Risk of mortality after spinal cord injury: an 8-year prospective study.

Abstract:

UNLABELLED:Krause JS, Zhai Y, Saunders LL, Carter RE. Risk of mortality after spinal cord injury: an 8-year prospective study. OBJECTIVE:To evaluate a theoretical model for mortality after spinal cord injury (SCI) by sequentially analyzing 4 sets of risk factors in relation to mortality (ie, adding 1 set of factors to the regression equation at a time). DESIGN:Prospective cohort study of data collected in late 1997 and early 1998 with mortality status ascertained in December 2005. We evaluated the significance of 4 successive sets of predictors (biographic and injury, psychologic and environmental, behavioral, health and secondary conditions) using Cox proportional hazards modeling and built a full model based on the optimal predictors. SETTING:A specialty hospital. PARTICIPANTS:Adults (N=1386) with traumatic SCI, at least 1 year postinjury, participated. There were 224 deaths. After eliminating cases with missing data, there were 1209 participants, with 179 deceased at follow-up. INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:Mortality status was determined using the National Death Index and the Social Security Death Index. RESULTS:The final model included 1 environmental variable (poverty), 2 behavioral factors (prescription medication use, binge drinking), and 4 health factors or secondary conditions (hospitalizations, fractures/amputations, surgeries for pressure ulcers, probable major depression). CONCLUSIONS:The results supported the major premise of the theoretical model that risk factors are more important the more proximal they are in a theoretical chain of events leading to mortality. According to this model, mortality results from declining health, precipitated by high-risk behaviors. These findings may be used to target those who are at high risk for early mortality as well as to direct interventions to the particular risk factor.

journal_name

Arch Phys Med Rehabil

authors

Krause JS,Zhai Y,Saunders LL,Carter RE

doi

10.1016/j.apmr.2009.04.020

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1708-15

issue

10

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(09)00410-9

journal_volume

90

pub_type

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