Abstract:
OBJECTIVES:To investigate long-term variability in serum high-sensitivity C-reactive protein (CRP) and interleukin-6 (IL-6) and to determine associated risk factors for high-risk inflammatory profiles. DESIGN:Prospective population-based cohort study. PARTICIPANTS:Participants (N = 1,443) of the Epidemiology of Hearing Loss Study and the Beaver Dam Eye Study, two population-based prospective studies of aging in the same cohort. MEASUREMENTS:In participants aged 43 to 79 at the initial examination (1988-1990), serum high-sensitivity CRP was measured from three time-points (1988-1990, 1998-2000, 2009-2010), and serum IL-6 was measured from two (1998-2000, 2009-2010). RESULTS:When IL-6 levels were categorized into tertiles, 50.8% of participants were in the same group 10 years later (weighted kappa (κ) = 0.34). When CRP was categorized into three risk groups, 53.4% of participants were in the same group 10 years later (κ = 0.36), and 32.4% were in the same group at all three examinations (κ = 0.27). IL-6 increased from a geometric mean of 1.54 pg/L to 1.78 pg/L over 10 years, whereas CRP increased from a geometric mean of 1.67 mg/L to 2.25 mg/L over 10 years and then decreased to 1.93 mg/L over the next 10 years. These 10-year decreases in CRP were not observed in those not reporting statin use. Factors associated with long-term higher levels of IL-6 and CRP were older age (IL-6), obesity, smoking, lower physical activity (IL-6), lower high-density lipoprotein cholesterol (IL-6), and a history of statin (non)use (CRP). CONCLUSION:Inflammatory marker levels tracked over the long term into older age with within-person increases were observed. Several potentially modifiable risk factors were associated with long-term higher levels of inflammatory markers.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Nash SD,Cruickshanks KJ,Klein R,Klein BE,Nieto FJ,Chappell R,Schubert CR,Tsai MYdoi
10.1111/jgs.12382subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1269-76issue
8eissn
0002-8614issn
1532-5415journal_volume
61pub_type
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abstract::A rough plan is proposed which may facilitate the care of geriatric patients. The plan is to introduce pilot programs of geriatric regional centers attached to Veteran's Administration hospitals. Thus, at minimal cost, the problems of geriatric medicine would be under the supervision of our excellent university medica...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1966.tb03082.x
更新日期:1966-05-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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journal_title:Journal of the American Geriatrics Society
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doi:10.1111/j.1532-5415.1986.tb03985.x
更新日期:1986-11-01 00:00:00
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更新日期:2005-02-01 00:00:00
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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