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Predictors and outcomes of antibiotic adequacy for bloodstream infections in veterans with spinal cord injury.

Abstract：

OBJECTIVE:To identify predictors and outcomes associated with receiving inadequate empirical antimicrobial treatment for bloodstream infections (BSIs) in persons with spinal cord injury (SCI). DESIGN:Retrospective cohort study from October 1, 1997, through September 30, 2004. SETTING:A Department of Veterans Affairs SCI center that serves approximately 700 patients a year. PARTICIPANTS:Hospitalized patients with SCI (N=123) who had 1 or more BSIs during the study period. INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:Adequacy of antimicrobial treatment (inadequate treatment was defined as the absence of antimicrobial agents for a particular organism within 2 days after the collection of blood cultures and/or the microorganism's resistance to the antimicrobial administered), hospital length of stay (LOS) post-BSI infection, and in-hospital and 30-day mortality. Cluster-adjusted multivariable models were assessed. RESULTS:Over one third (88; 37.4%) of the 235 episodes of BSI identified received inadequate empirical antibiotic treatment. Having a polymicrobial BSI was associated with inadequate treatment (odds ratio [OR]=3.28; 95% confidence interval [CI]=1.62-6.65; P=.001). Factors protective against inadequate therapy included having a comorbid pressure ulcer (OR=0.37; 95% CI=0.21-0.68; P=.001) or a BSI that was not primary (OR=0.30; 95% CI=0.15-0.58; P<.0001). Mortality did not differ between the inadequate and adequate treatment groups (11.4% vs 10.9%; P=.92). Similarly LOS postinfection was not affected by treatment status (inadequate treatment median=22d vs adequate treatment median=27d; P=.98). CONCLUSIONS:Over one third of patients received inadequate empirical treatment, which was associated with having a polymicrobial BSI. However, inadequate treatment was not associated with increased mortality or LOS postinfection.

journal_name

Arch Phys Med Rehabil

journal_title

Archives of physical medicine and rehabilitation

authors

Evans CT,Burns SP,Chin A,Weaver FM,Hershow RC

doi

10.1016/j.apmr.2009.02.012

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

1364-70

issue

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(09)00310-4

journal_volume

pub_type

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Predictors and outcomes of antibiotic adequacy for bloodstream infections in veterans with spinal cord injury.