Abstract：
:Solid tumors may modulate their environment and keep stromal cells in an immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not only cancer cells but also nonmalignant stromal cells by T cells is required for the eradication of established tumor. Interestingly, a single adoptive transfer of effector T cells that recognize tumor antigen-loaded stromal cells, but not the cancer cells themselves, causes long-term inhibition of tumor growth associated with T cell-mediated killing of stromal CD11b+/Gr1+ myeloid cells. Therefore, targeting tumor stroma by T cells points to an important alternative approach to the effective control of tumor growth, particularly in the absence of direct targeting of cancer cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Zhang Bdoi
10.1158/0008-5472.CAN-08-2414subject
Has Abstractpub_date
2008-12-01 00:00:00pages
9570-3issue
23eissn
0008-5472issn
1538-7445pii
68/23/9570journal_volume
68pub_type
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