Towards xenotransplantation of pig islets in the clinic.

Abstract:

PURPOSE OF REVIEW:Porcine islet xenotransplantation into humans faces two major hurdles - safety issues related to xenosis and xenorejection of the transplants. The former has been overcome mainly by selection of a suitable disease-free source herd. RECENT FINDINGS:Four strategies have been employed to date to overcome the rejection, all of which have shown some efficacy in animal models. SUMMARY:Immune suppression, Sertoli cell co-transplantation and microencapsulation have been tried in type 1 diabetic humans with some clinical benefit derived reported from the latter two. Unaware hypoglycemia in particular seems amenable to the microencapsulation approach.

authors

Elliott RB,Living Cell Technologies.

doi

10.1097/MOT.0b013e3283449dec

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

195-200

issue

2

eissn

1087-2418

issn

1531-7013

journal_volume

16

pub_type

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