Tumour necrosis factor antagonists and inflammatory bowel diseases: a national practice survey.

abstract：BACKGROUND:Diagnosis of inflammatory bowel disease (IBD) is based on clinical presentation, colonoscopy and histology. Differentiation of Crohn's disease (CD) and ulcerative colitis (UC) can be difficult in some patients. Endoscopic ultrasound (EUS) provides high resolution images of the gastrointestinal wall (GI) and ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ellrichmann M,Wietzke-Braun P,Dhar S,Nikolaus S,Arlt A,Bethge J,Kuehbacher T,Wintermeyer L,Balschun K,Klapper W,Schreiber S,Fritscher-Ravens A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Obeticholic acid (OCA) was recently approved as the only on-label alternative for patients with primary biliary cholangitis (PBC) with intolerance or suboptimal response to ursodeoxycholic acid (UDCA). However, few data are available outside clinical trials. AIM:To assess the effectiveness and safety of OCA...

journal_title：Alimentary pharmacology & therapeutics

authors： Gomez E,Garcia Buey L,Molina E,Casado M,Conde I,Berenguer M,Jorquera F,Simón MA,Olveira A,Hernández-Guerra M,Mesquita M,Presa J,Costa-Moreira P,Macedo G,Arenas JI,Manuel Sousa J,Ampuero J,Morillas RM,Santos A,De Car

更新日期：2020-12-12 00:00:00

abstract：:Proton pump inhibitor-based triple therapy is the most commonly used treatment for eradication of Helicobacter pylori, with pooled eradication rates of approximately 90%. In the USA, per protocol eradication rates with 10-day proton pump inhibitor-based triple therapy are approximately 85%. Esomeprazole, a new proton ...

journal_title：Alimentary pharmacology & therapeutics

authors： Laine L

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease is prevalent in affluent countries and is a cause of cirrhosis and possibly hepatocellular carcinoma. AIM:To examine the clinical and histological features of biopsy-proven non-alcoholic fatty liver disease and investigate the predictors of severe histological disease in Ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong VW,Chan HL,Hui AY,Chan KF,Liew CT,Chan FK,Sung JJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis C virus (HCV) infection. AIM:To evaluate the efficacy and safety of pegylated interferon (pegIFN) plus ribavirin (RBV) therapy in geriatric HCV-infected patients. METHODS:Ninety-one geria...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu CC,Lin CL,Kuo YL,Chien CH,Chen SW,Yen CL,Lin CY,Chien RN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Anaemia is a serious complication of Crohn's disease that triggers hospitalization and, if not interfered with, may lead to death. AIMS:To systematically summarize and compare the literature on anaemia in Crohn's disease. METHODS:For this systematic review the literature was searched for English-language a...

journal_title：Alimentary pharmacology & therapeutics

authors： Kulnigg S,Gasche C

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Intravenous esomeprazole may be beneficial for patients who cannot take oral medications. AIM:To compare intravenous esomeprazole with oral esomeprazole for effects on maximal acid output during pentagastrin stimulation in patients with gastro-oesophageal reflux disease symptoms. METHODS:In four separate o...

journal_title：Alimentary pharmacology & therapeutics

authors： Metz DC,Miner PB,Heuman DM,Chen Y,Sostek M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The diagnosis of covert hepatic encephalopathy (CHE) by means of portosystemic encephalopathy syndrome (PSE) test is costly and therefore infrequently performed. AIM:To determine the ability of critical flicker frequency (CFF) alone or in combination with laboratory findings, as an initial test to pre-selec...

journal_title：Alimentary pharmacology & therapeutics

authors： Greinert R,Ripoll C,Hollenbach M,Zipprich A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Fructose malabsorption, lactose malabsorption and an early rise in breath hydrogen after lactulose (ERBHAL) may play roles in induction of symptoms in gastrointestinal conditions. AIM:To compare prevalence and interactions of fructose malabsorption, lactose malabsorption and ERBHAL among healthy subjects an...

journal_title：Alimentary pharmacology & therapeutics

authors： Barrett JS,Irving PM,Shepherd SJ,Muir JG,Gibson PR

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:It is unclear whether adherence to prescribing standards has been achieved in inflammatory bowel disease (IBD). AIM:To determine how prescribing of 5-aminosalicylates (5-ASAs), steroids and thiopurines has changed in response to emerging evidence. METHODS:We examined trends in oral and topical therapies in...

journal_title：Alimentary pharmacology & therapeutics

authors： Chhaya V,Saxena S,Cecil E,Subramanian V,Curcin V,Majeed A,Pollok RC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Programmed cell death protein-1-targeted immunotherapy has shown promising results in phase II studies of hepatocellular carcinoma. AIM:To evaluate safety and efficacy of nivolumab and pembrolizumab in an international, multicentre, real-world cohort of patients with advanced hepatocellular carcinoma. METH...

journal_title：Alimentary pharmacology & therapeutics

authors： Scheiner B,Kirstein MM,Hucke F,Finkelmeier F,Schulze K,von Felden J,Koch S,Schwabl P,Hinrichs JB,Waneck F,Waidmann O,Reiberger T,Müller C,Sieghart W,Trauner M,Weinmann A,Wege H,Trojan J,Peck-Radosavljevic M,Vogel A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring is a powerful strategy known to improve the clinical outcomes and to optimise the healthcare resources in the treatment of autoimmune diseases. Currently, most of the methods commercially available for the quantification of infliximab (IFX) are ELISA-based, with a turnaround time ...

journal_title：Alimentary pharmacology & therapeutics

authors： Afonso J,Lopes S,Gonçalves R,Caldeira P,Lago P,Tavares de Sousa H,Ramos J,Gonçalves AR,Ministro P,Rosa I,Vieira AI,Dias CC,Magro F,Portuguese IBD Study Group (GEDII).

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Although lactulose and polyethylene glycol are osmotic laxatives widely used in the treatment of chronic constipation, no study has been conducted to compare their actions on the colonic bacterial ecosystem, which has an important influence on host health. AIM:To assess the effects of lactulose and polyethy...

journal_title：Alimentary pharmacology & therapeutics

authors： Bouhnik Y,Neut C,Raskine L,Michel C,Riottot M,Andrieux C,Guillemot F,Dyard F,Flourié B

更新日期：2004-04-15 00:00:00

abstract：:The 24-hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of administration of 300 mg ranitidine: post evening meal, or bedtime. This double-blind crossover trial involved 3 centres. Twenty-four-hour gastric pH was measured under s...

journal_title：Alimentary pharmacology & therapeutics

authors： Cortot A,Guillemot F,Moreau J,Soule JC,Veyrac M,Alberola B,Pappo M

更新日期：1992-08-01 00:00:00

abstract：AIM:To assess the decline in Helicobacter pylori antibodies after eradication of infection. METHODS:The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kit...

journal_title：Alimentary pharmacology & therapeutics

authors： Bergey B,Marchildon P,Peacock J,Mégraud F

更新日期：2003-09-15 00:00:00

abstract：:Deficiency of any of the vitamins and minerals essential for normal erythropoiesis (haematinics), including iron, copper, cobalt, vitamins A, B12, B6, C, E, folic acid, riboflavin and nicotinic acid, may be associated with defective erythropoiesis and anaemia. Iron, vitamin B12 and folate are the haematinics for which...

journal_title：Alimentary pharmacology & therapeutics

authors： Pawson R,Mehta A

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Online psychotherapy has been successfully used as supportive treatment in many chronic illnesses. However, there is a lack of evidence on its role in the management of gastrointestinal (GI) diseases. AIMS:To examine whether online psychological interventions improve mental and physical outcomes in gastroin...

journal_title：Alimentary pharmacology & therapeutics

authors： Hanlon I,Hewitt C,Bell K,Phillips A,Mikocka-Walus A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn's disease (SES-CD) and with histological findings are as yet limited. Aim To study the correlation of faecal calprotectin and...

journal_title：Alimentary pharmacology & therapeutics

authors： Sipponen T,Kärkkäinen P,Savilahti E,Kolho KL,Nuutinen H,Turunen U,Färkkilä M

更新日期：2008-11-15 00:00:00

abstract：BACKGROUND:Liver-related mortality varies across developed nations. AIM:To assess the relative role of various risk factors in relation to liver-related mortality in an ecological study approach. METHODS:Data for liver-related mortality, prevalence data for hepatitis B and C, human immunodeficiency virus (HIV), alcoh...

journal_title：Alimentary pharmacology & therapeutics

authors： von Wulffen M,Clark PJ,Macdonald GA,Raj AS,Kendall BJ,Powell EE,Jones MP,Holtmann G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Minimal hepatic encephalopathy (MHE) is characterised by subtle neurocognitive deficits without overt clinical manifestations. Although several trials have individually evaluated the role of prebiotics, probiotics and synbiotics, there is yet no consensus on the management of MHE. AIM:To estimate the effica...

journal_title：Alimentary pharmacology & therapeutics

authors： Shukla S,Shukla A,Mehboob S,Guha S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Two studies were carried out in order to investigate the issue of meal-provoked nocturnal gastrooesophageal reflux. METHODS:In Experiment 1, 20 symptomatic reflux patients underwent both pH and polysomnographic monitoring on two nights. On one night, patients ate a non-provocative meal prior to 19.00 hours,...

journal_title：Alimentary pharmacology & therapeutics

authors： Orr WC,Harnish MJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion. AIM:To determine the effect of PPI therapy on the gastric volume after a standard meal. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Babaei A,Bhargava V,Aalam S,Scadeng M,Mittal RK

更新日期：2009-04-15 00:00:00

abstract：BACKGROUND:Diagnosis and management of chronic antibiotic-refractory pouchitis and Crohn's disease of the pouch can be challenging. Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated. AIM:To as...

journal_title：Alimentary pharmacology & therapeutics

authors： Kariv R,Plesec TP,Gaffney K,Lian L,Fazio VW,Remzi FH,Lopez R,Goldblum JR,Shen B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) provide the most effective pharmacotherapy for treating acid-related disorders. However, PPIs do not completely control acid over 24 h with once-daily dosing. AIMS:To discuss limitations inherent in the pharmacokinetics (PK) and pharmacodynamics of conventional PPI formulations...

journal_title：Alimentary pharmacology & therapeutics

authors： Metz DC,Vakily M,Dixit T,Mulford D

更新日期：2009-05-01 00:00:00

abstract：:The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

更新日期：2003-06-01 00:00:00

abstract：:Erythromycin is a prokinetic agent for the lower oesophageal sphincter, the stomach, the gallbladder and the small bowel, acting directly on motilin receptors. Its effect on pressure activity of the human colon has not been investigated. Eight healthy volunteers were studied on 2 occasions and given intravenous or ora...

journal_title：Alimentary pharmacology & therapeutics

authors： Jameson JS,Rogers J,Misiewicz JJ,Raimundo AH,Henry MM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:A direct role for neutrophils in the pathophysiology of indomethacin-induced gastric damage is controversial. Therefore, such damage was evaluated in hamsters. METHODS:Gastric antral damage was evaluated 4 h after the oro-gastric administration of indomethacin (30 mg/kg). Prior to indomethacin, hamsters wer...

journal_title：Alimentary pharmacology & therapeutics

authors： Fitzpatrick LR,Sakurai K,Le T

更新日期：1999-02-01 00:00:00

abstract：:Antisecretory agents may affect the absorption, metabolism, and renal excretion of other drugs. Inhibition of gastric acid secretion may decrease the gastrointestinal absorption of drugs such as ketoconazole that dissolve poorly in the absence of adequate acid. With anti-secretory agents, the drug interaction mechanis...

journal_title：Alimentary pharmacology & therapeutics

authors： Hansten PD

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:A large proportion (25-46%) of adults with inflammatory bowel disease in remission has symptoms of irritable bowel syndrome (IBS), which are thought to reflect ongoing inflammation. Data on paediatric inflammatory bowel disease patients are lacking. AIM:To investigate (i) the prevalence of IBS-type symptoms...

journal_title：Alimentary pharmacology & therapeutics

authors： Diederen K,Hoekman DR,Hummel TZ,de Meij TG,Koot BG,Tabbers MM,Vlieger AM,Kindermann A,Benninga MA

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:None of the proposed materials tested for the management of perianal fistulae has proven to be a definitive treatment. AIM:To assess a new repair scaffold and drug delivery device conceived to target perianal fistula repair. METHODS:Poly(D,L-lactide-co-glycolide) porous microspheres containing either antib...

journal_title：Alimentary pharmacology & therapeutics

authors： Blaker JJ,Pratten J,Ready D,Knowles JC,Forbes A,Day RM

更新日期：2008-09-01 00:00:00