Abstract:
:This study aimed to evaluate the immunomodulatory effects of Pleurotus florida on cell-mediated immunity in Balb/c mice. Aqueous extract of P. florida was isolated, lyophilized, and stored in refrigerator until application. Forty female Balb/c mice were randomly divided into seven test and one control groups. Four groups received 10, 20, 50, or 100 mg/kg/day of P. florida extract intraperitoneally, whereas three others received 200, 500, or 1000 mg/kg/day by oral administration. Moreover, the control group received the same volume of normal saline intraperitoneally. The treatments were continued once a day for 2 weeks. Then, delayed type hypersensitivity (DTH), viability of splenic cells, and histology of secondary lymphoid tissues were examined. The results showed that DTH responses were not affected by various doses of the P. florida in different routes. However, a significant decrease in splenic cells viability was observed in groups treated with intraperitoneal injection of 10, 20, and 50 mg/kg of the P. florida extract. In contrast, oral administration of 1000 mg/kg of the extract caused a significant increase in viability of splenic cells. Although atrophic changes in spleen and lymph nodes were observed in some peritoneal injected groups, some doses of oral administration were lead to hyperplastic changes. The results of this study indicated that the effects of P. florida on cellular responses depends on dose and route of administration.
journal_name
Immunopharmacol Immunotoxicoljournal_title
Immunopharmacology and immunotoxicologyauthors
Sedaghat R,Ghazanfari Tdoi
10.3109/08923971003691916subject
Has Abstractpub_date
2011-03-01 00:00:00pages
28-33issue
1eissn
0892-3973issn
1532-2513journal_volume
33pub_type
杂志文章abstract::Enhanced glucose utilization was observed in continuous cultures of macrophages in medium containing 4mM Quadrol, [N,N,N',N',Tetrakis(2-hydroxypropyl)ethylenediamine]. This enhancement was both time and concentration dependent. Radiolabeled 4mM Quadrol, after incubation with macrophages for 60 minutes, was shown to be...
journal_title:Immunopharmacology and immunotoxicology
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abstract::The immunological effects of interferon (IFN)-alpha administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-alpha three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 sub...
journal_title:Immunopharmacology and immunotoxicology
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doi:10.3109/08923973.2013.790413
更新日期:2013-06-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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doi:10.1081/iph-100108607
更新日期:2001-11-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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更新日期:2015-01-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 临床试验,杂志文章
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journal_title:Immunopharmacology and immunotoxicology
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doi:10.3109/08923979209009210
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 临床试验,杂志文章
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journal_title:Immunopharmacology and immunotoxicology
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更新日期:2020-02-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章
doi:10.1080/08923970802504762
更新日期:2009-01-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章
doi:10.3109/08923979209005402
更新日期:1992-01-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章
doi:10.3109/08923979509037193
更新日期:1995-11-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章
doi:10.3109/08923979009006467
更新日期:1990-01-01 00:00:00
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journal_title:Immunopharmacology and immunotoxicology
pub_type: 杂志文章,收录出版
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更新日期:2004-08-01 00:00:00