Towards xenotransplantation of pig islets in the clinic.


PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcome the rejection, all of which have shown some efficacy in animal models. SUMMARY:Immune suppression, Sertoli cell co-transplantation and microencapsulation have been tried in type 1 diabetic humans with some clinical benefit derived reported from the latter two. Unaware hypoglycemia in particular seems amenable to the microencapsulation approach.


Elliott RB,Living Cell Technologies.




Has Abstract


2011-04-01 00:00:00












  • An updated Banff schema for diagnosis of antibody-mediated rejection in renal allografts.

    abstract:PURPOSE OF REVIEW:To introduce the updated Banff schema for antibody-mediated renal allograft rejection and related revisions to definitions within this schema agreed upon during and immediately subsequent to the 2013 Banff Conference on Allograft Pathology. RECENT FINDINGS:The original Banff schema for diagnosis of a...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Haas M

    更新日期:2014-06-01 00:00:00

  • The use of stem cells in kidney disease.

    abstract:PURPOSE OF REVIEW:Acute and chronic kidney disease is a leading cause of morbidity and mortality worldwide with overall mortality rates between 50 and 80%. An acute shortage of compatible organs coupled with limited adaptability of current dialysis techniques has created a sense of urgency to investigate new alternativ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Chhabra P,Brayman KL

    更新日期:2009-02-01 00:00:00

  • Antibody-mediated rejection after intestinal transplantation.

    abstract:PURPOSE OF REVIEW:In spite of impressive improvements in short-term outcomes for intestine transplant recipients, late allograft loss continues to plague the field. Attention has mostly been focused on T-cell-mediated cellular mechanisms of allograft rejection to explain these losses; however, as in other forms of soli...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Dick AA,Horslen S

    更新日期:2012-06-01 00:00:00

  • Expansion of the criteria for living donor liver transplantation for hepatocellular carcinoma.

    abstract:PURPOSE OF REVIEW:Several expanded criteria for liver transplantation for hepatocellular carcinoma (HCC) have been suggested out of concern that the Milan criteria may be too strict, and thereby exclude patients who could benefit from this surgical procedure. However, most expanded criteria were designed for deceased d...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Lee HW,Suh KS

    更新日期:2016-04-01 00:00:00

  • Mechanisms of lung ischemia-reperfusion injury.

    abstract:PURPOSE OF REVIEW:Lungs are extremely susceptible to injury, and despite advances in surgical management and immunosuppression, outcomes for lung transplantation are the worst of any solid organ transplant. The success of lung transplantation is limited by high rates of primary graft dysfunction because of ischemia-rep...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Laubach VE,Sharma AK

    更新日期:2016-06-01 00:00:00

  • Current outcomes after pediatric and adult intestinal transplantation.

    abstract:PURPOSE OF REVIEW:In this article, we will review the outcomes of patients with intestinal transplant (ITx) with a focus on factors affecting long-term graft and patient survival. RECENT FINDINGS:The most recent International Intestinal Transplant Registry reports a 1-, 5-, and 10-year graft survival of 71%, 50%, and ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Amin A,Farmer DG

    更新日期:2019-04-01 00:00:00

  • Critical issues related to porcine xenograft exposure to human viruses: lessons from allotransplantation.

    abstract:PURPOSE OF REVIEW:Xenotransplantation of tissues from swine into humans poses the threat of bidirectional transfer of porcine or human microorganisms to the recipient or to the xenograft, respectively. This review focuses on recipient-derived infection. Recent data are reviewed that assess the susceptibility of porcine...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Millard AL,Mueller NJ

    更新日期:2010-04-01 00:00:00

  • Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment.

    abstract:PURPOSE OF REVIEW:Transplantation of islets of Langerhans is an emerging treatment procedure for patients with severe type 1 diabetes, but despite recent progress the procedure is associated with massive tissue loss caused by an inflammatory reaction termed instant blood-mediated inflammatory reaction (IBMIR). This rea...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Nilsson B,Ekdahl KN,Korsgren O

    更新日期:2011-12-01 00:00:00

  • Evaluation and selection of the liver transplant candidate: updates on a dynamic and evolving process.

    abstract:PURPOSE OF REVIEW:Although conceptually unchanged, the evaluation and selection of the liver transplant candidate has seen significant recent advances. Expanding criteria for transplant candidacy, improved diagnostics for risk stratification and advances in prognostic models have paralleled recent changes in allocation...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章


    authors: Kriss M,Biggins SW

    更新日期:2021-02-01 00:00:00

  • ABO-incompatible kidney transplantation: current practice and the decade ahead.

    abstract:PURPOSE OF REVIEW:With rapidly growing deceased donor kidney transplant waiting lists, solutions to the shortage of kidney donors need to come from many corners. This review focuses on the current results and upcoming medications that will allow broad expansion of ABO-incompatible transplantation as one facet to combat...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Crew RJ,Ratner LE

    更新日期:2010-08-01 00:00:00

  • Are geographic differences in transplantation inherently wrong?

    abstract:PURPOSE OF REVIEW:Geographic variation in liver transplantation has been the subject of extensive scrutiny, reflecting concerns that location is unfairly determinative for people needing organ transplantation. Drawing upon a number of established ethical approaches, we examine whether geographic differences in access t...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Ladin K,Hanto DW

    更新日期:2017-04-01 00:00:00

  • The role of complement in regulating the alloresponse.

    abstract:PURPOSE OF REVIEW:This review emphasizes new information concerning the role of anaphylatoxins in the regulation of the immune response to allografts. Its timeliness relates the growing concept of the innate immune response as a regulator of the adaptive immune system and to how this concept lends itself to therapeutic...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Sacks S,Lee Q,Wong W,Zhou W

    更新日期:2009-02-01 00:00:00

  • Everolimus in pediatric transplantation.

    abstract:PURPOSE OF REVIEW:The use of everolimus has recently emerged for solid-organ transplantation in children. This review gives an overview of the relevant studies and clinical trials involving the immunosuppressive effects of everolimus in child organ transplant. RECENT FINDINGS:The use of everolimus in pediatric organ t...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Pape L,Ganschow R,Ahlenstiel T

    更新日期:2012-10-01 00:00:00

  • Mesenchymal stromal (stem) cells to improve solid organ transplant outcome: lessons from the initial clinical trials.

    abstract:PURPOSE OF REVIEW:Discuss the recent progress on the clinical use of mesenchymal stromal (stem) cells (MSC) in solid organ transplantation (SOT). RECENT FINDINGS:Tissue repair and immunomodulatory properties have been recognized for MSC obtained from different human tissues. MSC-based therapy has been proposed to redu...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Pileggi A,Xu X,Tan J,Ricordi C

    更新日期:2013-12-01 00:00:00

  • Rethinking clinical endpoints in kidney transplant trials.

    abstract:PURPOSE OF REVIEW:Clinical trials testing novel kidney transplant therapies are challenged by low rates of long-term clinical outcomes such as death and graft loss. Herein, we critically review traditional and more recent strategies to expedite new therapies by minimizing sample size and follow-up duration using surrog...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Maggiore U,Leventhal J,Cravedi P

    更新日期:2020-02-01 00:00:00

  • Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application?

    abstract:PURPOSE OF REVIEW:The present review summarizes current data on the induction of immunologic tolerance through mixed hematopoietic chimerism relevant to applying this approach to vascularized composite allotransplantation. RECENT FINDINGS:Clinical allograft tolerance has been achieved recently for kidney transplants, ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Cetrulo CL Jr,Drijkoningen T,Sachs DH

    更新日期:2015-12-01 00:00:00

  • Self-antigens and rejection: a proteomic analysis.

    abstract:PURPOSE OF REVIEW:Allo- and autoantibodies have been found to play important roles in both acute and chronic allograft rejection in organ transplantation, although only recently have non-human leukocyte antigen (non-HLA), nondonor-specific antibodies been given a more in-depth treatment. This review summarizes recent r...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Yang JY,Sigdel TK,Sarwal MM

    更新日期:2016-08-01 00:00:00

  • Considerations and experience driving expansion of combined heart-liver transplantation.

    abstract:PURPOSE OF REVIEW:Heart transplantation concomitant with a liver transplant may be warranted when end-stage heart failure results in irreversible liver failure. Previously reported outcomes have been excellent yet the specific immunoprotective role of the liver allograft is not known. We review the current literature a...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章


    authors: Gong T,Hall S

    更新日期:2020-10-01 00:00:00

  • Preservation strategies to reduce ischemic injury in kidney transplantation: pharmacological and genetic approaches.

    abstract:PURPOSE OF REVIEW:In the current graft shortage, it is paramount to improve the quality of transplanted organs. Organ preservation represents an underused therapeutic window with great potential to reduce ischaemia-reperfusion injury (IRI) and improve graft quality. Herein, we review strategies using this window as wel...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Chatauret N,Thuillier R,Hauet T

    更新日期:2011-04-01 00:00:00

  • Memory T cells and their exhaustive differentiation in allograft tolerance and rejection.

    abstract:PURPOSE OF REVIEW:Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T c...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Valujskikh A,Li XC

    更新日期:2012-02-01 00:00:00

  • Children as living organ donors: current views and practice in the United States.

    abstract:PURPOSE OF REVIEW:To summarize recent practices and views regarding children as living organ donors in the USA. RECENT FINDINGS:Living donors have become an increasingly important source of organs for transplantation. Concern for the rights of donors has resulted in reconsideration of the use of minors as living organ...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Olbrisch ME,Levenson JL,Newman JD

    更新日期:2010-04-01 00:00:00

  • Generating a self-organizing kidney from pluripotent cells.

    abstract:PURPOSE OF REVIEW:Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organizat...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Little MH,Takasato M

    更新日期:2015-04-01 00:00:00

  • Individualization of immunosuppression: concepts and rationale.

    abstract:PURPOSE OF REVIEW:New immunosuppressive agents have decreased the incidence of acute rejection rates without improvement in long-term outcomes. Drug toxicity due to a narrow therapeutic index and individual variations in pharmacokinetics and pharmacodynamics significantly contributes to the inferior outcomes. This revi...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Wavamunno MD,Chapman JR

    更新日期:2008-12-01 00:00:00

  • Deciphering antibody-mediated rejection: new insights into mechanisms and treatment.

    abstract:PURPOSE OF REVIEW:To outline recent studies describing the mechanisms of antibody-mediated rejection (AMR) and new clinical protocols aimed at prevention and/or treatment of this difficult clinical entity. RECENT FINDINGS:The natural history of acute AMR after positive cross-match kidney transplantation involves an ac...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Stegall MD,Gloor JM

    更新日期:2010-02-01 00:00:00

  • Lung re-transplantation: review.

    abstract:PURPOSE OF REVIEW:Re-transplantation of the lung has come of age. Here, we wish to review the recent literature on the topic and discuss clinical implications. RECENT FINDINGS:Many large volume transplant centres routinely perform lung re-transplantation with satisfactory outcomes. The main indication is bronchiolitis...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Warnecke G,Haverich A

    更新日期:2012-10-01 00:00:00

  • Ethical dilemmas in psychiatric evaluations in patients with fulminant liver failure.

    abstract:PURPOSE OF REVIEW:Fulminant hepatic failure (FHF) is one of the more dramatic and challenging syndromes in clinical medicine. Time constraints and the scarcity of organs complicate the evaluation process in the case of patients presenting with FHF, raising ethical questions related to fairness and justice. The challeng...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Appel J,Vaidya S

    更新日期:2014-04-01 00:00:00

  • The microbiome and its implications in intestinal transplantation.

    abstract:PURPOSE OF REVIEW:This article summarizes the complex interplay between the microbiota and host immune responses, and its impact on intestinal transplantation and allograft rejection. RECENT FINDINGS:Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control th...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Kroemer A,Elsabbagh AM,Matsumoto CS,Zasloff M,Fishbein TM

    更新日期:2016-04-01 00:00:00

  • Kidney transplantation across HLA and ABO antibody barriers.

    abstract:PURPOSE OF REVIEW:A significant number of kidney transplantations in industrialized countries is currently performed over human leukocyte antigen (HLA) or ABO antibody barriers after living donation to encounter the increasing shortage of organs from deceased donors. Although patients with moderate titers of anti-A/B a...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Becker LE,Süsal C,Morath C

    更新日期:2013-08-01 00:00:00

  • Lung transplantation for cystic fibrosis.

    abstract:PURPOSE OF REVIEW:There have been several recent articles which have attempted to refine the appropriate timing of listing for lung transplantation and the identification of factors which increase the risk with particular emphasis on pretransplant microbiology in patients with cystic fibrosis. Moreover, there are sever...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Corris PA

    更新日期:2008-10-01 00:00:00

  • State of the art: implantable ventricular assist devices.

    abstract:PURPOSE OF REVIEW:The first generation of implantable pulsatile ventricular assist devices (VADs) has proven to be successful as bridge to transplantation. Adverse events such as mechanical failure and infections, however, limit their use for long-term support (>1 year) or as alternative for heart transplantation. Newe...

    journal_title:Current opinion in organ transplantation

    pub_type: 杂志文章,评审


    authors: Lahpor JR

    更新日期:2009-10-01 00:00:00