Pulsatile perfusion of kidney allografts.

abstract：PURPOSE OF REVIEW:A significant shift in our understanding of the molecular and cellular basis for inflammatory bowel disease (IBD) mirrors research that has been ongoing in intestinal transplantation. The blurring of lines between these two disease states creates an avenue into potential therapeutic interventions whic...

journal_title：Current opinion in organ transplantation

authors： Belyayev L,Loh K,Fishbein TM,Kroemer A

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Bioengineering the lung based on its natural extracellular matrix (ECM) offers novel opportunities to overcome the shortage of donors, to reduce chronic allograft rejections, and to improve the median survival rate of transplanted patients. During the last decade, lung tissue engineering has advanced ...

journal_title：Current opinion in organ transplantation

authors： Uriarte JJ,Uhl FE,Rolandsson Enes SE,Pouliot RA,Weiss DJ

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:B cells are known to play a central role in humoral immunity and to boost cellular immunity, however, in a variety of experimental models, B-cell subsets ameliorate inflammation and autoimmune disease, indicating that they can also play a regulatory role. Here, we highlight the advances in regulatory ...

journal_title：Current opinion in organ transplantation

authors： Kim JI,Rothstein DM,Markmann JF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The review will discuss the current pathological criteria for the diagnosis and classification of antibody-mediated rejection (AMR) in the cardiac allograft. RECENT FINDINGS:Until recently, the diagnosis of AMR required clinical dysfunction, presence of donor specific antibodies and pathological alte...

journal_title：Current opinion in organ transplantation

authors： Berry GJ

更新日期：2012-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of diffuse splanchnic venous thrombosis continues to be a challenging undertaking for patients waiting for liver transplantation, requiring the utilization of highly complex surgical techniques. The aim of this article is to review the status of multivisceral transplantation (MVT) in t...

journal_title：Current opinion in organ transplantation

authors： Vianna R,Beduschi T

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Islet transplantation has made great progress in recent years. This is a remarkable technical feat but raises the question of what the long-term benefits and risks are for type I diabetes recipients. RECENT FINDINGS:Graft survival continues to improve, and recent multicenter studies show that islet t...

journal_title：Current opinion in organ transplantation

authors： Holmes-Walker DJ,Kay TW

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the latest investigations into the role of frailty and assessment of other aging-related issues in the solid organ transplant candidate and recipient. This information is relevant for all involved in the care of transplant patients, but is especially relevant in infectious diseases, given ...

journal_title：Current opinion in organ transplantation

authors： Schaenman J,Goldwater D,Malinis M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of lungs from those donors. Two major innovations in recent years include the use of lungs from donations after car...

journal_title：Current opinion in organ transplantation

authors： Cypel M,Keshavjee S

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcom...

journal_title：Current opinion in organ transplantation

authors： Elliott RB,Living Cell Technologies.

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation concomitant with a liver transplant may be warranted when end-stage heart failure results in irreversible liver failure. Previously reported outcomes have been excellent yet the specific immunoprotective role of the liver allograft is not known. We review the current literature a...

journal_title：Current opinion in organ transplantation

authors： Gong T,Hall S

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemic of obesity is having a marked impact on liver transplant candidates and recipients, and optimal approach for the obese liver transplant patient is not yet defined. The current review summarizes the role of bariatric surgery in obese liver transplant patients. RECENT FINDINGS:NASH is now ...

journal_title：Current opinion in organ transplantation

authors： Bonner K,Heimbach JK

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, there has been an increasing interest in nonhuman histocompatibility antigens as targets of injury in organ-transplant recipients. This increased interest has been spurred by the fact that human-histocompatibility-antigen-identical kidney transplants also undergo immunological r...

journal_title：Current opinion in organ transplantation

authors： Sumitran-Holgersson S

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiac allograft vasculopathy (CAV) is the leading cause of late morbidity and mortality in heart transplant patients and limits long-term survival. Immunosuppression following cardiac transplantation has traditionally comprised a calcineurin inhibitor in combination with mycophenolate mofetil or aza...

journal_title：Current opinion in organ transplantation

authors： Raichlin E,Kushwaha SS

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Blood loss in orthotopic liver transplantation has declined during the past decade. Recent papers addressed this issue and emphasized its importance, because there is a significant correlation between intraoperative blood transfusion requirements and postoperative morbidity. This review addresses chan...

journal_title：Current opinion in organ transplantation

authors： Groenland TH,Porte RJ,Metselaar HJ

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of T-cell exhaustion in the failure of clearance of viral infections and tumors is well established. There are several ongoing trials to reverse T-cell exhaustion for treatment of chronic viral infections and tumors. The mechanisms leading to T-cell exhaustion and its role in transplantation,...

journal_title：Current opinion in organ transplantation

authors： Thorp EB,Stehlik C,Ansari MJ

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

journal_title：Current opinion in organ transplantation

authors： Millard AL,Mueller NJ

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

journal_title：Current opinion in organ transplantation

authors： Little MH,Takasato M

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Antibody-mediated rejection (ABMR) is the leading cause of allograft failure in kidney transplant recipients. This article provides a summary of the clinical research relating to donor-specific antibodies (DSA) and ABMR in kidney transplant recipients at the University of Wisconsin-Madison Transplant ...

journal_title：Current opinion in organ transplantation

authors： Garg N,Parajuli S,Mandelbrot DA,Djamali A

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent practices and views regarding children as living organ donors in the USA. RECENT FINDINGS:Living donors have become an increasingly important source of organs for transplantation. Concern for the rights of donors has resulted in reconsideration of the use of minors as living organ...

journal_title：Current opinion in organ transplantation

authors： Olbrisch ME,Levenson JL,Newman JD

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreas transplantation is considered the optimal therapy for patients with insulin-dependent diabetes. Successful pancreas transplantation achieves euglycemia and allows freedom from insulin therapy. Long-term allograft success may be limited by the development of impaired glucose metabolism. The ob...

journal_title：Current opinion in organ transplantation

authors： Egidi MF,Lin A,Bratton CF,Baliga PK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides an overview of the mechanisms of Notch signaling, focusing on new insights into its diverse functions in T-cell act...

journal_title：Current opinion in organ transplantation

authors： Magee CN,Riella LV

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

journal_title：Current opinion in organ transplantation

authors： Haas M

更新日期：2014-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion ...

journal_title：Current opinion in organ transplantation

authors： Cheung KP,Kasimsetty SG,McKay DB

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Heart transplantation is the only curative treatment option for end-stage heart failure. However, a shortage of donor organs is a major limitation of this approach. Regenerative medicine targets the goal of increasing the number of available hearts for transplantation. In this review, we highlight the...

journal_title：Current opinion in organ transplantation

authors： Taylor DA,Elgalad A,Sampaio LC

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Organ shortage remains a major obstacle for liver transplantation, resulting in an increased mortality on the liver transplant waiting list. The usage of extended criteria donors (ECD) is a strategy to increase the number of available donor organs, however, with the risk of a higher rate of posttransp...

journal_title：Current opinion in organ transplantation

authors： Kollmann D,Selzner M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Geographic variation in liver transplantation has been the subject of extensive scrutiny, reflecting concerns that location is unfairly determinative for people needing organ transplantation. Drawing upon a number of established ethical approaches, we examine whether geographic differences in access t...

journal_title：Current opinion in organ transplantation

authors： Ladin K,Hanto DW

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of sensitized heart transplant candidates is rising. Highly sensitized patients are disadvantaged because they encounter longer waiting times to heart transplant. Strategies to reduce their waiting times include waitlist prioritization and desensitization therapies. The purpose of this revi...

journal_title：Current opinion in organ transplantation

authors： Aleksova N,Ross HJ

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of how intravenous omega-3 fatty acids (O3FAs) have been used to prevent and treat pediatric intestinal failure-associated liver disease (IFALD). This review will introduce the most recent and relevant human and basic science data on the topic, and comment on how alterative lipi...

journal_title：Current opinion in organ transplantation

authors： Venick RS,Calkins K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The use of nonheart-beating donors (NHBD), as a source for liver grafts, is the only way to objectively increase the activity in liver transplantation. Through the use of more strict criteria, 1-year graft survival has increased from 50% in initial series to 84-100%. With respect to type II NHBD (fail...

journal_title：Current opinion in organ transplantation

authors： García-Valdecasas JC,Fondevila C

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Although living donor transplantation is considered an ethically acceptable undertaking for the purpose of saving another's life, its safety remains under investigation. RECENT FINDINGS:Although living donors undertake considerable medical risks for no direct medical benefit, the question remains whe...

journal_title：Current opinion in organ transplantation

authors： Gordon EJ

更新日期：2013-04-01 00:00:00