Prevention of contrast-induced nephropathy: a single center randomized study.

Abstract:

BACKGROUND:Contrast-induced nephropathy (CIN) is the third cause of acute deterioration of renal function in hospitalized patients. HYPOTHESIS:The purpose of the study was to compare the efficacy of saline infusion, saline infusion plus N-acetylcysteine (NAC), and sodium bicarbonate (SB) infusion to prevent CIN in patients undergoing coronary angiography and/or percutaneous coronary intervention. METHODS:We prospectively studied 156 patients with a baseline creatinine level > or = 1.2 mg/dL. The primary endpoint was the development of CIN, defined as an increase in serum creatinine concentration > or = 25% over the baseline value within 5 days from contrast exposure. RESULTS:Contrast-induced nephropathy developed in 23 patients (14.7%). Incidence of the primary endpoint was similar in the 3 groups of treatment, occurring in 7 patients (14%) in the saline infusion group, in 9 (17%) in the saline infusion plus NAC group, and in 7 (14%) in the SB infusion group. CONCLUSIONS:Our findings suggest that neither the addition of NAC nor the administration of SB add further benefit in CIN prevention, compared to standard hydration with isotonic saline infusion.

journal_name

Clin Cardiol

journal_title

Clinical cardiology

authors

Castini D,Lucreziotti S,Bosotti L,Salerno Uriarte D,Sponzilli C,Verzoni A,Lombardi F

doi

10.1002/clc.20576

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

E63-8

issue

3

eissn

0160-9289

issn

1932-8737

journal_volume

33

pub_type

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