Abstract:
OBJECTIVES:The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs). METHODS:The report included workers exposed to diesel exhausts (low PAH exposure level, n = 39) as well as those exposed to emissions from asphalt (medium PAH exposure level, n = 26) and coke ovens (high PAH exposure level, n = 28). Levels of Nap and Phe were measured in urine from each subject using head space-solid phase microextraction and gas chromatography-mass spectrometry. Published levels of airborne Nap, Phe and other PAHs in the coke-producing and aluminium industries were also investigated. RESULTS:In post-shift urine, the highest estimated geometric mean concentrations of Nap and Phe were observed in coke-oven workers (Nap: 2490 ng/l; Phe: 975 ng/l), followed by asphalt workers (Nap: 71.5 ng/l; Phe: 54.3 ng/l), and by diesel-exposed workers (Nap: 17.7 ng/l; Phe: 3.60 ng/l). After subtracting logged background levels of Nap and Phe from the logged post-shift levels of these PAHs in urine, the resulting values (referred to as ln(adjNap) and ln(adjPhe), respectively) were significantly correlated in each group of workers (0.71 < or = Pearson r < or = 0.89), suggesting a common exposure source in each case. Surprisingly, multiple linear regression analysis of ln(adjNap) on ln(adjPhe) showed no significant effect of the source of exposure (coke ovens, asphalt and diesel exhaust) and further suggested that the ratio of urinary Nap/Phe (in natural scale) decreased with increasing exposure levels. These results were corroborated with published data for airborne Nap and Phe in the coke-producing and aluminium industries. The published air measurements also indicated that Nap and Phe levels were proportional to the levels of all combined PAHs in those industries. CONCLUSION:Levels of Nap and Phe in urine reflect airborne exposures to these compounds and are promising surrogates for occupational exposures to PAH mixtures.
journal_name
Occup Environ Medjournal_title
Occupational and environmental medicineauthors
Sobus JR,Waidyanatha S,McClean MD,Herrick RF,Smith TJ,Garshick E,Laden F,Hart JE,Zheng Y,Rappaport SMdoi
10.1136/oem.2008.041418subject
Has Abstractpub_date
2009-02-01 00:00:00pages
99-104issue
2eissn
1351-0711issn
1470-7926pii
oem.2008.041418journal_volume
66pub_type
杂志文章abstract:OBJECTIVES:To investigate the relation between shift work and death from ischaemic heart disease (IHD). METHODS:A nested case-control approach was used. The cohort comprised male manual workers who joined an industrial company aged 50 years or under between 1 January 1950 and 31 December 1992 and worked there for at l...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.53.6.367
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of lumbar supports, education, and exercise in the prevention of back pain in industry. METHODS:A computerised search for controlled clinical trials was conducted. A criteria list was used to assess the methodological quality of the studies. The available evidence for the effectiv...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oem.54.12.841
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:Mental disorders are associated with significant functional impairment, sickness absence and disability. The consequences of sickness absence warrant investigation into interventions aimed at enhancing return to work (RTW) for workers with mental disorders. The present systematic review and meta-analysis aim...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,meta分析
doi:10.1136/oemed-2018-105073
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:A medical surveillance programme was introduced into Ontario for workers exposed to diisocyanates in 1983, but no mandated surveillance programme is in effect in this province for other occupational respiratory sensitisers. This study assesses changes in incidence and severity of compensated claims for occup...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.59.1.58
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:Previous research has produced conflicting evidence on the relative merits of advancing and delaying shift systems. The current study assessed the effects of the direction of shift rotation within 8 hour systems, upon a range of measures including sleep, on shift alertness, physical health, and psychological...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.57.10.678
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVES:Rhinitis is common, but the risk factors are not well described. To investigate the association between current rhinitis and pesticide use, we used data from 2245 Iowa commercial pesticide applicators in the Agricultural Health Study. METHODS:Using logistic regression models adjusted for age, education and ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.041798
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To assess whether CFS-like caseness (meeting the criteria for chronic fatigue syndrome (CFS)) predicts work status in the long term. METHODS:Prospective study in a sample of fatigued employees absent from work. Data were collected at baseline and four years later, and included CFS-like caseness and work stat...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2005.023176
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:Compare rates of medical insurance claims for musculoskeletal disorders (MSD) between workers in a construction trade and a general worker population to determine if higher physical exposures in construction lead to higher rates of claims on personal medical insurance. METHODS:Health insurance claims betwee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2014-102313
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To verify in vivo whether lung cinescintigraphy confirms the effect of asbestos on the patency of the smallest airways and on the efficiency of mucociliary clearance in asbestos cement workers. METHODS:39 male subjects were examined: 30 asbestos cement workers and nine workers never exposed to occupational ...
journal_title:Occupational and environmental medicine
pub_type: 临床试验,杂志文章
doi:10.1136/oem.53.9.628
更新日期:1996-09-01 00:00:00
abstract::Although the neurological and cardiovascular effects of Freons have been extensively described, the respiratory effects have been less well documented. We report four cases of occupational asthma following accidental exposure to bromochlorodifluoromethane (Halon 1211) due to release of the contents of a fire extinguis...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.009837
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Assessment of level of exposure to platinum and platinum concentration in urine from platinum industry workers to evaluate internal exposures and excretion kinetics. METHODS:Platinum concentrations in urine samples from 34 workers were measured by adsorptive voltammetry after UV-photolysis. Morning and even...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.2.138
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVE:To describe the methods used in the nuclear industry family study for which a comprehensive database has been assembled that links employment in the nuclear industry and dosimetry records to information on employees' reproductive health and the health of their children. To discuss the response rates and chara...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.56.12.793
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and immunological measurements using blood samples from coke oven workers exposed to high and low PAH levels. METHODS:A population-based cross-sectional study was conducted from 2008-2009 with coke oven workers and stee...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2010.055020
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:Molecular epidemiological techniques, capable of detecting damage to DNA, were used to see if such damage occurred in the lymphocytes of a group of workers exposed to chromium. The two aims of this pilot study were to see if these new techniques might make useful biological monitoring tools for workers expos...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.10.663
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of cigarette smoking cessation and examine the association between cessation and various factors among workers in a nationally representative sample of US adults. METHODS:Data were derived from the 2010 National Health Interview Survey. Prevalence rates were calculated for intere...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101852
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. METHODS:This study analyses mortality in a pooled cohort of 93 771 crew members f...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101395
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:To examine the effect of occupation on respiratory symptoms in a randomly selected adult population aged 20-44 years. METHODS:It is based on the phase II sampling of the New Zealand part of the European Community respiratory health survey. 1609 people (63.9% response rate) completed a detailed respiratory q...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.54.5.301
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:Self-reported exposure to vapours, gas, dust or fumes (VGDF) has been widely used as an occupational exposure metric in epidemiological studies of chronic lung diseases. Our objective was to characterise the performance of VGDF for repeatability, systematic misclassification, and sensitivity and specificity ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.040022
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:It remains unclear over whether it is possible to develop an epidemic forecasting model for transmission of dengue fever in Queensland, Australia. OBJECTIVES:To examine the potential impact of El Niño/Southern Oscillation on the transmission of dengue fever in Queensland, Australia and explore the possibili...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2008.044966
更新日期:2010-05-01 00:00:00
abstract:AIMS:This study examines the impact of work-related psychosocial and mechanical exposure on the development of low back pain (LBP) in the general working population. METHODS:A randomly drawn cohort from the general population in Norway aged 18-66 years was followed up for 3 years (n=12 550, response rate at baseline=6...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2012-101116
更新日期:2013-05-01 00:00:00
abstract:AIMS:To investigate the longitudinal relation between strenuous leisure time physical activity and psychological complaints (depression and emotional exhaustion) in a Dutch working population in order to find evidence for the preventive role of physical activity in the development of psychological complaints. METHODS:...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/oem.2004.017541
更新日期:2006-01-01 00:00:00
abstract::Mortality data have been updated for a further 12 years for a cohort of workers in the reinforced plastics and composites industry with exposures to styrene monomer and other chemicals. The cohort consisted of 15,826 male and female employees who were exposed to styrene for at least six months between 1948 and 1977 at...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.51.6.386
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Vibration white finger (VWF) is characterised by arterial hyperresponsiveness and vasoconstriction following cold provocation. Several years after of removal from exposure, most subjects show improved finger systolic blood pressure (FSBP) under conditions of cold challenge, but continue to report cold hands ...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.12.962
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of enzyme sensitisation in the animal feed industry. METHODS:A cross sectional study was conducted in four animal feed factories, where several enzymes had been used in powder form for 7-9 years. Before this study, enzymes in liquid form had started to be used. Sensitisation to enzy...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.58.2.119
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:Analyses of secular trends in work-related fatal injury in New Zealand have previously only considered the total working population, potentially hiding trends for important subgroups of workers. This paper examines trends in work-related fatalities in worker subgroups between 2005 and 2014 to indicate wher...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2020-106812
更新日期:2020-10-26 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although past studies of workplace exposures have contributed greatly to our understanding of carcinogens, significant knowledge gaps still exist with regard to the actual extent of exposure among current workers, with no routinely collected population-based data being available in most countr...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oemed-2013-101651
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study assessed the efficacy of preventive measures in a graphite electrode plant aimed at reducing occupational exposure to polycyclic aromatic hydrocarbons (PAHs). METHODS:Electrode workers (n = 146) answered a questionnaire and provided an end of shift urine sample. Urinary 1-hydroxypyrene (1-hpur), a...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.55.6.401
更新日期:1998-06-01 00:00:00
abstract:AIMS:To investigate the acute systemic inflammatory response to welding fume exposure. METHODS:Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM2.5) was assessed using cyclone samplers. Markers of systemic inflammatio...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2004.014795
更新日期:2005-03-01 00:00:00
abstract::The "need for recovery scale" is suggested as an operationalisation for the measurement of (early symptoms of) fatigue at work. Definition of and background on the concept of need for recovery are briefly discussed. Details about scale construction are summarised. Correlations with other relevant measurement scales on...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.60.suppl_1.i3
更新日期:2003-06-01 00:00:00
abstract:AIMS:To determine the factors that affect why some infants receive higher exposures relative to the mother's body burden than do others. METHODS:A total of 159 mother-infant pairs from a cohort of women receiving prenatal care at Magee-Womens Hospital in Pittsburgh, PA from 1992 to 1995 provided blood samples at deliv...
journal_title:Occupational and environmental medicine
pub_type: 杂志文章
doi:10.1136/oem.2003.012492
更新日期:2005-04-01 00:00:00