Abstract:
OBJECTIVES:To report on the efficacy, safety, and tolerability of sertraline in the treatment of elderly depres-sed patients with and without comorbid medical illness. SETTING:Multicenter. DESIGN:Randomized, double-blind, placebo-controlled study. PARTICIPANTS:A total of 752 patients aged 60 and older with diagnosis of major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis. MEASUREMENTS:Outcome measures included the 17-item Hamilton Depression Scale (HAMD); the Clinical Global Depression-Severity/Improvement (CGI-S/CGI-I); efficacy and safety/adverse event assessments; Quality of Life, Enjoyment, and Satisfaction Questionnaire; and the Medical Outcomes Study 36-Item Short-Form Health Status Survey. RESULTS:In the overall sample, sertraline was superior to placebo on all three primary outcome measures, HAMD, and overall clinical severity and change (CGI-S/CGI-I). Furthermore, therapeutic response to sertraline was comparable in those with or without medical comorbidity, and there were no treatment-by-comorbidity group interactions. Sertraline was also associated with a faster time to response than placebo in the comorbid group (P<.006). Sertraline-treated patients in the comorbid group had similar adverse events and discontinuations when compared to those in the noncomorbid group. CONCLUSION:Sertraline was efficacious in reducing depressive symptomatology, regardless of the presence of comorbid medical illness. Sertraline was safe and well tolerated by patients with or without medical illness.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Sheikh JI,Cassidy EL,Doraiswamy PM,Salomon RM,Hornig M,Holland PJ,Mandel FS,Clary CM,Burt Tdoi
10.1111/j.1532-5415.2004.52015.xsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
86-92issue
1eissn
0002-8614issn
1532-5415pii
52015journal_volume
52pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To determine if home environmental hazards increase the risk of fall injury events among community-dwelling older persons. DESIGN:Population-based case-control study. SETTING:South Miami Beach, Florida. PARTICIPANTS:270 persons aged 65 years and older who sought treatment at six area hospitals for injuries...
journal_title:Journal of the American Geriatrics Society
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abstract:OBJECTIVES:To determine the effectiveness of vitamin D supplementation in preventing decline in physical function in older men. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Single-center study conducted at a Veterans Affairs Healthcare System. PARTICIPANTS:Sedentary men aged 65 to 90 (...
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journal_title:Journal of the American Geriatrics Society
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更新日期:2006-02-01 00:00:00
abstract::Patients with diabetes mellitus and an underlying mixed axonal and demyelinating polyneuropathy are particularly prone to compression neuropathies with consequent axonal degeneration and a poor prognosis for recovery. This hazard should be taken into account whenever a prolonged surgical procedure is contemplated. An ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1980.tb00515.x
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abstract:OBJECTIVES:To determine whether elderly people who meet national guidelines have higher physical function (PF) scores than those who do not and the effect on functional trajectory when physical activity (PA) levels change from above to below this threshold, or vice versa. DESIGN:Pooled data. SETTING:Two 6-month rando...
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doi:10.1111/j.1532-5415.1996.tb01437.x
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更新日期:1987-01-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1980.tb00004.x
更新日期:1980-12-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2007.01447.x
更新日期:2007-12-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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doi:10.1046/j.1532-5415.2002.50510.x
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abstract:OBJECTIVES:To determine the effect of new oral anticoagulants (NOACs) on prescribing practices in older adults with atrial fibrillation (AF). DESIGN:Retrospective observational cohort study. SETTING:Academic medical center in St. Louis, Missouri. PARTICIPANTS:Individuals aged 75 and older with AF admitted to the hos...
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更新日期:2017-11-01 00:00:00
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abstract:OBJECTIVE:Validation of a new instrument for screening dementia, the Cross Cultural Cognitive Examination (CCCE), is described. DESIGN:Criterion and concurrent validation and cross-cultural comparison of a new instrument. PARTICIPANTS:All individuals over the age of 40 in a village in southern Guam participated in a ...
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abstract:OBJECTIVES:To summarize the evidence on the prevalence and preventability of drug-related hospital readmissions. DESIGN:A systematic review was performed of studies that examined drug-related hospital readmissions. PubMed, EMBASE, and the Cochrane Library were searched from inception through August 2016. Reference lis...
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更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and outcomes of breathlessness in older Americans. SETTING:Community-dwelling older adults. PARTICIPANTS:Individuals aged 70 and older in the nationally representative Health and Retirement Study (2008, follow-up through 2012) (N = 3,671; mean age 78). MEASUREMENTS:Breathlessne...
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abstract::Historically, the medical subspecialties have not focused on the needs of older adults. This has changed with the implementation of initiatives to integrate geriatrics and aging research into the medical and surgical subspecialties and with the establishment of a home for internal medicine specialists within the annua...
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abstract:OBJECTIVES:To examine loss of community-dwelling status 9 months after hospitalization for high-acuity emergency general surgery (HA-EGS) disease among older Americans. DESIGN:Retrospective analysis of claims data. SETTING:US communities with Medicare beneficiaries. PARTICIPANTS:Medicare beneficiaries age 65 years o...
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journal_title:Journal of the American Geriatrics Society
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更新日期:1985-05-01 00:00:00
abstract:OBJECTIVES:To provide normative values of tests of cognitive and physical function based on a large sample representative of the population of Ireland aged 50 and older. DESIGN:Data were used from the first wave of The Irish Longitudinal Study on Ageing (TILDA), a prospective cohort study that includes a comprehensive...
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更新日期:2013-05-01 00:00:00