Abstract:
:Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimer's disease and as antitumour agents.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Weekes AA,Westwell ADdoi
10.2174/092986709788682137subject
Has Abstractpub_date
2009-01-01 00:00:00pages
2430-40issue
19eissn
0929-8673issn
1875-533Xjournal_volume
16pub_type
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