Abstract：
OBJECTIVES:To examine the association between serum albumin and cognitive impairment and decline in community-living older adults. DESIGNS:Population-based cohort study, followed up to 2 years; serum albumin, apolipoprotein E (APOE)-epsilon4, and cognitive impairment measured at baseline and cognitive decline (> or =2-point drop in Mini-Mental State Examination (MMSE) score). Odds ratios were controlled for age, sex, education, medical comorbidity, hypertension, diabetes mellitus, cardiac disease, stroke, smoking, alcohol drinking, depression, APOE-epsilon4, nutritional status, body mass index, anemia, glomerular filtration rate, and baseline MMSE. SETTINGS:Local area whole population. PARTICIPANTS:One thousand six hundred sixty-four Chinese older adults aged 55 and older. RESULTS:The mean age of the cohort was 66.0+/-7.3, 65% were women, mean serum albumin was 42.3+/-3.1 g/L, and mean MMSE score was 27.2+/-3.2. Lower albumin tertile was associated with greater risk of cognitive impairment in cross-sectional analysis (low, odds ratio (OR)=2.30, 95% confidence interval (CI)=1.31-4.03); medium, OR=1.59, 95% CI=0.88-2.88) versus high (P for trend=.002); and with cognitive decline in longitudinal analyses: low, OR=1.73, 95% CI=1.18-2.55; medium, OR=1.32, 95% CI=0.89-1.95, vs high (P for trend=.004). In cognitively unimpaired respondents at baseline (MMSE> or =24), similar associations with cognitive decline were observed (P for trends <.002). APOE-epsilon4 appeared to modify the association, due mainly to low rates of cognitive decline in subjects with the APOE-epsilon4 allele and high albumin. CONCLUSION:Low albumin was an independent risk marker for cognitive decline in community-living older adults.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Ng TP,Niti M,Feng L,Kua EH,Yap KBdoi
10.1111/j.1532-5415.2008.02086.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
101-6issue
1eissn
0002-8614issn
1532-5415pii
JGS2086journal_volume
57pub_type
杂志文章abstract：OBJECTIVES:To identify the strategies used by older persons to cope with chronic noncancer pain, determine the perceived effectiveness of the strategies, and ascertain factors associated with their use. DESIGN:Cross-sectional telephone survey. SETTING:Primary care practice located at a Veterans Affairs Medical Center...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2004.52263.x
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence and predictors of adverse postoperative outcomes in older surgical patients undergoing noncardiac surgery. DESIGN:Prospective cohort study of consecutive patients undergoing noncardiac surgery in 1997. SETTING:A medical school-affiliated teaching community hospital. PARTICIPANT...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2001.49212.x
更新日期：2001-08-01 00:00:00
abstract：:Physical health problems become more common as people age and are associated with a great deal of disability. Although racial and ethnic disparities have been reported in physical health, little is known about whether these disparities remain in the latest part of older adulthood. Accordingly, the current study sought...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2010.03033.x
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence of hypoalbuminemia and hypoprealbuminemia in hospitalized, elderly, skilled nursing facility residents and to correlate these findings with clinical outcomes. DESIGN:Prospective cohort study. SETTING:A 300-bed community hospital. PARTICIPANTS:Eighty-one hospitalized, skilled n...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1993.tb01893.x
更新日期：1993-05-01 00:00:00
abstract：:In a series of 934 elderly patients admitted to the geriatric department of a general hospital, several admission laboratory tests were found to provide prognostic information. When tests were combined as a discriminant function, the matter of death or survival at six weeks after admission was predicted with 84 percen...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1981.tb01767.x
更新日期：1981-05-01 00:00:00
abstract：:As nursing homes become increasingly important sites for biomedical and behavioral research, researchers must address the ethical problems of increased vulnerability and the high prevalence of mental and physical disorders in the nursing home population. Obtaining valid informed consent is but one of the many difficul...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.1993.tb07470.x
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVE:Based on the Canadian Study of Health and Aging (CSHA), to determine the importance of cognitive status, sociodemographic factors, functional status, and other health related factors as predictors of 5-year overall mortality in older Canadians. DESIGN, SETTING AND PARTICIPANTS:Two partially overlapping group...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1532-5415.1999.tb05207.x
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Mammographic screening for breast cancer is of uncertain clinical benefit for women 75 years of age and older. Some have argued against instituting routine screening in this age group, noting that disability and shorter life expectancy may diminish the desirability and cost-effectiveness of sc...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1998.tb02746.x
更新日期：1998-08-01 00:00:00
abstract：OBJECTIVES:Family caregiving is an integral part of the care system for persons with dementing disorders, such as Alzheimer's disease. This study tested role-training intervention as a way to help family caregivers appreciate and assume a more clinical belief set about caregiving and thereby ameliorate the adverse outc...
journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1532-5415.2001.49090.x
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVES:To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. DESIGN:Cross-sectional. SETTING:Medical oncology outpatient clinic at the Royal Adelaide Hospital. PARTICIPANTS:Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), o...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.13051
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVE:To develop and validate the Physical Performance and Mobility Examination (PPME), an observer-administered, performance-based instrument assessing 6 domains of physical functioning and mobility for hospitalized elderly. DESIGN:Development of a pass-fail and 3-level scoring system and training manuals for the...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1994.tb06535.x
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVES:To examine the effect of obesity (body mass index (BMI)≥30.0 kg/m2 ) on outcomes of older adults admitted to skilled nursing facilities (SNFs) for hip fracture postacute care (PAC). DESIGN:Retrospective cohort study. SETTING:U.S. Medicare- and Medicaid-certified SNFs from 2008 to 2015. PARTICIPANTS:Medica...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15334
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:To examine public opinion regarding certain elements of consent: disclosure, advance directives, substitute decisions, emergency treatment, and advocacy. DESIGN:Cross-sectional random-digit-dialing telephonic survey. SETTING:General public. PARTICIPANTS:One thousand randomly-selected adults living in Ontar...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1993.tb02042.x
更新日期：1993-02-01 00:00:00
abstract：PURPOSE:To determine whether the management of heart failure by specialized multidisciplinary heart failure disease-management programs was associated with improved outcomes. BACKGROUND:The advent of angiotensin-converting enzyme inhibitors, beta-blockers, and spironolactone has revolutionized the management of heart ...
journal_title：Journal of the American Geriatrics Society
pub_type： 评论,杂志文章
doi：10.1046/j.1532-5415.2002.50418.x
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:To compare the risk of serious hypoglycemia associated with the use of individual sulfonylureas in older people. DESIGN:A retrospective cohort study. SETTING:The Tennessee Medicaid Program. PATIENTS:A total of 13,963 Medicaid enrollees, aged 65 years or older, who were prescribed one of six sulfonylureas f...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb03729.x
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Guidelines recommend avoidance of several psychoactive medications such as hypnotics in older adults due to their adverse effects. Older patients on hemodialysis may be particularly vulnerable to complications related to use of these agents, but only limited data are available about the risks in this populat...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.15740
更新日期：2019-03-01 00:00:00
abstract：:The US Department of Health and Human Services and the Foundation for the National Institutes of Health, through private sector support, sponsored the National Research Summit on Dementia Care: Building Evidence for Services and Supports (Summit) in 2017. Various workgroups were asked to address topics of interest in ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16341
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVES:To evaluate whether age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity influences the effect of a high-intensity functional weight-bearing exercise program on functional balance. DESIGN:Preplanned subgroup analyses of a randomized controlled trial. SETTING:...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1532-5415.2011.03484.x
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Frailty in older vascular surgery patients is associated with increased mortality, hospital stay, and morbidity. The association of frailty with hospital-acquired geriatric syndromes such as delirium and functional decline has not been well studied. OBJECTIVES:To investigate the association between frailty ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16907
更新日期：2020-11-05 00:00:00
abstract：:(-)Deprenyl (Selegiline, Jumex, Eldepryl, Movergan), a close structural relative to phenylethylamine (PEA), is a drug with a unique pharmacological spectrum. (1) It is a highly potent and selective, irreversible inhibitor of B-type monoamine oxidase (MAO), a predominantly glial enzyme in the brain. The activity of thi...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：10.1111/j.1532-5415.1992.tb01860.x
更新日期：1992-08-01 00:00:00
abstract：:Although computerized physician order entry (CPOE) has been successfully implemented in many acute care hospitals, few descriptions of its use in the long-term care (LTC) setting are available. This report describes the experiences of one LTC facility in developing and implementing a CPOE system with clinical decision...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.53515.x
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVES:To investigate long-term variability in serum high-sensitivity C-reactive protein (CRP) and interleukin-6 (IL-6) and to determine associated risk factors for high-risk inflammatory profiles. DESIGN:Prospective population-based cohort study. PARTICIPANTS:Participants (N = 1,443) of the Epidemiology of Heari...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.12382
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:To describe longitudinal changes in the prevalence of major cardiovascular disease (CVD) risk factors in aging American Indians. DESIGN:Population-based ongoing epidemiological study. SETTING:The Strong Heart Study is a study of CVD and its risk factors. Standardized examinations were repeated in 1993 to 1...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2006.01018.x
更新日期：2007-01-01 00:00:00
abstract：:Physical performance measures, including cardiopulmonary exercise testing (CPXT), are widely used in geriatric practice and aging research. Theoretically, research participants and study personnel could get infected in the closed environment of the exercise laboratory by contact with respiratory droplets from an infec...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16968
更新日期：2021-01-01 00:00:00
abstract：OBJECTIVES:To report on the efficacy, safety, and tolerability of sertraline in the treatment of elderly depres-sed patients with and without comorbid medical illness. SETTING:Multicenter. DESIGN:Randomized, double-blind, placebo-controlled study. PARTICIPANTS:A total of 752 patients aged 60 and older with diagnosis...
journal_title：Journal of the American Geriatrics Society
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1532-5415.2004.52015.x
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN:A cross-sectional comparison of cognitive screening tests to an independent criterion standard evaluation using Diagnostic and Statisti...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2012.03967.x
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To examine the relationship between gender and specific types of behavior problems that occur in patients with Alzheimer's disease. DESIGN:This was an observational study using the Dementia Behavior Disturbance Scale to quantify and define behavioral problems encountered by caregivers. Multiple regressions w...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb01447.x
更新日期：1996-05-01 00:00:00
abstract：:Chronic atrial fibrillation is generally thought to cause stroke by atrial thrombus formation with subsequent embolization. Rheumatic heart disease previously led to most cases of atrial fibrillation, but recent substantial declines in the incidence of rheumatic fever have changed the distribution of causes of atrial ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1985.tb07121.x
更新日期：1985-04-01 00:00:00
abstract：:A history of systolic (greater than or equal to 160 mm Hg) or diastolic (greater than or equal to 90 mm Hg) hypertension, diabetes mellitus (fasting venous plasma glucose greater than or equal to 140 mg/dl), a history of cigarette smoking, fasting serum total cholesterol greater than or equal to 200 mg/dl and greater ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1987.tb01311.x
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVES:To examine the association between handgrip strength and mortality in older Mexican American men and women. DESIGN:A 5-year prospective cohort study. SETTING:Five southwestern states: Texas, New Mexico, Colorado, Arizona, and California. PARTICIPANTS:A population-based sample of 2,488 noninstitutionalized...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2002.50312.x
更新日期：2002-07-01 00:00:00
