Discordance of HIV and HSV-2 biomarkers and self-reported sexual behaviour among orphan adolescents in Western Kenya.

Abstract:

BACKGROUND:This paper examines the discordance between biological data of HIV and herpes simplex virus type 2 (HSV-2) infections and self-reported questionnaire responses among orphan adolescents in Western Kenya. METHODS:In 2011, 837 orphan adolescents from 26 primary schools were enrolled in an HIV prevention trial. At baseline, blood samples were drawn for HIV and HSV-2 infection biomarker testing, and participants completed an audio computer-assisted self-interviewing survey. RESULTS:Comparing biological data with self-reported responses indicated that 70% of HIV-positive (7 out of 10) and 64% of HSV-2-positive (18 out of 28 positive) participants reported never having had sex. Among ever-married adolescents, 65% (57 out of 88) reported never having had sex. Overall, 10% of study participants appeared to have inconsistently reported their sexual behaviour. Logistic regression analyses indicated that lower educational level and exam scores were significant predictors of inconsistent reporting. CONCLUSIONS:Our study demonstrates the discordance between infections measured by biomarkers and self-reports of having had sex among orphan adolescents in Kenya. In order to detect programme effects accurately in prevention research, it is necessary to collect both baseline and endline biological data. Furthermore, it is recommended to triangulate multiple data sources about adolescent participants' self-reported information about marriage and pregnancies from school records and parent/guardians to verify the information. Researchers should recognise potential threats to validity in data and design surveys to consider cognitive factors and/or cultural context to obtain more accurate and reliable information from adolescents regarding HIV/sexually transmitted infection risk behaviours. CLINICAL TRAIL REGISTRATION NUMBER:NCT01501864.

journal_name

Sex Transm Infect

authors

Cho H,Luseno W,Halpern C,Zhang L,Mbai I,Milimo B,Hallfors DD

doi

10.1136/sextrans-2014-051720

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

260-5

issue

4

eissn

1368-4973

issn

1472-3263

pii

sextrans-2014-051720

journal_volume

91

pub_type

杂志文章,多中心研究
  • Evidence of heterosexual bridging among syphilis-positive men who have sex with men.

    abstract:OBJECTIVE:To explore whether heterosexual bridging among syphilis-positive men who have sex with men (MSM) contributes to increased infection rates among adolescent women in Baltimore City, Maryland. METHODS:Interview data for patients with primary, secondary and early-latent syphilis from January 2001 to July 2005 we...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.019513

    authors: Cunningham SD,Olthoff G,Burnett P,Rompalo AM,Ellen JM

    更新日期:2006-12-01 00:00:00

  • HIV testing and self-reported HIV status in South African men who have sex with men: results from a community-based survey.

    abstract:OBJECTIVE:To investigate the characteristics of South African men who have sex with men (MSM) who (1) have been tested for HIV and (2) are HIV positive. METHODS:Data were collected from 1045 MSM in community surveys using questionnaires that were administered either face-to-face, by mail or on the internet. The mean a...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.031500

    authors: Sandfort TG,Nel J,Rich E,Reddy V,Yi H

    更新日期:2008-11-01 00:00:00

  • Assisting medical students to conduct empathic conversations with patients from a sexual medicine clinic.

    abstract:OBJECTIVE:To describe an exercise, the structure and content of which assists medical students to conduct potentially embarrassing conversations concerning sexual health which require expression of empathy, to integrate previous learning, to identify their further learning needs, and to develop and test strategies to m...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.4.246

    authors: Henderson P,Johnson MH

    更新日期:2002-08-01 00:00:00

  • HSV-2 incidence by sex over four age periods to age 38 in a birth cohort.

    abstract:OBJECTIVES:To examine herpes simplex virus type 2 (HSV-2) incidence over four periods to age 38 in a birth cohort, and to compare risks for men and women, taking into account sexual behaviour. METHODS:At ages 21, 26, 32 and 38, participants in the Dunedin Multidisciplinary Health and Development Study were invited to ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2013-051235

    authors: Dickson N,Righarts A,van Roode T,Paul C,Taylor J,Cunningham AL

    更新日期:2014-05-01 00:00:00

  • A comparison of respondent-driven and venue-based sampling of female sex workers in Liuzhou, China.

    abstract:OBJECTIVES:To compare two methods for sampling female sex workers (FSWs) for bio-behavioural surveillance. We compared the populations of sex workers recruited by the venue-based Priorities for Local AIDS Control Efforts (PLACE) method and a concurrently implemented network-based sampling method, respondent-driven samp...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050638

    authors: Weir SS,Merli MG,Li J,Gandhi AD,Neely WW,Edwards JK,Suchindran CM,Henderson GE,Chen XS

    更新日期:2012-12-01 00:00:00

  • Evaluation of syndromic patient management algorithm for urethral discharge.

    abstract:OBJECTIVE:To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia. METHODS:The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a complaint of urethral discharge and if dis...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:

    authors: Djajakusumah T,Sudigdoadi S,Keersmaekers K,Meheus A

    更新日期:1998-06-01 00:00:00

  • Which sexually active young female students are most at risk of pelvic inflammatory disease? A prospective study.

    abstract:OBJECTIVE:To identify risk factors for pelvic inflammatory disease (PID) in female students. METHODS:We performed a prospective study set in 11 universities and 9 further education colleges in London. In 2004-2006, 2529 sexually experienced, multiethnic, female students, mean age 20.8 years, provided self-taken vagina...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2015-052063

    authors: Hay PE,Kerry SR,Normansell R,Horner PJ,Reid F,Kerry SM,Prime K,Williams E,Simms I,Aghaizu A,Jensen J,Oakeshott P

    更新日期:2016-02-01 00:00:00

  • The incidence of Trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the USA.

    abstract:OBJECTIVES:Trichomoniasis (TV) is associated with an increased risk of acquisition of sexually transmitted diseases (STDs) and HIV. The purpose of this study is to evaluate factors associated with incidence TV among female STD clinic attendees in the USA. METHODS:Data were collected from women participating in a rando...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/sextrans-2015-052010

    authors: Alcaide ML,Feaster DJ,Duan R,Cohen S,Diaz C,Castro JG,Golden MR,Henn S,Colfax GN,Metsch LR

    更新日期:2016-02-01 00:00:00

  • Determinants of HIV testing.

    abstract:OBJECTIVE:To determine the characteristics of general practitioners (GPs) who test and patients who are tested for HIV in Australia. DESIGN AND SETTING:A secondary analysis of data from the Bettering the Evaluation and Care of Health programme; a cross-sectional, national survey of GP activity. METHODS:We identified ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2011.049601

    authors: Sawleshwarkar S,Harrison C,Britt H,Mindel A

    更新日期:2011-08-01 00:00:00

  • Who is being tested for genital chlamydia in primary care?

    abstract:OBJECTIVES:To explore current patterns of testing for genital chlamydial infection in primary care, and to identify practice characteristics influencing testing rates. METHOD:Aggregate numbers of chlamydia tests and results for each practice in Nottingham Health District were matched to practice characteristics. Age s...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.79.3.234

    authors: Kufeji O,Slack R,Cassell JA,Pugh S,Hayward A

    更新日期:2003-06-01 00:00:00

  • Changes in high-risk sexual behaviour among Estonian adults between 1996 and 2006.

    abstract:OBJECTIVE:To describe and compare sexual behaviour patterns in 1996 (before the explosion of the HIV epidemic in 2000) and 2006, and the correlates of high-risk sexual behaviour in Estonia. METHODS:Data on selected sexual behaviour characteristics were obtained by interviewing a probability sample of the adult populat...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050506

    authors: Liivlaid H,Uusküla A

    更新日期:2013-03-01 00:00:00

  • Chlamydia infection in individuals reporting contact with sexual partners with chlamydia: a cross-sectional study of sexual health clinic attendees.

    abstract:OBJECTIVES:We aimed to ascertain the proportion of positive, and predictive factors of chlamydia infection among females, heterosexual males and men who have sex with men (MSM) presenting to a sexual health service reporting contact with a chlamydia infected sexual partner. METHODS:A cross-sectional analysis of patien...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052068

    authors: Huffam S,Chow EP,Fairley CK,Hocking J,Peel J,Chen M

    更新日期:2015-09-01 00:00:00

  • Age at first anal sex and HIV/STI vulnerability among gay men in Australia.

    abstract:OBJECTIVES:To determine whether there is a link between age at first anal intercourse (AFAI) and gay men's HIV/sexually transmissible infection (STI) vulnerability, including tendencies to engage in higher risk sexual behaviour. METHODS:A nationwide cross-sectional survey was conducted online involving 845 Australian ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2011-050253

    authors: Lyons A,Pitts M,Grierson J,Smith A,McNally S,Couch M

    更新日期:2012-06-01 00:00:00

  • Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis.

    abstract:OBJECTIVE:To determine whether Mycoplasma genitalium is associated with balanitis and/or posthitis in a previous study of the role of M genitalium in men with acute non-gonococcal urethritis (NGU). METHODS:In a previous study of men with acute NGU, the existence of balanitis and/or posthitis was recorded. Chlamydia tr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2010.044487

    authors: Horner PJ,Taylor-Robinson D

    更新日期:2011-02-01 00:00:00

  • Role of widows in the heterosexual transmission of HIV in Manicaland, Zimbabwe, 1998-2003.

    abstract:BACKGROUND:AIDS is the main driver of young widowhood in southern Africa. METHODS:The demographic characteristics of widows, their reported risk behaviours and the prevalence of HIV were examined by analysing a longitudinal population-based cohort of men and women aged 15-54 years in Manicaland, eastern Zimbabwe. The ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2008.033043

    authors: Lopman BA,Nyamukapa C,Hallett TB,Mushati P,Spark-du Preez N,Kurwa F,Wambe M,Gregson S

    更新日期:2009-04-01 00:00:00

  • Sexually transmitted infections among married women in Dhaka, Bangladesh: unexpected high prevalence of herpes simplex type 2 infection.

    abstract:OBJECTIVES:To document the prevalence of reproductive tract infections (RTI) and sexually transmitted infections (STI) among women attending a basic healthcare clinic in Dhaka, Bangladesh, to identify risk factors associated with the diseases and to estimate the incidence of syphilis, hepatitis C (HCV), hepatitis B (HB...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.77.2.114

    authors: Bogaerts J,Ahmed J,Akhter N,Begum N,Rahman M,Nahar S,Van Ranst M,Verhaegen J

    更新日期:2001-04-01 00:00:00

  • Condomless sex in HIV-diagnosed men who have sex with men in the UK: prevalence, correlates, and implications for HIV transmission.

    abstract:OBJECTIVE:HIV transmission is ongoing among men who have sex with men (MSM) in the UK. Sex without a condom (condomless sex, CLS) is the main risk factor. We investigated the prevalence of and factors associated with types of CLS. METHODS:Cross-sectional questionnaire study in UK HIV clinics in 2011/2012 (ASTRA). MSM ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sextrans-2016-053029

    authors: Daskalopoulou M,Rodger AJ,Phillips AN,Sherr L,Elford J,McDonnell J,Edwards S,Perry N,Wilkins E,Collins S,Johnson AM,Burman WJ,Speakman A,Lampe FC,ASTRA Study Group.

    更新日期:2017-12-01 00:00:00

  • Superimposed primary chancre in a patient with Adamantiades-Behçet's disease.

    abstract::Adamantiades-Behçet's disease was diagnosed in a 42 year old Turkish patient with recurrent oral aphthae, genital ulcerations, papules, and sterile pustules, histologically presenting as cutaneous vasculitis, and intermittent arthritis with joint effusion particularly of the knees. Six months after initial improvement...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.75.2.124

    authors: Meljanac N,Dippel E,Zouboulis CC

    更新日期:1999-04-01 00:00:00

  • How long-distance truck drivers and villagers in rural southeastern Tanzania think about heterosexual anal sex: a qualitative study.

    abstract:OBJECTIVE:To explore ideas of truck drivers and villagers from rural Tanzania about heterosexual anal sex (HAS) and the associated health risks. METHODS:Qualitative study using 8 in-depth interviews (IDIs) and 2 focus group discussions (FGDs) with truck drivers and 16 IDIs and 4 FGDs with villagers from the Morogoro r...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052055

    authors: Mtenga S,Shamba D,Wamoyi J,Kakoko D,Haafkens J,Mongi A,Kapiga S,Geubbels E

    更新日期:2015-12-01 00:00:00

  • Maintenance of endemicity in urban environments: a hypothesis linking risk, network structure and geography.

    abstract::In industrialised countries, a rapid epidemic phase of HIV transmission has largely given way to more moderated endemic transmission. The dynamics of endemic transmission may differ substantially from those generating epidemic spread. We hypothesise that three elements play an important role in maintaining endemicity ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2006.017269

    authors: Rothenberg R

    更新日期:2007-02-01 00:00:00

  • Diagnosis of sexually transmitted infections in female prostitutes in Dakar, Senegal.

    abstract:OBJECTIVE:To study the validity and performance of a number of rapid indicators for the diagnosis of sexually transmitted infections (STIs) in female prostitutes in Dakar, Senegal; characteristics of these indicators were rapidly obtainable, easy to perform, accurate, useful at district level, and reasonable cost. MET...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:

    authors: Ndoye I,Mboup S,De Schryver A,Van Dyck E,Moran J,Samb ND,Sakho ML,Thior I,Wade A,Heymann DL,Meheus A

    更新日期:1998-06-01 00:00:00

  • Anonymous partnerships among MSM and transgender women (TW) recently diagnosed with HIV and other STIs in Lima, Peru: an individual-level and dyad-level analysis.

    abstract:OBJECTIVES:Partner notification (PN) following sexually transmitted disease (STI) diagnosis is a key strategy for controlling HIV/STI transmission. Anonymous partnerships are an important barrier to PN and often associated with high-risk sexual behaviour. Limited research has examined the profile of men who have sex wi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052310

    authors: Perez-Brumer AG,Oldenburg CE,Segura ER,Sanchez J,Lama JR,Clark JL

    更新日期:2016-11-01 00:00:00

  • Estimating the number of men who have sex with men in low and middle income countries.

    abstract:OBJECTIVES:To collect and analyse published and unpublished surveillance and research data on the prevalence of same sex sexual activity among male adults (including male-to-female transgenders and sex workers) in low and middle income countries. METHODS:Key indicators were operationalised (ever sex with a man, sex wi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2005.019489

    authors: Cáceres C,Konda K,Pecheny M,Chatterjee A,Lyerla R

    更新日期:2006-06-01 00:00:00

  • Role of core and bridging groups in the transmission dynamics of HIV and STIs in Cotonou, Benin, West Africa.

    abstract::The potential for exposure of low and high risk women to HIV and sexually transmitted infections (STI) through unprotected sex with male clients of female sex workers in Cotonou could account for most if not all of the estimated yearly numbers of HIV infections in Cotonou women (approximately 1000). As ongoing transmi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.suppl_1.i69

    authors: Lowndes CM,Alary M,Meda H,Gnintoungbé CA,Mukenge-Tshibaka L,Adjovi C,Buvé A,Morison L,Laourou M,Kanhonou L,Anagonou S

    更新日期:2002-04-01 00:00:00

  • Healthcare provider and service user perspectives on STI risk reduction interventions for young people and MSM in the UK.

    abstract:OBJECTIVE:Behavioural interventions have been shown to reduce sexual behaviours associated with increased risk of sexually transmitted infections in young people (<25 years) and men who have sex with men (MSM) internationally, but evidence from England is limited. We aimed to explore service provider and user experienc...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2018-053903

    authors: Roy A,King C,Gilson R,Richardson D,Burns F,Rodger A,Clark L,Miners A,Pollard A,Desai S,Bailey J,Shahmanesh M,Llewellyn C

    更新日期:2020-02-01 00:00:00

  • A fruitful alliance: the synergy between Atopobium vaginae and Gardnerella vaginalis in bacterial vaginosis-associated biofilm.

    abstract:OBJECTIVES:Bacterial vaginosis (BV) is characterised by a change in the microbial composition of the vagina. The BV-associated organisms outnumber the health-associated Lactobacillus species and form a polymicrobial biofilm on the vaginal epithelium, possibly explaining the difficulties with antibiotic treatment. A bet...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052475

    authors: Hardy L,Jespers V,Abdellati S,De Baetselier I,Mwambarangwe L,Musengamana V,van de Wijgert J,Vaneechoutte M,Crucitti T

    更新日期:2016-11-01 00:00:00

  • Diagnosis of bacterial vaginosis: need for validation of microscopic image area used for scoring bacterial morphotypes.

    abstract:BACKGROUND:The diagnosis of bacterial vaginosis (BV) is often made according to Nugent's classification, a scoring system based on bacterial counting of Gram stained slides of vaginal secretion. However as the image area of the microscope field will influence the number of morphotypes seen there is a need to standardis...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2003.006106

    authors: Larsson PG,Carlsson B,Fåhraeus L,Jakobsson T,Forsum U

    更新日期:2004-02-01 00:00:00

  • Trichomonas vaginalis and Mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in Amsterdam, the Netherlands.

    abstract:BACKGROUND:Men are not routinely tested for Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) in the Netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the Dutch male population. OBJECTIVE:To describe the age-specific prevalence and disease bu...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052118

    authors: van der Veer C,van Rooijen MS,Himschoot M,de Vries HJ,Bruisten SM

    更新日期:2016-02-01 00:00:00

  • A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis.

    abstract:BACKGROUND:Mother-to-child transmission (MTCT) of syphilis and HIV continue to be important yet preventable causes of perinatal and infant morbidity and mortality. OBJECTIVES:To systematically review, critically appraise and perform a meta-analysis to evaluate the operational characteristics of dual rapid diagnostic t...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/sextrans-2016-053069

    authors: Gliddon HD,Peeling RW,Kamb ML,Toskin I,Wi TE,Taylor MM

    更新日期:2017-12-01 00:00:00

  • First case of "bubonulus" in L2 lymphogranuloma venerum.

    abstract::Since 2003, an ongoing lymphogranuloma venereum (LGV) proctitis outbreak has been reported in industrialised countries with a new variant designated L2b. Only men who have sex with men (MSM) are affected and most are HIV co-infected; delayed or incorrect diagnoses are frequent. We report a rare clinical case of LGV pr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2007.025395

    authors: Spenatto N,Boulinguez S,de Barbeyrac B,Viraben R

    更新日期:2007-07-01 00:00:00