietnam (Lai Chau, Quang Tri, Dong Thap, An Giang, and Kien Giang) were enrolled in a cross sectional study. Subjects were interviewed u...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2005.016097
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of rectal chlamydia infection in a cohort of men who have sex with men (MSM) and the proportion of infection that would be missed without routine screening. METHODS:MSM presenting to four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust between...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.031773
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Poor knowledge regarding STI and HIV transmission, testing and treatment among men who have sex with men (MSM) may be contributing to their disproportionate burden of STIs. However, factors which predispose MSM to having this low knowledge are less understood. AIM:The aim of this study was to identify facto...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054469
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVE:To determine the characteristics of general practitioners (GPs) who test and patients who are tested for HIV in Australia. DESIGN AND SETTING:A secondary analysis of data from the Bettering the Evaluation and Care of Health programme; a cross-sectional, national survey of GP activity. METHODS:We identified ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2011.049601
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:We undertook a prospective evaluation of the Qualpro Syphicheck-WB rapid syphilis test to measure its diagnostic performance and utility as a point-of-care (POC) screening test among female sex workers (FSWs) in Bangalore, India. METHODS:From August 2008 to May 2009, FSWs without a laboratory-confirmed hist...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2009.038778
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:AIDS is the main driver of young widowhood in southern Africa. METHODS:The demographic characteristics of widows, their reported risk behaviours and the prevalence of HIV were examined by analysing a longitudinal population-based cohort of men and women aged 15-54 years in Manicaland, eastern Zimbabwe. The ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.033043
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:This paper examines the discordance between biological data of HIV and herpes simplex virus type 2 (HSV-2) infections and self-reported questionnaire responses among orphan adolescents in Western Kenya. METHODS:In 2011, 837 orphan adolescents from 26 primary schools were enrolled in an HIV prevention trial....
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2014-051720
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To investigate the pathogen profile in men with inflammation of the paraurethral glands. METHODS:We enrolled 40 patients with first-onset, drug-naive inflammation of the paraurethral glands. Discharge from the lesions was collected for Gram staining. Microscopy was performed for screening for trichomonads an...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051180
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Prior studies have shown that men who have sex with men (MSM) who attend sex clubs or parties are at higher risk for HIV and other STIs than those who do not. We sought to provide data about MSM who attend sex clubs/parties in New York City (NYC) in the era of biomedical HIV prevention. METHODS : We conducted...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2018-053816
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To examine the views of educated people in Togo on the acceptability of criminal prosecution of a male partner for sexual transmission of infectious diseases (STIDs) to his female partner. METHODS:199 adults living in Kara, Togo judged acceptability of criminal prosecution for STID in 45 scenarios composed o...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050964
更新日期:2013-06-01 00:00:00