Abstract：
:Stem cells are unique cells in the ability that can self-renew and differentiate into a wide variety of cell types, suggesting that a specific molecular control network underlies these features. To date, stem cells have been applied to many clinical therapeutic approaches. For example, hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are the cells responding to ischemia or injury and engage in effective revascularization to repair within impairment regions. Transplantation of MSCs after stroke and hindlimb ischemia results in remarkable recovery through enhancing angiogenesis. MicroRNAs are a novel class of endogenous, small, noncoding RNAs that work via translational inhibition or degradation of their target mRNAs to downregulate gene expression. MicroRNAs have been strongly linked to stem cells, which have a remarkable role in development. In this study, we focused on the microRNA regulation in multiple stem cells. For example, miR-520h was upregulated and miR-129 was downregulated in HSC. MiR-103, 107, 140, 143, 638, and 663 were associated with MSCs while miR-302s and miR-136 were associated with ESCs. In NSCs, miR-92b, let-7, and miR-125 were the critical regulators. This overview of the recent advances in the aspects of molecular control of stem cell biology reveals the importance of microRNAs, which may be helpful for future work.
journal_name
Cell Transplantjournal_title
Cell transplantationauthors
Liu SP,Fu RH,Yu HH,Li KW,Tsai CH,Shyu WC,Lin SZdoi
10.3727/096368909X471224subject
Has Abstractpub_date
2009-01-01 00:00:00pages
1039-45issue
9eissn
0963-6897issn
1555-3892pii
CT-2060journal_volume
18pub_type
杂志文章,评审abstract：:The ability to replace damaged myocardial tissue with new striated muscle would constitute a major advance in the treatment of diseases that irreversibly injure cardiac muscle cells. The creation of focal grafts of skeletal muscle has been reported following the intramural injection of skeletal myoblasts into both nor...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/0963-6897(95)02016-0
更新日期：1996-01-01 00:00:00
abstract：:The midbrain inferior colliculus (IC), a major integrating center for auditory processing, provides a model for structural, functional, and behavioral recovery. The present study examined the role of IC in spatial sound detection, and the effects of neural transplantation in sparing of behavioral performance. Hooded r...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/0963-6897(95)02036-5
更新日期：1996-03-01 00:00:00
abstract：:Mononuclear stem cells have been studied for their potential in myocardial ischemia. In our previous published article, ReACT(®) phase I/II clinical trial, our results suggest that a certain cell population, promonocytes, directly correlated with the perceived angiogenesis in refractory angina patients. This study is ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368914X681595
更新日期：2015-01-01 00:00:00
abstract：:Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury. Several recessive mutations, including Purkinje Cell Degeneration, affect the number of Purkinje cells in homozygosis; heterozygous young animals have an apparently...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X638900
更新日期：2012-01-01 00:00:00
abstract：:Hepatocyte transplantation (HT) has become an effective therapy for patients with metabolic inborn errors. We report the clinical outcome of four children with metabolic inborn errors that underwent HT, describing the cell infusion protocol and the metabolic outcome of transplanted patients. Cryopreserved hepatocytes...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X637505
更新日期：2012-01-01 00:00:00
abstract：:The aim of this work was to determine the effect of nicotine desensitization on dopamine (DA) release in the dorsal striatum and shell of the nucleus accumbens (NAc) from brain slices. In vitro fast-scan cyclic voltammetry analysis was used to evaluate dopamine release in the dorsal striatum and the NAc shell of Sprag...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689718775382
更新日期：2019-03-01 00:00:00
abstract：:Airway epithelial cell injury is a key triggering event to activate allergic airway inflammation, such as asthma. We previously reported that administration of mesenchymal stem cells (MSCs) significantly alleviated allergic inflammation in a mouse model of asthma, and the mmu-miR-21/ACVR2A axis may be involved. Howeve...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689718767159
更新日期：2018-03-01 00:00:00
abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is the third most frequent inherited myopathy. We previously demonstrated that mesoangioblasts can be efficiently isolated from FSHD muscles, although their differentiation ability into skeletal muscle was variably impaired. This correlates with overall disease severity a...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368910X546571
更新日期：2011-01-01 00:00:00
abstract：:Multipotent adult progenitor cells (MAPCs) are bone marrow-derived nonhematopoietic stem cells with a broad differentiation potential and extensive expansion capacity. A comparative study between human mesenchymal stem cells (hMSCs) and human MAPCs (hMAPCs) has shown that hMAPCs have clearly distinct phenotypical and ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X657369
更新日期：2013-01-01 00:00:00
abstract：:Ten mongrel dogs were used in this study. Diabetes was chemically induced in 7 dogs, and 3 dogs served as normal controls. For each diabetic dog, 5 million human bone marrow-derived mesenchymal stem cells/kg were differentiated to form insulin-producing cells using a trichostatin-based protocol. Cells were then loaded...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689718759913
更新日期：2018-06-01 00:00:00
abstract：:Studies of human neurodevelopmental disorders and stem cell-based regenerative transplants have been hampered by the lack of a model of the developing human brain. Stem cell-derived neurons suffer major limitations, including the ability to recapitulate the 3-dimensional architecture of a brain tissue and the represen...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689717752946
更新日期：2018-03-01 00:00:00
abstract：:The use of biomaterials has been demonstrated as a viable strategy to promote cell survival and cardiac repair. However, limitations on combinational cell-biomaterial therapies exist, as cellular behavior is influenced by the microenvironment and physical characteristics of the material. Among the different scaffolds ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368915X689794
更新日期：2016-01-01 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is an inherited disease and a main target of myogenic cell transplantation (MT). After the failure of the first clinical trials with DMD patients, the poor migration of transplanted cells has been suspected to be a major problem for a more effective clinical application of MT. Previou...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368909X470900
更新日期：2009-01-01 00:00:00
abstract：:Potential labels for identifying embryonic raphe neurons and a clonal, neuronally differentiating, raphe-derived cell line, RN33B, in CNS transplantation studies were tested by first characterizing the labels in vitro. The labels that were tested included 4',6-diamidino-2-phenylindole hydrochloride, 1,1'-dioctadecyl-3...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/096368979300200207
更新日期：1993-03-01 00:00:00
abstract：:During the isolation of human islets of Langerhans the digest has repeated direct contact with the ambient atmosphere. In order to fulfill GMP requirements in clinical applications, the entire cell preparation must be performed in clean room facilities. We hypothesized that the use of a closed system, which avoids the...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000007783465091
更新日期：2007-01-01 00:00:00
abstract：:Human embryonic stem (hES) cells have the ability to differentiate into a variety of different cell lineages and potentially provide a source of differentiated cells for many therapeutic uses. Here we investigated an efficient method of hepatic differentiation from hES cells. A human ES cell line, KhES-1, was used and...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000006783981305
更新日期：2006-01-01 00:00:00
abstract：:Natural immunological tolerance can be induced in certain types of allogeneic liver transplantation in rats. To screen for genes associated with the induction of tolerance, suppression subtractive hybridization was performed in the rat liver transplantation model between a DA donor and PVG recipient combination where ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000008783906955
更新日期：2008-01-01 00:00:00
abstract：:In Alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. The fimbria-fornix aspiration is a well-known animal model mimicking hippocampal cholinergic deficiency. The aim of the present study was to use in vivo lipid-mediated gene transfer to introduce an expression vector ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Cardiovascular disease is a major cause of morbidity, disability, and mortality in kidney transplant patients. Cumulative reports indicate that the excessive risk of cardiovascular events is not entirely explained by the increased prevalence of traditional cardiovascular risk factors. Atherosclerosis is a chronic infl...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.1177/0963689717735404
更新日期：2017-09-01 00:00:00
abstract：:Expression of a fluorescent reporter gene has been studied using two alternate promoters to transcribe the green fluorescent protein (gfp) from Aequorea victoria. The human cytomegalovirus (CMV) enhancer/ promoter or the human muscle-specific creatine kinase promoter (CKM) were inserted along with the gfp cDNA into a ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1016/0963-6897(95)02026-8
更新日期：1996-05-01 00:00:00
abstract：:Recently, FDA approved the clinical use of autologous fibroblasts (LAVIV™) for the improvement of nasolabial fold wrinkles in adults. The use of autologous fibroblasts for the augmentation of dermal and subcutaneous defects represents a potentially exciting natural alternative to the use of other filler materials for ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368912X659844
更新日期：2014-01-01 00:00:00
abstract：:The technologies for adipose tissue harvesting, processing, and transplantation have substantially evolved in the past two decades. Clinically driven advancements have paralleled a significant improvement in the understanding of cellular, molecular, and immunobiological events surrounding cell and tissue transplantati...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.3727/096368910X507187
更新日期：2010-01-01 00:00:00
abstract：:Endothelial progenitor cells (EPCs) have been applied for cell therapy because of their roles in angiogenesis and neovascularization in ischemic tissue. However, adverse responses caused by EPC therapy have not been fully investigated. In this study, a human peripheral blood sample was collected from a healthy donor a...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689718821686
更新日期：2019-07-01 00:00:00
abstract：:Islet-like cell clusters generated from human fetal pancreases between 18-24 wk gestation were able to grow and mature both morphologically and functionally after transplantation under the kidney capsule of athymic nude mice. Grafted tissue, predominantly ductal in appearance was unresponsive to glucose 2 wk after gra...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/096368979400300509
更新日期：1994-09-01 00:00:00
abstract：:Adoptive cell transfer (ACT) of antigen (Ag)-specific CD8(+) cytotoxic T lymphocytes (CTLs) is a highly promising treatment for a variety of diseases. Naive or central memory T-cell-derived effector CTLs are optimal populations for ACT-based immunotherapy because these cells have a high proliferative potential, are le...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368916X690467
更新日期：2016-01-01 00:00:00
abstract：:The mechanisms of donor hepatocyte integration into recipient liver are not fully understood. We investigated mechanisms of both the integration and interaction of transplanted hepatocytes with host liver cells as well as the repopulation of the host organ following intraportal transplantation. Mature hepatocytes were...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/000000005783983322
更新日期：2005-01-01 00:00:00
abstract：:Stroke is one of the most devastating diseases worldwide. In recent years, a great number of studies have focused on the effects of microRNAs (miRNAs) on stroke and the results demonstrated that the expressions of miRNAs are associated with the prognosis of stroke. In the present study, we review relevant articles reg...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.1177/0963689718773361
更新日期：2018-12-01 00:00:00
abstract：:Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attrac...
journal_title：Cell transplantation
pub_type： 杂志文章,评审
doi：10.3727/096368909788341243
更新日期：2009-01-01 00:00:00
abstract：:Osteoarthritis (OA) is degenerative disease, leading to pain and functional disability. It is reported that polydeoxyribonucleotide (PDRN) is a suitable therapy for OA. However, the therapeutic mechanisms of PDRN in OA are not fully understood. To investigate the effect of PDRN in an in vitro model of OA, interleukin ...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.1177/0963689718804130
更新日期：2018-11-01 00:00:00
abstract：:Magnetic targeting has the potential to enhance the therapeutic effects of stem cells through increasing retention of transplanted cells. To investigate the effects of magnetic targeting intensities on cell transplantation, we performed different magnetic intensities for mesenchymal stem cell (MSC)-targeting therapy i...
journal_title：Cell transplantation
pub_type： 杂志文章
doi：10.3727/096368914X685302
更新日期：2015-01-01 00:00:00
