The immunomodulatory effects of Pleurotus florida on cell-mediated immunity and secondary lymphoid tissues in Balb/c mice.

Abstract:

:This study aimed to evaluate the immunomodulatory effects of Pleurotus florida on cell-mediated immunity in Balb/c mice. Aqueous extract of P. florida was isolated, lyophilized, and stored in refrigerator until application. Forty female Balb/c mice were randomly divided into seven test and one control groups. Four groups received 10, 20, 50, or 100 mg/kg/day of P. florida extract intraperitoneally, whereas three others received 200, 500, or 1000 mg/kg/day by oral administration. Moreover, the control group received the same volume of normal saline intraperitoneally. The treatments were continued once a day for 2 weeks. Then, delayed type hypersensitivity (DTH), viability of splenic cells, and histology of secondary lymphoid tissues were examined. The results showed that DTH responses were not affected by various doses of the P. florida in different routes. However, a significant decrease in splenic cells viability was observed in groups treated with intraperitoneal injection of 10, 20, and 50 mg/kg of the P. florida extract. In contrast, oral administration of 1000 mg/kg of the extract caused a significant increase in viability of splenic cells. Although atrophic changes in spleen and lymph nodes were observed in some peritoneal injected groups, some doses of oral administration were lead to hyperplastic changes. The results of this study indicated that the effects of P. florida on cellular responses depends on dose and route of administration.

authors

Sedaghat R,Ghazanfari T

doi

10.3109/08923971003691916

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

28-33

issue

1

eissn

0892-3973

issn

1532-2513

journal_volume

33

pub_type

杂志文章
  • Investigation into the mechanism of stimulation of macrophages by Quadrol.

    abstract::Enhanced glucose utilization was observed in continuous cultures of macrophages in medium containing 4mM Quadrol, [N,N,N',N',Tetrakis(2-hydroxypropyl)ethylenediamine]. This enhancement was both time and concentration dependent. Radiolabeled 4mM Quadrol, after incubation with macrophages for 60 minutes, was shown to be...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923978709035206

    authors: Bhide MV,Smith DJ

    更新日期:1987-01-01 00:00:00

  • IFN-β, IFN-γ, and TNF-α decrease erythrophagocytosis by human monocytes independent of SIRP-α or SHP-1 expression.

    abstract:BACKGROUND:Many cases of autoimmune hemolytic anemia have been reported after viral infection. Phagocyte activation and accompanying erythrophagocytosis are thought to result from proinflammatory cytokines released during viral infection. SIRP-α (signal regulatory protein-α), a receptor expressed on phagocytes, inhibit...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2012.697470

    authors: de Almeida AC,Barbosa SM,de Lourdes Rios Barjas-Castro M,Olalla-Saad ST,Condino-Neto A

    更新日期:2012-12-01 00:00:00

  • Tubeimoside-1 inhibits the proliferation and activation of mouse T lymphocytes through signal transduction pathways.

    abstract::Tubeimoside-1 (TBMS1) is one of the important components in Bolbostemma paniculatum (Maxim.) Franque. In the study, its immunosuppressive effects on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that TBMS1 inhibited ConA-induced T lymphocyte proliferation, decreased the ratio of CD...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2015.1063644

    authors: Huang Y,Ren M,Xiong Y,Wang T,Chen H,Deng X,Lu J

    更新日期:2015-01-01 00:00:00

  • AMPK/Nrf2 signaling is involved in the anti-neuroinflammatory action of Petatewalide B from Petasites japonicus against lipopolysaccharides in microglia.

    abstract:OBJECTIVES:Abnormal microglia secrete neuroinflammatory factors that play a pivotal role in neurodegenerative-disorder development. Thus, regulating abnormal microglia-activation could be a promising therapeutic strategy. The purposes of this study included investigating the effect of Petatewalide B on lipopolysacchari...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2018.1434791

    authors: Park SY,Choi MH,Li M,Li K,Park G,Choi YW

    更新日期:2018-06-01 00:00:00

  • Immunological effects following administration of interferon-alpha in patients with chronic hepatitis C virus (cHCV) infection.

    abstract::The immunological effects of interferon (IFN)-alpha administration were evaluated in 15 patients with cHCV infection. Individuals were treated with 6 MU of lymphoblastoid IFN-alpha three times a week for 6 months and with 3 MU three times a week for an additional 6 months. Patients were divided into responders (12 sub...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979609052741

    authors: Jirillo E,Greco B,Caradonna L,Satalino R,Amati L,Cozzolongo R,Cuppone R,Manghisi OG

    更新日期:1996-08-01 00:00:00

  • Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis.

    abstract::The etiology of inflammatory bowel diseases which include ulcerative colitis (UC) and Crohn disease has not yet been clarified. Several hypotheses suggest a change in composition of gut microflora along with an impaired mucosal barrier that lead to excessive mucosal immunologic responses. Increased production of nitri...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2013.790413

    authors: Toumi R,Abdelouhab K,Rafa H,Soufli I,Raissi-Kerboua D,Djeraba Z,Touil-Boukoffa C

    更新日期:2013-06-01 00:00:00

  • Immunomodulating effects of black seed and oxytetracycline in pigeons.

    abstract::Chronic administration of oxytetracycline (OXT) (incorporated at a level of 0.05 g per kg of feed for 50 days) to pigeons, significantly decreased total leukocyte and lymphocyte counts, increased heterophil:lymphocyte ratio and lysosomal enzyme activity, and decreased reticuloendothelial system function compared with ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970500242327

    authors: Al-Ankari AS

    更新日期:2005-01-01 00:00:00

  • Tolerance test in patients with multiple drug allergy syndrome.

    abstract::Multiple Drug Allergy Syndrome (MDAS) is a frequent clinical condition characterized by reactions to more than one different class of antibiotics. Even if some studies have previously reported an increased rate of allergic reactions to drugs in patients with a history of antimicrobials and NSAIDs allergy, risk factors...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-100108607

    authors: Nettis E,Colanardi MC,Paola RD,Ferrannini A,Tursi A

    更新日期:2001-11-01 00:00:00

  • A copper chelate selectively triggers apoptosis in myeloid-derived suppressor cells in a drug-resistant tumor model and enhances antitumor immune response.

    abstract::Myeloid-derived suppressor cells (MDSCs), one of the major orchestrators of immunosuppressive network are present in the tumor microenvironment suppress antitumor immunity by subverting Th1 response in tumor site and considered as a great obstacle for advancement of different cancer immunotherapeutic protocols. Till d...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2014.897727

    authors: Chakraborty P,Das S,Banerjee K,Sinha A,Roy S,Chatterjee M,Choudhuri SK

    更新日期:2014-04-01 00:00:00

  • Lupus nephritis improvement after anti-tumor necrosis factor alpha monoclonal antibody (infliximab) treatment for Crohn's disease: a case report.

    abstract::Association between Crohn's disease (CD) and lupus nephritis is very rare and, to the best of our knowledge, it has been described only once. We report here a clinical case of CD occurred in a young woman 8 years after a diagnosis of lupus nephritis according to clinical, laboratory and histological criteria. CD was u...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-120037721

    authors: Principi M,Di Leo A,Ingrosso M,Pisani A,Marangi S,Amoruso A,Panella C,Francavilla A,Ierardi E

    更新日期:2004-05-01 00:00:00

  • Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients.

    abstract:CONTEXT:To develop a personalized peptide vaccine (PPV) for recurrent ovarian cancer patients and evaluate its efficacy from the point of view of overall survival (OS), Phase II study of PPV was performed. PATIENTS AND METHODS:Forty-two patients, 17 with platinum-sensitive and 25 with platinum-resistant recurrent ovar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2014.913617

    authors: Kawano K,Tsuda N,Matsueda S,Sasada T,Watanabe N,Ushijima K,Yamaguchi T,Yokomine M,Itoh K,Yamada A,Kamura T

    更新日期:2014-06-01 00:00:00

  • Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity.

    abstract::Myricetin, a common dietary flavonoid, is widely distributed in fruits and vegetables. It is known to be a food supplement contributing to human health because of its immune modulatory function, and its antioxidation, antitumor, and anti-inflammatory properties. In the present study, myricetin was shown to directly in...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2015.1096942

    authors: Yuan X,Liu Y,Hua X,Deng X,Sun P,Yu C,Chen L,Yu S,Liu S,Pang H

    更新日期:2015-01-01 00:00:00

  • Effects of androgen disruption by DDE on the development and functioning of the immune system in Japanese quail.

    abstract::We hypothesized that immunosuppression in birds that is caused by exposure to antiandrogenic chemicals occurs mainly through disruption of the development of the androgen-sensitive avian lymphoid organ, the bursa of Fabricius. Injections of 20.0 or 40.0 mug of p,p'-DDE [ethylene, 1,1-dichloro-2,2-bis(p-chlorophenyl)],...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970600927850

    authors: Quinn MJ,Summitt CL,Ottinger MA

    更新日期:2006-01-01 00:00:00

  • WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line.

    abstract::In the present study, we investigated the possibility that the WNT/β-catenin pathway plays a role in inflammatory responses both in an human inflammatory condition and in an in vitro inflammation model. First, we analyzed gene expression patterns of the peripheral blood cells from asthma patients compared with those f...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08923973.2011.574704

    authors: Lee H,Bae S,Choi BW,Yoon Y

    更新日期:2012-02-01 00:00:00

  • Toxic effects of mercuric sulfide on immune organs in mice.

    abstract::Mercuric sulfide (HgS) is a major component of cinnabar, which has been used as a sedative drug in China for more than 2000 years. Because its toxicological effects are still unclear, we attempted to verify the toxic effects of HgS, focused on liver and immune organs such as the spleen and thymus. Male ICR mice were a...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923970903305499

    authors: Son HY,Lee S,Park SB,Kim MS,Choi EJ,Singh TS,Bae Y,Kwack SJ,Kang TS,Shin HI,Baek MC,Kim SH

    更新日期:2010-06-01 00:00:00

  • Preclinical assessment of β-d-mannuronic acid (M2000) as a non-steroidal anti-inflammatory drug.

    abstract:CONTEXT:β-d-Mannuronic acid (M2000) has shown its therapeutic effects with the greatest tolerability and efficacy in various experimental models such as experimental autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis. Despite pharmacological effects of...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2015.1113296

    authors: Fattahi MJ,Abdollahi M,Agha Mohammadi A,Rastkari N,Khorasani R,Ahmadi H,Tofighi Zavareh F,Sedaghat R,Tabrizian N,Mirshafiey A

    更新日期:2015-01-01 00:00:00

  • Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice.

    abstract::We reported recently that a novel immunomodulator, 7-thia-8-oxoguanosine (7T8OG)2 inhibited formation of pulmonary melanoma metastases (1), prevented against viral infection in mice (2) and potentiated the efficacy of a weakly immunogenic leukemia vaccine (3). Since certain tumor metastases and virus infected cells ar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979209009210

    authors: Sharma BS,Mhaskar S,Balazs L,Siaw M

    更新日期:1992-01-01 00:00:00

  • Effect of fluoride exposure on different immune parameters in humans.

    abstract:CONTEXT:T regulatory (Treg) cells play an important role in the modulation of the immune response, and are implicated in the pathogenesis of autoimmune diseases. Many people is exposed to fluoride (F), mainly through drinking water. OBJECTIVE:The aim of this work was to assess the possible effect of F exposure on diff...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2010.491081

    authors: Hernández-Castro B,Vigna-Pérez M,Doníz-Padilla L,Ortiz-Pérez MD,Jiménez-Capdeville E,González-Amaro R,Baranda L

    更新日期:2011-03-01 00:00:00

  • Study of innervation, sensory neuropeptides, and serotonin in murine contact allergic skin.

    abstract::Density of nerve fibers, axonal growth, calcitonin gene-related peptide (CGRP), and substance P, and serotonin immunoreactivity as well as concentration were all determined in a murine model of contact allergy. Female Balb/c mice were sensitized on the back with oxazolone and 6 days later challenged with the same anti...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-51617

    authors: El-Nour H,Lundeberg L,Boman A,Beck O,Harvima IT,Theodorsson E,Nordlind K

    更新日期:2005-01-01 00:00:00

  • Effects of palladacycle complex on hematopoietic progenitor cells proliferation in vivo and in vitro and its relation with the inhibitory properties of this compound on the angiotensin-I converting enzyme activity.

    abstract::In the present study, we introduce a new class of organometallic compound, the Biphosphinic Palladacycle Complex [Pd (C2, N-S(-)(dmpa)(dppf)] Cl (BPC), as an angiotensin-I converting-enzyme inhibitor (ACEI) with hematological regulation properties. When BPC was assayed as a competitive inhibitor over the hydrolysis of...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1081/iph-200042263

    authors: Caires AC,Oliveira CR,Smith MC,Hemerly JP,Juliano MA,Bincoletto C

    更新日期:2004-01-01 00:00:00

  • Unusual presentation of carpal tunnel syndrome with cutaneous signs: a case report and review of the literature.

    abstract::Carpal tunnel syndrome (CTS) is a neurological impairment caused by compression of the median nerve throughout the carpal tunnel, which consequently induces ischemia and mechanical disruption, dysfunctional axonal transport, and epidural blood flow. Most common symptoms include numbness, rather than pain, with a typic...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/08923973.2010.551214

    authors: Foti C,Romita P,Vestita M

    更新日期:2011-12-01 00:00:00

  • Anti-inflammatory activities of Reynoutria elliptica through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.

    abstract::Reynoutria elliptica has been used in traditional Korean medicine to promote blood circulation, relieve pain, increase dieresis, and alleviate respiratory problems, through as yet undefined mechanisms. We set out to determine whether the anti-inflammatory effects of this plant are linked with its ability to suppress m...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923973.2011.619195

    authors: Lee G,Choi TW,Kim C,Nam D,Lee SG,Jang HJ,Lee JH,Um JY,Jung SH,Shim BS,Ahn KS,Ahn KS

    更新日期:2012-06-01 00:00:00

  • Immunomodulatory effects of the pentapeptide YGSRS on human peripheral-blood mononuclear cells.

    abstract:CONTEXT:The pentapeptide YGSRS is originated from coffee bean, while its pharmacological features have little been examined. OBJECTIVES:We investigated the effects of YGSRS on proliferation, cytokine production and CD4+ CD25+ Foxp3+ regulatory T (Treg) cell frequency of human peripheral blood mononuclear cells (PBMCs)...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 临床试验,杂志文章

    doi:10.3109/08923973.2015.1038752

    authors: Nakamura Y,Hayakawa A,Ishizawa H,Kamei Y,Tanaka S,Onda K,Sugiyama K,Hirano T

    更新日期:2015-06-01 00:00:00

  • Effect of rifampicin to inhibit rapamycin-induced autophagy via the suppression of protein phosphatase 2A activity.

    abstract::Recently, a number of studies have focused on the secondary effects of rifampicin. In the present study, we assessed whether rifampicin influences the rapamycin-induced autophagy of RAW 264.7 cells. Here, we demonstrate that the rapamycin-induced autophagy is dependent on protein phosphatase (PP) 2A activity and rifam...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970802135732

    authors: Park IH,Yeum CE,Chae GT,Lee SB

    更新日期:2008-01-01 00:00:00

  • Immunomodulatory role of recombinant human erythropoietin in acute kidney injury induced by crush syndrome via inhibition of the TLR4/NF-κB signaling pathway in macrophages.

    abstract::Objective: The present study aimed to investigate whether recombinant human erythropoietin (rHuEPO) plays an immunomodulatory function by regulating the TLR4/NF-κB signaling pathway.Materials and methods: C57BL/6 mice were intraperitoneally injected with rHuEPO and, half an hour later, with 50% glycerol at the dose of...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923973.2019.1706555

    authors: Zhou J,Bai Y,Jiang Y,Tarun P,Feng Y,Huang R,Fu P

    更新日期:2020-02-01 00:00:00

  • Role of CD4(+) T cells in the modulation of neurotrophin production in mice exposed to low-level toluene.

    abstract::To investigate the role of CD4(+) T cells in neurotrophin production following toluene exposure, male C3H mice were exposed to filtered air (control) or 9 ppm of toluene in a nose-only exposure chamber for 30 min on 3 consecutive days followed by weekly sessions for 4 weeks. All the mice were immunized with ovalbumin ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/08923970802504762

    authors: Fujimaki H,Win-Shwe TT,Yamamoto S,Nakajima D,Goto S

    更新日期:2009-01-01 00:00:00

  • Thymostimulin administration modulates polymorph metabolic pathway in patients with chronic obstructive pulmonary disease.

    abstract::Several studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD). In this regard, here, we have assessed either monocyte- and polymorphonuclear cell (PMN)-mediated chemotactic, phagocytic and killing capacities or PMN-triggered metabolic pathway in a group of COPD patients b...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979209005402

    authors: Tortorella C,Ottolenghi A,Moretti AM,Jirillo E,Antonaci S

    更新日期:1992-01-01 00:00:00

  • The effects of methimazole on haematopoiesis in mice.

    abstract::The effects of anti-thyroid drug, methimazole (MMI), on haematopoiesis in inbred C57BL/6 mice were studied. The in vitro proliferative response of bone marrow (BM) cells to interleukin-3 (IL-3) was significantly increased when mice were provided with 0.1% MMI in water (w/v) ad librium for 4 to 6 weeks. Using soft agar...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979509037193

    authors: Mak NK,Lai WH,Liu WK,Leung KN,Fung MC

    更新日期:1995-11-01 00:00:00

  • Enhanced protection of cyclophosphamide-treated mice against infection with Pseudomonas aeruginosa after treatment with Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis Aoyama B.

    abstract::We investigated the effect of Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis strain Aoyama B, on the protection of immunocompromised mice against infection with Pseudomonas aeruginosa. Mice were given cyclophosphamide and then treated with varying doses of Z-100 for 5 days or left untreated. One ...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/08923979009006467

    authors: Kawamura I,Mitsuyama M,Nomoto K

    更新日期:1990-01-01 00:00:00

  • Induction of a TC1-mediated experimental autoimmune thyroiditis by deglycosylated porcine thyroglobulin.

    abstract::Contribution of cytotoxic T lymphocytes (CTL) to experimental autoimmune thyroiditis (EAT) was well defined (Speidel et al., Eur. J. Immunol. 1997, 27, 2391-2399, Ref. 7). The native porcine thyroglobulin (pTg) showed high sensitivity to endo-o-N-acetylglucosaminidase F (Endo F) and its molecular weights, correspondin...

    journal_title:Immunopharmacology and immunotoxicology

    pub_type: 杂志文章,收录出版

    doi:10.1081/iph-200026872

    authors: Kang BS,Chung TW,Moon JY,Lim JK,Shon YH,Nam KS,Kim DS,Jeon BH,Kim CH

    更新日期:2004-08-01 00:00:00