Systemic dendritic cell mobilization associated with administration of FLT3 ligand to SIV- and SHIV-infected macaques.

abstract：:A sharp increase in the number of people living with HIV has been documented in the Philippines. In response, the government has instituted antiretroviral therapy (ART) nationwide through HIV treatment hubs. However, no data presently exist on the status of ART drug-resistance-associated mutations (DRMs). In this stud...

journal_title：AIDS research and human retroviruses

authors： SahBandar IN,Samonte G,Telan E,Siripong N,Belcaid M,Schanzenbach D,Leano S,Chagan-Yasutan H,Hattori T,Shikuma CM,Ndhlovu LC

更新日期：2017-11-01 00:00:00

abstract：:Simian species of Asian and African origin are naturally infected with the simian T cell leukemia virus type I (STLV-I). Like the closely related human T cell leukemia virus type I (HTLV-I), STLV-I is primarily cell associated, and typical infections exhibit low viral burdens. Four macaques experimentally inoculated w...

journal_title：AIDS research and human retroviruses

authors： Liska V,Fultz PN,Su L,Ruprecht RM

更新日期：1997-09-01 00:00:00

abstract：:There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha...

journal_title：AIDS research and human retroviruses

authors： Johnston MI,Noe JS,Killen JY

更新日期：1994-01-01 00:00:00

abstract：:To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and ...

journal_title：AIDS research and human retroviruses

authors： Sasaki M,Kotaki T,Khairunisa SQ,Tachibana S,Ophinni Y,Hayashi Y,Nasronudin,Kameoka M

更新日期：2020-03-01 00:00:00

abstract：:Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 67 newly isolated HTLV-I proviral DNA...

journal_title：AIDS research and human retroviruses

authors： Vidal AU,Gessain A,Yoshida M,Mahieux R,Nishioka K,Tekaia F,Rosen L,De Thé G

更新日期：1994-11-01 00:00:00

abstract：:Maraviroc (MVC) is an allosteric inhibitor of human immunodeficiency virus type 1 (HIV-1) entry, and is the only CCR5 antagonist licensed for use as an anti-HIV-1 therapeutic. It acts by altering the conformation of the CCR5 extracellular loops, rendering CCR5 unrecognizable by the HIV-1 envelope (Env) glycoproteins. ...

journal_title：AIDS research and human retroviruses

authors： Flynn JK,Ellenberg P,Duncan R,Ellett A,Zhou J,Sterjovski J,Cashin K,Borm K,Gray LR,Lewis M,Jubb B,Westby M,Lee B,Lewin SR,Churchill M,Roche M,Gorry PR

更新日期：2017-12-01 00:00:00

abstract：:We have evaluated the genetic diversity of HIV-1 strains infecting injecting drug users (IDUs) in Lisbon, Portugal. Heteroduplex mobility assay and/or phylogenetic analysis revealed that env (C2V3C3 or gp41) subtype B is present in 63.7% of the 135 viral samples studied, followed by subtypes G (23.7%), A (6.7%), F (5....

journal_title：AIDS research and human retroviruses

authors： Esteves A,Parreira R,Piedade J,Venenno T,Franco M,Germano de Sousa J,Patrício L,Brum P,Costa A,Canas-Ferreira WF

更新日期：2003-06-01 00:00:00

abstract：:In the context of an emerging aging epidemic affecting people living with HIV (PLWH), we critically discuss existing data regarding two different conceptual models of aging-frailty and intrinsic capacity, respectively, both in a clinical and public health perspective. These constructs have not yet been integrated in t...

journal_title：AIDS research and human retroviruses

authors： Guaraldi G,Milic J

更新日期：2019-11-01 00:00:00

abstract：:Simian immunodeficiency virus (SIV) variant SIVsmmPBj14 is unique in producing an acutely lethal enteropathic syndrome in pigtail macaques. To determine whether the nature of the PBj14 disease would be attenuated by decreasing virus input and to relate tissue virus burden to the severity of disease, we infected pigtai...

journal_title：AIDS research and human retroviruses

authors： O'Neil SP,Mossman SP,Maul DH,Hoover EA

更新日期：1999-01-20 00:00:00

abstract：:To design a vaccine that will remain potent against HIV-1, the immunogenic regions in the viral envelope that tend to change as well as those that remain constant over time must be identified. To determine the neutralization profiles of sequential viruses over time and study whether neutralization patterns correlate w...

journal_title：AIDS research and human retroviruses

authors： Nyambi P,Burda S,Urbanski M,Heyndrickx L,Janssens W,Vanham G,Nadas A

更新日期：2008-12-01 00:00:00

abstract：:Immunoliposomes containing monoclonal antibodies (MAbs) to the costimulatory molecules CD28 and CTLA4 and their counterreceptors B7-1 (CD80) and B7-2 (CD86) were evaluated for the ability to increase the immune response to recombinant envelope protein rgp120 of the MN strain of human immunodeficiency virus type 1 (HIV...

journal_title：AIDS research and human retroviruses

authors： Ozpolat B,Rao XM,Powell MF,Lachman LB

更新日期：1998-03-20 00:00:00

abstract：:In Taiwan, sexual transmission is responsible for most HIV-1 infections with two dominant subtypes, subtype B and CRF01_AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of...

journal_title：AIDS research and human retroviruses

authors： Chang SY,Sheng WH,Lee CN,Sun HY,Kao CL,Chang SF,Liu WC,Yang JY,Wong WW,Hung CC,Chang SC

更新日期：2006-11-01 00:00:00

abstract：:We performed a placebo-controlled study to evaluate the effects of immunomodulatory treatment with thalidomide on HIV levels, TNF-alpha levels, and immune status of 31 HIV-infected individuals, after temporary suppression of viral replication with antiretroviral drugs. Treatment with a combination of zidovudine and la...

journal_title：AIDS research and human retroviruses

authors： Haslett PA,Klausner JD,Makonkawkeyoon S,Moreira A,Metatratip P,Boyle B,Kunachiwa W,Maneekarn N,Vongchan P,Corral LG,Elbeik T,Shen Z,Kaplan G

更新日期：1999-09-01 00:00:00

abstract：:HIV subtype characterization is an important tool to monitor the genetic variation of the HIV epidemic. This study investigated the current HIV subtype distribution and recombination among the northern Thai population. An in-house genotypic assay of HIV protease and reverse transcriptase genes was performed on 420 pla...

journal_title：AIDS research and human retroviruses

authors： Praparattanapan J,Tragoolpua Y,Pathom-aree W,Kotarathitithum W,Chaiwarith R,Nuntachit N,Sirisanthana T,Supparatpinyo K

更新日期：2011-11-01 00:00:00

abstract：:In October of 2019, researchers and community members from around the world met at the NIH for the fifth annual International Workshop on Microbiome in HIV. New research was presented on the role of the microbiome on chronic inflammation and vaccine design, interactions of genetics, environment, sexual practice and HI...

journal_title：AIDS research and human retroviruses

authors： Sherrill-Mix S,Connors K,Aldrovandi GM,Brenchley JM,Boucher C,Bushman FD,Collman RG,Dandekar S,Klatt NR,Lagenaur LA,Paredes R,Tachedjian G,Turpin JA,Landay AL,Ghosh M

更新日期：2020-11-01 00:00:00

abstract：:This study explores whether previous failures on antiretroviral drug regimens preclude the possibility of immune restoration. This was assessed by evaluating T cell subset changes in individuals who received a salvage regimen of highly active antiretroviral therapy (HAART) after initially failing protease inhibitor mo...

journal_title：AIDS research and human retroviruses

authors： Gray CM,Schapiro JM,Winters MA,Merigan TC

更新日期：1998-05-01 00:00:00

abstract：:We evaluated associations of serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) levels in a cohort of HIV-infected and HIV-uninfected men at risk for infection in the United States. Stored samples collected between 1999 and 2008 were tested for vitamin D metabolites between 2014 and 2015. Vit...

journal_title：AIDS research and human retroviruses

authors： Zhang L,Tin A,Brown TT,Margolick JB,Witt MD,Palella FJ Jr,Kingsley LA,Hoofnagle AN,Jacobson LP,Abraham AG

更新日期：2017-03-01 00:00:00

abstract：:Antibodies to the carboxy-terminal constant (C5) region 5 of the HIV-1 envelope glycoprotein gp120 have previously been associated with slow disease progression. This is one of the regions on gp120 that interact with the transmembrane glycoprotein, gp41, anchoring it to the viral and infected cell membrane. This study...

journal_title：AIDS research and human retroviruses

authors： Sørensen B,Sommerfelt MA,Stjernholm G,Smith PL,Ökvist M,Hovden AO,Hoddevik G,Redfield R,Ustina V,Jelmert Ø,Zeldis J,Dalgleish A

更新日期：2017-06-01 00:00:00

abstract：:The genetic diversity of HIV-1 is well documented. Except for the HIV-1 isolate LAV-1BRU, no nucleic acid sequence of a European isolate of HIV-1 has been published to date. To further investigate the extent of the genetic variability and the evolution of HIV-1, we have isolated, cloned, and subsequently sequenced HIV...

journal_title：AIDS research and human retroviruses

authors： Sauermann U,Schneider J,Mous J,Brunckhorst U,Schedel I,Jentsch KD,Hunsmann G

更新日期：1990-06-01 00:00:00

abstract：:Chemokine receptors are molecules involved in the fusion of immunodeficiency viruses after their attachment. As chimpanzees are the animal model for infection by HIV-1, we cloned and sequenced chimpanzee CXCR4 and CCR5 from PBMCs. Chimpanzee CXCR4 was found to be identical to human CXCR4, which provides an explanation...

journal_title：AIDS research and human retroviruses

authors： Prétet JL,Zerbib AC,Girard M,Guillet JG,Butor C

更新日期：1997-12-10 00:00:00

abstract：:To examine the genetic features of the long terminal repeat (LTR) derived from six HIV-1-infected individuals enrolled in the Mexico City Cohort, we cloned and sequenced a 505-bp fragment of the proviral LTR from their peripheral blood mononuclear cells (PBMCs). All patients harbored HIV-1 LTR quasispecies correspondi...

journal_title：AIDS research and human retroviruses

authors： Gómez-Román VR,Vázquez JA,del Carmen Basualdo M,Estrada FJ,Ramos-Kuri M,Soler C

更新日期：2000-03-20 00:00:00

abstract：:Murine monoclonal antibodies (MAbs) raised against a recombinant nef protein fragment of human immunodeficiency virus type 1 (HIV-1) strain BH10 were characterized by an epitope mapping system using overlapping decapeptides. Four different immunogenic regions were identified. Ten human HIV-1-positive sera were tested ...

journal_title：AIDS research and human retroviruses

authors： Schneider T,Harthus HP,Hildebrandt P,Niedrig M,Bröker M,Weigelt W,Beck A,Pauli G

更新日期：1991-01-01 00:00:00

abstract：:The human foamy virus (HFV) is a complex retrovirus that contains several regulatory and auxiliary bel genes besides the gag, pol, and env genes. In contrast to the gene products of bel 1 and bel 2/bet that were identified previously, the Bel 3 protein has not been described to date. Here we report the identification ...

journal_title：AIDS research and human retroviruses

authors： Weissenberger J,Flügel RM

更新日期：1994-05-01 00:00:00

abstract：:Information about the efficacy of antiretroviral drugs in HIV-1 group O strains as well on the virus evolution in terms of resistance development in vivo is very limited. We assessed the clinical, immunological, and virological response to antiretroviral therapy as well as the selection of drug resistance in six HIV-1...

journal_title：AIDS research and human retroviruses

authors： Rodes B,de Mendoza C,Rodgers M,Newell A,Jimenez V,Lopez-Brugada RM,Soriano V

更新日期：2005-07-01 00:00:00

abstract：:The use of abacavir (ABC) may be associated with a hypersensitivity reaction (HSR) that requires discontinuation of the drug. The HLA-B*5701 allele has been linked to this HSR. Information on the strength of this association across distinct geographic regions and ethnicities is scarce. We tested HLA-B*5701 in 53 Spani...

journal_title：AIDS research and human retroviruses

authors： Rodríguez-Nóvoa S,García-Gascó P,Blanco F,González-Pardo G,Castellares C,Moreno V,Jiménez-Nácher I,González-Lahoz J,Soriano V

更新日期：2007-11-01 00:00:00

abstract：:We show that the squirrel monkey Saimiri sciureus is susceptible to experimental infection with either syngeneic or allogeneic HTLV-1-immortalized cells. As in humans, such experimental inoculation leads to chronic infection, and HTLV-1 provirus was detected in PBMCs by PCR. Chronically infected monkeys developed high...

journal_title：AIDS research and human retroviruses

authors： Kazanji M

更新日期：2000-11-01 00:00:00

abstract：:Vaginal SHIVSF162P3 acquisition in pigtail macaques (Macaca nemestrina) is dependent on time point during the menstrual cycle. Susceptibility is higher around menstruation and lower at ovulation in mid cycle. This complicates the design of repeat low-dose (RLD) SHIV exposure studies because virus challenges given duri...

journal_title：AIDS research and human retroviruses

authors： Kersh EN,Henning TR,Dobard C,Heneine W,McNicholl JM

更新日期：2015-11-01 00:00:00

abstract：:In order to obtain more information about the presence of HIV-1 in mononuclear cells of colostrum, research was carried out on both the HIV-1 genome in the cellular fraction of colostrum and the viral antibody in cell-free colostrum of eight anti-HIV-1 seropositive asymptomatic mothers. In five cases cell fractions of...

journal_title：AIDS research and human retroviruses

authors： Vonesch N,Sturchio E,Humani AC,Cordiali Fei P,Cosenza D,Caprilli F,Pezzella M

更新日期：1992-07-01 00:00:00

abstract：:Enrolling and tracking cohorts for HIV vaccine efficacy trials requires that participants disclose behaviors that place them at risk for exposure to HIV. Brief screening procedures have been suggested for this purpose. In a previous study gay and bisexual men in three U.S. cities reported unprotected anal intercourse ...

journal_title：AIDS research and human retroviruses

authors： McKirnan DJ,Doetsch J,Vanable P,Buchbinder S,Douglas JM,Judson F

更新日期：1994-01-01 00:00:00

abstract：:Characterization of HIV-1 from slow progressors is important to facilitate vaccine and antiviral drug development. To identify virus attenuations that may contribute to slower rates of disease progression, the full-length viral genomes from primary isolates of six slow progressing HIV-positive children were sequenced....

journal_title：AIDS research and human retroviruses

authors： Tzitzivacos DB,Tiemessen CT,Stevens WS,Papathanasopoulos MA

更新日期：2009-11-01 00:00:00