Efficacy, safety, and tolerability of sertraline in patients with late-life depression and comorbid medical illness.

Abstract:

OBJECTIVES:To report on the efficacy, safety, and tolerability of sertraline in the treatment of elderly depres-sed patients with and without comorbid medical illness. SETTING:Multicenter. DESIGN:Randomized, double-blind, placebo-controlled study. PARTICIPANTS:A total of 752 patients aged 60 and older with diagnosis of major depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis. MEASUREMENTS:Outcome measures included the 17-item Hamilton Depression Scale (HAMD); the Clinical Global Depression-Severity/Improvement (CGI-S/CGI-I); efficacy and safety/adverse event assessments; Quality of Life, Enjoyment, and Satisfaction Questionnaire; and the Medical Outcomes Study 36-Item Short-Form Health Status Survey. RESULTS:In the overall sample, sertraline was superior to placebo on all three primary outcome measures, HAMD, and overall clinical severity and change (CGI-S/CGI-I). Furthermore, therapeutic response to sertraline was comparable in those with or without medical comorbidity, and there were no treatment-by-comorbidity group interactions. Sertraline was also associated with a faster time to response than placebo in the comorbid group (P<.006). Sertraline-treated patients in the comorbid group had similar adverse events and discontinuations when compared to those in the noncomorbid group. CONCLUSION:Sertraline was efficacious in reducing depressive symptomatology, regardless of the presence of comorbid medical illness. Sertraline was safe and well tolerated by patients with or without medical illness.

journal_name

J Am Geriatr Soc

authors

Sheikh JI,Cassidy EL,Doraiswamy PM,Salomon RM,Hornig M,Holland PJ,Mandel FS,Clary CM,Burt T

doi

10.1111/j.1532-5415.2004.52015.x

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

86-92

issue

1

eissn

0002-8614

issn

1532-5415

pii

52015

journal_volume

52

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Home environmental hazards and the risk of fall injury events among community-dwelling older persons. Study to Assess Falls Among the Elderly (SAFE) Group.

    abstract:OBJECTIVE:To determine if home environmental hazards increase the risk of fall injury events among community-dwelling older persons. DESIGN:Population-based case-control study. SETTING:South Miami Beach, Florida. PARTICIPANTS:270 persons aged 65 years and older who sought treatment at six area hospitals for injuries...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1998.tb03799.x

    authors: Sattin RW,Rodriguez JG,DeVito CA,Wingo PA

    更新日期:1998-06-01 00:00:00

  • Vitamin D and Physical Function in Sedentary Older Men.

    abstract:OBJECTIVES:To determine the effectiveness of vitamin D supplementation in preventing decline in physical function in older men. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Single-center study conducted at a Veterans Affairs Healthcare System. PARTICIPANTS:Sedentary men aged 65 to 90 (...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgs.14510

    authors: Levis S,Gómez-Marín O

    更新日期:2017-02-01 00:00:00

  • Hyponatremia and arginine vasopressin dysregulation: mechanisms, clinical consequences, and management.

    abstract::Hyponatremia, the most common electrolyte disorder, occurs frequently in older people and in hospitalized patients. Physiological changes of aging that interact with diseases and drugs commonly present in older people put this population at greater risk for hyponatremia. It can accompany central nervous system disorde...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.2005.00609.x

    authors: Miller M

    更新日期:2006-02-01 00:00:00

  • Compression injury of the sciatic nerve during a prolonged surgical procedure in a diabetic patient.

    abstract::Patients with diabetes mellitus and an underlying mixed axonal and demyelinating polyneuropathy are particularly prone to compression neuropathies with consequent axonal degeneration and a poor prognosis for recovery. This hazard should be taken into account whenever a prolonged surgical procedure is contemplated. An ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1980.tb00515.x

    authors: Massey EW,Pleet AB

    更新日期:1980-04-01 00:00:00

  • Effect of physical activity guidelines on physical function in older adults.

    abstract:OBJECTIVES:To determine whether elderly people who meet national guidelines have higher physical function (PF) scores than those who do not and the effect on functional trajectory when physical activity (PA) levels change from above to below this threshold, or vice versa. DESIGN:Pooled data. SETTING:Two 6-month rando...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2008.01937.x

    authors: Morey MC,Sloane R,Pieper CF,Peterson MJ,Pearson MP,Ekelund CC,Crowley GM,Demark-Wahnefried W,Snyder DC,Clipp EC,Cohen HJ

    更新日期:2008-10-01 00:00:00

  • Restarting the cycle: incidence and predictors of first acute care use after nursing home discharge.

    abstract:OBJECTIVES:To describe the time to first acute care use (e.g., emergency department (ED) use without hospitalization or rehospitalization) for older adults discharged to home after receiving postacute care in skilled nursing facilities (SNFs); to identify predictors of first acute care use. DESIGN:Retrospective cohort...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12602

    authors: Toles M,Anderson RA,Massing M,Naylor MD,Jackson E,Peacock-Hinton S,Colón-Emeric C

    更新日期:2014-01-01 00:00:00

  • Cognitive Performance Among Older Persons in Japan and the United States.

    abstract:OBJECTIVE:To compare cognitive performance among Japanese and American persons, aged 68 years and older, using two nationally representative studies and to examine whether differences can be explained by differences in the distribution of risk factors or in their association with cognitive performance. DESIGN:National...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16163

    authors: Saito Y,Kim JK,Davarian S,Hagedorn A,Crimmins EM

    更新日期:2020-02-01 00:00:00

  • Left ventricular hypertrophy on electrocardiogram: prognostic implications from a 10-year cohort study of older subjects: a report from the Bronx Longitudinal Aging Study.

    abstract:OBJECTIVE:The objective of this study was to report on the prevalence, incidence and prognosis of left ventricular hypertrophy (LVH) on the electrocardiogram (ECG) in a cohort of ambulatory older men and women. DESIGN:A prospective, longitudinal study of 10 years duration with ECGs obtained at baseline and on an annua...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb01437.x

    authors: Kahn S,Frishman WH,Weissman S,Ooi WL,Aronson M

    更新日期:1996-05-01 00:00:00

  • Risk factors for atherothrombotic brain infarction in persons over 62 years of age in a long-term health care facility.

    abstract::A history of systolic (greater than or equal to 160 mm Hg) or diastolic (greater than or equal to 90 mm Hg) hypertension, diabetes mellitus (fasting venous plasma glucose greater than or equal to 140 mg/dl), a history of cigarette smoking, fasting serum total cholesterol greater than or equal to 200 mg/dl and greater ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1987.tb01311.x

    authors: Aronow WS,Starling L,Etienne F,D'Alba P,Edwards M,Lee NH,Parungao RF,Sales FF

    更新日期:1987-01-01 00:00:00

  • Leadership, Inside and Out: The Tideswell-AGS-ADGAP Emerging Leaders in Aging Program.

    abstract:BACKGROUND/OBJECTIVES:To optimize health and well-being for all older people, we must collectively develop leaders to pioneer models of care, educate the healthcare workforce, advance research, and engage the community. METHODS:The Emerging Leaders in Aging (ELIA) program was created to train a multiprofessional cadre...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15702

    authors: Chang A,Lundebjerg NE,Abrams J,Barnes DE,Fain MJ,Hall WJ,Johnson TM 2nd,Michael Harper G,Williams B,Ritchie CS

    更新日期:2019-03-01 00:00:00

  • Demographic characteristics of elderly drug overdose patients admitted to a hospital emergency department.

    abstract::This study was undertaken to identify the demographic characteristics of patients aged 55 or older in a drug-overdose group admitted to the Emergency Department of Arizona Health Sciences Center during the 3-year period, August 1975-July 1978. Of the 646 overdose patients observed, 60 (9.5 percent) were aged 55 or old...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1980.tb00004.x

    authors: Schernitski P,Bootman JL,Byers J,Likes K,Hughes JH

    更新日期:1980-12-01 00:00:00

  • Objectively Measured Physical Activity Reduces the Risk of Mortality among Brazilian Older Adults.

    abstract:OBJECTIVES:Use of objectively measured physical activity (PA) in older adults to assess relationship between PA and risk of all-causes mortality is scarce. This study evaluated the associations of PA based on accelerometry and a questionnaire with the risk of mortality among older adults from a city in Southern Brazil....

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16180

    authors: Bielemann RM,LaCroix AZ,Bertoldi AD,Tomasi E,Demarco FF,Gonzalez MC,Crespo da Silva PA,Wendt A,Mohnsam da Silva IC,Brage S,Ekelund U,Pratt M

    更新日期:2020-01-01 00:00:00

  • Effectiveness of multidimensional exercises for the treatment of stress urinary incontinence in elderly community-dwelling Japanese women: a randomized, controlled, crossover trial.

    abstract:OBJECTIVES:To evaluate the effectiveness of pelvic floor muscle (PFM) and fitness exercises in reducing urine leakage in elderly women with stress urinary incontinence (UI). DESIGN:Randomized, crossover, follow-up trial. SETTING:Urban community in Japan. PARTICIPANTS:Seventy women aged 70 and older who reported urin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2007.01447.x

    authors: Kim H,Suzuki T,Yoshida Y,Yoshida H

    更新日期:2007-12-01 00:00:00

  • Description of the National Pressure Ulcer Long-Term Care Study.

    abstract:OBJECTIVES:To describe and provide baseline data from The National Pressure Ulcer Long-Term Care Study (NPULS). DESIGN:Retrospective cohort study of detailed resident characteristics, treatments, and outcomes using convenience sampling. SETTING:One hundred nine long-term care facilities throughout the United States. ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2002.50510.x

    authors: Horn SD,Bender SA,Bergstrom N,Cook AS,Ferguson ML,Rimmasch HL,Sharkey SS,Smout RJ,Taler GA,Voss AC

    更新日期:2002-11-01 00:00:00

  • Effect of New Oral Anticoagulants on Prescribing Practices for Atrial Fibrillation in Older Adults.

    abstract:OBJECTIVES:To determine the effect of new oral anticoagulants (NOACs) on prescribing practices in older adults with atrial fibrillation (AF). DESIGN:Retrospective observational cohort study. SETTING:Academic medical center in St. Louis, Missouri. PARTICIPANTS:Individuals aged 75 and older with AF admitted to the hos...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15058

    authors: Fohtung RB,Novak E,Rich MW

    更新日期:2017-11-01 00:00:00

  • Detecting Delirium: A Systematic Review of Identification Instruments for Non-ICU Settings.

    abstract:BACKGROUND/OBJECTIVES:Delirium manifests clinically in varying ways across settings. More than 40 instruments currently exist for characterizing the different manifestations of delirium. We evaluated all delirium identification instruments according to their psychometric properties and frequency of citation in publishe...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/jgs.16879

    authors: Helfand BKI,D'Aquila ML,Tabloski P,Erickson K,Yue J,Fong TG,Hshieh TT,Metzger ED,Schmitt EM,Boudreaux ED,Inouye SK,Jones RN

    更新日期:2020-11-02 00:00:00

  • Cross-cultural cognitive examination: validation of a dementia screening instrument for neuroepidemiological research.

    abstract:OBJECTIVE:Validation of a new instrument for screening dementia, the Cross Cultural Cognitive Examination (CCCE), is described. DESIGN:Criterion and concurrent validation and cross-cultural comparison of a new instrument. PARTICIPANTS:All individuals over the age of 40 in a village in southern Guam participated in a ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1993.tb06758.x

    authors: Glosser G,Wolfe N,Albert ML,Lavine L,Steele JC,Calne DB,Schoenberg BS

    更新日期:1993-09-01 00:00:00

  • Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies.

    abstract:OBJECTIVES:To investigate the natural history, cause of death, and end-of-life experiences of individuals diagnosed with dementia with Lewy bodies (DLB). DESIGN:Twenty-question online survey administered through the Lewy Body Dementia Association. SETTING:United States. PARTICIPANTS:Caregivers, family, and friends o...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15608

    authors: Armstrong MJ,Alliance S,Corsentino P,DeKosky ST,Taylor A

    更新日期:2019-01-01 00:00:00

  • Stroke prophylaxis in institutionalized elderly patients with atrial fibrillation.

    abstract:OBJECTIVES:To identify patterns and predictors of antithrombotic use and to evaluate the appropriateness of antithrombotic therapy for stroke prophylaxis in institutionalized elderly patients with atrial fibrillation. DESIGN:Retrospective study. SETTING:Seventeen long-term care institutions in Edmonton, Alberta. SUB...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52117.x

    authors: Lau E,Bungard TJ,Tsuyuki RT

    更新日期:2004-03-01 00:00:00

  • Environmental Factors Associated with Chinese Older Immigrants' Social Engagement.

    abstract:BACKGROUND/ OBJECTIVES:Prior research has shown that social engagement is beneficial to older adults' health and well-being. This study examined the association between environmental factors and social engagement of older Chinese immigrants in the United States. SAMPLE:A cross-sectional data set of Chinese immigrants ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15899

    authors: Lai DWL,Li J,Lee VWP,Dong X

    更新日期:2019-08-01 00:00:00

  • Treatment of hypertension in the elderly with pindolol and clopamide.

    abstract::After a 2-week washout period, 30 elderly hypertensive patients were treated with pindolol (a beta-adrenergic blocker) for 3 weeks. In 13 patients the reduction in blood pressure was satisfactory and treatment with pindolol was continued for another 4 weeks. In 17 patients the subsequent treatment was supplemented wit...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1978.tb03680.x

    authors: Persson I

    更新日期:1978-08-01 00:00:00

  • Prevalence and Preventability of Drug-Related Hospital Readmissions: A Systematic Review.

    abstract:OBJECTIVES:To summarize the evidence on the prevalence and preventability of drug-related hospital readmissions. DESIGN:A systematic review was performed of studies that examined drug-related hospital readmissions. PubMed, EMBASE, and the Cochrane Library were searched from inception through August 2016. Reference lis...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15244

    authors: El Morabet N,Uitvlugt EB,van den Bemt BJF,van den Bemt PMLA,Janssen MJA,Karapinar-Çarkit F

    更新日期:2018-03-01 00:00:00

  • Practical problems with medication use that older people experience: a qualitative study.

    abstract:OBJECTIVES:To identify the practical problems that older people experience with the daily use of their medicines and their management strategies to address these problems and to determine the potential clinical relevance thereof. DESIGN:Qualitative study with semistructured face-to-face interviews. SETTING:A communit...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.13126

    authors: Notenboom K,Beers E,van Riet-Nales DA,Egberts TC,Leufkens HG,Jansen PA,Bouvy ML

    更新日期:2014-12-01 00:00:00

  • Prevalence and Outcomes of Breathlessness in Older Adults: A National Population Study.

    abstract:OBJECTIVES:To determine the prevalence and outcomes of breathlessness in older Americans. SETTING:Community-dwelling older adults. PARTICIPANTS:Individuals aged 70 and older in the nationally representative Health and Retirement Study (2008, follow-up through 2012) (N = 3,671; mean age 78). MEASUREMENTS:Breathlessne...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14313

    authors: Smith AK,Currow DC,Abernethy AP,Johnson MJ,Miao Y,Boscardin WJ,Ritchie CS

    更新日期:2016-10-01 00:00:00

  • Pneumonia versus aspiration pneumonitis in nursing home residents: diagnosis and management.

    abstract:OBJECTIVES:To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis of pneumonia and to compare the clinical characteristics, management, and outcome of aspiration pneumonitis with those of pneumonia. DESIGN:Retrospective chart review. SETTING:Hospital geriatric unit fo...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1034/j.1601-5215.2002.51004.x

    authors: Mylotte JM,Goodnough S,Naughton BJ

    更新日期:2003-01-01 00:00:00

  • Aging, the Medical Subspecialties, and Career Development: Where We Were, Where We Are Going.

    abstract::Historically, the medical subspecialties have not focused on the needs of older adults. This has changed with the implementation of initiatives to integrate geriatrics and aging research into the medical and surgical subspecialties and with the establishment of a home for internal medicine specialists within the annua...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14708

    authors: Hurria A,High KP,Mody L,McFarland Horne F,Escobedo M,Halter J,Hazzard W,Schmader K,Klepin H,Lee S,Makris UE,Rich MW,Rogers S,Wiggins J,Watman R,Choi J,Lundebjerg N,Zieman S

    更新日期:2017-04-01 00:00:00

  • Value of neuropsychological tests, neuroimaging, and biomarkers for diagnosing Alzheimer's disease in younger and older age cohorts.

    abstract:OBJECTIVES:To examine the influence of age on the value of four techniques for diagnosing Alzheimer's disease (AD). DESIGN:Observational cohort study. SETTING:Alzheimer's Disease Neuroimaging Initiative. PARTICIPANTS:Individuals with mild cognitive impairment (MCI; n = 179), individuals with AD (n = 91), and normal ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03539.x

    authors: Schmand B,Eikelenboom P,van Gool WA,Alzheimer's Disease Neuroimaging Initiative.

    更新日期:2011-09-01 00:00:00

  • Loss of Community-Dwelling Status Among Survivors of High-Acuity Emergency General Surgery Disease.

    abstract:OBJECTIVES:To examine loss of community-dwelling status 9 months after hospitalization for high-acuity emergency general surgery (HA-EGS) disease among older Americans. DESIGN:Retrospective analysis of claims data. SETTING:US communities with Medicare beneficiaries. PARTICIPANTS:Medicare beneficiaries age 65 years o...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16046

    authors: Smith JW,Knight Davis J,Quatman-Yates CC,Waterman BL,Strassels SA,Wong JD,Heh VK,Baselice HE,Brock GN,Clark BC,Bridges JFP,Santry HP

    更新日期:2019-11-01 00:00:00

  • The use of quality-of-life considerations in medical decision making.

    abstract::Quality-of-life considerations in physicians' decisions on life-sustaining therapy were explored using a patient management problem (PMP) depicting acute respiratory failure in an elderly man with chronic pulmonary disease; 205 internal medicine and family medicine physicians were interviewed. The physicians' percepti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1985.tb07135.x

    authors: Pearlman RA,Jonsen A

    更新日期:1985-05-01 00:00:00

  • Normative values of cognitive and physical function in older adults: findings from the Irish Longitudinal Study on Ageing.

    abstract:OBJECTIVES:To provide normative values of tests of cognitive and physical function based on a large sample representative of the population of Ireland aged 50 and older. DESIGN:Data were used from the first wave of The Irish Longitudinal Study on Ageing (TILDA), a prospective cohort study that includes a comprehensive...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12195

    authors: Kenny RA,Coen RF,Frewen J,Donoghue OA,Cronin H,Savva GM

    更新日期:2013-05-01 00:00:00